Review
Medicine, General & Internal
Angela Saviano, Mattia Brigida, Alessio Migneco, Gayani Gunawardena, Christian Zanza, Marcello Candelli, Francesco Franceschi, Veronica Ojetti
Summary: Lactobacillus reuteri DSM 17938 is a probiotic that has shown to be beneficial in modulating gut microbiota and alleviating gastrointestinal symptoms such as diarrhea, constipation, and abdominal pain. It is effective in shortening the duration of acute infectious diarrhea, improving abdominal pain in colitis and inflammatory bowel disease patients, and enhancing gut motility and chronic constipation.
MEDICINA-LITHUANIA
(2021)
Article
Medicine, Research & Experimental
Huiyong Jiang, Ren Yan, Kaicen Wang, Qiangqiang Wang, Xiaoxiao Chen, Lifeng Chen, Lanjuan Li, Longxian Lv
Summary: The study demonstrated that pretreatment with DSM 17938 could alleviate liver failure induced by D-galactosamine in rats by regulating liver function, reducing histological abnormalities in the terminal ileum and liver, affecting gut microbiota, metabolome, and transcriptome. These findings suggest that DSM 17938 is a potential probiotic for the prevention or treatment of liver failure.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Nutrition & Dietetics
Rossella Turco, Marina Russo, Dario Bruzzese, Annamaria Staiano
Summary: The study compared the efficacy of a partially hydrolysed formula with reduced lactose content and Lactobacillus reuteri with a standard formula in infant colic, showing that the standard formula had a better effect in reducing infant crying time.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Luca Lavalle, Nicolas Sauvageot, Colin Ivano Cercamondi, Ivana Jankovic, Delphine Egli, Yvan Vandenplas
Summary: This study found that formula milk containing L. reuteri was associated with better gastrointestinal tolerance in infants, compared to standard formula milk without any probiotics or prebiotics. Infants fed with L. reuteri-containing formula had fewer reports of difficulty passing stools, less hard stools, and reduced incidence of colic compared to those fed with standard formula. They also had lower crying time, less spitting up/vomiting, and decreased fussiness due to spitting up/vomiting. The study highlights the positive effects of L. reuteri on digestive tolerance and behavior in infants.
Review
Microbiology
V. N. Dargenio, F. Cristofori, C. Dargenio, P. Giordano, F. Indrio, G. Celano, R. Francavilla
Summary: This study reviewed the evidence on Limosilactobacillus reuteri DSM 17938 (LR DSM 17938), which secretes reuterin and other substances to inhibit pathogen growth and restore intestinal homeostasis. LR DSM 17938 has been shown to have beneficial effects in functional gastrointestinal disorders and in the treatment of acute diarrhea, acute gastroenteritis, and Helicobacter pylori infection. The correct dosage, frequency of administration, and therapy duration need to be further investigated.
BENEFICIAL MICROBES
(2022)
Article
Biotechnology & Applied Microbiology
Bingyong Mao, Qunran Xiang, Xin Tang, Qiuxiang Zhang, Xiaoming Liu, Jianxin Zhao, Shumao Cui, Hao Zhang
Summary: This study found that Lactobacillus reuteri CCFM1175 and Lactobacillus paracasei CCFM1176 can effectively prevent CAP-induced intestinal injury and improve gastrointestinal health. By regulating the expression of TRPV1, increasing the level of short-chain fatty acids, and modulating the composition of gut microbiota, these two strains of lactic acid bacteria improve intestinal structure, reduce inflammation, and enhance anti-inflammatory capacity.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Biochemistry & Molecular Biology
Yu Gu, Xiali Qin, Guoqiong Zhou, Chen Wang, Chenlu Mu, Xiang Liu, Weilong Zhong, Xin Xu, Bangmao Wang, Kui Jiang, Jinghua Liu, Hailong Cao
Summary: In this study, it was found that LGGs upregulated the expression of 5-HT4R, promoting the production of MUC2 and regulating the gut microbiota. These findings provide new evidence for the application of LGG in relieving gastrointestinal motility disorders.
