Article
Oncology
Karthik Rajasekaran, Ryan M. Carey, Xiang Lin, Tyler D. Seckar, Zhi Wei, Kevin Chorath, Jason G. Newman, Bert W. O'Malley, Gregory S. Weinstein, Michael D. Feldman, Erle Robertson
Summary: This study found that the microbiome of patients with HPV-related OPSCC shifted towards more gram-negative bacteria, and urogenital pathogens associated with lymph node metastasis included Proteus mirabilis, Chlamydia trachomatis, among others. Further studies are needed to determine the effects of the OPSCC microbiome on disease progression and clinical outcomes.
Review
Biochemistry & Molecular Biology
Riccardo Nevola, Domenico Beccia, Valerio Rosato, Rachele Ruocco, Davide Mastrocinque, Angela Villani, Pasquale Perillo, Simona Imbriani, Augusto Delle Femine, Livio Criscuolo, Maria Alfano, Marco La Montagna, Antonio Russo, Raffaele Marfella, Domenico Cozzolino, Ferdinando Carlo Sasso, Luca Rinaldi, Aldo Marrone, Luigi Elio Adinolfi, Ernesto Claar
Summary: Hepatitis B virus (HBV) is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Despite the availability of vaccines and antiviral agents, chronic HBV infection is difficult to eliminate due to the complex interactions between the virus and the host immune system. The integration of viral genome and the production of covalently closed circular DNA (cccDNA) contribute to viral persistence and make eradication challenging. Understanding the mechanisms of viral persistence and oncogenesis is crucial for the development of functional cures for chronic HBV infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Divya Natesan, Christina K. Cramer, Taofik Oyekunle, Donna Niedzwiecki, David M. Brizel, Yvonne M. Mowery
Summary: The study suggests that ipsilateral neck radiotherapy (IRT) may be an effective treatment for tonsillar squamous cell carcinoma (SCC) with multiple involved ipsilateral nodes, especially when baseline staging is performed with PET/CT.
Article
Biochemistry & Molecular Biology
Ha Young Park, Joong Seob Lee, Jee Hye Wee, Jeong Wook Kang, Eun Soo Kim, Taeryool Koo, Hee Sung Hwang, Hyo Jung Kim, Ho Suk Kang, Hyun Lim, Nan Young Kim, Eun Sook Nam, Seong Jin Cho, Mi Jung Kwon
Summary: Data on driver mutation profiles in tonsillar squamous cell carcinomas (TSCCs) are limited. This study investigated the incidence of clinically relevant mutations and their association with HPV infection and adjuvant therapy. The results showed high rates of oncogenic mutations, with TP53 and RTK mutations potentially serving as predictors for poor prognosis in the adjuvant therapy and HPV-positive groups, respectively.
Review
Oncology
Ankita Pandey, Divyesh Kumar, Parikshaa Gupta, Divya Khosla, Kannan Periasamy, Rakesh Kapoor
Summary: Retroperitoneal squamous cell carcinoma is a rare type of retroperitoneal tumor with unknown etiology and origin. This article reviews the literature and treatment options available based on available data. Surgical resection followed by adjuvant or definitive radiotherapy with concurrent chemotherapy seems to be a feasible treatment option.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Xin Li, Shuang Zhao, Xiaohui Bian, Lining Zhang, Lixia Lu, Shiyao Pei, Liang Dong, Wensheng Shi, Lingjuan Huang, Xiyuan Zhang, Mingliang Chen, Xiang Chen, Mingzhu Yin
Summary: Our study investigates the changes in tumor microenvironment (TME) between primary and recurrent cutaneous squamous cell carcinoma (cSCC) using single-cell RNA sequencing (scRNA-seq). We identified an immunosuppressed microenvironment in recurrent cSCC, with T cell exclusion and enrichment of SPP1+ tumor-associated macrophages (TAMs). CD8+ T cells showed exhaustion and low inflammatory features, while SPP1+ TAMs displayed pro-tumor characteristics. Different subgroups of SPP1+ TAMs exhibited distinct functions. A subset of tumor-specific keratinocytes (TSKs) showed significant epithelial-mesenchymal transition (EMT) features, possibly due to their interaction with IL7R+ cancer-associated fibroblasts (CAFs). We also found that the growth factor/cytokine Midkine (MDK) played a role in different cell-cell interactions in cSCC with different staging.
Review
Hematology
Charles R. M. Bangham
Summary: Human T-cell leukemia virus type 1 (HTLV-1) causes ATL in 5% of infected people and HTLV-1-associated myelopathy in 0.3% to 4% of them. Reliable treatments are lacking, but there have been recent advances in ATL prevention and treatment. Understanding the virus's persistence in the host and its role in oncogenesis is crucial.
Article
Microbiology
Man Xu, Maria Fernanda Perdomo, Salla Mattola, Lari Pyoria, Mari Toppinen, Jianming Qiu, Maija Vihinen-Ranta, Klaus Hedman, Johanna Nokso-Koivisto, Leena-Maija Aaltonen, Maria Soderlund-Venermo
Summary: The study revealed that HBoV1 DNA persists mainly in lymphoid germinal centers in healthy children with preexisting HBoV1 immunity, with the main host cells being B cells and monocytes, and the virus uptake occurring primarily through the Fc receptor.
