Article
Nutrition & Dietetics
Yuki Isobe, Hiroki Asakura, Hiromasa Tsujiguchi, Takayuki Kannon, Hiroaki Takayama, Yumie Takeshita, Kiyo-aki Ishii, Takehiro Kanamori, Akinori Hara, Tatsuya Yamashita, Atsushi Tajima, Shuichi Kaneko, Hiroyuki Nakamura, Toshinari Takamura
Summary: The study found that serum selenium levels were positively correlated with liver enzymes and alcohol intake, while they were negatively correlated with body mass index. Serum selenoprotein P levels were positively correlated with age, liver enzymes, and alcohol intake. Additionally, alcohol intake was found to be positively correlated with serum levels of both selenium and selenoprotein P independently of other factors.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Amra Jujic, John Molvin, Lutz Schomburg, Oliver Hartmann, Andreas Bergmann, Olle Melander, Martin Magnusson
Summary: A recent study found that high selenium levels are associated with reduced mortality and incidence of heart failure (HF), but only in non-smokers. This study aimed to investigate whether selenoprotein P (SELENOP) is associated with incident HF. The results showed that low SELENOP levels are associated with a higher risk of incident HF in the general population.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Teresa Urbano, Marco Vinceti, Jessica Mandrioli, Annalisa Chiari, Tommaso Filippini, Roberta Bedin, Manuela Tondelli, Cecilia Simonini, Giovanna Zamboni, Misaki Shimizu, Yoshiro Saito
Summary: This study found abnormalities in the concentrations of selenium-transporter protein selenoprotein P in the central nervous system and blood, which are associated with amyotrophic lateral sclerosis (ALS) and neurocognitive disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Farshad Amirkhizi, Mahdiyeh Taghizadeh, Banafshe Khalese-Ranjbar, Soudabeh Hamedi-Shahraki, Somayyeh Asghari
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in reproductive-age women, characterized by reproductive and metabolic disorders. Oxidative stress (OS) plays a role in the pathogenesis of PCOS, and the study aimed to investigate the relationship between selenium (Se) and selenoprotein P (SELENOP) levels with OS markers. The results showed that higher Se and SELENOP levels were associated with lower TBARS levels and higher TAC levels and erythrocytes GPx activity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Nutrition & Dietetics
Arlene C. P. Kiyohara, Daniel J. Torres, Ayaka Hagiwara, Jenna Pak, Rachel H. L. H. Rueli, C. William R. Shuttleworth, Frederick P. Bellinger
Summary: SELENOP1 plays an important role in regulating Zn2+ levels in the brain, with knockout mice showing altered Zn2+ distribution and impaired release in response to neuron depolarization. Additionally, SELENOP1 deficiency may lead to increased levels of tau phosphorylation, possibly due to changes in intracellular zinc content.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Jiao Luo, Liqin Su, Xiaohong He, Yegang Du, Ning Xu, Rangpeng Wu, Yunfeng Zhu, Ting Wang, Ranqi Shao, Frederick W. Unverzagt, Ann M. Hake, Yinlong Jin, Sujuan Gao
Summary: This study found that higher blood selenium levels are associated with lower serum A beta 42 and A beta 40 levels, as well as a higher A beta 42/A beta 40 ratio. These results are specific to different selenoproteins.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Jeremy Lamarche, Luisa Ronga, Joanna Szpunar, Ryszard Lobinski
Summary: SELENOP as an emerging marker for selenium nutritional status and various diseases still requires further investigation on its chemical characteristics and improvement in accurate quantitation methods; the presence of multiple isoforms and post-translationally modified variants of SELENOP poses challenges for accurate quantification; mass spectrometry techniques offer many advantages and complementary features in the characterization and quantification of SELENOP and should be carefully evaluated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Marek Szwiec, Wojciech Marciniak, Roza Derkacz, Tomasz Huzarski, Jacek Gronwald, Cezary Cybulski, Tadeusz Debniak, Anna Jakubowska, Marcin Lener, Michal Falco, Jozef Kladny, Piotr Baszuk, Jerzy Duszynski, Joanne Kotsopoulos, Steven A. Narod, Jan Lubinski
Summary: A recent prospective study found an association between low serum selenium level and five- and ten-year survival rates among breast cancer patients. Further research is needed to confirm the protective effect of selenium on breast cancer survival, and potential investigation into selenium supplementation for patients.
