Article
Endocrinology & Metabolism
Alexander J. Moody, Marjorie Molina-Wilkins, Geoffrey D. Clarke, Aurora Merovci, Carolina Solis-Herrera, Eugenio Cersosimo, Robert J. Chilton, Patricia Iozzo, Amalia Gastaldelli, Muhammad Abdul-Ghani, Ralph A. DeFronzo
Summary: This study aimed to investigate the effects of pioglitazone on epicardial and paracardial adipose tissue, as well as diastolic function and insulin sensitivity in patients with type 2 diabetes mellitus. The results showed that pioglitazone reduced the areas of epicardial and paracardial adipose tissue, improved left ventricular diastolic function, and increased insulin sensitivity.
DIABETES OBESITY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Wei Ma, Baowei Zhang, Ying Yang, Litong Qi, Jin Zhou, Min Li, Jia Jia, Yan Zhang, Huo Yong
Summary: The study found a correlation between epicardial fat thickness (EFT) and left ventricular diastolic function parameters, with EFT2 showing a negative correlation with mean e', indicating the need for attention to this type of fat in cardiovascular disease therapy.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Endocrinology & Metabolism
Christopher M. Hearon, Shiva Reddy, Katrin A. Dias, Aditi Shankar, James MacNamara, Benjamin Levine, Satyam Sarma
Summary: This retrospective study aimed to determine the localized effects of regional epicardial adipose tissue (EAT) on adjacent myocardial left ventricular (LV) function. The results showed that EAT was associated with visceral adiposity and markers of diastolic function. However, there was no evidence for localized effects of regional EAT deposition on adjacent regional LV segment function.
Article
Cardiac & Cardiovascular Systems
B. Coyle-Asbil, E. J. B. Holjak, J. P. Marrow, R. Alshamali, L. M. Ogilvie, B. A. Edgett, L. D. Hopkinson, K. R. Brunt, J. A. Simpson
Summary: Cardiac reserve is a widely used health indicator and prognostic tool, but assessing it in preclinical models is challenging. There is less focus on diastolic reserve compared to systolic reserve. This study aimed to determine the techniques and parameters for assessing systolic and diastolic reserves in preclinical models. The findings showed that systolic reserve can be assessed using all techniques, but current methods are ineffective for evaluating diastolic reserve in healthy mice in vivo.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Sona M. Al Younis, Leontios J. Hadjileontiadis, Cesare Stefanini, Ahsan H. Khandoker
Summary: This article explores innovative methods for the early diagnosis and classification of heart failure using non-invasive sensor-based technologies. These technologies have significantly advanced cardiac care by enabling research, early detection, and support for clinical decision-making. The article discusses validated enhancements, challenges, and future trends in heart failure and dysfunction modeling, with a focus on non-invasive sensing technologies. The methodologies identified in the article highlight the importance of non-contact sensing setups and machine learning approaches in home, remote, and continuous monitoring of myocardial performance.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Mehmet Ege Ince, Kursad Turgut, Amir Naseri
Summary: The study aimed to determine sepsis-induced myocardial dysfunction in dogs with severe sepsis and septic shock using transthoracic echocardiography. It found that left ventricular diastolic dysfunction was common in septic dogs and may be a negative prognostic factor. Transthoracic echocardiography is a useful tool for identifying and monitoring myocardial dysfunction in dogs with septic shock.
Article
Peripheral Vascular Disease
So-Ryoung Lee, Kyung-Do Han, Eue-Keun Choi, Hyo-Jeong Ahn, Seil Oh, Gregory Y. H. Lip
Summary: The study found that in young adults, stage 1 isolated diastolic hypertension and isolated systolic hypertension were associated with a higher risk of incident atrial fibrillation compared to normal blood pressure, while stage 2 hypertension (including diastolic, systolic, and systolic-diastolic combined) was associated with even higher risks of atrial fibrillation.
Article
Cardiac & Cardiovascular Systems
Banafsheh Arshi, Hamid A. Aliahmad, M. Arfan Ikram, Daniel Bos, Maryam Kavousi
Summary: A larger epicardial fat volume (EFV) is associated with increased risks of cardiovascular disease and atrial fibrillation. This study found that EFV is also associated with impaired cardiac function and an increased risk of heart failure (HF).
