Article
Business
Abhijeet Satwekar, Tiziano Volpentesta, Paolo Spagnoletti, Mara Rossi
Summary: This article introduces a digital innovation management framework that aims to guide the pursuit of digital innovations. The framework provides practical guidance through a phased and incremental approach, improving the visibility of the digital innovation process and enhancing organizational decision-making effectiveness.
IEEE TRANSACTIONS ON ENGINEERING MANAGEMENT
(2023)
Review
Clinical Neurology
Holger Froehlich, Noemi Bontridder, Dijana Petrovska-Delacreta, Enrico Glaab, Felix Kluge, Mounim El Yacoubi, Mayca Marin Valero, Jean-Christophe Corvol, Bjoern Eskofier, Jean-Marc Van Gyseghem, Stephane Lehericy, Juergen Winkler, Jochen Klucken
Summary: There has been an increasing interest in the use of digital technology, such as sensor devices and smartphone apps, in medicine and specifically in neurology. The use of digital biomarkers (DMs) derived from digital technology could allow for continuous monitoring of disease symptoms and potentially complement or replace traditional outcome measures and biomarkers. However, further research is needed to develop advanced data analytical methods, validate candidate DMs, and address ethical and social concerns associated with the use of sensitive patient data and machine learning methods. This article critically reviews the current state of research on DMs in the context of Parkinson's Disease and discusses future directions.
FRONTIERS IN NEUROLOGY
(2022)
Article
Management
Silvia Cosimato, Nadia Di Paola, Roberto Vona
Summary: This study examines digital social innovation in healthcare ecosystems and contributes to the discussion on the ability of ecosystems to respond to unexpected crises. Through a real-world case study, the research shows how digital platforms facilitate multi-actor interactions to find innovative solutions to emerging social issues. The findings demonstrate the ecosystem's capability to reshape itself in the face of crises like the COVID-19 pandemic.
TECHNOLOGY ANALYSIS & STRATEGIC MANAGEMENT
(2022)
Article
Computer Science, Information Systems
David Soto Setzke, Tobias Riasanow, Markus Boehm, Helmut Krcmar
Summary: Digital technologies are transforming the way organizations design services, and digital transformation strategies are used to transition from product-centric to service-centric business models. However, little is known about the configurations of these strategies that lead to successful digital service innovation (DSI). This study identifies different configurations of digital transformation strategies that contribute to both successful and unsuccessful DSI. The threat of digital disruption negatively impacts innovation activities, strategic partnerships are important for organizations facing digital disruption, and the involvement of C-level executives is crucial for successful DSI.
INFORMATION SYSTEMS FRONTIERS
(2023)
Article
Health Care Sciences & Services
Elena Roxana Tucmeanu, Alin Iulian Tucmeanu, Madalina Gabriela Iliescu, Justyna Zywiolek, Zahid Yousaf
Summary: This study investigates specific issues regarding the successful management of IT projects in healthcare institutions after the COVID-19 pandemic. The findings reveal that digital orientation plays a critical role in achieving successful IT management, with innovation adaption mediating the relationship between digital orientation and successful IT management.
Article
Engineering, Industrial
Francesco Santarsiero, Giovanni Schiuma, Daniela Carlucci, Nina Helander
Summary: Digital Transformation (DT) is crucial for healthcare organizations, providing new ways to improve quality of care, medical practice, management, and overall value creation. However, implementing DT in healthcare is complex and requires consideration of technological, political, social, cultural, and economic aspects. Innovation Labs are recognized as a way to facilitate innovation and address DT challenges in healthcare, but there is a need for more understanding of their role and management in this context.
Review
Biochemistry & Molecular Biology
Jasmin Galper, Woojin S. Kim, Nicolas Dzamko
Summary: Genetic alterations in the LRRK2 gene are a common risk factor for Parkinson's disease. LRRK2 alterations are associated with changes in lipid pathways, which can lead to cellular pathology.
