☆ 4.7 Article

Cationic Poly(Amino Acid) Vaccine Adjuvant for Promoting Both Cell-Mediated and Humoral Immunity Against Influenza Virus

ADVANCED HEALTHCARE MATERIALS (2019)

期刊

ADVANCED HEALTHCARE MATERIALS

卷 8, 期 2, 页码 -

出版社

WILEY

DOI: 10.1002/adhm.201800953

关键词

adjuvants; poly(amino acid); poly-l-lysine; squalene; vaccines

类别

Engineering, Biomedical Nanoscience & Nanotechnology Materials Science, Biomaterials

资金

Bio & Medical Technology Development Program of the National Research Foundation (NRF) - Ministry of Science ICT [NRF-2018M3A9H4056340]
National Research Foundation of Korea [2018M3A9H4056340] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

Protocol

Reagent

摘要

Powerful adjuvants to augment vaccine efficacy with a less immunogenic vaccine system are in great demand. In this study, a novel squalene-based cationic poly(amino acid) adjuvant (CASq) that elicits both cellular (Th1) and humoral (Th2) immune responses is developed. CASq is demonstrated to promote cellular uptake of viral antigen and stimulate macrophages, leading to active production of interleukin-12. Furthermore, co-administration of inactivated pdm H1N1 vaccine with CASq significantly increases the generation of antigen-specific antibodies and T cell immune responses in mice, as well as resulting in complete prevention of disease symptoms and protection against lethal infection.

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Article Biotechnology & Applied Microbiology

Characterization of an L-α,β-diaminopropionic acid polymer with comb-like structure isolated from a poly(ε-L-lysine)-producing Streptomyces sp.

Munenori Takehara, Masayuki Saimura, Haruka Inaba, Yoshinao Kato, Shogo Muro, Tatsuki Matsunaga, Kazuya Yamanaka

Summary: Polymers of basic amino acids function as polycationic compounds with various biological properties under physiological conditions, such as antimicrobial and antiviral activities, immunopotentiating ability, and DNA-binding activity. The ε-PL and PAP produced by some Streptomyces strains have potential as food preservatives and inhibitors with wide applications in various fields.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2021)

添加到收藏夹

Article Agriculture, Multidisciplinary

Co-production of L-Lysine and Heterologous Squalene in CRISPR/dCas9-Assisted Corynebacterium glutamicum

Jaehyun Park, Han Min Woo

Summary: Corynebacterium glutamicum has been engineered for co-production of L-lysine and heterologous squalene, and metabolic fluxes were controlled by regulating the concentration of pyruvate, an intermediate in the central metabolism. In situ extraction with oil overlay showed high efficiency in co-production.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

添加到收藏夹

Article Chemistry, Applied

L-Arginine and L-lysine retard aggregation and polar residue modifications of myofibrillar proteins: Their roles in solubility of myofibrillar proteins in frozen porcine Longissimus lumborum

Pengqi Bao, Li Chen, Yue Hu, Yan Wang, Cunliu Zhou

Summary: This study investigated the ability of L-arginine and L-lysine to mitigate the adverse effects of freezing on the structure and solubility of myofibrillar protein extract (MPE) in porcine Longissimus lumborum. The results showed that both L-arginine and L-lysine were effective in alleviating the adverse effects of freezing. These findings are important in the meat industry.

FOOD CHEMISTRY (2022)

添加到收藏夹

Article Food Science & Technology

Epsilon-poly-l-lysine increases disease resistance of citrus against postharvest green mold by activating amino acid metabolism and phenolic compounds biosynthesis

Xiong Zhang, Qian Deng, Wenjun Wang, Hongyan Zhang, Ou Chen, Kaifang Zeng

Summary: Citrus, a famous fruit worldwide, is prone to green mold caused by Penicillium digitatum, resulting in significant economic losses. e-Poly-l-lysine (e-PL), a novel preservative, has strong inhibitory effects on fungi and can induce disease resistance in fruit. However, the mechanism of e-PL-induced resistance in citrus has been rarely reported. In this study, it was found that e-PL effectively inhibited the development of green mold in citrus without direct contact with P. digitatum, indicating the activation of disease resistance. Transcriptome analysis revealed that e-PL activated amino acid metabolism and phenylpropanoid biosynthesis, leading to the accumulation of phenolic compounds. These findings enhance our understanding of e-PL-induced disease resistance and provide a theoretical basis for its application in postharvest citrus preservation.

