Article
Cardiac & Cardiovascular Systems
Qing Lin, Santosh Kumar, Udeshika Kariyawasam, Xiaomei Yang, Wei Yang, John T. Skinner, Wei Dong Gao, Roger A. Johns
Summary: This study found that overexpression of cardiac-specific Hresistin is sufficient to cause cardiac dysfunction and remodeling. Activation of Hresistin triggers inflammation in heart tissues and leads to right ventricular hypertrophy and failure. However, the researchers also discovered that protection from hypertrophy and failure can be achieved by generating an anti-Hresistin human antibody.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Immunology
Jinqiu Jiang, Tao Qin, Liang Zhang, Qiao Liu, Jiabin Wu, Rongxin Dai, Lina Zhou, Qin Zhao, Xiaoyan Luo, Hua Wang, Xiaodong Zhao
Summary: Deficiencies in DOCK8 result in quantitative and qualitative defects in IL-10-producing Breg cells, potentially due to abnormal Dock8(-/-) CD4(+) T cells. The study found that recombinant murine IL-21 can restore Bregs function and reduce inflammatory cell infiltration in the lung in a murine asthma model. This provides new insights into potential therapeutic strategies for allergic diseases, such as asthma associated with DOCK8 deficiency.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Martyna Scibiorek, Nontobeko Mthembu, Sandisiwe Mangali, Amkele Ngomti, Paul Ikwegbue, Frank Brombacher, Sabelo Hadebe
Summary: Atopic dermatitis (AD) is a common inflammatory skin disease characterized by primary skin barrier dysfunction and aberrant TH2 responses. Targeting IL-4R alpha with dupilumab shows efficacy in AD treatment. In this study, we investigated the importance of IL-4R alpha signaling in B and T cells in acute and chronic models of AD.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
T. M. Brombacher, D. C. Ajonijebu, M. Scibiorek, I Berkiks, B. O. Moses, T. Mpotje, F. Brombacher
Summary: This study demonstrates that mice lacking interleukin-4 receptor alpha can successfully learn spatial tasks while their reference memory is impaired. The absence of interleukin-4 receptor alpha leads to an increase in the proportions of CD11b+ myeloid cells in the hippocampus and thalamus, with alterations in interferon gamma and brain-derived neurotrophic factor expression. These findings suggest that interleukin-4 receptor alpha is essential for cognitive performance and training-induced changes in immune mediators may modulate memory encoding and consolidation.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Immunology
Tae-Shin Kim, Min-Seok Rha, Eui-Cheol Shin
Summary: IL-15 plays a pleiotropic role in NK and CD8(+) T cells and contributes to host protection or immunopathology during infection. This study shows that IFN-gamma more effectively upregulates IL-15 expression in Huh-7 cells compared to IFN-alpha and IFN-beta. IRF1 and Kappa B kinase alpha/beta are involved in the upregulation of IL-15. Additionally, IL-15 on IFN-gamma-treated Huh-7 cells activates NK cells through trans-presentation.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Cell Biology
Janice Ortega, Grace Sanghee Lee, Liya Gu, Wei Yang, Guo-Min Li
Summary: The study reveals that the sliding of MutS alpha is necessary for mismatch removal in MMR, MutS alpha recruits MutL alpha to form a mismatch-bound complex and initiates MMR by nicking the daughter strand 5' to the mismatch, Exo1 conducts excision, solving the mechanism of MMR initiation and mispair removal.
