Article
Nutrition & Dietetics
Priscila dos Santos Gomes Olivares, Ana Beatriz Furlanetto Pacheco, Luciana Nicolau Aranha, Bianca da Silva Oliveira, Allan Amorim Santos, Paula Cristina Moreira dos Santos, Jose Firmino Nogueira Neto, Glorimar Rosa, Glaucia Maria Moraes Oliveira
Summary: This study investigated the gut microbiota of individuals with different metabolic phenotypes and found that metabolically healthy individuals had lower saturated fat intake and fasting glycemia. Those with unhealthy phenotypes had inflammation-associated microbiota, lower potential for butyrate production, and reduced bacterial diversity.
Review
Food Science & Technology
Martina De Siena, Pauline Raoul, Lara Costantini, Emidio Scarpellini, Marco Cintoni, Antonio Gasbarrini, Emanuele Rinninella, Maria Cristina Mele
Summary: The use of emulsifiers in processed foods and the increasing prevalence of metabolic syndrome in Western countries have sparked interest in understanding their potential impact on gut microbiota and metabolic disorders. This review provides a summary of the current clinical evidence on the effects of emulsifiers on gut microbiota composition and functions, highlighting the presence and role of common emulsifiers in daily foods. Recent studies on the impact of different emulsifiers on gut microbiota have shed light on their potential contribution to metabolic diseases, as well as their prebiotic effects. However, further research is needed to uncover the optimal consumption amounts and individual microbial responses to emulsifier intake.
Article
Microbiology
Zubaidah Hasain, Raja Affendi Raja Ali, Shairah Abdul Razak, Kamalrul Azlan Azizan, Emad El-Omar, Nurul Huda Razalli, Norfilza Mohd Mokhtar
Summary: The study found that dietary intake is an important predictor of gut microbiota dysbiosis in post-GDM women, and is associated with obesity, low-grade inflammation, and poor glycemic control. Hence, modifying dietary intake to reshape gut microbiota composition is a promising strategy for preventing T2DM in post-GDM women.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Nutrition & Dietetics
M. Alcazar, J. Escribano, N. Ferre, R. Closa-Monasterolo, M. Selma-Royo, A. Feliu, G. Castillejo, V Luque
Summary: This study aimed to describe and characterize the gut microbiota composition and diversity in children with obesity according to their metabolic health status. The results showed that children with metabolic unhealthy status had lower microbial diversity and richness, as well as distinct relative abundances of specific microbial taxa.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Wei-Chung Chiou, Bei-Hau Chang, Hsiao-Hsuan Tien, Yu-Lin Cai, Ya-Chi Fan, Wei-Jen Chen, Hui-Fang Chu, Yu-Hsin Chen, Cheng Huang
Summary: The novel ASEC-based synbiotic intervention showed beneficial effects in improving HFD-induced obesity, metabolic disorders, and dysbiosis in mice by reducing body weight gain, hyperlipidemia, impaired glucose tolerance, insulin resistance, and inflammation, as well as fostering gut bacterial diversity and composition.
Article
Microbiology
Alessandro Atzeni, Serena Galie, Jananee Muralidharan, Nancy Babio, Francisco Jose Tinahones, Jesus Vioque, Dolores Corella, Olga Castaner, Josep Vidal, Isabel Moreno-Indias, Laura Torres-Collado, Rebeca Fernandez-Carrion, Montserrat Fito, Romina Olbeyra, Miguel Angel Martinez-Gonzalez, Monica Bullo, Jordi Salas-Salvado
Summary: This observational study conducted within the PREDIMED-Plus clinical trial aimed to assess the association between fecal microbiota, body composition, and weight loss in response to a 12-month lifestyle intervention. The study found specific bacteria to be associated with weight loss and suggested fecal microbiota plays an important role in controlling body weight, supporting specific genera as potential targets for personalized nutrition in obesity management. Further investigation with more in-depth taxonomic identification and metabolic information is encouraged.
Review
Endocrinology & Metabolism
Jui Tu, Yangmeng Wang, Lihua Jin, Wendong Huang
Summary: Metabolic surgery, such as vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB), is the most effective approach for treating obesity. The precise mechanisms of how these surgeries work are still unclear, but gut hormones, bile acids and gut microbiota have been identified as potential factors. The long-term goal of metabolic/bariatric surgery research is to develop new pharmacotherapeutic options for obesity and diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Dong Han, Hongmin Zhen, Xiaoyan Liu, Justyna Zulewska, Zhennai Yang
Summary: This study used both rRNA and gDNA sequencing on mouse cecal contents and found differences in microbial composition and functional predictions between the two methods. rRNA-derived sequencing improved identification capability of specific microorganisms and was more suitable for functional predictions.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Ecology
Loreley Castelli, Belen Branchiccela, Hector Romero, Pablo Zunino, Karina Antunez
Summary: Honey bees play a crucial role in food production and biodiversity maintenance through pollination. They have different survival strategies in cold temperate regions and experience lifecycle alterations in tropical or subtropical climates. The gut microbiota of honey bees in subtropical colonies changes seasonally, with environmental variables impacting its composition.
