标题
Gene Editing of HIV-1 Co-receptors to Prevent and/or Cure Virus Infection
作者
关键词
-
出版物
Frontiers in Microbiology
Volume 9, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2018-12-17
DOI
10.3389/fmicb.2018.02940
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Broad spectrum and personalized gRNAs for CRISPR/Cas9 HIV-1 therapeutics
- (2018) Will Dampier et al. AIDS RESEARCH AND HUMAN RETROVIRUSES
- Rapid rebound of a preexisting CXCR4-tropic HIV variant after allogeneic transplantation with CCR5 delta32 homozygous stem cells
- (2018) J Verheyen et al. CLINICAL INFECTIOUS DISEASES
- Comparison of the editing patterns and editing efficiencies of TALEN and CRISPR-Cas9 when targeting the human CCR5 gene
- (2018) Arildo Nerys-Junior et al. GENETICS AND MOLECULAR BIOLOGY
- Simultaneous Knockout of CXCR4 and CCR5 Genes in CD4+ T Cells via CRISPR/Cas9 Confers Resistance to Both X4- and R5-Tropic Human Immunodeficiency Virus Type 1 Infection
- (2018) Songlin Yu et al. HUMAN GENE THERAPY
- Targeting the Latent Reservoir for HIV-1
- (2018) Srona Sengupta et al. IMMUNITY
- Polyethylenimine-Mediated CCR5 Gene Knockout Using Transcription Activator-Like Effector Nucleases
- (2018) Lian Jin et al. Journal of Biomedical Nanotechnology
- Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells
- (2018) Szu-Han Huang et al. JOURNAL OF CLINICAL INVESTIGATION
- Therapeutic Efficacy of Vectored PGT121 Gene Delivery in HIV-1-Infected Humanized Mice
- (2018) Alexander Badamchi-Zadeh et al. JOURNAL OF VIROLOGY
- Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1
- (2018) Kai Xu et al. NATURE MEDICINE
- A single injection of crystallizable fragment domain–modified antibodies elicits durable protection from SHIV infection
- (2018) Rajeev Gautam et al. NATURE MEDICINE
- Next-generation in situ hybridization approaches to define and quantify HIV and SIV reservoirs in tissue microenvironments
- (2018) Claire Deleage et al. Retrovirology
- HIV-1 inhibition in cells with CXCR4 mutant genome created by CRISPR-Cas9 and piggyBac recombinant technologies
- (2018) Shuai Liu et al. Scientific Reports
- Differential impact of transplantation on peripheral and tissue-associated viral reservoirs: Implications for HIV gene therapy
- (2018) Christopher W. Peterson et al. PLoS Pathogens
- Mechanisms for Cell-to-Cell Transmission of HIV-1
- (2018) Lucie Bracq et al. Frontiers in Immunology
- A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells
- (2018) Christopher A. Vakulskas et al. NATURE MEDICINE
- TALEN-Mediated Knockout of CCR5 Confers Protection Against Infection of Human Immunodeficiency Virus
- (2017) Bingjie Shi et al. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
- Reduced Potency and Incomplete Neutralization of Broadly Neutralizing Antibodies against Cell-to-Cell Transmission of HIV-1 with Transmitted Founder Envs
- (2017) Hongru Li et al. JOURNAL OF VIROLOGY
- TALENs-mediated homozygous CCR5Δ32 mutations endow CD4+ U87 cells with resistance against HIV‑1 infection
- (2017) Ai Yu et al. Molecular Medicine Reports
- CRISPR/Cas9-Mediated CCR5 Ablation in Human Hematopoietic Stem/Progenitor Cells Confers HIV-1 Resistance In Vivo
- (2017) Lei Xu et al. MOLECULAR THERAPY
- Early antibody therapy can induce long-lasting immunity to SHIV
- (2017) Yoshiaki Nishimura et al. NATURE
- Defining total-body AIDS-virus burden with implications for curative strategies
- (2017) Jacob D Estes et al. NATURE MEDICINE
- CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets
- (2017) Shengdar Q Tsai et al. NATURE METHODS
- Genome modification of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection
- (2017) Qiankun Wang et al. Retrovirology
- A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy
- (2017) Mariluz Araínga et al. Retrovirology
- Genome editing of the HIV co-receptors CCR5 and CXCR4 by CRISPR-Cas9 protects CD4+ T cells from HIV-1 infection
- (2017) Zhepeng Liu et al. Cell and Bioscience
- Designing broad-spectrum anti-HIV-1 gRNAs to target patient-derived variants
- (2017) Will Dampier et al. Scientific Reports
- Dissecting How CD4 T Cells Are Lost During HIV Infection
- (2016) Gilad Doitsh et al. Cell Host & Microbe
- Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth
- (2016) Jinghe Huang et al. IMMUNITY
- Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity
- (2016) Josh Tycko et al. MOLECULAR CELL
- High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
- (2016) Benjamin P. Kleinstiver et al. NATURE
- In Vivo HIV-1 Cell-to-Cell Transmission Promotes Multicopy Micro-compartmentalized Infection
- (2016) Kenneth M. Law et al. Cell Reports
- Zinc finger nuclease technology: Advances and obstacles in modelling and treating genetic disorders
- (2015) Hamid Reza Jabalameli et al. GENE
- Genome editing strategies: potential tools for eradicating HIV-1/AIDS
- (2015) Kamel Khalili et al. JOURNAL OF NEUROVIROLOGY
- Engineered CRISPR-Cas9 nucleases with altered PAM specificities
- (2015) Benjamin P. Kleinstiver et al. NATURE
- Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
- (2015) Kathrin Schumann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rationally engineered Cas9 nucleases with improved specificity
- (2015) I. M. Slaymaker et al. SCIENCE
- HIV cell-to-cell transmission: effects on pathogenesis and antiretroviral therapy
- (2015) Luis M. Agosto et al. TRENDS IN MICROBIOLOGY
- Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection
- (2015) Panpan Hou et al. Scientific Reports