FOOD QUALITY AND SAFETY (2023)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Poly(ε-L-lysine) and poly(L-diaminopropionic acid) co-produced from spent mushroom substrate fermentation: potential use as food preservatives

Mingxuan Wang, Chunchi Rong

Summary: Poly(L-diaminopropionic acid) and poly(epsilon-L-lysine) were co-produced using waste biomass and spent mushroom substrate in solid-state fermentation. After optimization, the maximum yield of the two polymers was achieved with reduced fermentation time. The antimicrobial effects of the polymers were evaluated in freshly pressed grape juice.

BIOENGINEERED (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Hyaluronic Acid-Glycine-Cholesterol Conjugate-Based Nanoemulsion as a Potent Vaccine Adjuvant for T Cell-Mediated Immunity

Chih-An Lin, Hui-Min Ho, Parthiban Venkatesan, Chiung-Yi Huang, Yu-Jhen Cheng, Yu-Hsing Lin, Hua-Yang Lin, Tzu-Yang Chen, Ming-Hsi Huang, Ping-Shan Lai

Summary: The study demonstrated that the use of hyaluronic acid-glycine cholesterol conjugate as an excipient for vaccine formulation showed promising results by stabilizing the emulsion interface, enhancing immune responses, and reducing local inflammation compared to traditional adjuvants, showcasing its potential in vaccine formulations for boosting T cell-mediated immunity.

PHARMACEUTICS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Poly-L-Lysine-Lactobionic Acid-Capped Selenium Nanoparticles for Liver-Targeted Gene Delivery

Shaigan Naidoo, Aliscia Daniels, Saffiya Habib, Moganavelli Singh

Summary: This study designed and characterized functionalized selenium nanoparticles that efficiently bind, protect, and deliver DNA to liver cancer cells, exhibiting favorable features as gene nanocarriers for liver cancer treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Oncology

Cytotoxic activity of L-lysine alpha-oxidase against leukemia cells

Mariana N. Costa, Roberto N. Silva

Summary: Cancer cells have higher proliferation rates and increased demand for amino acids compared to normal cells, which has been exploited for the development of anticancer drugs like L-asparaginase. Additionally, L-lysine alpha-oxidase, an enzyme of L-amino acid oxidase family, has been studied as a potential antineoplastic agent.

SEMINARS IN CANCER BIOLOGY (2022)

添加到收藏夹

Review Chemistry, Physical

Chiral Nanomaterials for Cancer Vaccines

Aihua Qu, Maozhong Sun, Liguang Xu, Liqiang Liu, Lingling Guo, Panpan Chen, Qing Wang, Zhiyong Du, Zhimeng Wu, Chuanlai Xu, Hua Kuang

Summary: Chiral nanomaterials play a crucial role in the field of vaccines by promoting antigen presentation and activating the immune system for tumor immunotherapy. However, there are still challenges in this research, such as finding better synthesis methods and addressing the issue of immune system regulation.

SMALL METHODS (2023)

添加到收藏夹

Review Chemistry, Medicinal

L-Lysine α-Oxidase: Enzyme with Anticancer Properties

Elena V. Lukasheva, Gulalek Babayeva, Saida Sh. Karshieva, Dmitry D. Zhdanov, Vadim S. Pokrovsky

Summary: L-lysine alpha-oxidase (LO), as a type of anticancer enzyme, exhibits various activities such as antitumor and antimetastatic effects, targeting tumor growth by depleting L-lysine and producing H2O2.

