Exosomes derived from siRNA against GRP78 modified bone-marrow-derived mesenchymal stem cells suppress Sorafenib resistance in hepatocellular carcinoma

Targeted iron nanoparticles with platinum-(IV) prodrugs and anti-EZH2 siRNA show great synergy in combating drug resistance in vitro and in vivo

(2018) Chang Yu et al.   BIOMATERIALS

MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity

(2018) Shipin Zhang et al.   BIOMATERIALS

GRP78 Promotes Hepatocellular Carcinoma proliferation by increasing FAT10 expression through the NF-κB pathway

(2018) Chenglin Luo et al.   EXPERIMENTAL CELL RESEARCH

Overexpression of endoplasmic reticulum stress-related proteins, XBP1s and GRP78, predicts poor prognosis in pulmonary adenocarcinoma

(2018) Dohee Kwon et al.   LUNG CANCER

Exosome Therapy for Stroke

(2018) Jieli Chen et al.   STROKE

Novel ADAM-17 inhibitor ZLDI-8 enhances the in vitro and in vivo chemotherapeutic effects of Sorafenib on hepatocellular carcinoma cells

(2018) Yingshi Zhang et al.   Cell Death & Disease

Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19

(2018) Jing Ren et al.   Theranostics

Immunomodulatory effects of mesenchymal stem cell-derived exosomes on experimental type-1 autoimmune diabetes

(2018) Shahrzad Nojehdehi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mesenchymal stem cells deliver exogenous miR-21 via exosomes to inhibit nucleus pulposus cell apoptosis and reduce intervertebral disc degeneration

(2017) Xiaofei Cheng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth

(2017) Daniele Bellavia et al.   Theranostics

Lipid nanoparticle-based co-delivery of epirubicin and BCL-2 siRNA for enhanced intracellular drug release and reversing multidrug resistance

(2017) Miao Yu et al.   Artificial Cells Nanomedicine and Biotechnology

Inhibition of acquired-resistance hepatocellular carcinoma cell growth by combining sorafenib with phosphoinositide 3-kinase and rat sarcoma inhibitor

(2016) Chang-Hao Wu et al.   JOURNAL OF SURGICAL RESEARCH

Effects of Sorafenib Dose on Acquired Reversible Resistance and Toxicity in Hepatocellular Carcinoma

(2015) E. A. Kuczynski et al.   CANCER RESEARCH

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Hepatocellular carcinoma surveillance with miRNAs

(2015) Alejandro Forner   LANCET ONCOLOGY

Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): a phase 3, randomised, double-blind, placebo-controlled trial

(2015) Jordi Bruix et al.   LANCET ONCOLOGY

CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA

(2015) Alice Conigliaro et al.   Molecular Cancer

Delivery of siRNA by MRI-visible nanovehicles to overcome drug resistance in MCF-7/ADR human breast cancer cells

(2014) Gan Lin et al.   BIOMATERIALS

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

(2014) M. Ono et al.   Science Signaling

Codelivery of an Optimal Drug/siRNA Combination Using Mesoporous Silica Nanoparticles To Overcome Drug Resistance in Breast Cancer in Vitro and in Vivo

(2013) Huan Meng et al.   ACS Nano

Additive antileukemia effects by GFI1B- and BCR–ABL-specific siRNA in advanced phase chronic myeloid leukemic cells

(2013) M Koldehoff et al.   CANCER GENE THERAPY

Exosomes as Intercellular Signaling Organelles Involved in Health and Disease: Basic Science and Clinical Applications

(2013) Chiara Corrado et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

(2013) Sander A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes for targeted siRNA delivery across biological barriers

(2012) Samir EL Andaloussi et al.   ADVANCED DRUG DELIVERY REVIEWS

Hepatocellular carcinoma

(2012) Alejandro Forner et al.   LANCET

Engineered Design of Mesoporous Silica Nanoparticles to Deliver Doxorubicin and P-Glycoprotein siRNA to Overcome Drug Resistance in a Cancer Cell Line

(2010) Huan Meng et al.   ACS Nano

Glucose-Regulated Protein 78 Is a Novel Contributor to Acquisition of Resistance to Sorafenib in Hepatocellular Carcinoma

(2009) Jeng-Fong Chiou et al.   ANNALS OF SURGICAL ONCOLOGY

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas

(2008) Hua-chuan Zheng et al.   HUMAN PATHOLOGY

Glucose-regulated protein 78 as a novel effector of BRCA1 for inhibiting stress-induced apoptosis

(2008) B H Y Yeung et al.   ONCOGENE