Article
Environmental Sciences
Boonsita Suwannakul, Ratana Sapbamrer, Natrujee Wiwattanadittakul, Surat Hongsibsong
Summary: This study revealed a potential association between prenatal urinary OP metabolite levels among pregnant agricultural workers and adverse birth outcomes in infants, emphasizing the need for effective strategies to reduce prenatal exposure to OP pesticides.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Nadiah P. Kristensen, Hisashi Ohtsuki, Ryan A. Chisholm
Summary: In this study, a mathematical model is used to explore the origin of human cooperation. The findings suggest that cooperation first evolved through kin selection in ancient humans due to genetic homophily, and continued to persist as social homophily decreased or interactions with strangers became common, explaining the coexistence of cooperators and defectors observed in the human population.
SCIENTIFIC REPORTS
(2022)
Article
Biodiversity Conservation
R. Fay, M. Schaub, M. Banik, J. A. Border, I. G. Henderson, G. Fahl, J. Feulner, P. Horch, F. Korner, M. Mueller, V Michel, H. Rebstock, D. Shitikov, D. Tome, M. Voegeli, M. U. Grueebler
Summary: The study found that the true adult survival rate of the whinchats may hardly differ between sexes, with the main demographic problem likely being insufficient reproduction. Conservation activities for whinchats should primarily focus on Europe, according to the study results.
ANIMAL CONSERVATION
(2021)
Article
Biodiversity Conservation
Ying Li, Qian Li, Li Xu, Mingxu Li, Zhi Chen, Zhaopeng Song, Jihua Hou, Nianpeng He
Summary: The study found that plant community traits, particularly leaf characteristics, are closely related to aboveground net primary productivity (ANPP) and can explain 78% of the variability in ecosystem productivity. This suggests that the traits of plant communities play a significant role in determining productivity and could be important considerations in ecological models.
ECOLOGICAL INDICATORS
(2021)
Article
Psychiatry
Aya Sasaki, Margaret E. Eng, Abigail H. Lee, Alisa Kostaki, Stephen G. Matthews
Summary: Research indicates that prenatal exposure to sGC in guinea pigs affects the DNA methylation features of offspring, with over 90% of common methylation signatures showing the same direction of change. There are tissue-specific and common methylation features in different tissues, including gene clusters related to brain development.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Public, Environmental & Occupational Health
Alonzo T. Folger, Nichole Nidey, Lili Ding, Hong Ji, Kimberly Yolton, Robert T. Ammerman, Katherine A. Bowers
Summary: This study examined the impact of maternal childhood adversity on offspring DNAm, finding an association between maternal ACEs and lower offspring DNAm, which was modified by the number of prenatal home visits.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Oncology
Jin Dai, Akihiro Nishi, Zhe-Xuan Li, Yang Zhang, Tong Zhou, Wei-Cheng You, Wen-Qing Li, Kai-Feng Pan
Summary: The study identified seven DNA methylation CpGs associated with overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI) in gastric cancer, with five of them also linked to disease-free interval (DFI). These findings could potentially aid patient stratification in clinical practices.
Article
Obstetrics & Gynecology
Jenny Y. Mei, Thalia Mok, Mary Catherine Cambou, Trevon Fuller, Viviana M. Fajardo, Tara Kerin, Christina S. Han, Karin Nielsen-Saines, Rashmi Rao
Summary: This study describes the sonographic characteristics of pregnancies after confirmed SARS-CoV-2 infection and assesses the association of prenatal ultrasound findings with adverse neonatal outcomes. The findings suggest that fetal growth restriction after SARS-CoV-2 infection is associated with an increased risk for adverse neonatal outcomes and requires close monitoring.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Multidisciplinary Sciences
Yanna Zhang, Xun Wang, Xiaogang Duan, Ting Du, Xiancheng Chen
Summary: This study explores the transcription patterns and prognostic significance of key epithelial-mesenchymal transformation (EMT) and N6-Methyladenosine (m6A) modification regulators in ovarian cancer. The research reveals a synergistic effect between m6A and EMT regulators in the development of ovarian cancer, and identifies ALKBH5, WTAP, ELAVL1, and CDH2 as key prognosis-related immunological signatures.