Article
Medicine, General & Internal
Rebecca Pakradooni, Nishka Shukla, Kalpana Gupta, Jatinder Kumar, Ilaha Isali, Ahmed O. Khalifa, Sanjeev Shukla
Summary: Growth signals are crucial for cancer progression, with IGF-1 and IL-6 known to activate downstream mechanisms. Modulating these pathways may offer therapeutic potential for disease outcome. Diosmetin shows promise as a novel therapeutic target in prostate cancer treatment by inhibiting the progression through Rictor/AKT/PKC alpha pathway.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Seon-Yeong Lee, A. Ram Lee, Jeong Won Choi, Chae Rim Lee, Keun-Hyung Cho, Jung Ho Lee, Mi-La Cho
Summary: Autophagy was defective in keloid tissue, leading to increased necroptosis and fibrosis. The IL-17-STAT3-HIF-1 alpha axis was involved in defective autophagy in keloid fibroblasts, indicating that targeting this axis could alleviate chronic inflammation in keloid disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhenzhen Zhang, Tiantian Yao, Nan Zhao, Hui Liu, Hao Cheng, Frank J. Gonzalez, Hua Wang, Guiqiang Wang, Aijuan Qu, Yan Wang
Summary: In this study, it was found that the expression of PPAR alpha in the liver was significantly decreased in drug-induced liver injury caused by acetaminophen. Knocking out the Ppara gene in hepatocytes can alleviate acetaminophen-induced liver injury by reducing oxidative stress and upregulating the hepatoprotective IL-6/STAT3 signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Irene Liparulo, Christian Bergamini, Marco Bortolus, Natalia Calonghi, Giuseppe Gasparre, Ivana Kurelac, Luca Masin, Nicola Rizzardi, Michela Rugolo, Wenping Wang, Serena J. Aleo, Alisar Kiwan, Cristian Torri, Claudia Zanna, Romana Fato
Summary: Inhibition of coq2 by the competitive inhibitor 4-NB reduces cellular CoQ content, impairs mitochondrial function, increases cholesterol levels, and disrupts plasma membrane properties. However, 4-NB treatment has minimal impact on cell viability, as cells adapt to glycolysis for metabolic rewiring.
Article
Medicine, Research & Experimental
Mingcan Yu, Subhashis Pal, Cameron W. Paterson, Jau-Yi Li, Abdul Malik Tyagi, Jonathan Adams, Craig M. Coopersmith, M. Neale Weitzmann, Roberto Pacifici
Summary: Estrogen deficiency leads to expansion of BM Th17 cells and TNF-alpha-producing T cells, causing bone loss. Blocking intestinal T cell migration may be a therapeutic strategy for postmenopausal bone loss.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Pharmacology & Pharmacy
Feixia Wang, Zhanghao Li, Li Chen, Ting Yang, Baoyu Liang, Zili Zhang, Jiangjuan Shao, Xuefen Xu, Guoping Yin, Shijun Wang, Hai Ding, Feng Zhang, Shizhong Zheng
Summary: ASCT2 plays an important role in liver fibrosis by controlling the senescence of hepatic stellate cells and modifying the proinflammatory senescence-associated secretory phenotype (SASP). Atractylenolide III, identified as an ASCT2 inhibitor, shows potential as a therapeutic candidate for liver fibrosis.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Multidisciplinary Sciences
Matthew S. Coates, Eric W. F. W. Alton, Garth W. Rapeport, Jane C. Davies, Kazuhiro Ito
Summary: The study identified the involvement of specific kinases in Pseudomonas aeruginosa-induced inflammation, with inhibition of p38MAPK and Syk kinase showing significant reduction in IL-6 and CXCL8 release. Additionally, a novel narrow spectrum kinase inhibitor (NSKI) demonstrated potential as an effective therapy for Pseudomonas aeruginosa-induced inflammation.
Article
Multidisciplinary Sciences
Francisco D. C. Guerra Liberal, Shannon J. J. Thompson, Kevin M. M. Prise, Stephen J. J. McMahon
Summary: There is a lack of clarity regarding the interaction between high-LET radiation and radiations of different qualities. This study aimed to quantify and model the effects of X-ray and alpha particle combinations. It was found that alpha particles generated more sublethal damage than X-rays, leading to a high RBE. These findings emphasize the importance of considering the synergistic effects of different radiation qualities in treatment design.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Hannes Forkel, Piotr Grabarczyk, Maren Depke, Sascha Troschke-Meurer, Stefan Simm, Elke Hammer, Stephan Michalik, Christian Hentschker, Bjoern Corleis, Lucie Loyal, Maxi Zumpe, Nikolai Siebert, Anca Dorhoi, Andreas Thiel, Holger Lode, Uwe Voelker, Christian A. Schmidt
Summary: BCL11B-depleted CD8+ T cells stimulated with IL-15 acquire innate characteristics, expressing multiple innate receptors and maintaining their T cell phenotype. These cells can effectively kill tumor cells and have promising therapeutic potential.
