Article
Nanoscience & Nanotechnology
Shuya Masuda, Saori Deguchi, Fumihiko Ogata, Joji Yoshitomi, Hiroko Otake, Kazutaka Kanai, Naohito Kawasaki, Noriaki Nagai
Summary: In this study, a 0.05% mometasone furoate (MF) nanocrystal dispersion was designed and found to enhance local absorption compared to traditional nasal MF formulations. The use of in situ gelling systems, however, attenuated the local absorption of the MF nanocrystals.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Instruments & Instrumentation
Priscila Zimath, Soraia Pinto, Sofia Dias, Alex Rafacho, Bruno Sarmento
Summary: This study loaded MF into zein NPs and evaluated the potential advantages of oral delivery and the application in treating intestinal inflammatory diseases.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Alessandra Cataldo Russomando, Doron Steinberg, Irith Gati, Ronit Vogt Sionov, Ron Eliashar, Michael Friedman, Menachem Gross
Summary: The aim of the study was to develop a sustained-release varnish containing mometasone furoate for sinonasal stents to reduce mucosa inflammation in the sinonasal cavity. The results showed that the coating of sinonasal stents with the sustained-release varnish provided a sustained delivery of mometasone furoate for at least 2 weeks, inhibiting pro-inflammatory cytokine release and potentially playing a significant role in the treatment of chronic rhinosinusitis.
Article
Otorhinolaryngology
Changcheng You, Ling-Fang Tseng, Alexander Pappas, Danny Concagh, Yina Kuang
Summary: The study aimed to evaluate the in vitro and in vivo drug release of novel MF matrices in a rabbit model, demonstrating sustained release of MF in sinus tissues. The results showed that, compared to daily nasal sprays, these matrices provided sustained therapeutic levels of MF through a single administration.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2022)
Article
Pharmacology & Pharmacy
Nayara Almeida Lage, Mayara Rodrigues Brandao de Paiva, Daniel Vitor Vasconcelos-Santos, Renes Resende Machado, Silvia Ligorio Fialho, Armando Silva-Cunha
Summary: The study investigated the anti-inflammatory activity of Mometasone furoate (MF) in ocular tissues. It was found that at appropriate doses, MF was non-toxic and could attenuate disease progression, improve clinical, morphological, and functional parameters. The levels of inflammatory markers were also significantly reduced. Therefore, MF should be further explored as a promising drug for the treatment of ocular inflammation.
Article
Pediatrics
Alice Baker, Anneke Grobler, Karen Davies, Amanda Griffiths, Harriet Hiscock, Haytham Kubba, Rachel L. Peters, Sarath Ranganathan, Joanne Rimmer, Elizabeth Rose, Katherine Rowe, Catherine M. Simpson, Andrew Davidson, Gillian Nixon, Kirsten P. Perrett
Summary: Obstructive sleep-disordered breathing (SDB) in children can be improved by intranasal corticosteroids, but the effect on symptoms and quality of life is unclear.
Article
Health Care Sciences & Services
Angela Rizzi, Giuseppe Parrinello, Eugenio De Corso, Laura Tricarico, Michele Centrone, Alessia Di Rienzo, Chiara Laface, Giulio Cesare Passali, Gabriella Cadoni, Riccardo Inchingolo, Gaetano Paludetti, Jacopo Galli, Eleonora Nucera
Summary: The study confirms the effectiveness of intranasal mometasone furoate in patients with NAR, with improvements in olfactory function and quality of life observed as therapeutic responses.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Chemistry, Physical
Yue Jiang, Xueting Pan, Tao Yu, Hai Wang
Summary: The existence of the blood-brain barrier (BBB) poses challenges for drug delivery to the central nervous system (CNS). Intranasal administration has emerged as an alternative method for delivering drugs to the brain by bypassing the BBB. This review focuses on the mechanisms, properties, and strategies of intranasal nanosystems for brain-targeted drug delivery. Despite promising results in animal models and clinical applications, significant challenges need to be overcome for the translation of these nanosystems into clinics. The future prospects of intranasal drug delivery nanosystems are discussed, aiming to provide insights and guidance for effective neurological disease treatment.
