期刊
FRONTIERS IN MICROBIOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2018.02468
关键词
NDM-7; carbapenemase; Escherichia coli; multi-drug resistance; China
类别
资金
- Focus on Research and Development Plan in Shandong Province [2016GSF201078]
- Medical and Health Development Plan of Shandong Province [2017WS471]
Infections due to New Delhi metallo-beta lactamase (NDM)-7-producing Escherichia coli are infrequent and sporadic. In this study, we report one case of recurrent urinary tract infection caused by bla(NDM-7)-producing E. coli belonging to phylogenetic group A, sequence type (ST) 167. In this study, we aimed to describe the genotype and phenotype of bla(NDM-7)-producing E. coli in China. The isolate exhibited resistance to beta-lectern antimicrobials, trirnethoprim-sulfarnethoxazole, quinolones, and aminoglycosides. bla(NDM-7) is located on a conjugative plasmid designated pJNO5NDM-7 belonging to type IncX3. pJNO5NDM-7 was fully sequenced and compared with all publicly available bla(NDM-7)-harboring plasmids. pJNO5NDM-7 is almost identical to pKpN01-NDM7 and pKW53T, although the plasrnids are geographically unrelated. The comparison of IncX3 plasmids harboring bla(NDM) in China showed high similarity, with genetic differences within insertion fragments. Notably, the differences in plasmids of animal and human origin were insignificant, because only one plasmid showed deletion inside the ISAba125 region compared with pJNO5NDM7. Our study demonstrates that E. coli carrying IncX3 plasmids play an important role as a reservoir and in the spread of bla(NDM). Further studies should be performed to control the dissemination of bla(NDM) among food animals.
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