Article
Neurosciences
Margarita Anisimova, Bas van Bommel, Rui Wang, Marina Mikhaylova, Joern Simon Wiegert, Thomas G. Oertner, Christine E. Gee
Summary: The study uses optogenetic stimulation to induce STDP and observes timing-dependent depression and potentiation. This study does not require electrodes and results suggest that synaptic depression after anticausal activation is a transient phenomenon.
Article
Neurosciences
Masanori Nomoto, Noriaki Ohkawa, Kaoru Inokuchi, Naoya Oishi
Summary: This study found that NRs in the hippocampal CA3 are crucial for supporting hippocampal functions, such as pattern completion and reverberatory association of sensory inputs. Previous research showed that synchronous activation of distinct cell populations in CA3 could result in the artificial association of independent events, indicating the role of NRs in mediating memory event association in CA3. However, it is still unclear whether NRs in CA3 are essential for the artificial association of memory events stored in CA3 ensembles.
Article
Cell Biology
Junfeng Su, Fengwen Huang, Yu Tian, Ran Tian, Qianqian Gao, Stephen Temitayo Bello, Dingxaun Zeng, Peter Jendrichovsky, C. Geoffrey Lau, Wenjun Xiong, Daiguan Yu, Micky Tortorella, Xi Chen, Jufang He
Summary: This study reveals the critical role of cholecystokinin (CCK) in heterosynaptic neuromodulation from the medial entorhinal cortex (MEC) to the hippocampus, affecting CA3-CA1 LTP and space-related performance.
Article
Pharmacology & Pharmacy
Wonseok Chang, Jihua An, Geun Hee Seol, Seung Ho Han, Jaeyong Yee, Sun Seek Min
Summary: Trans-anethole has neuroprotective effects and can positively influence synaptic plasticity, which suggests its potential for improving cognitive impairment caused by neurodegenerative diseases.
Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Karl Peter Giese
Summary: Autophosphorylation of calcium/calmodulin-dependent kinase II (CaMKII) plays a critical role in synaptic potentiation by allowing kinase signaling to outlast NMDA receptor-dependent calcium influx. However, the role of CaMKII is conditional, depending on the developmental stage and location of the synapse.
Article
Neurosciences
Randa Kassab
Summary: This article introduces a new method for modeling the CA3 network, focusing on the impact of long-term potentiation (LTP) on CA3 functional connectivity. The study found that only a small fraction of active synapses should be connected to activated cells to achieve optimal performance. This control of connectivity is achieved by acetylcholine modulating the trafficking and adjustment of the AMPA receptors.
Article
Multidisciplinary Sciences
Machhindra Garad, Elke Edelmann, Volkmar Lessmann
Summary: BDNF plays a crucial role in regulating synaptic plasticity, with studies showing a bidirectional mode of action involving different receptors. This study focused on the role of proBDNF/p75NTR signaling in MF-LTD and found that MF-LTD is not dependent on p75 neurotrophin receptors.
SCIENTIFIC REPORTS
(2021)
Review
Neurosciences
Qinghu Yang, Da Song, Zhen Xie, Guiqiong He, Juan Zhao, Zhe Wang, Zhifang Dong, Heao Zhang, Liang Yang, Ming Jiang, Yili Wu, Qing Shi, Junjie Li, Jun Yang, Zhantao Bai, Zhenzhen Quan, Hong Qing
Summary: This study reveals the role of optogenetic activation of CA3 pyramidal neurons in restoring the spatial memory of APP/PS1 mice. The stimulation enhances synaptic density/strength, synaptic plasticity, and activates astrocytes. Inhibiting the activity of CA3 astrocytes disrupts this restoration effect, resulting in reduced synaptic density/strength and cognitive impairments in the mice.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Neurosciences
Federico Brandalise, Stefano Carta, Roberta Leone, Fritjof Helmchen, Anthony Holtmaat, Urs Gerber
Summary: In this study, dendritic patch-clamp recordings and calcium imaging were used to investigate the integrative properties of single dendrites. It was found that local hyperpolarization of a single dendritic segment can prevent NMDA spikes, their associated calcium transients, and LTP in a branch-specific manner. This finding provides direct evidence that a single dendritic branch operates as a functional unit in regulating CA3 pyramidal cell plasticity.
