Article
Multidisciplinary Sciences
Samat Kozhakhmetov, Zarina Meiirmanova, Nurislam Mukhanbetzhanov, Zharkyn Jarmukhanov, Elizaveta Vinogradova, Shamil Mureyev, Saniya Kozhakhmetova, Marina Morenko, Kseniya Shnaider, Arailym Duisbayeva, Almagul Kushugulova
Summary: The inconsolable crying of a child for no apparent reason at an early age is a source of excitement and anxiety for parents. Previous studies suggest that the discomfort associated with the occupation of the newborn's intestines by microbiota and its activity may contribute to colic. In this study, fecal samples were collected from 62 newborns and their mothers, and metagenomic sequencing was conducted. The results showed that the intestinal microbiome of infants with colic developed differently compared to the non-colic group, with differences in microbial abundance and metabolic pathways.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Andrea Q. Holst, Pernille Myers, Paula Rodriguez-Garcia, Gerben D. A. Hermes, Cathrine Melsaether, Adam Baker, Stina R. Jensen, Katja Parschat
Summary: Breastmilk is the optimal source of infant nutrition, and human milk oligosaccharides (HMOs) play a significant role in the health benefits of breastmilk. This study investigated the effects of supplementing infant formula with a mix of five different HMOs, and found that the formula influenced the fecal microbiome composition and function, leading to an increase in bifidobacteria and shared features with breastfed infants.
Article
Nutrition & Dietetics
Margherita Caroli, Andrea Vania, Maria Anna Tomaselli, Immacolata Scotese, Giovanna Tezza, Maria Carmen Verga, Giuseppe Di Mauro, Angelo Antignani, Andrea Miniello, Marcello Bergamini
Summary: Suboptimal nutrient quality and quantity during complementary feeding can negatively impact infants' healthy growth, even with adequate energy intake. Differentiated complementary feeding schemes may be needed to properly satisfy the various nutritional needs of breastfed and formula/cow's milk fed infants. The type of milk fed to infants has a significant impact on their protein, iron, and calcium intake, with formula-fed infants achieving higher protein intakes compared to breastfed infants.
Article
Nutrition & Dietetics
Neha Chandrasekar, Kate Dehlsen, Steven T. Leach, Usha Krishnan
Summary: This study compared the gastrointestinal symptoms, inflammation, and stool microbiota composition between children receiving blenderised tube feeds (BTF) and commercial formula (CF). The results showed that children on BTF had fewer GI symptoms, lower inflammation levels, and healthier gut microbiota compared to those on CF.
Article
Veterinary Sciences
Holly L. Stewart, Dipti Pitta, Nagaraju Indugu, Bonnie Vecchiarelli, Meagan L. Hennessy, Julie B. Engiles, Louise L. Southwood
Summary: This study compared the faecal microbiota of horses with colic of different durations and lesion locations at hospital admission, day 1, and day 3/discharge. The results showed significant differences in bacterial community composition based on colic duration and lesion location. Additionally, differences in bacterial phyla and genera were observed at different time points and with different types of colic.
EQUINE VETERINARY JOURNAL
(2021)
Article
Microbiology
Katja C. W. van Dongen, Athanasia Ioannou, Sebastiaan Wesseling, Karsten Beekmann, Clara Belzer
Summary: This study compares the functional differences in microbial fructoselysine degradation between breast-fed and formula-fed infants and finds that formula-fed infants have higher fructoselysine degradation activity. The results suggest that the infant gut microbiota adapts to dietary fructoselysine exposure, which affects the bacterial composition and metabolic capacity.
FEMS MICROBIOLOGY ECOLOGY
(2022)
Article
Nutrition & Dietetics
Carlett Ramirez-Farias, Geraldine E. Baggs, Barbara J. Marriage
Summary: This study evaluated the effects of an extensively hydrolyzed formula with added 2'-FL on growth, tolerance, and compliance in infants. The results showed that the formula was well tolerated, safe, and supported growth in the intended population.
