Article
Biochemistry & Molecular Biology
Sevigean Ali, Mihaela Botnarciuc, Lavinia Carmen Daba, Sorina Ispas, Alina Mihaela Stanigut, Camelia Pana, Marian-Catalin Burcila, Liliana-Ana Tuta
Summary: There is limited research on decreased platelet count in chronic kidney disease (CKD), but platelet functions are altered in the uremic environment, leading to an increased risk of bleeding. This study monitored 104 CKD patients with thrombocytopenia who received platelet transfusion and evaluated their prognosis. The results showed that in patients with multiple comorbidities, 4.83% still experienced severe uncontrolled hemorrhages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yuji Oe, Nobuyuki Takahashi
Summary: Coagulation abnormalities are common in chronic kidney disease (CKD). Tissue factor plays a key role in promoting coagulation and inflammation, exacerbating renal injury.
Review
Food Science & Technology
Mara Lauriola, Ricard Farre, Pieter Evenepoel, Saskia Adriana Overbeek, Bjorn Meijers
Summary: Patients with CKD have a higher cardiovascular risk than the general population due to the accumulation of uremic toxins. Protein-bound uremic toxins originate from various sources and are difficult to remove with conventional therapies. Diet plays an important role in uremic toxicity, with most toxins derived from the gut. This review summarizes the sources of uremic toxins in foods and discusses their metabolism and potential dietary strategies for reducing their plasma levels.
Review
Food Science & Technology
Mateo Ondrussek-Sekac, Diana Navas-Carrillo, Esteban Orenes-Pinero
Summary: In chronic kidney disease, dysbiosis of intestinal microbiota can lead to uremic toxicity, inflammation and disease progression. Modulating gut microbiota through dietary changes and using probiotics, prebiotics, and low protein diets can offer therapeutic interventions to improve this imbalance and manage chronic kidney disease effectively.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Cell Biology
Jung Sun Park, Dong-Hyun Kim, Hoon-In Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Summary: This study investigated the effects of uremic toxins on ferroptosis in the kidney, finding that protein-bound uremic toxins can induce ferroptosis and result in cell death.
CELL DEATH & DISEASE
(2023)
Article
Nutrition & Dietetics
Zarina Ebrahim, Sebastian Proost, Raul Yhossef Tito, Jeroen Raes, Griet Glorieux, Mohammed Rafique Moosa, Renee Blaauw
Summary: There is growing evidence that gut dysbiosis contributes to the progression of chronic kidney disease. This study found that ss-glucan prebiotic has a positive effect on kidney function, uremic toxins, and the gut microbiome in CKD participants.
Article
Biotechnology & Applied Microbiology
Gerrit A. Stuivenberg, John A. Chmiel, Polycronis P. Akouris, Jessica White, Hannah Wilcox, Shannon Seney, Jeremy P. Burton, Gregor Reid
Summary: Chronic kidney disease (CKD) is a significant problem in developing countries, particularly in sub-Saharan Africa, where its prevalence is high and associated with cardiovascular issues. Uremic toxins, such as p-cresol and p-cresyl sulfate, play a role in CKD. This study found that adding specific bifidobacterial strains to probiotic yogurt produced in Tanzanian communities can potentially reduce uremic toxins and provide additional health benefits.
FERMENTATION-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Kuo-Chin Hung, Wei-Cheng Yao, Yi-Lien Liu, Hung-Jen Yang, Min-Tser Liao, Keong Chong, Ching-Hsiu Peng, Kuo-Cheng Lu
Summary: Patients with chronic kidney disease (CKD) often have a high accumulation of protein-bound uremic toxins (PBUTs), such as indoxyl sulfate (IS) and p-cresyl sulfate (pCS). The buildup of PBUTs inhibits bone and muscle function, worsens muscle wasting, and contributes to low bone turnover disorders. Understanding the underlying mechanisms of bone and muscle loss in CKD can aid in developing new therapies for musculoskeletal diseases.
Review
Biochemistry & Molecular Biology
Serena Altamura, Davide Pietropaoli, Francesca Lombardi, Rita Del Pinto, Claudio Ferri
Summary: This article explores the dynamic biological connections between oral health, gut, and renal pathology, emphasizing the importance of the oral-gut-kidney axis. It also discusses the potential role of periodontal diseases and gut microbiota as disease modifiers in CKD.
Article
Food Science & Technology
Carolla El Chamieh, Islam Amine Larabi, Solene M. Laville, Christian Jacquelinet, Christian Combe, Denis Fouque, Maurice Laville, Luc Frimat, Roberto Pecoits-Filho, Celine Lange, Benedicte Stengel, Natalia Alencar De Pinho, Jean-Claude Alvarez, Ziad A. Massy, Sophie Liabeuf
Summary: Proton-pump inhibitors (PPIs) are commonly used in patients with chronic kidney disease (CKD), and are associated with the retention of uremic toxins (UTs). In this cross-sectional study, we found that patients using PPIs had higher levels of certain UTs compared to other patients. These findings are important for understanding factors that modulate serum UT concentration in CKD patients.