Article
Oncology
Di Ou, Chen Ni, Jincao Yao, Min Lai, Chen Chen, Yajiao Zhang, Tian Jiang, Tingting Qian, Liping Wang, Dong Xu
Summary: This study analyzed the clinical features, ultrasonographic manifestations, pathological features, treatment, and prognosis of primary thyroid squamous cell carcinoma (PSCTC). PSCTC is most commonly seen in older men and progresses rapidly. Treatment options mainly include surgical resection, with the possibility of additional radiotherapy and chemotherapy. More data and cases are needed to establish a standardized treatment management system for PSCTC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Trisha Chattopadhyay, Bibekanand Mallick
Summary: This study investigates the role of piR-39980 and its target FDFT1 in the malignancy of tongue squamous cell carcinoma (TSCC). The results show that overexpression of piR-39980 can inhibit proliferation, migration, and ROS generation in TSCC cells, while increasing DNA damage and chromatin condensation causing cell death. The repression of FDFT1 is believed to induce hypoxia, leading to DNA damage and cell death in TSCC cells.
Article
Oncology
Angelina De Martin, Mechthild Lutge, Yves Stanossek, Celine Engetschwiler, Jovana Cupovic, Kirsty Brown, Izadora Demmer, Martina A. Broglie, Markus B. Geuking, Wolfram Jochum, Kathy D. McCoy, Sandro J. Stoeckli, Burkhard Ludewig
Summary: Squamous cell carcinoma of the tonsil, associated with high risk-human papilloma virus (HR-HPV) infections, has been found to have a distinct microbiome composition in the tonsillar crypts compared to sleep apnea patients. Specific bacterial species abundance such as Filifactor alocis and Prevotella melaninogenica are identified as traits of tonsil cancer.
Article
Multidisciplinary Sciences
Zaili Luo, Mingyang Xia, Wei Shi, Chuntao Zhao, Jiajia Wang, Dazhuan Xin, Xinran Dong, Yu Xiong, Feng Zhang, Kalen Berry, Sean Ogurek, Xuezhao Liu, Rohit Rao, Rui Xing, Lai Man Natalie Wu, Siying Cui, Lingli Xu, Yifeng Lin, Wenkun Ma, Shuaiwei Tian, Qi Xie, Li Zhang, Mei Xin, Xiaotao Wang, Feng Yue, Haizi Zheng, Yaping Liu, Charles B. Stevenson, Peter de Blank, John P. Perentesis, Richard J. Gilbertson, Hao Li, Jie Ma, Wenhao Zhou, Michael D. Taylor, Q. Richard Lu
Summary: In this study, single-cell profiling of human fetal cerebella was performed to investigate the cellular states and regulatory networks in medulloblastomas (MBs). The researchers found a unique transitional cerebellar progenitor population enriched in aggressive MB subgroups and identified transcriptional determinants HNRNPH1 and SOX11 that are correlated with prognosis in group 3 MBs. Genomic analysis revealed long-range chromatin loops connecting HNRNPH1/SOX11-targeted super-enhancers to regulatory elements of the oncogenic driver MYC in group 3 MBs. Targeting the transitional progenitor regulators inhibited MYC expression and MB growth. This study provides new insights into the cellular and molecular characteristics of MBs, which may have implications for disease prognosis and potential therapeutic strategies.
Review
Oncology
Ke Liang, Yichu Yuan, Bodong Lv, Zunjin Ke
Summary: A 52-year-old male patient was diagnosed with primary renal SCC, which was difficult to diagnose. Surgical treatment was performed and the patient had a good short-term prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alexander Ruehle, Marie Lies, Maren Strack, Ramon Lopez Perez, Birgit Bieber, Andreas R. Thomsen, Peter Bronsert, Peter E. Huber, Jochen Hess, Andreas Knopf, Patrick Wuchter, Anca-Ligia Grosu, Nils H. Nicolay
Summary: This study investigated the influence of mesenchymal stromal cells (MSCs) on the radiosensitivity of head-and-neck squamous cell carcinoma (HNSCC). The results showed that MSCs did not exert radioprotective effects on HNSCCs and can be safely used for radiotherapy-related issues in HNSCC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pathology
Ketav Desai, Brett Baskovich, Ahmad Alkhasawneh, Khaled Mohamed, Reeba Omman, Arun Gopinath
Summary: This article reports a rare case of HPV-associated squamous cell carcinoma of the rectal tonsil, highlighting the importance of appropriate nomenclature based on the pathogenesis of the tumor.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Pathology
Umberto Malapelle, Pasquale Pisapia, Antonino Iaccarino, Massimo Barberis, Claudio Bellevicine, Hans Brunnstrom, Dario de Biase, Giovanna De Maglio, Kajsa Ericson Lindquist, Matteo Fassan, Gabriella Fontanini, Elisa Gruppioni, Paul Hofman, Sabine Merkelbach-Bruse, Miguel A. Molina Vila, Anais Pujals, Ida Rapa, Luisella Righi, Rafael Rosell, Oliver Schildgen, Verena Schildgen, Fernando C. Schmitt, Giovanni Tallini, Sara Vander Borght, Elena Vigliar, Marco Volante, Svenja Wagener-Ryczek, Birgit Weynand, Giancarlo Troncone
Summary: The workload of molecular testing for patients with advanced-stage lung cancer during the lockdown showed little variations. Local strategies to overcome health emergency-related issues included the preference for RT-PCR tissue-based testing methodologies and, occasionally, for liquid biopsy.
JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Ophthalmology
R. Michael Dutescu, Peter Banasik, Oliver Schildgen, Norbert Schrage, Daniel Uthoff
Summary: This study found a higher percentage of coronavirus RNA in tears of SARS-CoV-2 positive patients using tear fluid sampling technique similar to oropharyngeal lavage compared to earlier reports using conjunctival swabs. Although patients in intensive care showed ocular symptoms, viral conjunctivitis was not observed in any patients.
Letter
Public, Environmental & Occupational Health
Jessica Luesebrink, Verena Schildgen, Oliver Schildgen
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2021)
Article
Medicine, General & Internal
Vanessa Vedder, Verena Schildgen, Jessica Lusebrink, Ramona Liza Tillmann, Birgitta Domscheit, Wolfram Windisch, Christian Karagiannidis, Michael Brockmann, Oliver Schildgen
Summary: The study compared the cytological profiles of BALs from patients infected with various respiratory pathogens, finding that different pathogens caused distinct cell pattern changes but no general cell distribution pattern. Although the cytology pattern of BAL fluid is not specific enough to be used as the sole diagnostic criterion for COVID-19, it may support clinical decision-making.
Article
Microbiology
Verena Schildgen, Sabrina Demuth, Jessica Luesebrink, Oliver Schildgen
Summary: This study analyzed the performance of three different rapid antigen tests in a clinical setting, showing varying specificities and sensitivities which did not entirely meet all expectations. Therefore, careful evaluation is needed when considering their benefits for specific testing strategies and settings.
Letter
Infectious Diseases
Andreas Kretschmer, Annelene Kossow, Barbara Gruene, Oliver Schildgen, Tim Mathes, Verena Schildgen
JOURNAL OF INFECTION
(2022)
Expression of Concern
Virology
Eric O. Freed, Oliver Schildgen
Letter
Infectious Diseases
Verena Schildgen, Jessica Luesebrink, Oliver Schildgen
JOURNAL OF INFECTION
(2022)
Letter
Infectious Diseases
Verena Schildgen, Jessica Luesebrink, Oliver Schildgen
JOURNAL OF INFECTION
(2023)
Letter
Infectious Diseases
M. Nitsch, T. Stahlhut, O. Schildgen, V. Schildgen
NEW MICROBES AND NEW INFECTIONS
(2022)
Letter
Infectious Diseases
Verena Schildgen, Jessica Luesebrink, Oliver Schildgen
NEW MICROBES AND NEW INFECTIONS
(2022)
Meeting Abstract
Medicine, Research & Experimental
Veronika Weyerer, Nadina Ortiz-Bruchle, Melanie Demes, Oliver Schildgen, Johannes Haybaeck, Gabriela Westphal, Philip Sander, Thomas Mairinger, Wolfgang Goering, Thomas Aigner, Udo Siebolts, Annika Moske, Achim Battmann, Hans Michael Kvasnicka, Karsten Neumann, Lars Tharun, Daniela Nussbeck, Marianna Sciortino, Bruno Markl, Eva Wardelmann, Arndt Hartmann, Nikola Holtkamp
LABORATORY INVESTIGATION
(2021)
Meeting Abstract
Pathology
Veronika Weyerer, Nadina Ortiz-Bruechle, Melanie Demes, Oliver Schildgen, Johannes Haybaeck, Gabriela Westphal, Philip Sander, Thomas Mairinger, Wolfgang Goering, Thomas Aigner, Udo Siebolts, Annika Moske, Achim Battmann, Hans Michael Kvasnicka, Karsten Neumann, Lars Tharun, Daniela Nussbeck, Marianna Sciortino, Bruno Markl, Eva Wardelmann, Arndt Hartmann, Nikola Holtkamp
Letter
Respiratory System
Matthias Obenaus, Oliver Schildgen, Dirk Schuermann, Ann-Christin von Bruenneck, Martin Janz, Ulrich Keller, Bernhard Gebauer, Johannes Schilling, Stefan Schwartz, Benedikt Weissbrich, Thomas Schneider, Joerg Hofmann, Stephan Mathas
Letter
Infectious Diseases
S. Demuth, S. Damaschek, O. Schildgen, V. Schildgen
Summary: European strategies on SARS-CoV-2 antigen testing focus on rapid tests conducted by healthcare professionals and self-tests, but evidence shows weak performance even under laboratory conditions.
NEW MICROBES AND NEW INFECTIONS
(2021)