Article
Neurosciences
Betina Awuson-David, Adrian C. Williams, Benjamin Wright, Lisa J. Hill, Valentina Di Pietro
Summary: MicroRNAs (miRNAs) have been found to be dysregulated in patients with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. This study aimed to identify common mechanisms and potential therapeutic targets between the two pathologies. Through systematic reviews, bioinformatic analysis, and experimentation, common miRNAs and pathways were identified. Let-7f-5p and miR-29b-3p were determined to be good predictors in blood samples from Parkinson's disease patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Business
Maria Cristina Pietronudo, Fuli Zhou, Andrea Caporuscio, Giuseppe La Ragione, Marcello Risitano
Summary: This article explores the role of digital platforms in addressing data challenges and fostering data-driven innovation in the healthcare industry. Through a case study of Apheris, it finds that innovative data-driven digital platforms have the potential to accelerate research and innovation and overcome challenges related to healthcare data.
EUROPEAN JOURNAL OF INNOVATION MANAGEMENT
(2022)
Article
Engineering, Industrial
Amir Shaygan, Tugrul Daim
Summary: This research proposes a multi-criteria model using Hierarchical Decision Model (HDM) to assess technology management maturity and continuous learning in research centers within university hospitals. It aims to help research centers identify their strengths and opportunities in terms of continuous learning while providing organizational self-awareness and guiding strategy and resource allocation.
Article
Clinical Neurology
Raphael Scherbaum, Andreas Moewius, Judith Oppermann, Johanna Geritz, Clint Hansen, Ralf Gold, Walter Maetzler, Lars Toenges
Summary: This study found that wearable device-based parameters (DBP) can objectively describe gait and balance impairment in Parkinson's disease (PD) and are correlated with clinical scores. PD-MCT significantly improves gait velocity and stride length and has a positive impact on other DBP. Motor complications and fear of falling may influence the response to PD-MCT. The results of this study suggest that a DBP-based assessment can provide more individualized therapy and improve outcomes for PD patients.
JOURNAL OF NEUROLOGY
(2022)
Article
Agriculture, Multidisciplinary
Simon Cook, Elizabeth L. Jackson, Myles J. Fisher, Derek Baker, Dean Diepeveen
Summary: Digital agriculture has attracted attention due to expectations of disrupting food systems through new technologies, improving precision, efficiency and product identity. Sustainability is a key background driver. Various technology applications are emerging unilaterally in food chains, with benefits realized through human acceptance and adoption in business processes.
INTERNATIONAL JOURNAL OF AGRICULTURAL SUSTAINABILITY
(2022)
Review
Biochemistry & Molecular Biology
Ailyn Irvita Ravinther, Hemaniswarri Dewi Dewadas, Shi Ruo Tong, Chai Nien Foo, Yu-En Lin, Cheng-Ting Chien, Yang Mooi Lim
Summary: Parkinson's disease is a common neurodegenerative disease affecting the ageing population, and its prevalence has increased in recent years. Mutations in Leucine-rich-repeat-kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease, and aberrant LRRK2 kinase activity is also associated with idiopathic Parkinson's disease. This review aims to categorize and synthesize current information on LRRK2-linked Parkinson's disease and identify potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Nicola D'Ascenzo, Emanuele Antonecchia, Antonella Angiolillo, Victor Bender, Marco Camerlenghi, Qingguo Xie, Alfonso Di Costanzo
Summary: This study identified PD blood metabolites and metabolic pathways significantly correlated with age, and proposed a personalized age-dependent approach to early PD diagnosis.