PHARMACEUTICALS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Retardant effect of different charge-carrying amino acids on the long-term retrogradation of normal corn starch gel

Yan Chen, Yu-Sheng Wang, Xing Zhang, Hai-Hua Chen

Summary: The study found that different charged amino acids (lysine, aspartic acid, and tyrosine) have inhibitory effects on the long-term retrogradation of normal corn starch gel, with lysine showing the most significant effect and tyrosine the least. These amino acids can reduce the retrogradation enthalpy, hardness, and R1047/1022 value of the gel, as well as inhibit the recrystallization process.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

添加到收藏夹

Article Food Science & Technology

Safety and efficacy of a feed additive consisting of l-lysine monohydrochloride and l-lysine sulfate produced by fermentation with Corynebacterium glutamicum CGMCC 17927 for all animal species (Barentz Animal Nutrition BV)

Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Mojca Fasmon Durjava, Maryline Kouba, Marta Lopez-Alonso, Secundino Lopez Puente, Francesca Marcon, Baltasar Mayo, Alena Pechova, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Montserrat Anguita, Rosella Brozzi, Joana Firmino, Jaume Galobart, Yolanda Garcia Cazorla, Jordi Ortuno Casanova, Elisa Pettenati, Joana Revez, Jordi Tarres-Call

Summary: In response to a request from the European Commission, the FEEDAP was asked to assess the safety of l-lysine monohydrochloride and l-lysine sulfate produced by Corynebacterium glutamicum CGMCC 17927 as nutritional additives in animal feed and water. The Panel concluded that there were no safety concerns regarding the production strain and that the additives were safe for the target species. However, administering amino acids simultaneously in feed and water may pose risks of nutritional imbalances and hygienic concerns. The use of both forms of l-lysine produced by fermentation using C. glutamicum CGMCC 17927 was considered safe for consumers and the environment. Limited data prevented the Panel from concluding on potential skin and eye irritation or dermal sensitization. l-Lysine HCl and l-lysine sulfate were deemed effective sources of the essential amino acid for non-ruminant animal species, but protection against rumen degradation would be necessary for efficacy in ruminants.

EFSA JOURNAL (2022)

添加到收藏夹

Article Agriculture, Dairy & Animal Science

Poly (lactic-co-glycolic acid) nanoparticle-based vaccines delivery systems as a novel adjuvant for H9N2 antigen enhance immune responses

Adelijiang Wusiman, Yi Zhang, Telieke Ayihengbieke, Xike Cheng, Tuerhong Kudereti, Dandan Liu, Deyun Wang, Saifuding Abula

Summary: In this study, immunopotentiator Alhagi honey polysaccharide encapsulated PLGA nanoparticles (AHPP) and assembled pickering emulsion with AHPP as shell and squalene as core (PPAS) were prepared and their characteristics were investigated. The results showed that PPAS possessed good adjuvant activity and could induce strong and long-lasting cellular and humoral immune responses.

POULTRY SCIENCE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

pH Responsive Poly(Amino Acid) Nanoparticles as Potent Carrier Adjuvants for Enhancing Cellular Immunity

Jiarui Zhang, Yian Liu, Lintao Bai, Gan Gao, Yuxuan Li, Heyun Shen

Summary: In this study, two types of amphiphilic poly(glutamic acid) nanoparticles as nanocarrier adjuvants were fabricated to effectively induce cellular immune response. The alpha-PGA-F NPs, with their pH-responsive alpha-helical secondary structure, demonstrated enhanced membrane fusion and antigen lysosomal escape compared to the gamma-PGA-F NPs. This led to higher secretion of inflammatory cytokines and increased expression of major biological histocompatibility complex class I and CD80, making the alpha-PGA-F NPs a potent candidate for vaccine applications.