Article
Pediatrics
Hanna Lee, Zailing Li, Britt Christensen, Yongmei Peng, Xiaonan Li, Olle Hernell, Bo Loennerdal, Carolyn M. Slupsky
Summary: Early childhood nutrition plays a crucial role in shaping the gut microbiota, with probiotics potentially mitigating some of the unfavorable metabolic impacts of formula-feeding by altering the microbiome structure.
FRONTIERS IN PEDIATRICS
(2022)
Article
Nutrition & Dietetics
Jean-Pierre Chouraqui, Sandra Brancato, Berenice Delmas, Thierry Hanh
Summary: This study aimed to assess the effectiveness of a modified formula in relieving regurgitation and colic in infants. The results showed that the formula improved the quality of life and reduced symptoms in the infants within 30 days.
FRONTIERS IN NUTRITION
(2023)
Article
Pediatrics
Julie A. Mennella, Alissa D. Smethers, Michelle T. Delahanty, Virginia A. Stallings, Jillian C. Trabulsi
Summary: This study investigated the intake of glutamic acid from infant formula and other food sources in healthy infants during the first year, and found that it exceeded the recommended daily intake. These findings may have implications for future guidelines and communications with parents, clinical care providers, and policy makers.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Nutrition & Dietetics
Eun Kyo Ha, Seung Won Lee, Ju Hee Kim, Somin Shim, Young Hyeon Kim, Joo Young Song, Hyun Yong Koh, Youn Ho Shin, Man Yong Han
Summary: This study investigated the effect of consuming soy-based infant formula at 9-12 mo after birth on the subsequent development of epilepsy, neurodevelopmental disorders, and developmental status. The results showed no apparent association between feeding with soy formula rather than cow's milk formula and increased risks of epilepsy, ADHD, ASD, and developmental status in a general pediatric population.
JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Miriam Aguilar-Lopez, Christine Wetzel, Alissa MacDonald, Thao T. B. Ho, Sharon M. Donovan
Summary: This study aimed to compare the metagenomic potential of the fecal microbiome of preterm infants consuming mother's own milk (MOM) with bovine milk-based fortifier versus preterm formula alone. The results showed that pathways for fatty acid and carbohydrate degradation were significantly higher in the MOM group compared to the formula group. Taxonomically, members of the phylum Actinobacteria and the genus Bifidobacterium were higher in preterm infants exposed to MOM.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Mariana Muelbert, Frank H. Bloomfield, Shikha Pundir, Jane E. Harding, Chris Pook
Summary: The volatile compounds in preterm breastmilk differ from other feeding options, with distinct compositions in infant formulas, breastmilk with bovine milk-based fortifier, and human milk-based products. Fatty acid oxidation products play a significant role in olfactory cues of infant feeds.
FRONTIERS IN NUTRITION
(2021)
Article
Pediatrics
Lili Shen, Weihua Huang, Xuebing Xu, Li Wang, Qingyun Wang, Shengqi Li, Xuewei Yuan
Summary: The study showed that adding a high concentration of OPO to formula is beneficial for the growth and development of infants, as it reduces fecal fatty acid content, decreases crying frequency, increases length, and promotes fecal excretion.
FRONTIERS IN PEDIATRICS
(2021)
Article
Pediatrics
Veronica Fabrizio, Cheryl L. Harris, Kelly R. Walsh, Jennifer L. Wampler, Weihong Zhuang, Steven S. Wu
Summary: This study evaluated the effect of a hydrolyzed protein formula with added prebiotics on stool consistency in infants. The results showed that infants fed the formula had softer and more frequent stools compared to the control group. Additionally, crying, fussing, and pain during stooling decreased in both groups. This study suggests that the formula may have a positive effect on improving stool consistency in infants with reported hard or infrequent stools.