CELL AND BIOSCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Ina Tapager, Kim Rose Olsen, Karsten Vrangbaek
Summary: This study examines equity in opportunities to access treatment for patients with recently diagnosed type 2 diabetes using a unique combination of register and survey data. By approximating need from treatment guidelines and focusing on patient reports of treatment offers, the study explores inequalities prior to utilization inequalities. The results highlight associations between healthcare gaps and poorer quality of care, suggesting the need for further research into causes, consequences, and remedies of healthcare inequities.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Medicine, Research & Experimental
Zi H. Su, Salil Patel, Bronwyn Gavine, Tim Buchanan, Marko Bogdanovic, Nagaraja Sarangmat, Alexander L. Green, Bastiaan R. Bloem, James J. FitzGerald, Chrystalina A. Antoniades
Summary: This study compared the effects of dopaminergic medication and subthalamic nucleus deep brain stimulation (STN DBS) on gait variability in Parkinson disease patients. The results showed that STN DBS reduced short-term variability in lower limb gait parameters, while medication did not have this effect. In addition, STN DBS had no effect on arm swing and trunk motion variability, while medication increased them.
Article
Clinical Neurology
Henrieke L. Frequin, Jason Schouten, Constant V. M. Verschuur, Sven R. Suwijn, Judith A. Boel, Bart Post, Bastiaan R. Bloem, Johannes J. van Hilten, Teus van Laar, Gerrit Tissingh, Alexander G. Munts, Joke M. Dijk, Gunther Deuschl, Anthony Lang, Marcel G. W. Dijkgraaf, Rob J. de Haan, Rob M. A. de Bie
Summary: The study found that levodopa had similar effects on bradykinesia, rigidity, and tremor in patients with early Parkinson's disease. The improvements in symptoms were larger at 22 weeks compared to 4 weeks. At 80 weeks, fewer patients in the early-start group experienced motor response fluctuations.
Article
Clinical Neurology
Eva-Juliane Vollstedt, Susen Schaake, Katja Lohmann, Shalini Padmanabhan, Alexis Brice, Suzanne Lesage, Christelle Tesson, Marie Vidailhet, Isabel Wurster, Faycel Hentati, Anat Mirelman, Nir Giladi, Karen Marder, Cheryl Waters, Stanley Fahn, Meike Kasten, Norbert Bruggemann, Max Borsche, Tatiana Foroud, Eduardo Tolosa, Alicia Garrido, Grazia Annesi, Monica Gagliardi, Maria Bozi, Leonidas Stefanis, Joaquim J. Ferreira, Leonor Correia Guedes, Micol Avenali, Simona Petrucci, Lorraine Clark, Ekaterina Y. Fedotova, Natalya Y. Abramycheva, Victoria Alvarez, Manuel Menendez-Gonzalez, Silvia Jesus Maestre, Pilar Gomez-Garre, Pablo Mir, Andrea Carmine Belin, Caroline Ran, Chin-Hsien Lin, Ming-Che Kuo, David Crosiers, Zbigniew K. Wszolek, Owen A. Ross, Joseph Jankovic, Kenya Nishioka, Manabu Funayama, Jordi Clarimon, Caroline H. Williams-Gray, Marta Camacho, Mario Cornejo-Olivas, Luis Torres-Ramirez, Yih-Ru Wu, Guey-Jen Lee-Chen, Ana Morgadinho, Teeratorn Pulkes, Pichet Termsarasab, Daniela Berg, Gregor Kuhlenbaumer, Andrea A. Kuhn, Friederike Borngraeber, Giuseppe de Michele, Anna De Rosa, Alexander Zimprich, Andreas Puschmann, George D. Mellick, Jolanta Dorszewska, Jonathan Carr, Rosangela Ferese, Stefano Gambardella, Bruce Chase, Katerina Markopoulou, Wataru Satake, Tatsushi Toda, Malco Rossi, Marcelo Merello, Timothy Lynch, Diana A. Olszewska, Shen-Yang