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hang Zhou, Dong-Aolei An, Zhaohui Ni, Jianrong Xu, Yan Zhou, Wei Fang, Renhua Lu, Liang Ying, Jiaying Huang, Qiuying Yao, Dawei Li, Jiani Hu, Binghua Chen, Jianxiao Shen, Haijiao Jin, Yuehan Wei, Lara M. Fahmy, Du Jing, Jing Ye, Lei Xu, Lian-Ming Wu, Shan Mou
Summary: Epicardial adipose tissue (EAT) volume is an independent risk factor for diastolic dysfunction (DD) in dialysis patients. EAT volume is positively correlated with the severity of DD and is significantly related to T1 mapping, T2* mapping, global longitudinal strain (GLS), left atrial strain, e' velocity, and E/e ratio. EAT accumulation may be an independent risk factor for DD among dialysis patients.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Alexander J. Ryu, Vinayak Kumar, Barry A. Borlaug, Armando Manduca, Chaitanya K. Rao, Raymond J. Gibbons, Samuel J. Asirvatham, Bernard J. Gersh, Krishnaswamy Chandrasekaran, Philip A. Araoz, Jae K. Oh, Alexander C. Egbe, Atta Behfar, Nandan S. Anavekar
Summary: The study investigated the ratio of myocardial volume in systole to myocardial volume in diastole (MVs/MVd) to differentiate between normal hearts and various cardiomyopathies with normal ejection fractions.
Results showed significant differences in MVs/MVd ratio between pathological subgroups and normal subjects, suggesting its potential as a novel and easily-captured metric for assessing ventricular function.
The study concluded that MVs/MVd ratio can effectively distinguish normal ventricular function from different cardiomyopathies, indicating its clinical utility in assessing heart disease.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Alexey N. Sumin, Anna V. Shcheglova, Ekaterina V. Korok, Tatjana Ju. Sergeeva
Summary: This study revealed an increased frequency of right ventricular systolic and diastolic dysfunction in CAD patients 18 months after CABG. Initial clinical, echocardiographic parameters, and perioperative complications were associated with these changes in the postoperative period.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Banafsheh Arshi, Sven Geurts, Martijn J. Tilly, Marten van den Berg, Jan A. Kors, Dimitris Rizopoulos, M. Arfan Ikram, Maryam Kavousi
Summary: HRV indices are associated with worse systolic function in men and improvement in left atrial size in women. Higher HRV is associated with a higher risk of new-onset HF in men.
Article
Cardiac & Cardiovascular Systems
Amir A. Mahabadi, Viktoria Anapliotis, Iryna Dykun, Stefanie Hendricks, Fadi Al-Rashid, Peter Luedike, Matthias Totzeck, Tienush Rassaf
Summary: This study aimed to investigate the association between epicardial adipose tissue (EAT) and the development of heart failure with preserved ejection fraction (HFpEF) in patients with coronary artery disease. The results showed that EAT index (EATi) at baseline and its change over time were both associated with the development of HFpEF. This finding supports the need for further research on regulating EAT as a treatment target for HFpEF.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
James P. MacNamara, Vivek Koshti, I-Jou Cheng, Katrin A. Dias, Christopher M. Hearon, William Cornwell, Erin J. Howden, Benjamin D. Levine, Satyam Sarma
Summary: The study found that systolic-diastolic coupling (EDexc/S-exc ratio) declines linearly with healthy aging and is further reduced in HFpEF patients. The EDexc/S-exc ratio is able to predict HFpEF more accurately than e' velocity alone, making it a potentially useful diagnostic tool for detecting HFpEF.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2021)
Article
Cardiac & Cardiovascular Systems
Sandor Batkai, Celina Genschel, Janika Viereck, Steffen Rump, Christian Baer, Tobias Borchert, Denise Traxler, Martin Riesenhuber, Andreas Spannbauer, Dominika Lukovic, Katrin Zlabinger, Ena Hasimbegovic, Johannes Winkler, Rita Garamvolgyi, Sonja Neitzel, Mariann Gyoengyoesi, Thomas Thum
Summary: In a chronic model of post-myocardial infarction heart failure, monthly administration of CDR132L improved cardiac function, reversed cardiac remodelling, and ameliorated diastolic function, indicating its safety and therapeutic efficacy for chronic heart failure treatment.
EUROPEAN HEART JOURNAL
(2021)
Article
Medicine, General & Internal
Satish Ramkumar, Hiroshi Kawakami, Edmond Wong, Mark Nolan, Thomas H. Marwick
Summary: This study compared the cost-effectiveness of two screening strategies for atrial fibrillation and found that imaging-guided screening was more cost-effective with lower costs and better outcomes. The study suggests that targeted screening for specific populations based on clinical and imaging risk parameters is more meaningful for detecting atrial fibrillation.