SCIENTIFIC REPORTS
(2023)
Article
Behavioral Sciences
Daniel A. A. Warner, Connor Kelly, Jenna E. E. Pruett, Amelie Fargevieille, Randy L. L. Klabacka
Summary: Nest site choice in female lizards is based on immediate environmental cues rather than the predictability of future conditions. This study found that female lizards always chose moist nest substrates regardless of the level of predictability of substrate moisture fluctuations. These results highlight the importance of immediate environmental cues in nest site selection.
BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY
(2023)
Article
Nutrition & Dietetics
Qi Fu, Warren A. Cheung, Amber V. Majnik, Xingrao Ke, Tomi Pastinen, Robert H. Lane
Summary: This study examined the impact of exposure to adverse early-life environments on the development of non-alcoholic fatty liver disease (NAFLD) and the connection between hepatic DNA methylation and late-onset diseases. The findings suggest that exposure to adverse environments leads to changes in hepatic DNA methylation before the onset of NAFLD, indicating that DNA methylation plays a role in the development of this disease.
Article
Oncology
D. M. Mens, J. M. van Rees, S. M. Wilting, C. Verhoef
Summary: Chemoradiation therapy (CRT) is the standard of care for treating rectal cancer, but it can cause damage to the surrounding healthy tissue and not all patients benefit from it. This study aims to develop a diagnostic innovation using DNA methylation to predict the effectiveness of CRT for rectal cancer patients.
Article
Multidisciplinary Sciences
Patricia Lastra Luque, Iraide Artetxe-Arrate, Gorka Bidegain, Saburo Sakai, Fanny Claverie, Christophe Pecheyran, Igaratza Fraile, Hilario Murua, Jose Luis Varela, Antonio Medina, Haritz Arrizabalaga
Summary: This study investigated the chemical information in the edges of fin spines of Atlantic bluefin tuna. The results showed that the chemical signatures in the fin spine edge can be used as a natural habitat marker and provide insights into habitat use and spatial population dynamics of fish species.
Article
Oncology
Douglas R. A. Silveira, Juan L. Coelho-Silva, Wellington F. Silva, Grant Vallance, Diego A. Pereira-Martins, Maria I. A. Madeira, Lorena L. Figueredo-Pontes, Elvira D. R. P. Velloso, Belinda P. Simoes, Andy Peniket, Robert Danby, Eduardo M. Rego, Paresh Vyas, Fabiola Traina, Israel Bendit, Lynn Quek, Vanderson Rocha
Summary: This study showed that AML patients in Brazil had worse outcomes compared to the UK, with higher early mortality, higher relapse rates, lower rates of HSCT, and longer wait times for HSCT. Efforts to improve AML outcomes in Brazil should focus on infection prevention and control, as well as increasing access to HSCT.
LEUKEMIA & LYMPHOMA
(2021)
Article
Pharmacology & Pharmacy
Lauren Jones, Alan M. Jones
Summary: This study investigated the relationship between the polypharmacology of dipeptidyl-peptidase IV inhibitors (DPP4i) and their suspected adverse drug reaction (ADR) profiles using a national registry. The results showed that DPP4i have limited polypharmacology and low suspected ADR rates. Minimal statistical differences were found between the ADR profiles of different DPP4i, except for total ADRs.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2022)
Article
Endocrinology & Metabolism
Elmar W. Tobi, Diana L. Juvinao-Quintero, Justiina Ronkainen, Raffael Ott, Rossella Alfano, Mickael Canouil, Madelon L. Geurtsen, Amna Khamis, Leanne K. Kupers, Ives Y. Lim, Patrice Perron, Giancarlo Pesce, Johanna Tuhkanen, Anne P. Starling, Toby Andrew, Elisabeth Binder, Robert Caiazzo, Jerry K. Y. Chan, Romy Gaillard, Peter D. Gluckman, Elina Keikkala, Neerja Karnani, Sanna Mustaniemi, Tim S. Nawrot, Francois Pattou, Michelle Plusquin, Violeta Raverdy, Kok Hian Tan, Evangelia Tzala, Katri Raikkonen, Christiane Winkler, Anette-G Ziegler, Isabella Annesi-Maesano, Luigi Bouchard, Yap Seng Chong, Dana Dabelea, Janine F. Felix, Barbara Heude, Vincent W. V. Jaddoe, Jari Lahti, Brigitte Reimann, Marja Vaarasmaki, Amelie Bonnefond, Philippe Froguel, Sandra Hummel, Eero Kajantie, Marjo-Riita Jarvelin, Regine P. M. Steegers-Theunissen, Caitlin G. Howe, Marie-France Hivert, Sylvain Sebert
Summary: Maternal hyperglycemia is associated with lower cord blood DNAm at TXNIP, and these CpGs may be candidate loci for future causal and mediation analyses.