Review
Endocrinology & Metabolism
Marion Regnier, Matthias Van Hul, Claude Knauf, Patrice D. Cani
Summary: Overweight and obesity are linked to cardiometabolic risk factors, potentially influenced by gut microbiota composition and activity. However, causality between the two is not fully proven. Low-grade inflammation and metabolic disorders are associated with metabolic endotoxaemia and increased gut permeability, but the mechanisms affecting gut barrier regulation and cardiometabolic disorders remain unclear.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Erfei Song, Vivian Vu, Thibault V. Varin, Amy Botta, Andre Marette, Gary Sweeney
Summary: Copper and copper alloys have antimicrobial activity and using copper-infused fabric bedding may have beneficial effects on metabolic health, including reduced body weight gain and improved glucose tolerance in mice with diet-induced obesity.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Review
Gastroenterology & Hepatology
Xinyu Qi, Chuyu Yun, Yanli Pang, Jie Qiao
Summary: The gut microbiota, considered a full-fledged endocrine organ, plays a major role in women's reproductive endocrine system by interacting with various hormones. Imbalance in microbiota composition can lead to diseases like pregnancy complications and PCOS, highlighting the need for further research and novel therapeutic strategies.
Article
Biochemical Research Methods
Siruo Zhang, Lu Yuan, Huan Li, Lei Han, Wanghui Jing, Xiaokang Wu, Shakir Ullah, Ruina Liu, Yonghong Wu, Jiru Xu
Summary: This study investigated the interaction between endogenous metabolites and gut microbiota following simvastatin treatment. The results identified potential therapeutic targets for improving the hypolipidemic efficacy of simvastatin, including the phenylalanine and tyrosine-associated amino acid metabolism pathways and the linoleic acid and 9-HODE-associated unsaturated fatty acid metabolism pathways involved in gut flora interactions.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Endocrinology & Metabolism
Xin Yuan, Ruimin Chen, Ying Zhang, Xiangquan Lin, Xiaohong Yang, Kenneth L. McCormick
Summary: The study found that the gut microbiome in obese children with insulin resistance was significantly different from those without resistance, and the abundance of certain metabolism-related bacteria was correlated with the serum concentrations of adropin and ANGPTL4.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Brittany M. Duggan, Akhilesh K. Tamrakar, Nicole G. Barra, Fernando F. Anhe, Gabriella Paniccia, Jessica G. Wallace, Hannah D. Stacey, Michael G. Surette, Matthew S. Miller, Deborah M. Sloboda, Jonathan D. Schertzer
Summary: Obesity and diabetes are associated with increased levels of microbial components from the gut microbiota in the bloodstream. Extracts from specific bacterial sources within the gut can improve blood glucose control in mice by engaging innate immunity mechanisms and promoting an IgG response against bacterial antigens. Furthermore, vaccination with microbiota-based extracts alters the composition of the microbiota in the intestines of mice, leading to long-lasting improvements in blood glucose control.
MOLECULAR METABOLISM
(2022)
Article
Microbiology
Fernando Hernandez-Quiroz, Selvasankar Murugesan, Cintia Flores-Rivas, Alberto Pina-Escobedo, Josue Isaac Juarez-Hernandez, Matilde Garcia-Espitia, Alejandra Chavez-Carbajal, Khemlal Nirmalkar, Jaime Garcia-Mena
Summary: This study analyzed the fecal microbiota of different horse breeds living in Mexico and found significant differences in the microbial communities among the breeds.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Microbiology
Antonio Gonzalez-Sanchez, Jose J. Reyes-Lagos, Miguel A. Pena-Castillo, Khemlal Nirmalkar, Jaime Garcia-Mena, Gustavo Pacheco-Lopez
Summary: This study conducted a longitudinal investigation on the vaginal microbiota composition of 10 Mexican pregnant women, revealing the stability of vaginal microbiota composition during the third trimester of pregnancy and childbirth, with the Lactobacillus genus being the dominant taxa.
CURRENT MICROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Tania Smith, Carlos Hoyo-Vadillo, Akosua Agyeman Adom, Liliana Favari-Perozzi, Silke Gastine, Hakim-Moulay Dehbi, Beatriz Villegas-Lara, Eduardo Mateos, Yessica Sara Perez Gonzalez, Maria D. Navarro-Gualito, Alejandra S. Cruz-Carbajal, Miguel A. Cortes-Vazquez, Carolina Bekker-Mendez, Charmina Aguirre-Alvarado, Gisela Aguirre-Gil, Lucero Delgado-Pastelin, Andrew Owen, David Lowe, Joseph Standing, Jorge Escobedo
Summary: This study proposes a placebo-controlled clinical trial of favipiravir plus or minus nitazoxanide in the Mexican Social Security Institute (IMSS) facilities. The aim is to evaluate the impact of early antiviral treatment on the later phase of COVID-19. The trial will be conducted with a randomised, double-blind design, and the primary outcome will be the difference in viral load in the upper respiratory tract after 5 days of therapy.