Article
Immunology
Robson E. Silva, Eliziaria C. Santos, Patricia B. Justino, Margarida P. Santos, Giovane Galdino, Reggiani Goncalves, Romulo D. Novaes
Summary: The relationship between dialysis adequacy and circulating levels of inflammatory mediators was investigated, showing that low Kt/V results and creatinine accumulation may serve as potential indicators of systemic inflammatory stress.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Urology & Nephrology
Laetitia Koppe, Christophe O. Soulage
Summary: Chronic kidney disease is associated with changes in the gut microbiota, and diet plays a crucial role in managing the disease. This review discusses the latest research on the interactions between diet and gut microbiota in the context of uremia, and how this knowledge can be used to develop personalized nutrition strategies to prevent the progression of chronic kidney disease to kidney failure and its complications.
KIDNEY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Vasily A. Popkov, Anastasia A. Zharikova, Evgenia A. Demchenko, Nadezda V. Andrianova, Dmitry B. Zorov, Egor Y. Plotnikov
Summary: This study presents a novel bioinformatics approach to identify the origin of uremic retention solutes and uremic toxins, particularly those produced by gut microbiota. The research utilizes database analysis and enzymatic reaction data to determine the potential toxins synthesized by bacteria residing in the human gut. The findings reveal the link between toxin concentration in uremia and the proportion of different bacterial species that can produce the toxin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Bert Zwaenepoel, Tine De Backer, Griet Glorieux, Francis Verbeke
Summary: This study evaluated the association between plasma protein-bound uremic toxins concentrations, echocardiographic parameters of heart failure, and incident heart failure events in chronic kidney disease patients not on dialysis. The results showed that elevated free concentrations of indoxyl sulfate, p-cresyl glucuronide, and p-cresyl sulfate were independently associated with an increased risk of heart failure events in these patients.
Review
Physiology
Willem B. van Ham, Carlijn M. Cornelissen, Toon A. B. van Veen
Summary: Chronic kidney disease and cardiovascular disease are prevalent worldwide, with a high incidence of cardiovascular events in CKD patients. The relationship between kidney function, uremic toxins, and cardiac electrophysiology in the context of cardiorenal syndrome requires further investigation to understand potential arrhythmic events and improve clinical outcomes.
Article
Pharmacology & Pharmacy
PauloC Gregorio, Regiane S. da Cunha, Gilson Biagini, Bruna Bosquetti, Julia Budag, Alberto Ortiz, Maria Dolores Sanchez-Nino, Fellype C. Barreto, Andrea E. M. Stinghen
Summary: COVID-19 pandemic continues with limited antiviral agents available. Chloroquine, despite showing in vitro antiviral activity, had disappointing results in clinical trials and may harm outcomes. The adverse effects of chloroquine on endothelial cells were mitigated by agalsidase-beta treatment, suggesting a potential role of endothelial cell injury in the failure of chloroquine therapy for COVID-19.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Laila Santos de Andrade, Fabiana Andrea Hoffmann Sarda, Natalia Barros Ferreira Pereira, Renata Rodrigues Teixeira, Silvia Daniele Rodrigues, Jordana Dinora de Lima, Maria Aparecida Dalboni, Danilo Takashi Aoike, Lia Sumie Nakao, Lilian Cuppari
Summary: This study aimed to evaluate the effect of unripe banana flour on the serum concentrations of certain metabolites in individuals undergoing peritoneal dialysis. The results showed that unripe banana flour did not change the levels of IS, pCS, and IAA in all participants, but a decrease in IS concentration was observed in some participants who consumed 21g of unripe banana flour daily.
Review
Physiology
Carlos Alexandre Falconi, Carolina Victoria da Cruz Junho, Fernanda Fogaca-Ruiz, Imara Caridad Stable Vernier, Regiane Stafim da Cunha, Andrea Emilia Marques Stinghen, Marcela Sorelli Carneiro-Ramos
Summary: The accumulation of uremic toxins in the body can lead to a loss of various body functions, affecting other tissues and potentially causing cardiovascular issues. Understanding the impact of uremic toxins on the cardiovascular system is crucial for the treatment of patients with chronic kidney disease and high mortality rates among patients with cardiac comorbidities.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Toxicology
Giane Favretto, Regiane Stafim da Cunha, Andressa Flores Santos, Amanda Leitolis, Elberth Manfron Schiefer, Paulo Cezar Gregorio, Celia Regina Cavichiolo Franco, Ziad Massy, Maria Aparecida Dalboni, Andrea Emilia Marques Stinghen
Summary: This study investigated the impact of uremic toxins on the formation and function of endothelial extracellular vesicles (EVs), revealing that uremic toxins can induce the formation of different types of EVs and stimulate cell adhesion and migration. EVs may serve as biomarkers of endothelial injury and the inflammatory process.