Article
Biochemistry & Molecular Biology
Kamil Demircan, Qian Sun, Ylva Bengtsson, Petra Seemann, Johan Vallon-Christersson, Martin Malmberg, Lao H. Saal, Lisa Ryd, Waldemar B. Minich, Ake Borg, Jonas Manjer, Lutz Schomburg
Summary: The presence of SELENOP autoantibodies in breast cancer patients is associated with poor prognosis, particularly in patients with low selenium levels. These autoantibodies may disrupt the transport function of SELENOP, leading to an increased risk of recurrence and mortality.
Article
Biochemistry & Molecular Biology
Yanan Wang, Yuanjie Zou, Tong Wang, Shan Han, Xu Liu, Yiyi Zhang, Shengqi Su, Huihui Zhou, Xiao Zhang, Hong Liang
Summary: This study investigated the serum SELENOP levels in residents of KD endemic and non-endemic counties in Heilongjiang province, China. Results showed that some KD endemic counties still have selenium deficiency, with higher serum SELENOP levels in non-endemic areas positively correlated with per capita GDP. Including selenium in the national surveillance of KD could provide more evidence for the assessment of KD elimination.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Nutrition & Dietetics
Lei Cao, Tibor Pechan, Sanggil Lee, Wen-Hsing Cheng
Summary: This study identified different SELENOH isoforms and investigated the impact of selenium flux on selenoprotein expression, revealing a Se-independent, shortened SELENOH variant and competition with other selenoproteins at the protein level in selenium insufficiency.
JOURNAL OF NUTRITION
(2021)
Article
Immunology
A. Skesters, D. Kustovs, A. Lece, E. Moreino, E. Petrosina, K. D. Rainsford
Summary: This study aimed to assess the tendency of oxidative stress in COVID-19 patients depending on severity. The results showed that patients with severe disease had significantly lower selenium and seleno-protein P levels and higher oxidative stress levels.
INFLAMMOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tommaso Filippini, Teresa Urbano, Peter Grill, Carlotta Malagoli, Angela Ferrari, Cristina Marchesi, Nicoletta Natalini, Bernhard Michalke, Marco Vinceti
Summary: This study aimed to investigate the relationship between human serum albumin-bound selenium (Se-HSA) and total selenium as well as specific organic and inorganic selenium species. The findings indicated that Se-HSA was positively associated with inorganic selenium species and inversely associated with organic selenium species. Se-HSA incorporated more selenium when circulating levels of inorganic compounds were higher.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Nutrition & Dietetics
Yuehui Jia, Ruixiang Wang, Shengqi Su, Lei Qi, Yuanyuan Wang, Yanan Wang, Yuanjie Zou, Xu Liu, Yiyi Zhang, Jie Hou, Hongqi Feng, Qi Li, Tong Wang
Summary: This study provided geographically precise evidence of selenium nutrition at the molecular level to assess KD prevention and control. The globally clustered SELENOP levels and identification of cold spots in KD endemic provinces highlight the importance of precision prevention and control efforts.
FRONTIERS IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Dekel Abeles, Jasmine Herszage, Moni Shahar, Nitzan Censor
Summary: There is considerable variability in skill performance and learning among individuals. This study aimed to predict participants' future performance and learning based on their behavior during initial skill acquisition. A large online multi-session sample of participants performing a sequential tapping skill learning task was recruited. Machine learning was used to predict future performance and learning from raw data and engineered features. Strong correlations were found between initial and final performance, but individual learning was not predictable. Developing novel tasks may provide insights into the underlying mechanism of individual skill learning, relevant for real-life scenarios.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Yumie Takeshita, Chisato Teramura, Kyoko Kamoshita, Hiroaki Takayama, Hiromi Nakagawa, Yasufumi Enyama, Kiyo-Aki Ishii, Takeo Tanaka, Hisanori Goto, Yujiro Nakano, Sachie Osada, Yoshiaki Tanaka, Kumpei Tokuyama, Toshinari Takamura