Article
Evolutionary Biology
Mariska M. Beekman, Suzanne H. Donner, Jordy J. H. Litjens, Marcel Dicke, Bas J. Zwaan, Eveline C. Verhulst, Bart A. Pannebakker
Summary: This study investigates the genetic variation and microbiome composition of aphids in Dutch sweet pepper greenhouses and finds no evidence that protective endosymbionts or endogenous resistance affect the success of parasitoid-based biocontrol of aphids.
EVOLUTIONARY APPLICATIONS
(2022)
Article
Plant Sciences
Niccolo Bassetti, Lotte Caarls, Gabriella Bukovinszkine'Kiss, Mohamed El-Soda, Jeroen van Veen, Klaas Bouwmeester, Bas J. Zwaan, M. Eric Schranz, Guusje Bonnema, Nina E. Fatouros
Summary: This study reveals the genetic basis of HR-like cell death induced by Pieris eggs in Brassica crops, providing directions for breeders to further investigate and validate candidate genes.
Review
Microbiology
Matthew C. Fisher, Ana Alastruey-Izquierdo, Judith Berman, Tihana Bicanic, Elaine M. Bignell, Paul Bowyer, Michael Bromley, Roger Brueggemann, Gary Garber, Oliver A. Cornely, Sarah J. Gurr, Thomas S. Harrison, Ed Kuijper, Johanna Rhodes, Donald C. Sheppard, Adilia Warris, P. Lewis White, Jianping Xu, Bas Zwaan, Paul E. Verweij
Summary: This review emphasizes the important threat of invasive fungal infections to public health and the emergence of antifungal resistance. It discusses the main mechanisms of antifungal resistance and compares them with bacterial resistance to antimicrobial control. The review also explores the research and innovation topics needed to minimize the occurrence and impact of antifungal resistance, including environmental links, surveillance, diagnostics, transmission routes, novel therapeutics, and hotspot mitigation strategies. The need for global efforts to manage existing antifungal drugs and direct future research and development of therapies and interventions is highlighted.
NATURE REVIEWS MICROBIOLOGY
(2022)
Article
Evolutionary Biology
Anneloes E. Groenenboom, Joost van den Heuvel, Bas J. Zwaan, Eddy J. Smid, Sijmen E. Schoustra
Summary: Our experimental work shows how selective pressures shape microbial ecosystems over long-term ecological time scales. Short-term selection can cause changes in the composition and functionality of microbial communities, influenced by factors such as initial composition and random processes. Using the natural bacterial community in the traditional Zambian fermented food Mabisi, we conducted experiments in a laboratory environment to examine the factors affecting community composition. The results indicate that initial composition and random processes play key roles in driving changes, and highlight the ability of different species combinations to achieve similar ecosystem functionality.