MACROMOLECULAR BIOSCIENCE (2023)

添加到收藏夹

Article Agriculture, Dairy & Animal Science

Dietary L-Lysine Requirement of Coho Salmon (Oncorhynchus kisutch) Alevins

Leyong Yu, Hairui Yu, Ziyi Yuan, Jiayi Zhang, Lingyao Li, Chengyu Ma, Weiguang Kong

Summary: The suitable dietary L-lysine concentration for coho salmon alevins was determined through a dose-response feeding trial. The study found that the specific growth rate, protein efficiency ratio, and body protein deposition increased significantly with increasing dietary lysine concentration up to 3.80%. However, further increases in lysine level led to a decrease in these growth parameters. The highest contents of lysine, arginine, and total essential amino acids were observed in the group with 4.27% dietary lysine concentration.

ANIMALS (2023)

添加到收藏夹

Article Chemistry, Analytical

Serially Ordered Magnetization of Nanoclusters via Control of Various Transition Metal Dopants for the Multifractionation of Cells in Microfluidic Magnetophoresis Devices

Byunghoon Kang, Bumjoon Cha, Bongsoo Kim, Seungmin Han, Moo-Kwang Shin, Eunji Jang, Hyun-Ouk Kim, Seo Ryung Bae, Unyong Jeong, Il Moon, Hye Yeong Son, Yong -Min Huh, Seungjoo Haam

ANALYTICAL CHEMISTRY (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Preparation of gold core-mesoporous iron-oxide shell nanoparticles and their application as dual MR/CT contrast agent in human gastric cancer cells

Aastha Kukreja, Byunghoon Kang, Hyun-Ouk Kim, Eunji Jang, Hye Young Son, Yong-Min Huh, Seungjoo Haam

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Reactive Oxygen Species-Regulating Polymersome as an Antiviral Agent against Influenza Virus

Hyun-Ouk Kim, Minjoo Yeom, Jihye Kim, Aastha Kukreja, Woonsung Na, Jihye Choi, Aram Kang, Dayeon Yun, Jong-Woo Lim, Daesub Song, Seungjoo Haam

SMALL (2017)

添加到收藏夹

Article Materials Science, Biomaterials

Anchored protease-activatable polymersomes for molecular diagnostics of metastatic cancer cells

Hyun-Ouk Kim, Jong-Woo Lim, Jihye Choi, Hwunjae Lee, Hye Young Son, Jihye Kim, Geunseon Park, Haejin Chun, Daesub Song, Yong-Min Huh, Seungjoo Haam

JOURNAL OF MATERIALS CHEMISTRY B (2017)

添加到收藏夹

Article Materials Science, Biomaterials

Stent containing CD44-targeting polymeric prodrug nanoparticles that release paclitaxel and gemcitabine in a time interval-controlled manner for synergistic human biliary cancer therapy

Dayeon Yun, Hyun-Ouk Kim, Hye Young Son, Yuna Choi, Ilkoo Noh, Jong-Woo Lim, Jihye Kim, Haejin Chun, Geunseon Park, Dong Ki Lee, Sung Il Jang, Eunji Jang, Yong-Min Huh, Seungjoo Haam

JOURNAL OF MATERIALS CHEMISTRY B (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Host Cell Mimic Polymersomes for Rapid Detection of Highly Pathogenic Influenza Virus via a Viral Fusion and Cell Entry Mechanism

Hyun-Ouk Kim, Woonsung Na, Minjoo Yeom, Jihye Choi, Jihye Kim, Jong-Woo Lim, Dayeon Yun, Haejin Chun, Geunseon Park, Chaewon Park, Jeong-Ki Kim, Dae Gwin Jeong, Van Phan Le, Kwangyeol Lee, Jae Myun Lee, Hyoung Hwa Jeong, Daesub Song, Seungjoo Haam

ADVANCED FUNCTIONAL MATERIALS (2018)

添加到收藏夹

Article Polymer Science

Efficient antiviral co-delivery using polymersomes by controlling the surface density of cell-targeting groups for influenza A virus treatment

Haejin Chun, Minjoo Yeom, Hyun-Ouk Kim, Jong-Woo Lim, Woonsung Na, Geunseon Park, Chaewon Park, Aram Kang, Dayeon Yun, Jihye Kim, Daesub Song, Seungjoo Haam