TOXICOLOGY LETTERS
(2021)
Article
Plant Sciences
Andressa F. Santos, Nadia S. R. Santos Mota, Elberth M. Schiefer, Regiane S. da Cunha, Allan M. Junkert, Andrea E. M. Stinghen, Roberto Pontarolo, Amanda R. Crisma, Almeriane M. Weffort-Santos, Rozangela C. Pedrosa, Wesley M. de Souza, Karina B. Felipe
Summary: The indole alkaloid-rich fraction (IAF) of A. subincanum selectively induces toxic and antiproliferative effects on MCF7 cells by regulating apoptosis markers and oxidative status, suggesting its potential as a novel anti-cancer agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Andressa Flores Santos, Elberth Manfron Schiefer, Guilherme Lanzi Sassaki, Leociley Menezes, Renato Fonseca, Regiane Cunha, Wesley Souza, Roberto Pecoits-Filho, Andrea E. M. Stinghen
Summary: The study found that there was no significant difference in the clearance rates of metabolites between high flux HD and HDF in a single treatment session, but in the long-term evolution, 16 metabolites were identified that differentiated the two modalities. Most of these metabolites are involved in important metabolic pathways related to UTs and cardiovascular disease development. HDF samples showed stable concentrations of CKD-relevant metabolites and associated pathologies over a six-month period, suggesting that HDF enhances long-term stability.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Physiology
Paulo C. Gregorio, Gilson Biagini, Regiane S. da Cunha, Julia Budag, Ana Maria Martins, Lara Valino Rivas, Elberth M. Schiefer, Maria Dolores Sanchez-Nino, Alberto Ortiz, Andrea E. M. Stinghen, Fellype C. Barreto
Summary: Inflammation and endothelial damage play a pivotal role in Fabry disease manifestations. Traditional biomarkers of target organ injury provide no information about inflammation and endothelial damage. This study found that the serum levels of 3-nitrotyrosine, growth differentiation factor-15, and syndecan-1 were associated with cardiac and renal involvement in Fabry disease patients on enzyme replacement therapy.
KIDNEY & BLOOD PRESSURE RESEARCH
(2022)
Review
Food Science & Technology
Carolina Amaral Bueno Azevedo, Regiane Stafim da Cunha, Carolina Victoria Cruz Junho, Jessica Veronica da Silva, Andrea N. Moreno-Amaral, Thyago Proenca de Moraes, Marcela Sorelli Carneiro-Ramos, Andrea Emilia Marques Stinghen
Summary: Cardiorenal syndrome (CRS) can be classified into five groups, with uremic toxin (UT) accumulation observed in all types. Protein-bound uremic toxin (PBUT) accumulation results in permanent damage to renal tissue, compromising renal function and potentially requiring renal replacement therapy such as peritoneal dialysis (PD). The formation of extracellular vesicles (EVs) can be related to endothelial dysfunction when UTs interact with the endothelial monolayer.
Article
Pharmacology & Pharmacy
Regiane Stafim da Cunha, Paulo Cezar Gregorio, Rayana Ariane Pereira Maciel, Giane Favretto, Celia Regina Cavichiolo Franco, Jenifer Pendiuk Goncalves, Marina Luise Viola de Azevedo, Roberto Pecoits-Filho, Andrea Emilia Marques Stinghen
Summary: Uremic toxins PCS and IS contribute to endothelial dysfunction in chronic kidney disease. This study found that CREB/ATF1 is activated by PCS, IS, and US in uremic conditions and may play a relevant role in endothelial dysfunction.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Food Science & Technology
Regiane Stafim da Cunha, Carolina Amaral Bueno Azevedo, Carlos Alexandre Falconi, Fernanda Fogaca Ruiz, Sophie Liabeuf, Marcela Sorelli Carneiro-Ramos, Andrea Emilia Marques Stinghen
Summary: Uremic toxins are molecules that accumulate in the body due to chronic kidney disease (CKD), and are associated with kidney dysfunction and comorbidity development. Drugs may interact with protein-bound uremic toxins (PBUTs) and cell membrane transporters, affecting toxin levels and elimination. This review explores the interaction mechanisms between uremic toxins, albumin, and membrane transporters in relation to clinical drug use.
Meeting Abstract
Transplantation
Paulo C. Gregorio, Regiane Cunha, Gilson Biagini, Bruna Bosquetti, Julia Budag, Alberto Ortiz, Maria Dolores Sanchez-Nino, Fellype Barreto, Andrea E. M. Stinghen
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Paulo C. Gregorio, Sergio Bucharles, Regiane S. da Cunha, Tarcio Braga, Ana Clara Almeida, Railson Henneberg, Andrea E. M. Stinghen, Fellype C. Barreto
Summary: Vitamin D supplementation improves hypovitaminosis D in hemodialysis patients but its effects on secondary hyperparathyroidism control are unclear. While exhibiting anti-inflammatory effects in vitro, short-term supplementation does not effectively improve the inflammatory profile of hemodialysis patients.