FRONTIERS IN PEDIATRICS
(2022)
Article
Microbiology
Francesco Candeliere, Stefano Raimondi, Gloria Spampinato, Moon Yue Feng Tay, Alberto Amaretti, Joergen Schlundt, Maddalena Rossi
Summary: Leuconostoc carnosum is a known colonizer of meat-related food matrices, reaching high levels in packaged meat products and playing a role in spoilage. The bacteria is a compact group sharing metabolic features adapted to nitrogen-rich environments, with plasmids containing various functional genes but lacking antibiotic resistance determinants.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Engineering, Biomedical
Stefano Raimondi, Alfonso Zambon, Raffaella Ranieri, Francesca Fraulini, Alberto Amaretti, Maddalena Rossi, Gigliola Lusvardi
Summary: Cerium-doped bioactive glasses have high biocompatibility, antimicrobial activity, and the potential to regulate environmental pH; the presence of cerium not only reduces E. coli charge, but also accelerates the increase of pH in the medium, contributing to the antibacterial effect.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Multidisciplinary Sciences
Stefano Raimondi, Eliana Musmeci, Francesco Candeliere, Alberto Amaretti, Maddalena Rossi
Summary: The study investigated gut mucin degraders of healthy subjects and found that various bacteria exhibited different metabolic capabilities and effects on the intestines when utilizing mucins.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Stefano Raimondi, Gloria Spampinato, Francesco Candeliere, Alberto Amaretti, Paola Brun, Ignazio Castagliuolo, Maddalena Rossi
Summary: Twelve strains of Leuconostoc carnosum from meat products were investigated in terms of their biochemical, physiological, and functional properties. Some strains showed potential protective effects against Listeria monocytogenes, while others displayed potential immunomodulatory effects. Furthermore, these strains did not survive in simulated gastric juice.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Stefano Raimondi, Rosalba Calvini, Francesco Candeliere, Alan Leonardi, Alessandro Ulrici, Maddalena Rossi, Alberto Amaretti
Summary: This study enriched intestinal microbiota in a protein-based medium and utilized ASCA to analyze the relationship between metabolites and bacteria. The results revealed a consistent association between indole and Escherichia-Shigella, as well as the relationship of butyric, 3-methyl butanoic, and benzenepropanoic acids with certain bacterial taxa major in cultures at 6 hours.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Eliana Musmeci, Francesco Candeliere, Alberto Amaretti, Maddalena Rossi, Stefano Raimondi
Summary: The draft genome sequence of Clostridium tertium WC0709, a gut bacterium capable of utilizing mucin as the sole carbon and nitrogen source, has been presented. This genome sequence will serve as a valuable reference for comparative genome analysis and for investigating the relationship with the host.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2021)
Article
Behavioral Sciences
Laura Turriziani, Arianna Ricciardello, Francesca Cucinotta, Fabiana Bellomo, Giada Turturo, Maria Boncoddo, Silvestro Mirabelli, Maria Luisa Scattoni, Maddalena Rossi, Antonio M. Persico
Summary: The study shows that gut mobilization significantly reduces symptoms such as hyperactivity, anxiety, irritability, and repetitive behaviors in chronically constipated autistic children. While urinary p-cresol levels varied, they were not significantly correlated with changes in behavioral parameters.
Article
Nutrition & Dietetics
Francesco Savino, Francesca Giuliani, Stefano Giraudi, Ilaria Galliano, Paola Montanari, Valentina Dapra, Massimiliano Bergallo
Summary: The aim of this study was to assess the serum values of IL-4, IL-5, IL-10, and IL-13 in infants with non-IgE mediated food allergies treated with a hydrolyzed formula. The study found that the levels of IL-4 and IL-13 were significantly higher in the non-IgE food allergy group compared to the control group, while IL-5 and IL-10 levels were significantly lower.
Article
Medicine, General & Internal
Francesco Savino, Valentina Dapra, Andrea Savino, Cristina Calvi, Paola Montanari, Ilaria Galliano, Massimiliano Bergallo
Summary: This study aimed to measure IFN-gamma and IDO1 values in infants' White blood cells during respiratory tract infections. The results showed a significant reduction in IFN-gamma expression in infants with RSV bronchiolitis, compared with healthy controls, while there was no significant difference in IDO1 expression between the two groups. New investigations focusing on RSV-infected subjects at different stages of infancy could provide further insights into the relationship between IDO1 expression and age.
