期刊
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
卷 6, 期 11, 页码 15301-15305出版社
AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.8b03752
关键词
Metal-free; Radical reaction; Nitrative cyclization; t-BuONO
资金
- National Natural Science Foundation of China [21801142]
- Natural Science Foundation of Zhejiang Province [LQ18B020002]
- Education Foundation of Zhejiang Province [Y201737123]
- State Key Laboratory of Analytical Chemistry for Life Science [SKLACLS1804]
- Open Subject of State Key Laboratory of Chemo/Biosensing and Chemometrics [2017016]
- K. C. Wong Magna Fund in Ningbo University
A new pattern for nitrative cyclization of 1,6-enynes with t-BuONO has been reported for the synthesis of various 2-pyrrolidinone derivatives in 45-88% yields. This novel method is operationally simple and proceeds under very mild conditions without using any additives. The reaction pathway involves nitro radical addition toward an alkenyl group/5-exo-cyclization/H-abstraction sequence, allowing a highly regioselective and practical protocol toward the formation of new C-N and C-C bonds.
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