Article
Immunology
Carla Borrell Garcia, Marta Ribelles Llop, Maria Angeles Garcia Esparza, Antonio Juan Flichy-Fernandez, Laura Marques Martinez, Regina Izquierdo Fort
Summary: This study aimed to assess the effects of a probiotic on oral health indices in adolescents and found that the use of Lactobacillus reuteri DSM 17938/ATCC 5289 can reduce the growth of Streptococcus mutans, improve plaque, gingivitis, and bleeding indices, although statistical significance was not reached. The study also showed that poorer eating habits were significantly correlated with increased plaque, and the probiotics had a positive impact on oral hygiene despite not reaching statistical significance.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Hye-Yeon Lee, Ji-Hyeon Lee, Seung Hyung Kim, Su-Yeon Jo, Kyung-Jin Min
Summary: This study evaluated the anti-aging effects of Lactobacillus reuteri on the lifespan and physiology of fruit flies. It found that L. reuteri significantly increased the mean lifespan of fruit flies without affecting reproductive output, food intake, or locomotor activity. The study suggests that the longevity effect of L. reuteri is mediated by the reduction of the insulin/IGF-1 signaling pathway and the action of reuterin.
Review
Nutrition & Dietetics
Ameer Al-Hadidi, Jason Navarro, Steven D. Goodman, Michael T. Bailey, Gail E. Besner
Summary: Necrotizing enterocolitis (NEC) is a devastating disease mainly found in premature infants, associated with gastrointestinal dysbiosis. Probiotics have been proposed as a new avenue for therapy, with a novel enterally delivered formulation showing promise in experimental models of NEC.
Article
Food Science & Technology
Linlin Wang, Shurong Yang, Chunxia Mei, Nan Tang, Jialiang Wang, Qiangqing Yu, Gang Wang, Gaojue Wu, Jianxin Zhao, Wei Chen
Summary: This study selected ten strains of lactobacilli and found that Lactobacillus paracasei effectively relieved constipation by stimulating enterochromaffin cells and promoting the synthesis of 5-HT in the colon. It also changed the abundance of bacteria related to acetic acid and enhanced intestinal motility.
Article
Microbiology
Sahal Alforaidi, Andrea Bresin, Naif Almosa, Anna Lehrkinder, Peter Lingstrom
Summary: The study investigated the effect of probiotics on biofilm acidogenicity and the number of salivary Streptococcus mutans and lactobacilli in orthodontic patients. It found that the probiotics could reduce plaque pH after three weeks, but had no significant impact on the number of bacteria in saliva and dental biofilm.
Article
Geriatrics & Gerontology
Hye-Yeon Lee, Ji-Hyeon Lee, Seung Hyung Kim, Su-Yeon Jo, Kyung-Jin Min
Summary: This study found that L. reuteri has anti-aging effects and can significantly extend the average lifespan of fruit flies. Furthermore, the effects of L. reuteri do not affect the reproductive output, food intake, or locomotor activity of fruit flies. The results suggest that the anti-aging effects of L. reuteri are mediated by the reduction of the insulin/IGF-1 signaling pathway and the action of reuterin.
Article
Biochemistry & Molecular Biology
Fuli Zheng, Zhi Wang, Catherine Stanton, R. Paul Ross, Jianxin Zhao, Hao Zhang, Bo Yang, Wei Chen
Summary: In this study, it was found that strains of L. reuteri and L. rhamnosus significantly slowed weight gain in mice, alleviated blood glucose and lipid disorders, tissue damage, and gut microbiota disorders, produced SCFAs to induce satiety hormones, inhibit food intake, and increase satiety, ultimately improving metabolic syndrome.
Article
Gastroenterology & Hepatology
Richard A. Forsgard, Julia Rode, Karin Lobenius-Palmer, Annalena Kamm, Snehal Patil, Mirriam G. J. Tacken, Marleen A. H. Lentjes, Jakob Axelsson, Gianfranco Grompone, Scott Montgomery, Robert J. Brummer
Summary: Studies have shown that probiotics can decrease symptoms of respiratory tract infections and enhance antibody responses. This study examined the effect of probiotic supplementation on anti-SARS-CoV-2 specific antibody responses after infection and COVID-19 vaccination. The results suggest that supplementation with specific probiotics may improve the long-term efficacy of mRNA-based COVID-19 vaccines through enhanced IgA response.