Lim, Azlina Ahmad-Annuar, Ai Huey Tan, Bashayer Al-Mubarak, Hasmet Hanagasi, Dariusz Koziorowski, Sibel Ertan, Gencer Genc, Patricia de Carvalho Aguiar, Melinda Barkhuizen, Marcia M. G. Pimentel, Rachel Saunders-Pullman, Bart van de Warrenburg, Susan Bressman, Mathias Toft, Silke Appel-Cresswell, Anthony E. Lang, Matej Skorvanek, Agnita J. W. Boon, Rejko Kruger, Esther M. Sammler, Vitor Tumas, Bao-Rong Zhang, Gaetan Garraux, Sun Ju Chung, Yun Joong Kim, Juliane Winkelmann, Carolyn M. Sue, Eng-King Tan, Joana Damasio, Peter Klivenyi, Vladimir S. Kostic, David Arkadir, Mika Martikainen, Vanderci Borges, Jens Michael Hertz, Laura Brighina, Mariana Spitz, Oksana Suchowersky, Olaf Riess, Parimal Das, Brit Mollenhauer, Emilia M. Gatto, Maria Skaalum Petersen, Nobutaka Hattori, Ruey-Meei Wu, Sergey N. Illarioshkin, Enza Maria Valente, Jan O. Aasly, Anna Aasly, Roy N. Alcalay, Avner Thaler, Matthew J. Farrer, Kathrin Brockmann, Jean-Christophe Corvol, Christine Klein
Summary: Through a worldwide online survey, we established an international cohort of individuals with PD-linked variants, providing harmonized and quality-controlled clinical and genetic data for each participant and promoting collaboration among researchers in the field of monogenic PD.
MOVEMENT DISORDERS
(2023)
Editorial Material
Neurosciences
Bastiaan R. Bloem, Lorraine V. Kalia
JOURNAL OF PARKINSONS DISEASE
(2023)
Editorial Material
Clinical Neurology
Milan Beckers, Bastiaan R. Bloem, Rick C. Helmich
JOURNAL OF MOVEMENT DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Ayami Okuzumi, Taku Hatano, Gen Matsumoto, Shuko Nojiri, Shin-ichi Ueno, Yoko Imamichi-Tatano, Haruka Kimura, Soichiro Kakuta, Akihide Kondo, Takeshi Fukuhara, Yuanzhe Li, Manabu Funayama, Shinji Saiki, Daisuke Taniguchi, Taiji Tsunemi, Deborah McIntyre, Jean-Jacques Gerardy, Michel Mittelbronn, Rejko Kruger, Yasuo Uchiyama, Nobuyuki Nukina, Nobutaka Hattori
Summary: A modified assay system (IP/RT-QuIC) has been developed to detect pathogenic alpha-synuclein seeds in the serum of individuals with synucleinopathies. The system showed high diagnostic performance for differentiating Parkinson's disease and multiple system atrophy from controls.
Article
Cell & Tissue Engineering
Axel Chemla, Giuseppe Arena, Claudia Saraiva, Clara Berenguer-Escuder, Dajana Grossmann, Anne Grunewald, Christine Klein, Philip Seibler, Jens C. Schwamborn, Rejko Kruger
Summary: In this study, two Parkinson's disease patients' primary skin fibroblasts carrying distinct heterozygous mutations in the RHOT1 gene encoding Miro1 were reprogrammed into induced pluripotent stem cells (iPSCs) using episomal reprogramming. Isogenic gene-corrected lines were generated using CRISPR/Cas9 technology. Both isogenic pairs were comprehensively characterized and quality assured to study the Miro1-related molecular mechanisms underlying neurodegeneration in iPSC-derived neuronal models.
STEM CELL RESEARCH
(2023)
Article
Neurosciences
Odette Fruendt, Anne-Marie Hanff, Annika Moehl, Tobias Mai, Christiane Kirchner, Ali Amouzandeh, Carsten Buhmann, Rejko Kruger, Martin Suedmeyer
Summary: Data on the use of device-aided therapies (DATs) in people with Parkinson's disease (PwP) are scarce. German DAT application rate is rather low, indicating a need for precise identification of symptoms and implementation in future treatment strategies.