Summary: The study found that EPA did not significantly affect circulating SeP levels and insulin sensitivity in humans with type 2 diabetes, but it did enhance hepatic insulin sensitivity. Changes in EPA levels were positively correlated with SeP levels and hepatic insulin sensitivity, while negatively correlated with skeletal muscle insulin sensitivity.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Cell Biology
Machiko Honda, Tatsuya Segawa, Kiyoshi Ishikawa, Masahiro Maeda, Yoshiro Saito, Shigeyuki Kon
Summary: Blood levels of nephronectin (Npnt), a protein critical for kidney development, are elevated in EAE mice. Treatment with anti-Npnt antibody inhibits EAE development. The interaction between Npnt and SeP regulates the Th17/Treg balance via the ROS level.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Kyoko Kamoshita, Hirohiko Tsugane, Kiyo-Aki Ishii, Hiroaki Takayama, Xingyu Yao, Halimulati Abuduwaili, Ryota Tanida, Yasumasa Taniguchi, Hein Ko Oo, Guzel Gafiyatullina, Shuichi Kaneko, Seiichi Matsugo, Toshinari Takamura
Summary: Lauric acid induces hepatic insulin resistance by upregulating Selenop. These findings caution the metabolic risk of excessive lauric acid intake, especially in people with hepatic insulin resistance associated with type 2 diabetes.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Nanako Kitabayashi, Shohei Nakao, Yuichiro Mita, Kotoko Arisawa, Takayuki Hoshi, Kiyo-aki Ishii, Toshinari Takamura, Noriko Noguchi, Yoshiro Saito, Takashi Toyama
Summary: Selenoprotein P (SELENOP) is a selenium-containing protein that plays a significant role in pancreatic beta cell function by maintaining the levels of cellular selenoproteins. Knockdown of the Selenop gene resulted in decreased cell viability, insulin levels, and insulin secretion, which were recovered by the addition of selenium. These findings suggest that SELENOP expression is important for the function of pancreatic beta cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Swe Mar Oo, Hein Ko Oo, Hiroaki Takayama, Kiyo-Aki Ishii, Yumie Takeshita, Hisanori Goto, Yujiro Nakano, Susumu Kohno, Chiaki Takahashi, Hiroyuki Nakamura, Yoshiro Saito, Mami Matsushita, Yuko Okamatsu-Ogura, Masayuki Saito, Toshinari Takamura
Summary: The study found that serum levels of selenoprotein P (SeP) are negatively correlated with brown adipose tissue (BAT) activity. Physiological cold exposure downregulates the expression of Selenop in BAT. Selenop knockout mice have higher rectal temperatures and UCP1 sulfenylation during cold exposure. Treatment with SeP in brown adipocytes reduces NA-induced mitochondrial reactive oxygen species (ROS) production by upregulating glutathione peroxidase 4, impairing cellular thermogenesis. A high-fat/high-sucrose diet increases serum SeP levels and diminishes NA-induced thermogenesis in BAT-Selenop knockout mice. Therefore, SeP acts as an intrinsic factor inducing reductive stress and impairing thermogenesis in BAT, making it a potential therapeutic target for obesity and diabetes.
Review
Environmental Sciences
Marco Vinceti, Tommaso Filippini, Ewa Jablonska, Yoshiro Saito, Lauren A. Wise
Summary: Recent evidence suggests that previous research underestimated the adverse effects of selenium exposure at low levels and the potential drawbacks of maximizing selenoprotein expression. This calls for a reassessment of the recommended range of selenium exposure and dietary reference values.
ENVIRONMENTAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Xingyu Yao, Hiroaki Takayama, Kyoko Kamoshita, Hein Ko Oo, Ryota Tanida, Kaisei Kato, Kiyo-Aki Ishii, Toshinari Takamura
Summary: This study reveals that Cyclosporine A (CsA) downregulates Selenop, an antioxidant protein, by suppressing the signal transducer and activator of transcription 3-forkhead box protein O1 pathway in hepatocytes, possibly one of the causations of CsA-induced oxidative stress in hepatocytes. The present study sheds light on the previously unrecognized CsA-redox axis.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Teresa Urbano, Marco Vinceti, Jessica Mandrioli, Annalisa Chiari, Tommaso Filippini, Roberta Bedin, Manuela Tondelli, Cecilia Simonini, Giovanna Zamboni, Misaki Shimizu, Yoshiro Saito
Summary: This study found abnormalities in the concentrations of selenium-transporter protein selenoprotein P in the central nervous system and blood, which are associated with amyotrophic lateral sclerosis (ALS) and neurocognitive disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Kyoko Kamoshita, Kiyo-aki Ishii, Yumiko Tahira, Akihiro Kikuchi, Halimulati Abuduwaili, Natsumi Tajima-Shirasaki, Qifang Li, Hiroaki Takayama, Kunio Matsumoto, Toshinari Takamura
Summary: Insulin activates proteasome function by inhibiting protein ubiquitination through USP14, providing protection in hepatic cells. This study sheds light on the activation mechanism of USP14 and its pleiotropic effects, offering potential therapeutic strategies for obesity-related metabolic disorders.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Yumie Takeshita, Takeo Tanaka, Hiroaki Takayama, Yuki Kita, Hisanori Goto, Yujiro Nakano, Yoshiro Saito, Toshinari Takamura
Summary: This study found that circulating SeP levels are associated with the glucose-lowering effect of metformin in patients with poorly controlled type 2 diabetes. Higher baseline levels of SeP can predict the glucose-lowering and insulinotropic effects of metformin.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Halimulati Abuduwaili, Kyoko Kamoshita, Kiyo-aki Ishii, Kenta Takahashi, Tuerdiguli Abuduyimiti, Li Qifang, Yuki Isobe, Hisanori Goto, Yujiro Nakano, Yumie Takeshita, Hiroaki Takayama, Kenichi Harada, Toshinari Takamura
Summary: Selenoprotein P (SeP) is a hepatokine that is upregulated in type 2 diabetes and aging and causes signal resistances via reductive stress. Immobilization significantly reduced skeletal muscle mass in mice, which was prevented in SeP knockout (KO) mice. The upregulation of Foxos/KLF15-atrogene induced by immobilization was suppressed in the skeletal muscle of KO mice. These findings suggest that SeP-mediated reductive stress is involved in and may be a therapeutic target for physical inactivity-mediated muscle atrophy.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Qifang Li, Kiyo-aki Ishii, Kyoko Kamoshita, Kenta Takahashi, Halimulati Abuduwaili, Hiroaki Takayama, Cynthia M. Galicia-Medina, Ryota Tanida, Hein Ko Oo, Guzel Gafiyatullina, Xingyu Yao, Tuerdiguli Abuduyimiti, Jun Hamazaki, Hisanori Goto, Yujiro Nakano, Yumie Takeshita, Kenichi Harada, Shigeo Murata, Toshinari Takamura
Summary: Muscle atrophy is both a cause and consequence of obesity. Disruption of proteasome function in the skeletal muscles mediates obesity-induced ER stress and insulin resistance. The specific role of proteasome function in skeletal muscles and its regulation by obesity is not well understood.
Article
Biochemistry & Molecular Biology
Takayuki Kaneko, Yuichiro Mita, Kanako Nozawa-Kumada, Masana Yazaki, Mieko Arisawa, Etsuo Niki, Noriko Noguchi, Yoshiro Saito
Summary: This study reveals the role of hydrogen sulfide, hydropersulfides, and hydropolysulfides in cell signaling and protection against oxidative stress. The mechanism of action involves both two-electron and one-electron redox reactions, with the former receiving more attention. The study also highlights the antioxidant effects of these compounds in inhibiting lipid peroxidation.
FREE RADICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Kyoko Kamoshita, Natsumi Tajima-Shirasaki, Kiyo-Aki Ishii, Takayoshi Shirasaki, Hiroaki Takayama, Halimulati Abuduwaili, Tuerdiguli Abuduyimiti, Hein Ko Oo, Xingyu Yao, Qifang Li, Cynthia M. Galicia-Medina, Shuichi Kaneko, Toshinari Takamura
Summary: This study reveals that EPA downregulates Selenop gene expression by upregulating Foxo1 mRNA expression, independent of SREBP-1c. ERK1/2 pathway is involved in this regulation, while nuclear translocation of FoxO1 protein remains unaffected.
Article
Endocrinology & Metabolism
Kyoko Kamoshita, Natsumi Tajima-Shirasaki, Kiyo-aki Ishii, Takayoshi Shirasaki, Hiroaki Takayama, Halimulati Abuduwaili, Tuerdiguli Abuduyimiti, Hein Ko Oo, Xingyu Yao, Qifang Li, Cynthia M. Galicia-Medina, Shuichi Kaneko, Toshinari Takamura
Summary: Selenoprotein P is upregulated in type 2 diabetes, causing insulin and exercise resistance. EPA regulates Selenop gene expression by upregulating Foxo1 mRNA via the ERK1/2 pathway, without affecting its protein and nuclear translocation. FoxO1 knockdown accelerates EPA-mediated Selenop downregulation without involving SREBP-1c.