Article
Multidisciplinary Sciences
Kif Liakath-Ali, Jai S. Polepalli, Sung-Jin Lee, Jean-Francois Cloutier, Thomas C. Sudhof
Summary: This study reveals the crucial role of presynaptic neurexin-ligand cerebellin-4 (Cbln4) in long-term potentiation (LTP) at EC -> DG synapses. Binding of presynaptic Cbln4 to postsynaptic neogenin-1 enables the EC -> DG synapses to undergo LTP, but is not necessary for the establishment or function of these synapses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Can Dong, Antoine D. Madar, Mark E. J. Sheffield
Summary: The study found that CA1 and CA3 play different roles in spatial memory processing. Place fields in CA1 emerge rapidly but tend to shift backwards from trial-to-trial and remap upon re-exposure to the environment a day later, while place fields in CA3 develop gradually and show more stable trial-to-trial and day-to-day dynamics, indicating distinct functional roles in representing space for each subfield.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Silvia Oldani, Laura Moreno-Velasquez, Lukas Faiss, Alexander Stumpf, Christian Rosenmund, Dietmar Schmitz, Benjamin R. Rost
Summary: Optogenetic manipulations have revolutionized neuroscience by enabling precise control of neural activity. The development of synaptoPAC as an optogenetic tool allows for acute light-controlled potentiation of transmitter release at specific synapses, providing new insights into the role of presynaptic potentiation in network function and animal behavior.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Neurosciences
Olivia A. Shipton, Clara S. Tang, Ole Paulsen, Mariana Vargas-Caballero
Summary: The study shows that both A beta and tau protein play a role in the development of Alzheimer's disease. A beta affects synaptic deficits in wild-type mice, but not in mice without tau protein. Additionally, CA3-CA1 synapses in the hippocampus with presynaptic axons from the left CA3 are more vulnerable to A beta.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Review
Neurosciences
Javier Diaz-Alonso, Roger A. Nicoll
Summary: AMPARs play crucial roles in excitatory synaptic transmission and plasticity, with LTP depending on the accumulation of AMPARs at the postsynapse. Recent research has proposed an updated model of AMPAR trafficking and LTP, incorporating both intracellular and extracellular mechanisms.
Article
Multidisciplinary Sciences
Akinobu Suzuki, Sakurako Kosugi, Emi Murayama, Eri Sasakawa, Noriaki Ohkawa, Ayumu Konno, Hirokazu Hirai, Kaoru Inokuchi
Summary: Animals refer to past experiences when processing current sensory inputs, and update previous memories through neural networks. This study reveals that a cellular ensemble in the posterior parietal cortex of mice interacts with the anterior cingulate cortex through a circuit to update memory by incorporating past and current information.
NATURE COMMUNICATIONS
(2022)
Article
Physics, Applied
Hiroto Sekiguchi, Hayate Matsuhira, Ryota Kanda, Shuto Tada, Taiki Kitade, Masataka Tsutsumi, Atsushi Nishikawa, Alexander Loesing, Izumi Fukunaga, Susumu Setogawa, Noriaki Ohkawa
Summary: In this study, a biocompatible optical stimulation device was developed that can adhere to the brain surface and activate spatially separated brain regions. By using a hollow structure and a thermal release sheet, microLEDs were successfully transferred onto a biocompatible parylene film without any rotation or misalignment while retaining their characteristics.
APPLIED PHYSICS EXPRESS
(2022)
Article
Biochemistry & Molecular Biology
Yuka Kusui, Naotaka Izuo, Kyosuke Uno, Bin Ge, Shin-ichi Muramatsu, Atsumi Nitta
Summary: Piccolo in the NAc is involved in METH-induced behavioral alterations and may serve as a potential therapeutic target for the treatment of drug addiction.
NEUROCHEMICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kakeru Chino, Naotaka Izuo, Hiroshi Noike, Kyosuke Uno, Tomoharu Kuboyama, Chihiro Tohda, Shin-Ichi Muramatsu, Atsumi Nitta
Summary: Alzheimer's disease is characterized by the deposition of amyloid beta in the brain. Overexpression of Shati/Nat8l can prevent cognitive dysfunction in AD model mice, suggesting it as a potential therapeutic target for AD.