Article
Microbiology
Francesco Candeliere, Stefano Raimondi, Raffaella Ranieri, Eliana Musmeci, Alfonso Zambon, Alberto Amaretti, Maddalena Rossi
Summary: GUS enzymes produced by intestinal bacteria can affect the metabolism of drugs and xenobiotics by removing glucuronic acid from glucuronides. The number and structural categories of GUS enzymes vary in the gut microbiomes of different geographical populations, but they do not have significant correlations with drug response. L1 and mL1 are the most important categories of GUS enzymes involved in the hydrolysis of small molecules, with Bacteroides being a major contributor. Interindividual variations in GUS profiles, particularly in the L1 and mL1 categories, likely play a major role in the variability of pharmacomicrobiomics, which can influence drug response and toxicity.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Gloria Spampinato, Francesco Candeliere, Alberto Amaretti, Fabio Licciardello, Maddalena Rossi, Stefano Raimondi
Summary: Sliced cooked ham packaged in a modified atmosphere is prone to microbial contamination, which can affect its sensorial properties and safety. In this study, the microbial load and chemical-physical features of cooked ham were monitored during the secondary shelf life. Lactic acid bacteria played a protective role in preventing contamination by other bacteria, and the production and packaging stages were crucial in managing the safety risk associated with the product.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Stefano Raimondi, Francesco Candeliere, Alberto Amaretti, Stefania Costa, Silvia Vertuani, Gloria Spampinato, Maddalena Rossi
Summary: This study analyzed the genome sequences of Leuconostoc and used ANI and core genome to check the species classification and infer the evolutionary lineage. The results showed that the minimum evolution ANI tree had the most similar topology with the core genome tree, while single gene trees were less adherent. Based on an ANI threshold of 95%, the organization of the genus Leuconostoc could be amended, and new species and subspecies were identified.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Stefano Raimondi, Giorgia Foca, Alessandro Ulrici, Lorenza Destro, Alan Leonardi, Raissa Buzzi, Francesco Candeliere, Maddalena Rossi, Alberto Amaretti
Summary: The yeast Wickerhamomyces anomalus WC 1501 has been shown to be an excellent producer of D-arabitol, with high conversion yield and productivity, using glycerol as a substrate.
MICROBIAL CELL FACTORIES
(2022)
Article
Engineering, Biomedical
Francesca Fraulini, Stefano Raimondi, Francesco Candeliere, Raffaella Ranieri, Alfonso Zambon, Gigliola Lusvardi
Summary: Mesoporous bioactive glasses (MBGs) have been widely used in tissue engineering for hard tissue regeneration. In order to develop biomaterials with antibiotic properties, cerium-doped MBGs were investigated as controlled drug delivery systems (DDSs) for gentamicin (Gen), a wide spectrum antibiotic commonly used against postoperative infections. The results showed that the optimized Gen-loaded cerium-doped MBGs retained significant bioactivity, antioxidant properties, and exhibited antibacterial efficacy for up to 10 days of controlled release. These findings make Gen-loaded cerium-doped MBGs promising candidates for simultaneous hard tissue regeneration and in situ antibiotic release.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Microbiology
Chiara Nasuti, Jennifer Ruffini, Laura Sola, Mario Di Bacco, Stefano Raimondi, Francesco Candeliere, Lisa Solieri
Summary: Craft beer is driving the search for novel ale yeast cultures, and the aging of sour beer in wooden barrels is found to be a source of suitable craft ale yeast candidates. During the aging process, different biotypes of yeast dominate the mycobiota, including Saccharomyces cerevisiae, Pichia membranifaciens, Brettanomyces bruxellensis, Brettanomyces anomalus, and S. cerevisiae x S. uvarum hybrids. The identified strains have relevant brewing properties and produce volatile organic compounds (VOCs), such as phenylethyl alcohol, that contribute to unique sensorial attributes in craft beer.