Article
Nutrition & Dietetics
Francesco Russo, Guglielmina Chimienti, Caterina Clemente, Carla Ferreri, Antonella Orlando, Giuseppe Riezzo
EUROPEAN JOURNAL OF NUTRITION
(2017)
Article
Medicine, General & Internal
Anna Picca, Giuseppe Riezzo, Angela M. S. Lezza, Caterina Clemente, Vito Pesce, Antonella Orlando, Guglielmina Chimienti, Francesco Russo
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Biochemistry & Molecular Biology
Guglielmina Chimienti, Anna Picca, Giuseppe Sirago, Flavio Fracasso, Riccardo Calvani, Roberto Bernabei, Francesco Russo, Christy S. Carter, Christiaan Leeuwenburgh, Vito Pesce, Emanuele Marzetti, Angela Maria Serena Lezza
FREE RADICAL BIOLOGY AND MEDICINE
(2018)
Article
Materials Science, Biomaterials
Paola Semeraro, Guglielmina Chimienti, Emiliano Altamura, Paola Fini, Vito Rizzi, Pinalysa Cosma
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2018)
Article
Biotechnology & Applied Microbiology
Francesco Russo, Guglielmina Chimienti, Giuseppe Riezzo, Michele Linsalata, Benedetta D'Attoma, Caterina Clemente, Antonella Orlando
Article
Biochemistry & Molecular Biology
Antonella Orlando, Guglielmina Chimienti, Vito Pesce, Flavio Fracasso, Angela Maria Serena Lezza, Francesco Russo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Guglielmina Chimienti, Anna Picca, Flavio Fracasso, Emanuele Marzetti, Riccardo Calvani, Christiaan Leeuwenburgh, Francesco Russo, Angela Maria Serena Lezza, Vito Pesce
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Guglielmina Chimienti, Vito Pesce, Flavio Fracasso, Francesco Russo, Nadja Cristhina de Souza-Pinto, Vilhelm A. Bohr, Angela Maria Serena Lezza
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Nutrition & Dietetics
Antonella Orlando, Guglielmina Chimienti, Angela Maria Serena Lezza, Vito Pesce, Isabella Gigante, Benedetta D'Attoma, Francesco Russo
Article
Biochemistry & Molecular Biology
Guglielmina Chimienti, Anna Picca, Flavio Fracasso, Francesco Russo, Antonella Orlando, Giuseppe Riezzo, Christiaan Leeuwenburgh, Vito Pesce, Angela Maria Serena Lezza
Summary: The study indicates that calorie restriction has certain effects in delaying aging, reducing oxidative damage to mitochondrial DNA and increasing the expression of mitochondrial-related proteins in aged rats. However, it also suggests a potential age-related boundary for the efficacy of calorie restriction after 28 months.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Guglielmina Chimienti, Antonella Orlando, Angela Maria Serena Lezza, Benedetta D'Attoma, Maria Notarnicola, Isabella Gigante, Vito Pesce, Francesco Russo
Summary: The study suggests that a ketogenic diet can reduce inflammation and oxidative stress, restore mitochondrial function and baseline autophagy by regulating the PPAR-gamma/PGC-1 alpha axis, which is effective in alleviating gut mitochondrial damage caused by stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Guglielmina Chimienti, Antonella Orlando, Francesco Russo, Benedetta D'Attoma, Manuela Aragno, Eleonora Aimaretti, Angela Maria Serena Lezza, Vito Pesce
Summary: The study demonstrates the significance of mitochondrial oxidative stress and sequential organelle dysfunction in an obesogenic diet animal model of NAFLD. All diets induced marked mitochondrial oxidative stress and decreased mitochondrial DNA content, leading to impaired mitochondrial biogenesis and reduced autophagy. The supplementation of DHEA did not prevent the diet-induced changes.
Article
Biochemistry & Molecular Biology
Maria Tolomeo, Guglielmina Chimienti, Martina Lanza, Roberto Barbaro, Alessia Nisco, Tiziana Latronico, Piero Leone, Giuseppe Petrosillo, Grazia Maria Liuzzi, Bryony Ryder, Michal Inbar-Feigenberg, Matilde Colella, Angela M. S. Lezza, Rikke K. J. Olsen, Maria Barile
Summary: The study investigated cell morphological and mitochondrial alterations in a LSMFLAD patient with a homozygous truncating FLAD1 variant, revealing increased cellular reactive oxygen species content and mtDNA oxidative damage, accompanied by an active response to mitochondrial stress. High doses of Rf treatment may provide a solution for the secondary RFVT2 molecular defect.
FREE RADICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Antonella Orlando, Guglielmina Chimienti, Maria Notarnicola, Francesco Russo
Summary: This study evaluated the effects of a neuroprotective diet on the levels of neurotransmitters and neurotrophins in the gut and brain of rats with irritable bowel syndrome. The diet was found to improve the dysregulation of the 5-HT and BDNF systems, reducing intestinal 5-HT levels and increasing brain BDNF levels. This suggests that the diet may have therapeutic potential for managing intestinal dysfunctions associated with irritable bowel syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)