Article
Immunology
Tara E. Sutherland, Tovah N. Shaw, Rachel Lennon, Sarah E. Herrick, Dominik Rueckerl
Summary: Peritoneal dialysis initially benefits patients with chronic kidney disease, but long-term use may lead to significant pathology, increasing the risk of infection and inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Alexandra N. Donlan, Tara E. Sutherland, Chelsea Marie, Saskia Preissner, Ben T. Bradley, Rebecca M. Carpenter, Jeffrey M. Sturek, Jennie Z. Ma, G. Brett Moreau, Jeffrey R. Donowitz, Gregory A. Buck, Myrna G. Serrano, Stacey L. Burgess, Mayuresh M. Abhyankar, Cameron Mura, Philip E. Bourne, Robert Preissner, Mary K. Young, Genevieve R. Lyons, Johanna J. Loomba, Sarah J. Ratcliffe, Melinda D. Poulter, Amy J. Mathers, Anthony Day, Barbara J. Mann, Judith E. Allen, William A. Petri
Summary: Research shows that elevated IL-13 levels are associated with severe COVID-19. In a mouse model, neutralizing IL-13 reduced disease severity and lung HA deposition. Administration of IL-13 induced HA in the lungs. Blocking the HA receptor CD44 prevented mortality, highlighting a potentially novel mechanism for IL-13-mediated HA synthesis in pulmonary pathology.
Article
Biology
Alistair L. Chenery, Silvia Rosini, James E. Parkinson, Jesuthas Ajendra, Jeremy A. Herrera, Craig Lawless, Brian H. K. Chan, P'ng Loke, Andrew S. MacDonald, Karl E. Kadler, Tara E. Sutherland, Judith E. Allen
Summary: IL-13 plays a critical role in limiting tissue injury and hemorrhaging in the lung during acute lung damage. Through proteomic and transcriptomic profiling analysis, IL-13-dependent changes in matrix remodeling and epithelial cell responses were identified. IL-13 is also required for the induction of epithelial-derived type 2 effector molecules and cellular stress responses in the context of acute lung damage.
LIFE SCIENCE ALLIANCE
(2021)
Article
Parasitology
Aya Masuda, Judith E. Allen, Jos G. M. Houdijk, Spiridoula Athanasiadou
Summary: The study found that dietary protein supplementation during pregnancy and lactation enhances Th2 immunity in rats, leading to increased splenic macrophage populations following reinfection with N. brasiliensis, helping to reduce the degree of immunity relaxation.
Article
Immunology
Calum C. Bain, Pieter A. Louwe, Nicholas J. Steers, Alberto Bravo-Blas, Lizi M. Hegarty, Clare Pridans, Simon W. F. Milling, Andrew S. MacDonald, Dominik Rueckerl, Stephen J. Jenkins
Summary: This study reveals the existence of a rare population of F4/80(lo)MHCII(+) macrophages in murine serous cavities, which are regulated by microbiota. Furthermore, the cytokine RELM-alpha plays a sex and site-specific role in regulating the survival and differentiation of these macrophages.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Editorial Material
Immunology
Tara E. Sutherland, Philippe E. Van den Steen
PARASITE IMMUNOLOGY
(2022)
Review
Immunology
Jesuthas Ajendra, Judith E. Allen
Summary: Infections caused by filarial nematodes pose significant public health challenges, and new strategies for treatment and prevention are urgently needed. Understanding the role of neutrophils in controlling and eliminating the infection is crucial. Neutrophils play an important role in helminth infections, including those caused by filarial nematodes.
PARASITE IMMUNOLOGY
(2022)
Review
Cell Biology
Alvaro Diaz, Anabella A. Barrios, Leticia Grezzi, Camila Mouhape, Stephen J. Jenkins, Judith E. Allen, Cecilia Casaravilla
Summary: This article updates the immunobiology of the laminated layer (LL) in larval stages of cestode parasites belonging to the genus Echinococcus. The LL is a unique acellular structure, characterized by mucins decorated with galactose-rich O-glycans and nano-deposits of the calcium salt of myo-inositol hexakisphosphate (Insp(6)). Recent advances include the discovery of LL debris at infection sites and draining lymph nodes, the characterization of calcium Insp(6)'s decoy activity with respect to complement, the specific interaction of LL mucin carbohydrates with a lectin receptor expressed in Kupffer cells (Clec4F), and receptor-independent effects of LL particles on dendritic cells and macrophages. However, there is still much information missing on the immunology of LL, and further research is needed to fill these gaps.
