A novel enhancer near the Pitx1 gene influences development and evolution of pelvic appendages in vertebrates

Disrupting the three-dimensional regulatory topology of thePitx1locus results in overtly normal development

(2018) Richard Sarro et al.   DEVELOPMENT

Genetics of clubfoot; recent progress and future perspectives

(2018) Sulman Basit et al.   European Journal of Medical Genetics

Enhancer redundancy provides phenotypic robustness in mammalian development

(2018) Marco Osterwalder et al.   NATURE

Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis

(2018) Bjørt K. Kragesteen et al.   NATURE GENETICS

Unique pelvic fin in a tetrapod-like fossil fish, and the evolution of limb patterning

(2018) Jonathan E. Jeffery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Limb development: a paradigm of gene regulation

(2017) Florence Petit et al.   NATURE REVIEWS GENETICS

Evolution of the patellar sesamoid bone in mammals

(2017) Mark E. Samuels et al.   PeerJ

Progressive Loss of Function in a Limb Enhancer during Snake Evolution

(2016) Evgeny Z. Kvon et al.   CELL

Loss and Re-emergence of Legs in Snakes by Modular Evolution of Sonic hedgehog and HOXD Enhancers

(2016) Francisca Leal et al.   CURRENT BIOLOGY

Characterization of hundreds of regulatory landscapes in developing limbs reveals two regimes of chromatin folding

(2016) Guillaume Andrey et al.   GENOME RESEARCH

Molecular shifts in limb identity underlie development of feathered feet in two domestic avian species

(2016) Eric T Domyan et al.   eLife

On the development of the patella

(2015) S. Eyal et al.   DEVELOPMENT

Next generation limb development and evolution: old questions, new perspectives

(2015) Aimée Zuniga   DEVELOPMENT

Shared Enhancer Activity in the Limbs and Phallus and Functional Divergence of a Limb-Genital cis-Regulatory Element in Snakes

(2015) Carlos R. Infante et al.   DEVELOPMENTAL CELL

Pelvic girdle and fin of Tiktaalik roseae

(2014) N. H. Shubin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species

(2013) Keith R Bradnam et al.   GigaScience

Homeotic Arm-to-Leg Transformation Associated with Genomic Rearrangements at the PITX1 Locus

(2012) Malte Spielmann et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Geneious Basic: An integrated and extendable desktop software platform for the organization and analysis of sequence data

(2012) M. Kearse et al.   BIOINFORMATICS

An antiarch placoderm shows that pelvic girdles arose at the root of jawed vertebrates

(2012) M. Zhu et al.   Biology Letters

Deletions in PITX1 cause a spectrum of lower-limb malformations including mirror-image polydactyly

(2012) Eva Klopocki et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

ENCODE Data in the UCSC Genome Browser: year 5 update

(2012) Kate R. Rosenbloom et al.   NUCLEIC ACIDS RESEARCH

Pitx1 haploinsufficiency causes clubfoot in humans and a clubfoot-like phenotype in mice

(2011) D. M. Alvarado et al.   HUMAN MOLECULAR GENETICS

Phenotypic robustness conferred by apparently redundant transcriptional enhancers

(2010) Nicolás Frankel et al.   NATURE

Adaptive Evolution of Pelvic Reduction in Sticklebacks by Recurrent Deletion of a Pitx1 Enhancer

(2009) Y. F. Chan et al.   SCIENCE

Asymmetric Lower-Limb Malformations in Individuals with Homeobox PITX1 Gene Mutation

(2008) Christina A. Gurnett et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Dual hindlimb control elements in the Tbx4 gene and region-specific control of bone size in vertebrate limbs

(2008) D. B. Menke et al.   DEVELOPMENT