期刊
STEM CELLS TRANSLATIONAL MEDICINE
卷 8, 期 1, 页码 75-81出版社
WILEY
DOI: 10.1002/sctm.18-0123
关键词
Cancer stem cells; Epigenetics; Immunotherapy; Metastasis
Cancer stem cells (CSCs) are a subpopulation of cells within tumors that possess the stem cell characteristics of self-renewal, quiescence, differentiation, and the ability to recapitulate the parental tumor when transplanted into a host. CSCs are correlated with poor clinical outcome due to their contribution to chemotherapy resistance and metastasis. Multiple cell surface and enzymatic markers have been characterized to identify CSCs within a heterogeneous tumor, and here we summarize ongoing preclinical and clinical efforts to therapeutically target these cells and improve patient outcomes. Stem Cells Translational Medicine 2019;8:75-81
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