Review
Biochemistry & Molecular Biology
Michael Latour, Nam-Gu Her, Santosh Kesari, Elmar Nurmemmedov
Summary: The WNT signaling pathway plays a crucial role in glioblastoma genesis and therapy resistance, presenting a therapeutic challenge. Current targeted therapies under clinical investigation may offer new treatment options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jiawen Bu, Yixiao Zhang, Sijin Wu, Haonan Li, Lisha Sun, Yang Liu, Xudong Zhu, Xinbo Qiao, Qingtian Ma, Chao Liu, Nan Niu, Jinqi Xue, Guanglei Chen, Yongliang Yang, Caigang Liu
Summary: The KK-LC-1-FAT1-Hippo-ALDH1A1 pathway is identified as a therapeutic target in ALDH(+) cells of TNBC. The small-molecule inhibitor Z839878730 (Z8) can disrupt KK-LC-1 and FAT1 binding, reactivates the Hippo pathway, and suppresses TNBC tumor growth.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Samyuktha Suresh, Solene Huard, Amelie Brisson, Fariba Nemati, Rayan Dakroub, Coralie Poulard, Mengliang Ye, Elise Martel, Cecile Reyes, David C. Silvestre, Didier Meseure, Andre Nicolas, David Gentien, Hussein Fayyad-Kazan, Muriel Le Romancer, Didier Decaudin, Sergio Roman-Roman, Thierry Dubois
Summary: This study identified PRMT1 as a potential therapeutic target for TNBC patients, as it is highly expressed in TNBC tumor samples and essential for breast cancer cell survival. Targeting PRMT1 in combination with chemotherapies may improve the survival outcome of TNBC patients.
Article
Environmental Sciences
Yuzhuo Chen, Zhirong Yang, Xingqiang He, Wanglong Zhu, Yujun Wang, Jiaofeng Li, Zhengyu Han, Jie Wen, Wei Liu, Yuhan Yang, Kun Zhang
Summary: Proanthocyanidins (PC) have powerful antioxidant and anti-aging effects, and play an important role in tumor cell growth, drug resistance, recurrence, and metastasis. Recent studies have found that PC exhibits inhibitory effects on colorectal cancer stem cells (CSCs) through the Wnt/β-catenin pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Oncology
Valdenizia R. Silva, Luciano de S. Santos, Rosane B. Dias, Claudio A. Quadros, Daniel P. Bezerra
Summary: This review outlines strategies for eradicating CRC stem cells by modulating dysregulated pathways, with the aim of enhancing potential therapeutic schemes through the combination of conventional drugs and CSC-targeting drugs, leading to improved cure rates in anti-CRC therapy.
CANCER COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Shalini Mani, Geeta Swargiary, Sakshi Tyagi, Manisha Singh, Niraj Kumar Jha, Keshav K. Singh
Summary: Nanotechnology-based approaches offer incredible potential in cancer therapeutics due to their higher target specificity, demonstrating a potential and efficient way to target mitochondria of cancer cells for improved survival rates of cancer patients.
Review
Immunology
Emily K. Moore, Marianne Strazza, Adam Mor
Summary: Cancer is the second leading cause of death in the US, and immunotherapy techniques have brought significant improvements to cancer treatments. While anti-PD-1 therapy is successful in some patients, it can fail or lead to complications in others. More research is needed to better understand the PD-1 signaling pathway and develop new and improved combination strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hui Zhao, Tianqi Ming, Shun Tang, Shan Ren, Han Yang, Maolun Liu, Qiu Tao, Haibo Xu
Summary: The Wnt signaling pathway is a complex network involved in embryonic development and cancer, as well as normal physiological processes. It plays a crucial role in cell differentiation and the progression of colorectal cancer.
Editorial Material
Biochemistry & Molecular Biology
Ermanno Malagola, Yoku Hayakawa, Timothy C. Wang
Summary: Recent research has identified distinct roles for Lgr4 and Lgr5 in directing gland reconstitution following H. pylori infection, shedding new light on the complexities of Rspo signaling during gastric regeneration and raising questions about antral stem cell hierarchy.
Review
Microbiology
Merve Cakir, Kirsten Obernier, Antoine Forget, Nevan J. Krogan
Summary: The current global health challenges posed by diseases like AIDS, flu, and the COVID-19 pandemic highlight the importance of not only vaccination but also the development of efficient therapeutic solutions. Understanding host-pathogen interactions can help identify vulnerabilities in the host that can be targeted to reduce viral replication. Utilizing proteomics-based strategies can aid in identifying potential compounds with host-directed antiviral activity for testing in preclinical models.
Review
Biochemistry & Molecular Biology
Andrew Sulaiman, Sarah McGarry, Sai Charan Chilumula, Rohith Kandunuri, Vishak Vinod
Summary: This article examines the complexity of the TGF-β pathway and its role in promoting oncogenic properties in TNBC, while also pointing out the significance of CSCs in breast cancer tumorigenesis, metastasis, relapse, resistance, and patient prognosis.
Article
Oncology
Ayumi Kanemaru, Yuki Ito, Michiko Yamaoka, Yuki Shirakawa, Kou Yonemaru, Shunsuke Miyake, Misaki Ando, Masako Ota, Takeshi Masuda, Akitake Mukasa, Jian-Dong Li, Hideyuki Saito, Takuichiro Hide, Hirofumi Jono
Summary: The downregulation of tumor suppressor CYLD is associated with poor prognosis in GBM patients. The Wnt/β-catenin signaling pathway is significantly activated in CYLD-downregulated GBM patients. Inhibiting this pathway can suppress the malignant characteristics induced by CYLD downregulation in GBM.
Article
Plant Sciences
Sonal Srivastava, Jayant Dewangan, Sakshi Mishra, Aman Divakar, Swati Chaturvedi, Muhammad Wahajuddin, Sadan Kumar, Srikanta Kumar Rath
Summary: The study demonstrates that the combination of CXB and PIP offers a novel approach for the treatment of colon cancer, with significant anti-proliferative effects and modulation of apoptotic and Wnt/beta-catenin signaling pathways observed in HT-29 cells.
Article
Chemistry, Multidisciplinary
Yanmei Zhang, Zixuan Wang, Qifan Hu, Hao Luo, Bingchuan Lu, Yunhe Gao, Zhi Qiao, Yongsen Zhou, Yongcong Fang, Jin Gu, Ting Zhang, Zhuo Xiong
Summary: This study identifies a new biomaterial and method for inducing and enriching colorectal cancer stem cells (CSCs) using three-dimensional bioprinting. The use of GelMA-nanoclay hydrogels promotes the formation of spheroids expressing stemness markers and enhances the self-renewal, differentiation, and tumorigenic capacity of cancer cells in vitro and in vivo. The study also demonstrates that spheroids from GelMA-nanoclay hydrogels have increased stemness and sensitivity to anti-CSC compounds compared to traditional methods. This research is significant for facilitating effective CSC-targeting drug screening.
Review
Oncology
Amrutha Mohan, Reshma Raj R., Gayathri Mohan, K. P. Padmaja, Tessy Thomas Maliekal
Summary: Despite the importance of cancer stem cells in chemoresistance, metastasis and recurrence, a successful CSC-targeting drug has yet to be identified. The lack of a high-throughput adaptable screening strategy for CSCs is a bottleneck in drug development. This review aims to identify suitable reporters for CSCs and analyze the tumor microenvironment regulating CSCs.
FRONTIERS IN ONCOLOGY
(2021)