Article
Immunology
Rinal Sahputra, Krittee Dejyong, Adrian S. Woolf, Matthias Mack, Judith E. Allen, Dominik Ruckerl, Sarah E. Herrick
Summary: Peritoneal adhesions commonly occur after abdominal or pelvic surgery and there are currently no effective treatments available. Peritoneal macrophages have complex and nuanced responses after surgery, and differences in response among specific macrophage subpopulations partially explain the risk of developing peritoneal scars. In a mouse experiment, it was found that monocyte-derived macrophages play an important protective role in reducing adhesion formation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Eirini Kalliara, Malgorzata Kardynska, James Bagnall, David G. Spiller, Werner Muller, Dominik Ruckerl, Jaroslaw Smieja, Subhra K. Biswas, Pawel Paszek
Summary: In this study, the researchers investigated interferon-induced JAK-STAT signaling in innate immune macrophages using live-cell confocal microscopy and mathematical modeling. They found that transient exposure to IFN-γ stimulation leads to long-term desensitization of STAT1 signaling and gene expression responses. The study also revealed that IFN-α/β 1 and IFN-γ elicit different levels of desensitization, with cells that are refractory to IFN-α/β 1 being sensitive to IFN-γ, but not vice versa.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Kristina Ritter, Jochen Behrends, Dominik Rueckerl, Alexandra Hoelscher, Johanna Volz, Immo Prinz, Christoph Hoelscher
Summary: IL-17A and IL-17F play a compensatory role in protecting against tuberculosis, and excessive neutrophil infiltration has detrimental effects on the response to Mtb infection.
Article
Immunology
Conor M. Finlay, James E. Parkinson, Lili Zhang, Brian H. K. Chan, Jesuthas Ajendra, Alistair Chenery, Anya Morrison, Irem Kaymak, Emma L. Houlder, Syed Murtuza Baker, Ben R. Dickie, Louis Boon, Joanne E. Konkel, Matthew R. Hepworth, Andrew S. MacDonald, Gwendalyn J. Randolph, Dominik Ruckert, Judith E. Allen
Summary: The recent revolution in tissue-resident macrophage biology has largely relied on studies performed in C57BL/6 mice. In this study, using both C57BL/6 and BALB/c mice, researchers analyzed immune cells in the pleural cavity. They found that the tissue-resident macrophages of BALB/c mice failed to fully implement the tissue-residency program compared to C57BL/6 mice. Infection with a pleural-dwelling nematode further accentuated these differences, with only C57BL/6 mice showing expansion of tissue-resident macrophages.
Review
Multidisciplinary Sciences
Tara E. Sutherland, Douglas P. Dyer, Judith E. Allen
Summary: For decades, immunologists have focused on studying circulating immune cells, but recently there is a growing appreciation for the role of immune cells within the tissue microenvironment. However, the understanding of the extracellular matrix (ECM) and its interaction with the immune system remains limited. This review aims to explore the potential for biological discovery at the intersection of immunology and matrix biology.
Article
Cell Biology
Pedro H. Papotto, Bahtiyar Yilmaz, Goncalo Pimenta, Sofia Mensurado, Carolina Cunha, Gina J. Fiala, Daniel Gomes da Costa, Natacha Goncalves-Sousa, Brian H. K. Chan, Birte Blankenhaus, Rita G. Domingues, Tania Carvalho, Matthew R. Hepworth, Andrew J. Macpherson, Judith E. Allen, Bruno Silva-Santos
Summary: This study reveals the important role of maternal immune cells in regulating offspring immunity. Mice born from TCR(1-/- dams display increased inflammation and type 2 immune response in the lungs. This effect is independent of the genotype of the pups and is associated with a distinct intestinal microbiota and decreased levels of SCFAs.