POLYMER CHEMISTRY (2018)

添加到收藏夹

Article Nanoscience & Nanotechnology

Dengue Virus-Polymersome Hybrid Nanovesicles for Advanced Drug Screening Using Real-Time Single Nanoparticle-Virus Tracking

Hyun-Ouk Kim, Woonsung Na, Minjoo Yeom, Jong -Woo Lim, Eun-Hye Bae, Geunseon Park, Chaewon Park, Hwunjae Lee, Hye Kwon Kim, Dae Gwin Jeong, Kwang-Soo Lyoo, Van Phan Le, Seungjoo Haam, Daesub Song

ACS APPLIED MATERIALS & INTERFACES (2020)

添加到收藏夹

Article Infectious Diseases

Morphological features and pathogenicity of mutated canine influenza viruses from China and South Korea

Woonsung Na, Xing Xie, Minjoo Yeom, Aram Kang, Hyun-Ouk Kim, Jong-Woo Lim, Geunseon Park, Sun-Woo Yoon, Dae Gwin Jeong, Hye Kwon Kim, Seungjoo Haam, Yongjie Liu, Daesub Song

TRANSBOUNDARY AND EMERGING DISEASES (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Application of Nanomaterials as an Advanced Strategy for the Diagnosis, Prevention, and Treatment of Viral Diseases

Jong-Woo Lim, Yu-Rim Ahn, Geunseon Park, Hyun-Ouk Kim, Seungjoo Haam

Summary: The ongoing COVID-19 pandemic, characterized by emerging variants, presents serious global health challenges, prompting concerns about future infectious pathogens. Nano-based approaches, including sensors, vaccines, and therapeutics, show promise for developing more effective strategies to combat infectious diseases.

PHARMACEUTICS (2021)

添加到收藏夹

Article Materials Science, Biomaterials

Kinetic stability modulation of polymeric nanoparticles for enhanced detection of influenza virus via penetration of viral fusion peptides

Chaewon Park, Jong-Woo Lim, Geunseon Park, Hyun-Ouk Kim, Sojeong Lee, Yuri H. Kwon, Seong-Eun Kim, Minjoo Yeom, Woonsung Na, Daesub Song, Eunjung Kim, Seungjoo Haam

Summary: Specific interactions between viruses and host cells are crucial for combating viral diseases, and using nanomaterials with host-mimetic membranes for virus detection is an effective approach. By modulating the fraction of hydrophilic segments in PNPs, their ability to interact with viral membranes can be altered, enabling rapid detection of influenza viruses.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

添加到收藏夹

Article Materials Science, Biomaterials

Active colorimetric lipid-coated polyaniline nanoparticles for redox state sensing in cancer cells

Hwunjae Lee, Hyun-Ouk Kim, Hyun Soo Kim, Ohwon Kwon, Hyun-Wook Rho, Yong-Min Huh, Yoochan Hong

Summary: The lipid-coated polyaniline (LiPAni) nanoparticles showed unique absorbance and color-changing properties, significantly affecting the cell viability of cancer cells compared to control nanoparticles.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

添加到收藏夹

Article Materials Science, Biomaterials

Cell-mimic polymersome-shielded islets for long-term immune protection of neonatal porcine islet-like cell clusters

Hyun-Ouk Kim, Sang Hoon Lee, Woonsung Na, Jong-Woo Lim, Geunseon Park, Chaewon Park, Hwunjae Lee, Aram Kang, Seungjoo Haam, Inho Choi, Jung-Taek Kang, Daesub Song

JOURNAL OF MATERIALS CHEMISTRY B (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bandgap-controlled hollow polyaniline nanostructures synthesized by Mn-dependent nano-confined polymerization

Jihye Choi, Byunghoon Kang, Hyun-Ouk Kim, Jin-Suck Suh, Seungjoo Haam, Jaemoon Yang

NANOSCALE (2019)

添加到收藏夹

暂无数据

© Peeref 2019-2024. All rights reserved.