Article
Neurosciences
Martin E. Johansson, Nina M. van Lier, Roy P. C. Kessels, Bastiaan R. Bloem, Rick C. Helmich
Summary: Heterogeneity in Parkinson's disease (PD) makes it difficult to understand the disease and develop treatments. Stratifying patients into subtypes based on clinical characteristics may help overcome this challenge. A recent study classified de novo PD patients into three subtypes and found that the diffuse-malignant subtype had more severe symptoms and faster progression compared to the mild-motor predominant subtype. These findings suggest different pathophysiological mechanisms underlie distinct PD subtypes.
NPJ PARKINSONS DISEASE
(2023)
Review
Clinical Neurology
Anneli Langbroek-Amersfoort, Sabine Schootemeijer, Lars Bouten, Bastiaan R. Bloem, Nienke M. De Vries
Summary: There is increasing evidence supporting the positive effects of community-based exercise for individuals with Parkinson's disease. However, the studies on this topic vary greatly in terms of exercise types, study designs, and outcome measures. While this review acknowledges the feasibility and potential benefits of community-based exercise, it also emphasizes the need for improvement in the overall quality of these studies.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2023)
Article
Clinical Neurology
Anne-Marie Hanff, Christopher McCrum, Armin Rauschenberger, Gloria A. Aguayo, Maurice P. Zeegers, Anja K. Leist, Rejko Kruger
Summary: This study aimed to validate the algorithm calculating the Functional Mobility Composite Score (FMCS) based on the Parkinson's Disease Questionnaire-39 (PDQ-39). The results showed that the FMCS has good convergent and discriminative validity, making it a reliable measure for assessing functional mobility through patient reports in people with Parkinson's disease.
PARKINSONISM & RELATED DISORDERS
(2023)
Review
Clinical Neurology
Carlo Alberto Artusi, Christian Geroin, Jorik Nonnekes, Camila Aquino, Divyani Garg, Marian L. Dale, Darbe Schlosser, Yijie Lai, Mohammad Al-Wardat, Mehri Salari, Robin Wolke, Valery Tsinda Labou, Gabriele Imbalzano, Serena Camozzi, Marcelo Merello, Bastiaan R. Bloem, Tamine Capato, Ruth Djaldetti, Karen Doherty, Alfonso Fasano, Houyam Tibar, Leonardo Lopiano, Nils G. Margraf, Caroline Moreau, Yoshikazu Ugawa, Roongroj Bhidayasiri, Michele Tinazzi
Summary: Axial postural abnormalities are common in patients with Parkinson's disease and atypical parkinsonism, and have a significant impact on the patients' quality of life. However, there is limited understanding of the pathophysiology and clinical predictors of these symptoms, highlighting the need for further research in this area.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Editorial Material
Clinical Neurology
Tessa F. Peerbolte, Rozanne J. A. van Diggelen, Marjan J. Meinders, Bastiaan R. Bloem, Sanne W. van den Berg
PRACTICAL NEUROLOGY
(2023)
Letter
Clinical Neurology
Rui Araujo, Jos J. Kole, Joaquim J. Ferreira, Bastiaan R. Bloem
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Francisco Cardoso, Christopher G. Goetz, Tiago A. Mestre, Cristina Sampaio, Charles H. Adler, Daniela Berg, Bastiaan R. Bloem, David J. Burn, Michael S. Fitts, Thomas Gasser, Christine Klein, Marina A. J. de Tijssen, Anthony E. Lang, Shen-Yang Lim, Irene Litvan, Wassilios G. Meissner, Brit Mollenhauer, Njideka Okubadejo, Michael S. Okun, Ronald B. Postuma, Per Svenningsson, Louis C. S. Tan, Taiji Tsunemi, Sarah Wahlstrom-Helgren, Oscar S. Gershanik, Victor S. C. Fung, Claudia Trenkwalder
MOVEMENT DISORDERS
(2023)