EVOLUTIONARY APPLICATIONS
(2022)
Meeting Abstract
Infectious Diseases
Jianhua Zhang, Bram de Rooij, Peter Leendertse, Bas Zwaan, Sijmen Schoustra
Meeting Abstract
Infectious Diseases
Krithi Nandimath, Ben Auxier, Joost van den Heuvel, Eric Bastiaans, Mirre Klatter, Marijke Slakhorst, Sijmen Schoustra, Alfons J. M. Debets, Vidyanand Nanjundiah, Bas J. Zwaan, Duur K. Aanen, J. A. G. M. de Visser
Article
Biotechnology & Applied Microbiology
Bwalya Katati, Pierre Schoenmakers, Henry Njapau, Paul W. Kachapulula, Bas J. Zwaan, Anne D. van Diepeningen, Sijmen E. Schoustra
Summary: Fungi contamination in maize crops is influenced by weather conditions. The abundance and composition of preharvest maize mycobiome vary based on rainfall pattern and dry spell. Aspergillus and Fusarium genera play a significant role in mycotoxin production, with Aspergillus associated with dry conditions and Fusarium unaffected by weather patterns. Understanding the spectrum of preharvest fungi and their relationship with weather conditions can help in managing crop health and mycotoxin contamination.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Sabine M. E. Vreeburg, Ben Auxier, Bas Jacobs, Peter M. Bourke, Joost van den Heuvel, Bas J. Zwaan, Duur K. Aanen
Summary: This study produced the first linkage map of a species of Termitomyces and found that the reduced rate of recombination is primarily due to genome expansion of gene-poor repetitive sequences. This highlights the importance of genomic context in cross-species comparisons of recombination rate.
Article
Ecology
Giannoula Bogka, Eirini Anastasaki, Panagiotis G. G. Milonas, Aikaterini Psoma, Emmanouil M. M. Kabourakis, Bas J. J. Zwaan, Bart A. A. Pannebakker, Nina E. E. Fatouros
Summary: This study investigated the effect of infochemicals derived from the habitat, host plant, and host insect on the foraging behavior of the olive fruit fly larval parasitoid. The results showed that the parasitoid strongly preferred volatiles emitted by B. oleae larval-infested fruits and cues emitted by B. oleae females. Volatile analysis revealed qualitative differences in volatile profiles of egg- and larval-infested fruits, indicating that olives change volatile emissions in response to larval infestation. These findings suggest that infochemicals play an important role in the host location behavior of the parasitoid.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2023)
Article
Microbiology
Bwalya Katati, Stan Kovacs, Henry Njapau, Paul W. Kachapulula, Bas J. Zwaan, Anne D. van Diepeningen, Sijmen E. Schoustra
Summary: Aflatoxins have important functions in Aspergillus section Flavi, including antioxidative, antifungal, and antibiosis roles. Atoxigenic Flavi degrade AF-B1 while toxigenic Flavi modulate its levels through an antioxidative mechanism. Atoxigenic strains have higher fitness than toxigenic strains at a plant non-lethal dose.
Article
Biotechnology & Applied Microbiology
S. Helena Donner, Mariska M. Beekman, Kathrin Barth, Marcel Dicke, Bas J. Zwaan, Eveline C. Verhulst, Bart A. Pannebakker
Summary: This study assesses the aphid species present in Dutch strawberry crops, the facultative endosymbionts they carry, and how these endosymbionts affect the parasitism success of biocontrol parasitoid wasps. The results show that facultative endosymbiont infections can protect aphids against certain parasitoids, but the level of protection varies among aphid species and parasitoid species.
BIOLOGICAL CONTROL
(2023)
Article
Plant Sciences
Niccolo Bassetti, Lotte Caarls, Klaas Bouwmeester, Patrick Verbaarschot, Ewan van Eijden, Bas J. Zwaan, Guusje Bonnema, M. Eric Schranz, Nina E. Fatouros
Summary: This study identified a single locus, named PEK, potentially involved in HR-like cell death induced by insect eggs in Brassica nigra. Further research will shed light on the role of TIR-NBS-LRR receptors in egg-killing hypersensitive response.
PLANT CELL AND ENVIRONMENT
(2023)
Meeting Abstract
Agriculture, Dairy & Animal Science
Y. C. J. Wientjes, P. Bijma, J. van den Heuvel, B. J. Zwaan, Z. G. Vitezica, M. P. L. Calus
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Yvonne C. J. Wientjes, Piter Bijma, Mario P. L. Calus, Bas J. Zwaan, Zulma G. Vitezica, Joost van den Heuvel
Summary: Our stochastic simulations demonstrate that genomic selection outperforms pedigree selection in terms of long-term genetic gain, while genetic variance reduction is similar between the two methods. The genetic architecture of traits changed considerably across generations, particularly under accurate selection and when non-additive effects were present.
GENETICS SELECTION EVOLUTION
(2022)