Population structure in genetic studies: Confounding factors and mixed models

Rare and low-frequency coding variants alter human adult height

(2017) Eirini Marouli et al.   NATURE

Concepts, estimation and interpretation of SNP-based heritability

(2017) Jian Yang et al.   NATURE GENETICS

Reevaluation of SNP heritability in complex human traits

(2017) Doug Speed et al.   NATURE GENETICS

The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)

(2016) Jacqueline MacArthur et al.   NUCLEIC ACIDS RESEARCH

GCTA-GREML accounts for linkage disequilibrium when estimating genetic variance from genome-wide SNPs

(2016) Jian Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accounting for Population Structure in Gene-by-Environment Interactions in Genome-Wide Association Studies Using Mixed Models

(2016) Jae Hoon Sul et al.   PLoS Genetics

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

(2015) Tristan J. Hayeck et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Discovering genes involved in disease and the mystery of missing heritability

(2015) Eleazar Eskin   COMMUNICATIONS OF THE ACM

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Efficient Bayesian mixed-model analysis increases association power in large cohorts

(2015) Po-Ru Loh et al.   NATURE GENETICS

Accurate liability estimation improves power in ascertained case-control studies

(2015) Omer Weissbrod et al.   NATURE METHODS

Effective Genetic-Risk Prediction Using Mixed Models

(2014) David Golan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases

(2014) Alexander Gusev et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A polygenic burden of rare disruptive mutations in schizophrenia

(2014) Shaun M. Purcell et al.   NATURE

Advantages and pitfalls in the application of mixed-model association methods

(2014) Jian Yang et al.   NATURE GENETICS

Improving the Accuracy and Efficiency of Partitioning Heritability into the Contributions of Genomic Regions

(2013) Emrah Kostem et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Improved Heritability Estimation from Genome-wide SNPs

(2012) Doug Speed et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Differential confounding of rare and common variants in spatially structured populations

(2012) Iain Mathieson et al.   NATURE GENETICS

Genome-wide efficient mixed-model analysis for association studies

(2012) Xiang Zhou et al.   NATURE GENETICS

Improved linear mixed models for genome-wide association studies

(2012) Jennifer Listgarten et al.   NATURE METHODS

The continuing value of twin studies in the omics era

(2012) Jenny van Dongen et al.   NATURE REVIEWS GENETICS

The nature of confounding in genome-wide association studies

(2012) Bjarni J. Vilhjálmsson et al.   NATURE REVIEWS GENETICS

Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies

(2012) Noah Zaitlen et al.   PLoS Genetics

Genomic inflation factors under polygenic inheritance

(2011) Jian Yang et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genome partitioning of genetic variation for complex traits using common SNPs

(2011) Jian Yang et al.   NATURE GENETICS

FaST linear mixed models for genome-wide association studies

(2011) Christoph Lippert et al.   NATURE METHODS

Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population

(2010) E. E. Kenny et al.   HUMAN MOLECULAR GENETICS

Integrating common and rare genetic variation in diverse human populations

(2010)   NATURE

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

Variance component model to account for sample structure in genome-wide association studies

(2010) Hyun Min Kang et al.   NATURE GENETICS

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Efficient Control of Population Structure in Model Organism Association Mapping

(2008) H. M. Kang et al.   GENETICS

Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

(2008) Chiara Sabatti et al.   NATURE GENETICS