INTERNAL MEDICINE JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Edgar M. Hidalgo, Leah Wright, Mats Isaksson, Gavin Lambert, Thomas H. Marwick
Summary: With advances in robotics and telecommunications, robot-assisted teleoperated ultrasound examination can help with medical diagnosis in remote areas, reducing health inequalities. Studies have shown that robots can safely perform ultrasound examinations by following the hand movements of sonographers and researchers. However, real-time transmission of video and ultrasound images requires high bandwidth, and improvements are needed in robot control and interface design.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Quan Huynh, Alison J. Venn, Costan G. Magnussen, Hong Yang, Prasanna Venkataraman, Terence Dwyer, Thomas H. Marwick
Summary: This study examined the use of a simple cardiovascular health tool, the Fuster-BEWAT score (FBS), to predict subclinical atherosclerosis without the need for laboratory tests. The results showed that the baseline FBS was able to predict the presence of carotid plaque at 13-year follow-up. The predictive ability of FBS was similar to the Pooled Cohort Equation (PCE) score. The study also highlighted the importance of early damage to vascular health and suggested that FBS may be a feasible risk score for identifying low-risk young people at risk for future cardiovascular events.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Nicholas D'Elia, Seana Gall, Elizabeth Potter, Leah Wright, Hilda Yang, Thomas H. Marwick
Summary: Valvular heart disease is becoming more prevalent in Australia, with 5% of the population currently having clinically significant valve disease, most commonly mitral regurgitation. The projected numbers of people with valve disease are expected to increase significantly by 2060.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Thomas H. Marwick, Y. Chandrashekhar
JACC-CARDIOVASCULAR IMAGING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Neville Tan, Thomas H. Marwick, Nitesh Nerlekar
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Review
Cardiac & Cardiovascular Systems
Neville Tan, Damini Dey, Thomas H. Marwick, Nitesh Nerlekar
Summary: Coronary computed tomography can quantify coronary inflammation by mapping changes in pericoronary adipose tissue, but there are significant knowledge gaps in its interpretation.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jonathan Sen, Quan Huynh, Thomas H. Marwick
Summary: This study found that the use of DICOM structured reporting may lead to misclassifying severe AS as moderate. After validating the data, it was observed that several echocardiographic parameters in DICOM-SR showed significant differences compared to manual validation. This misclassification had an impact on the severity of AS and its association with outcomes. Clinicians' evaluation of AS severity was found to be unable to accurately distinguish between moderate and severe AS.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Medicine, General & Internal
Prasanna Venkataraman, Amanda L. Neil, Geoffrey K. Mitchell, Tony Stanton, Stephen Nicholls, Andrew M. Tonkin, Gerald F. Watts, Thomas H. Marwick
Summary: This study compared the cost-effectiveness of coronary artery calcium (CAC) score-guided statin therapy criteria and American College of Cardiology/American Heart Association (ACC/AHA) guidelines with selection according to Australian guidelines. The findings showed that CAC score-guided selection was cost-effective for people with 5-year ACVDR of at least 5%.
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Health Care Sciences & Services
James A. Black, Conor Lees, Niamh Chapman, Liam Kelleher, Julie A. Campbell, Petr Otahal, Kevin Cheng, Thomas H. Marwick, James E. Sharman
Summary: This study evaluated the effectiveness of a telehealth chest pain clinic established during the COVID-19 pandemic. The results showed that telehealth patients had a reduced need for additional testing compared to face-to-face consultations, and achieved similar clinical outcomes with high patient satisfaction.
TELEMEDICINE AND E-HEALTH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Y. Chandrashekhar, Thomas H. Marwick, Leslee J. Shaw
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Roberto Enrique Azcui Aparicio, Melinda J. Carrington, Quan Huynh, Jocasta Ball, Thomas H. Marwick
Summary: The study investigated the association between Fuster-BEWAT Score (FBS), Framingham Risk Score (FRS), and Pooled Cohort Equation (PCE) with carotid plaque presence, aiming to develop a stepped screening process for the primary prevention of cardiovascular disease (CVD). The results showed that FBS was able to identify carotid plaque in asymptomatic individuals, suggesting its potential use in initial risk delineation could improve patient selection for further assessment and reduce cost and time.
CARDIOVASCULAR DIGITAL HEALTH JOURNAL
(2023)
Review
Oncology
Yueyang Bao, John Lee, Udit Thakur, Satish Ramkumar, Thomas H. Marwick
Summary: This study compared the atrial fibrillation (AF) detection rate between cancer survivors and the general population and found that the AF risk in cancer survivors was not significantly increased.
Article
Medicine, General & Internal
Quan Huynh, Noah Wexler, Joel Smith, Leah Wright, Felicia Ho, Richard Allwood, Yusuke Sata, Stefano Manca, Erin Howden, Thomas H. Marwick
Summary: This study compared the symptoms and functional impairment of patients with previous COVID-19 infection to uninfected community controls. It found that patients with COVID-19 had lower functional capacity and more depression compared to controls. A pilot group also showed an increase in peak workload after exercise training. The study suggests that an exercise training program might be beneficial for selected patients.
INTERNAL MEDICINE JOURNAL
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Neville Tan, Nitesh Nerlekar, Thomas H. Marwick
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)