NEUROCHEMICAL RESEARCH
(2022)
Article
Optics
Hiroki Yasunaga, Hibiki Takeuchi, Koyo Mizuguchi, Atsushi Nishikawa, Alexander Loesing, Mikiko Ishikawa, Chikako Kamiyoshihara, Susumu Setogawa, Noriaki Ohkawa, Hiroto Sekiguchi
Summary: This study investigates the temperature rise characteristics in brain tissue using a MicroLED probe. The findings show that the temperature rise strongly depends on the surrounding environment and the area of contact. Additionally, a new method for in situ temperature monitoring using the electrical characteristics of the MicroLED is proposed. Furthermore, the study demonstrates the effective control of optogenetic neural activity through optical stimulation by MicroLEDs.
Article
Multidisciplinary Sciences
Masanori Nomoto, Emi Murayama, Shuntaro Ohno, Reiko Okubo-Suzuki, Shin-ichi Muramatsu, Kaoru Inokuchi
Summary: The hippocampus utilizes reverberatory activity to link conditioned and unconditioned stimuli and avoid interference during sensory inputs. It is still unknown how the hippocampus executes these processes simultaneously during learning.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Masanori Nomoto, Noriaki Ohkawa, Kaoru Inokuchi, Naoya Oishi
Summary: This study found that NRs in the hippocampal CA3 are crucial for supporting hippocampal functions, such as pattern completion and reverberatory association of sensory inputs. Previous research showed that synchronous activation of distinct cell populations in CA3 could result in the artificial association of independent events, indicating the role of NRs in mediating memory event association in CA3. However, it is still unclear whether NRs in CA3 are essential for the artificial association of memory events stored in CA3 ensembles.
Article
Biology
Akiyo Kameyama, Hirotaka Asai, Masanori Nomoto, Shuntaro Ohno, Khaled Ghandour, Noriaki Ohkawa, Yoshito Saitoh, Mitsuaki Yamazaki, Kaoru Inokuchi
Summary: General anesthesia can cause retrograde amnesia by suppressing neuronal ensemble activity in the hippocampus. In the experiments, sevoflurane treatment impaired memory and prevented neural activity in the CA1 region. Further analysis revealed a reduction in the reactivation of neuronal ensembles caused by sevoflurane treatment.
Correction
Neurosciences
Masanori Nomoto, Noriaki Ohkawa, Kaoru Inokuchi, Naoya Oishi
Article
Neurosciences
Susumu Setogawa, Ryota Kanda, Shuto Tada, Takuya Hikima, Yoshito Saitoh, Mikiko Ishikawa, Satoshi Nakada, Fumiko Seki, Keigo Hikishima, Hideyuki Matsumoto, Kenji Mizuseki, Osamu Fukayama, Makoto Osanai, Hiroto Sekiguchi, Noriaki Ohkawa
Summary: Characterization of inter-regional interactions in the brain is important for understanding brain function and neurological disease. The development of a flexible micro-electrocorticography device allows large-scale cortical activity examination. This study presents a sheet-shaped 64-channel device that allows access to the mouse temporal cortex and establishes surgical techniques for its implantation. The device successfully records activity in somatosensory and olfactory cortices in awake and anesthetized mice.
Review
Integrative & Complementary Medicine
Shin-ichi Muramatsu, Mayumi Tamada, Yoshinao Harada, Masaki Raimura, Seungwon Kwon
Summary: This article introduces several effective examples of Kampo treatment for neurological diseases, including parasomnia in the elderly, chronic subdural hematomas, and migraines. These traditional herbal medicines have shown good results in alleviating symptoms and preventing disease recurrence.
TRADITIONAL & KAMPO MEDICINE
(2023)
Letter
Integrative & Complementary Medicine
Shin-ichi Muramatsu, Mayumi Tamada, Yoshinao Harada, Masaki Raimura, Seungwon Kwon
TRADITIONAL & KAMPO MEDICINE
(2022)