- Macrophage Infection via Selective Capture of HIV-1-Infected CD4+ T Cells
- (2014) Amy E. Baxter et al. Cell Host & Microbe
- CD169-Dependent Cell-Associated HIV-1 Transmission: A Driver of Virus Dissemination
- (2014) S. Gummuluru et al. JOURNAL OF INFECTIOUS DISEASES
- HIV infection: epidemiology, pathogenesis, treatment, and prevention
- (2014) Gary Maartens et al. LANCET
- Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
- (2014) Yanfang Fu et al. NATURE BIOTECHNOLOGY
- GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
- (2014) Shengdar Q Tsai et al. NATURE BIOTECHNOLOGY
- Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity
- (2014) John P Guilinger et al. NATURE METHODS
- Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV
- (2014) Pablo Tebas et al. NEW ENGLAND JOURNAL OF MEDICINE
- TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity
- (2014) Claudio Mussolino et al. NUCLEIC ACIDS RESEARCH
- CCR5 Gene Disruption via Lentiviral Vectors Expressing Cas9 and Single Guided RNA Renders Cells Resistant to HIV-1 Infection
- (2014) Weiming Wang et al. PLoS One
- Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection
- (2014) Lin Ye et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
- (2014) W. Hu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The new frontier of genome engineering with CRISPR-Cas9
- (2014) J. A. Doudna et al. SCIENCE
- Highly Active Antiretroviral Therapies Are Effective against HIV-1 Cell-to-Cell Transmission
- (2014) Luis M. Agosto et al. PLoS Pathogens
- CCR5 Gene Editing of Resting CD4+ T Cells by Transient ZFN Expression From HIV Envelope Pseudotyped Nonintegrating Lentivirus Confers HIV-1 Resistance in Humanized Mice
- (2014) Guohua Yi et al. Molecular Therapy-Nucleic Acids
- Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection
- (2013) C. A. Didigu et al. BLOOD
- Efficient Clinical Scale Gene Modification via Zinc Finger Nuclease–Targeted Disruption of the HIV Co-receptor CCR5
- (2013) Dawn A. Maier et al. HUMAN GENE THERAPY
- Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission
- (2013) Marine Malbec et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Using defined finger–finger interfaces as units of assembly for constructing zinc-finger nucleases
- (2013) Cong Zhu et al. NUCLEIC ACIDS RESEARCH
- HIV-1 transcription and latency: an update
- (2013) Carine Van Lint et al. Retrovirology
- Cell-to-cell spread of HIV-1 and evasion of neutralizing antibodies
- (2013) Torben Schiffner et al. VACCINE
- Newer Gene Editing Technologies toward HIV Gene Therapy
- (2013) N. Manjunath et al. Viruses-Basel
- Targeted gene disruption to cure HIV
- (2013) Daniel Stone et al. Current Opinion in HIV and AIDS
- Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient
- (2013) Steven A. Yukl et al. PLoS Pathogens
- Differential HIV-1 Endocytosis and Susceptibility to Virus Infection in Human Macrophages Correlate with Cell Activation Status
- (2012) L.-A. Gobeil et al. JOURNAL OF VIROLOGY
- Zinc-finger Nuclease Editing of Human cxcr4 Promotes HIV-1 CD4+ T Cell Resistance and Enrichment
- (2012) Jinyun Yuan et al. MOLECULAR THERAPY
- Targeted gene knockout by direct delivery of zinc-finger nuclease proteins
- (2012) Thomas Gaj et al. NATURE METHODS
- TALENs: a widely applicable technology for targeted genome editing
- (2012) J. Keith Joung et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Cell-to-Cell Transfer of HIV-1 via Virological Synapses Leads to Endosomal Virion Maturation that Activates Viral Membrane Fusion
- (2011) Benjamin M. Dale et al. Cell Host & Microbe
- A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity
- (2011) Claudio Mussolino et al. NUCLEIC ACIDS RESEARCH
- Engineering HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases
- (2011) Craig B. Wilen et al. PLoS Pathogens
- Structure-activity relationships of polybiguanides with activity against human immunodeficiency virus type 1
- (2010) Shendra R. Passic et al. BIOMEDICINE & PHARMACOTHERAPY
- Evidence for the cure of HIV infection by CCR5 32/ 32 stem cell transplantation
- (2010) K. Allers et al. BLOOD
- Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
- (2010) Nathalia Holt et al. NATURE BIOTECHNOLOGY
- RNA-Based Gene Therapy for HIV with Lentiviral Vector-Modified CD34+ Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma
- (2010) D. L. DiGiusto et al. Science Translational Medicine
- A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model
- (2009) S. Shimizu et al. BLOOD
- Quantitating the Multiplicity of Infection with Human Immunodeficiency Virus Type 1 Subtype C Reveals a Non-Poisson Distribution of Transmitted Variants
- (2009) M.-R. Abrahams et al. JOURNAL OF VIROLOGY
- Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand
- (2009) Supachai Rerks-Ngarm et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inflammatory Genital Infections Mitigate a Severe Genetic Bottleneck in Heterosexual Transmission of Subtype A and C HIV-1
- (2009) Richard E. Haaland et al. PLoS Pathogens
- Specific Interactions between the Viral Coreceptor CXCR4 and the Biguanide-Based Compound NB325 Mediate Inhibition of Human Immunodeficiency Virus Type 1 Infection
- (2008) N. Thakkar et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
- (2008) Elena E Perez et al. NATURE BIOTECHNOLOGY
- Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
- (2008) B. F. Keele et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started