Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation

CRISPR Screen Reveals that EHEC’s T3SS and Shiga Toxin Rely on Shared Host Factors for Infection

(2018) Alline R. Pacheco et al.   mBio

Genome-wide siRNA screen identifies UNC50 as a regulator of Shiga toxin 2 trafficking

(2017) Andrey S. Selyunin et al.   JOURNAL OF CELL BIOLOGY

Galactose Supplementation in Patients With TMEM165-CDG Rescues the Glycosylation Defects

(2017) Willy Morelle et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genome-Wide Screening Uncovers the Significance of N-Sulfation of Heparan Sulfate as a Host Cell Factor for Chikungunya Virus Infection

(2017) Atsushi Tanaka et al.   JOURNAL OF VIROLOGY

TMEM165 deficiencies in Congenital Disorders of Glycosylation type II (CDG-II): Clues and evidences for roles of the protein in Golgi functions and ion homeostasis

(2017) Eudoxie Dulary et al.   TISSUE & CELL

Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens

(2017) David W. Morgens et al.   Nature Communications

Glycosylation abnormalities in Gdt1p/TMEM165 deficient cells result from a defect in Golgi manganese homeostasis

(2016) Sven Potelle et al.   HUMAN MOLECULAR GENETICS

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B

(2016) Liang Tao et al.   NATURE

LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation

(2015) X. Tan et al.   EMBO JOURNAL

Secretome Analysis Identifies Novel Signal Peptide Peptidase-Like 3 (SPPL3) Substrates and Reveals a Role of SPPL3 in Multiple Golgi Glycosylation Pathways

(2015) Peer-Hendrik Kuhn et al.   MOLECULAR & CELLULAR PROTEOMICS

LAPTM4B facilitates late endosomal ceramide export to control cell death pathways

(2015) Tomas Blom et al.   Nature Chemical Biology

A structure of the COPI coat and the role of coat proteins in membrane vesicle assembly

(2015) S. O. Dodonova et al.   SCIENCE

LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation

(2015) Ruth Milkereit et al.   Nature Communications

Solving Glycosylation Disorders: Fundamental Approaches Reveal Complicated Pathways

(2014) Hudson H. Freeze et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Shedding of glycan‐modifying enzymes by signal peptide peptidase‐like 3 (SPPL3) regulates cellular N‐glycosylation

(2014) Matthias Voss et al.   EMBO JOURNAL

Sphingolipid Metabolism and Interorganellar Transport: Localization of Sphingolipid Enzymes and Lipid Transfer Proteins

(2014) Toshiyuki Yamaji et al.   TRAFFIC

A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility

(2013) Michael C. Bassik et al.   CELL

Retrograde transport of protein toxins through the Golgi apparatus

(2013) Kirsten Sandvig et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Failure of Manganese to Protect from Shiga Toxin

(2013) Marsha A. Gaston et al.   PLoS One

Deciphering the Glycosylome of Dystroglycanopathies Using Haploid Screens for Lassa Virus Entry

(2013) L. T. Jae et al.   SCIENCE

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

TMEM165 Deficiency Causes a Congenital Disorder of Glycosylation

(2012) François Foulquier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Manganese Blocks Intracellular Trafficking of Shiga Toxin and Protects Against Shiga Toxicosis

(2012) S. Mukhopadhyay et al.   SCIENCE

Shiga toxins

(2012) Jonas Bergan et al.   TOXICON

"Add-on" domains of Drosophila β1,4-N-acetylgalactosaminyltransferase B in the stem region and its pilot protein

(2011) Benjamin Kraft et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genome-Wide RNAi Screens Identify Genes Required for Ricin and PE Intoxications

(2011) Dimitri Moreau et al.   DEVELOPMENTAL CELL

A Role for the Ubiquitin Ligase Nedd4 in Membrane Sorting of LAPTM4 Proteins

(2011) Ruth Milkereit et al.   PLoS One

Golgi Glycosylation

(2011) P. Stanley   Cold Spring Harbor Perspectives in Biology

Inhibition of Retrograde Transport Protects Mice from Lethal Ricin Challenge

(2010) Bahne Stechmann et al.   CELL

A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking

(2010) Pablo S Aguilar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transmembrane nine proteins in yeast and Arabidopsis affect cellular metal contents without changing vacuolar morphology

(2010) Josefine N. Hegelund et al.   PHYSIOLOGIA PLANTARUM

Cholera Toxin: An Intracellular Journey into the Cytosol by Way of the Endoplasmic Reticulum

(2010) Naomi L. B. Wernick et al.   Toxins

The Endoplasmic Reticulum Chaperone Cosmc Directly Promotesin VitroFolding of T-synthase

(2009) Rajindra P. Aryal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Golgi targeting ofDrosophila melanogasterβ4GalNAcTB requires a DHHC protein family–related protein as a pilot

(2009) Anita Johswich et al.   JOURNAL OF CELL BIOLOGY

Shiga toxins — from cell biology to biomedical applications

(2009) Ludger Johannes et al.   NATURE REVIEWS MICROBIOLOGY

Tracing the Retrograde Route in Protein Trafficking

(2008) Ludger Johannes et al.   CELL

Regulation of protein O-glycosylation by the endoplasmic reticulum–localized molecular chaperone Cosmc

(2008) Tongzhong Ju et al.   JOURNAL OF CELL BIOLOGY

TM9SF4 is required for Drosophila cellular immunity via cell adhesion and phagocytosis

(2008) E. Bergeret et al.   JOURNAL OF CELL SCIENCE

The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics

(2008) B. L. Cantarel et al.   NUCLEIC ACIDS RESEARCH