Review
Pharmacology & Pharmacy
Ta-Hsin Tsung, Yi-Hao Chen, Da-Wen Lu
Summary: The complex nature of the ocular drug delivery barrier poses challenges to effective drug administration. One promising approach is the use of biodegradable formulations, such as hydrogels, implants, and polymeric nanocarriers. Research in these areas is rapidly growing. This review provides an overview of recent updates in biodegradable formulations for ocular drug delivery, exploring their clinical use in different ocular diseases and highlighting their potential for future trends and practical clinical applications.
Review
Pharmacology & Pharmacy
Roland Buhl, Ivan Nikolaev, Hanns-Christian Tillmann, Soniya Vaidya, Christian Bartels, Monish Jain, Juergen Jauernig, Huib A. M. Kerstjens
Summary: This article describes the bridging steps for different dose strengths of mometasone furoate in the fixed-dose combination MF/IND/GLY, and confirms the comparable efficacy of mometasone furoate in treating asthma with different dose strengths.
PULMONARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Biotechnology & Applied Microbiology
Yixiu Liu, Xu Li, A. Liang
Summary: Chronic osteomyelitis is a challenging disease in orthopedic treatment. Local drug delivery systems based on biodegradable polymers provide new hope for treating this condition by reducing drug side effects and promoting bone healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Frank Maigler, Simone Ladel, Johannes Flamm, Stella Gaenger, Barbara Kurpiers, Stefanie Kiderlen, Ronja Voelk, Carmen Hamp, Sunniva Hartung, Sebastian Spiegel, Arghavan Soleimanizadeh, Katharina Eberle, Rebecca Hermann, Lukas Krainer, Claudia Pitzer, Katharina Schindowski
Summary: This study validated a refined technique for region-specific drug delivery to the olfactory mucosa in mice, demonstrating improved brain targeting and reduced peripheral targeting. The potential clinical implications of these findings were discussed in the context of intranasal drug delivery to the CNS.
Article
Chemistry, Analytical
Amira F. El-Yazbi, Faten M. Aboukhalil, Essam F. Khamis, Rasha M. Youssef, Mahmoud A. El-Sayed
Summary: The green capillary zone electrophoretic method showed linear response for both MF and SAL in concentration ranges. It is sensitive, selective, inexpensive, rapid, and requires fewer quantities of solvents and analytical reagents. The method was validated according to ICH guidelines and was found to be more eco-friendly than reported methods.
MICROCHEMICAL JOURNAL
(2021)
Article
Polymer Science
Pradip Jana, Mousumi Shyam, Sneha Singh, Venkatesan Jayaprakash, Abhimanyu Dev
Summary: Biodegradable polymers have emerged as promising materials in drug delivery and vaccination due to their biocompatibility, biodegradability, and minimal toxicity. Targeting mucosal immune system in particulate carriers for oral vaccine delivery can provide desired immunological response for longer period without the need for repetitive injections or skilled personnel.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Moritz Radbruch, Hannah Pischon, Fang Du, Rainer Haag, Fabian Schumacher, Burkhard Kleuser, Lars Mundhenk, Achim D. Gruber
Summary: The polymeric core-multishell nanocarrier (CMS) shows promise as a carrier for topical delivery of tacrolimus (TAC). However, in vivo, it does not increase TAC penetration into the skin compared to ointment. Nevertheless, the therapeutic efficacy of TAC delivered by CMS is equivalent to standard TAC ointment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Medical Laboratory Technology
Stephanie A. Fong, Amanda J. Drilling, Mian Li Ooi, Sathish Paramasivan, John W. Finnie, Sandra Morales, Alkis J. Psaltis, Sarah Vreugde, Peter-John Wormald
TRANSLATIONAL RESEARCH
(2019)
Article
Medicine, Research & Experimental
Darren Rom, Ahmed Bassiouni, Elizabeth Eykman, Zhixin Liu, Sathish Paramasivan, Raquel Alvarado, Peter Earls, Alkis J. Psaltis, Richard J. Harvey
Article
Multidisciplinary Sciences
Mahnaz Ramezanpour, Jason L. P. Smith, Mian Li Ooi, Michael Gouzos, Alkis J. Psaltis, P. J. Wormald, Sarah Vreugde
SCIENTIFIC REPORTS
(2019)
Article
Otorhinolaryngology
Lisa Mary Cherian, Clare Cooksley, Katharina Richter, Mahnaz Ramezanpour, Sathish Paramasivan, Peter-John Wormald, Sarah Vreugde, Alkis James Psaltis
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2019)
Article
Immunology
Jian Li, Mahnaz Ramezanpour, Stephanie A. Fong, Clare Cooksley, Jae Murphy, Masanobu Suzuki, Alkis J. Psaltis, Peter John Wormald, Sarah Vreugde
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2019)
Article
Otorhinolaryngology
John R. Scott, Alkis J. Psaltis, Peter-John Wormald
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2020)
Review
Otorhinolaryngology
Luis Macias-Valle, Alkis J. Psaltis
Summary: The scholarly review presents an update on the efficacy, safety, and distribution of intranasal corticosteroids (INCS) for chronic rhinosinusitis (CRS) treatment. Studies show significant improvement in disease-specific and general quality of life measures with all formulations of INCS, indicating the effectiveness and safety of both FDA and non-FDA approved options. Novel distribution devices may further enhance penetration to specific areas within the sinuses.
