期刊
CONTACT LENS & ANTERIOR EYE
卷 42, 期 5, 页码 497-501出版社
ELSEVIER
DOI: 10.1016/j.clae.2018.11.009
关键词
Dry eye; Ocular surface; Tear film; TFOS DEWS II; Diagnosis; Screening
资金
- University of Auckland
- New Zealand Association of Optometrists
Purpose: To evaluate the discriminative ability of a rapid non-invasive dry eye assessment algorithm (global evaluation component: SANDE questionnaire, and non-invasive tear film breakup time; subtype classification testing component: tear film lipid layer grade, and tear meniscus height) in detecting dry eye disease, as defined by the TFOS DEWS II diagnostic criteria. Methods: Two hundred and thirty-five participants (77 male, 158 female), with a mean +/- SD age of 43 +/- 17 years, were recruited into a prospective diagnostic accuracy study. OSDI, DEQ-5, and SANDE dry eye symptomology scores; non-invasive tear film breakup time; absolute and inter-ocular differences in tear osmolarity; corneal, conjunctival, and lid margin staining scores; tear film lipid layer, meibum expressibility, meibomian gland orifice plugging, and eyelid margin telangiectasia grades; and tear meniscus height were evaluated in a single clinical session. Results: The areas under the ROC curves exceeded 0.80 for all individual components of the rapid non-invasive dry eye assessment algorithm, and the discriminative abilities were significantly greater than chance (all p < 0.001). At the Youden optimal diagnostic thresholds for the global evaluation component of the rapid noninvasive assessment algorithm (SANDE score >= 30, non-invasive tear film break-up time < 10 s), the overall sensitivity was 86%, specificity 94%, positive likelihood ratio 15.0, and negative likelihood ratio 0.15. Conclusions: The abridged non-invasive dry eye assessment algorithm may be a useful rapid screening instrument for the full TFOS DEWS II diagnostic test battery, of particular benefit in resource or time-constrained settings.
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