ENT-EAR NOSE & THROAT JOURNAL
(2021)
Article
Biophysics
Sholeh Feizi, Clare M. Cooksley, George S. Bouras, Clive A. Prestidge, Tom Coenye, Alkis James Psaltis, Peter-John Wormald, Sarah Vreugde
Summary: The study demonstrates a novel, green synthesis method for stable CS with good safety and efficacy profiles. CS shows high antibacterial effects against MRSA and P. aeruginosa, without toxicity to bronchial epithelial cells and Caenorhabditis elegans.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Editorial Material
Otorhinolaryngology
James Connell, Ahmed Bassiouni, Peter-John Wormald, Sarah Vreugde, Alkis Psaltis
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2021)
Article
Microbiology
Martha Alemayehu Menberu, Clare Cooksley, Mahnaz Ramezanpour, George Bouras, Peter-John Wormald, Alkis James Psaltis, Sarah Vreugde
Summary: This study investigated the probiotic potential of Corynebacterium accolens strains, specifically strains C781 and C787, and found that these strains exhibited good adhesion capacity, antimicrobial activity, and protection against infection. These findings suggest that C. accolens strains hold promise for clinical applications in treating dysbiosis in chronic rhinosinusitis.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Biology
Mahnaz Ramezanpour, Harrison Bolt, Karen Hon, Gohar Shaghayegh, Hadi Rastin, Kevin Aaron Fenix, James Psaltis Alkis, Peter -John Wormald, Sarah Vreugde
Summary: This study investigates the characteristics and cellular morphology of organoids derived from primary human nasal epithelial cells (HNECs) of chronic rhinosinusitis (CRS) patients. The results showed that nasal organoids expressed stem cell markers and markers for ciliated cells, and could regrow and expand well after freezing and thawing. This study provides an effective and feasible method for the development of human nasal organoids suitable for phenotypic high-throughput screening and drug response research.
Article
Immunology
Gohar Shaghayegh, Clare Cooksley, George Bouras, Roshan Nepal, Ghais Houtak, Beula Subashini Panchatcharam, Kevin Aaron Fenix, Alkis James Psaltis, Peter-John Wormald, Sarah Vreugde
Summary: Chronic rhinosinusitis (CRS) is a chronic inflammation of the sinus mucosa characterized by dysfunction of the sinuses' defense mechanisms and induction of different inflammatory pathways. The presence of Staphylococcus aureus (S. aureus) in the sinonasal mucosa is associated with CRS, but it is also observed in healthy individuals, which challenges its significance in CRS pathogenesis. This study investigated the relationship between CRS inflammatory markers, S. aureus biofilm properties/virulence genes, and disease severity.
Article
Ophthalmology
Swati Singh, Dinesh Selva, Arpita Nayak, Alkis Psaltis, Mohammad Javed Ali
ORBIT-THE INTERNATIONAL JOURNAL ON ORBITAL DISORDERS-OCULOPLASTIC AND LACRIMAL SURGERY
(2020)
Article
Surgery
Ingrid Salna, Joshua Jervis-Bardy, David Wabnitz, Guy Rees, Alkis Psaltis, Adam Johnson
JOURNAL OF CRANIOFACIAL SURGERY
(2019)
Article
Ophthalmology
David S. Curragh, Alkis J. Psaltis, Neil C. Tan, Dinesh Selva
ORBIT-THE INTERNATIONAL JOURNAL ON ORBITAL DISORDERS-OCULOPLASTIC AND LACRIMAL SURGERY
(2019)