Article
Biochemistry & Molecular Biology
Carmen Josefina Juarez-Castelan, Juan Manuel Velez-Ixta, Karina Corona-Cervantes, Alberto Pina-Escobedo, Yair Cruz-Narvaez, Alejandro Hinojosa-Velasco, Maria Esther Landero-Montes-de-Oca, Eduardo Davila-Gonzalez, Eduardo Gonzalez-del-Olmo, Fernando Bastida-Gonzalez, Paola Berenice Zarate-Segura, Jaime Garcia-Mena
Summary: This study provides insights into the gut microbiota of pregnant women during SARS-CoV-2 infection, revealing a high abundance of the Firmicutes phylum. Some bacteria belonging to the Firmicutes phylum have been associated with anti-inflammatory effects, which may explain the ability of women to overcome the infection. Furthermore, the presence of certain bacterial diversity in colostrum suggests a potential association between the gut microbiota and a better outcome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Arun Prasath Lakshmanan, Selvasankar Murugesan, Souhaila Al Khodor, Annalisa Terranegra
Summary: Akkermansia muciniphila (A. muciniphila) is a widely studied probiotic that has been found to have potential positive and negative impacts on hypertension. This review aims to discuss the role of A. muciniphila in the pathophysiology of hypertension and its potential effects on hypertension management.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Tizziani Benitez-Guerrero, Juan Manuel Velez-Ixta, Carmen Josefina Juarez-Castelan, Karina Corona-Cervantes, Alberto Pina-Escobedo, Helga Martinez-Corona, Amapola De Sales-Millan, Yair Cruz-Narvaez, Carlos Yamel Gomez-Cruz, Tito Ramirez-Lozada, Gustavo Acosta-Altamirano, Monica Sierra-Martinez, Paola Berenice Zarate-Segura, Jaime Garcia-Mena
Summary: This study assessed the changes in gut microbiota diversity, short-chain fatty acids production, and fecal metabolites profile in Mexican women affected by gestational diabetes, pre-gestational diabetes, and pre-eclampsia. The results showed an association between these disorders and fecal bacterial microbiota profiles, as well as distinct predictive metagenomes.
Article
Nutrition & Dietetics
Rebeca Rosas-Campos, Alejandra Meza-Rios, J. Samael Rodriguez-Sanabria, Ricardo de la Rosa-Bibiano, Karina Corona-Cervantes, Jaime Garcia-Mena, Arturo Santos, Ana Sandoval-Rodriguez, Juan Armendariz-Borunda
Summary: This study evaluated the effect of supplementation with a mixture of Mexican functional foods on an obesogenic mice model, finding that MexMix significantly reduced body weight, fat content, and various metabolic markers, while promoting beneficial bacteria.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Jessica Roelands, Peter J. K. Kuppen, Eiman I. Ahmed, Raghvendra Mall, Tariq Masoodi, Parul Singh, Gianni Monaco, Christophe Raynaud, Noel F. C. C. de Miranda, Luigi Ferraro, Tatiana C. Carneiro-Lobo, Najeeb Syed, Arun Rawat, Amany Awad, Julie Decock, William Mifsud, Lance D. Miller, Shimaa Sherif, Mahmoud G. Mohamed, Darawan Rinchai, Marc Van den Eynde, Rosalyn W. Sayaman, Elad Ziv, Francois Bertucci, Mahir Abdulla Petkar, Stephan Lorenz, Lisa Sara Mathew, Kun Wang, Selvasankar Murugesan, Damien Chaussabel, Alexander L. Vahrmeijer, Ena Wang, Anna Ceccarelli, Khalid A. Fakhro, Gabriele Zoppoli, Alberto Ballestrero, Rob A. E. M. Tollenaar, Francesco M. Marincola, Jerome Galon, Souhaila Al Khodor, Michele Ceccarelli, Wouter Hendrickx, Davide Bedognetti
Summary: The lack of multi-omics cancer datasets with extensive follow-up information hinders the identification of accurate biomarkers of clinical outcome. In this cohort study, comprehensive genomic analyses were performed on fresh-frozen samples from 348 patients with primary colon cancer. The study revealed a gene expression signature called Immunologic Constant of Rejection that outperformed conventional prognostic molecular biomarkers. Additionally, a favorable outcome was associated with a microbiome signature driven by Ruminococcus bromii.
Article
Chemistry, Multidisciplinary
Raul Garcia-Garcia, Virgilio Bocanegra-Garcia, Lourdes Vital-Lopez, Jaime Garcia-Mena, Marco Antonio Zamora-Antunano, Maria Antonia Cruz-Hernandez, Juvenal Rodriguez-Resendiz, Alberto Mendoza-Herrera
Summary: This study aims to determine the bacterial composition in crude oil-contaminated soil from Tabasco and Tamaulipas states, Mexico. The structure and diversity of bacterial communities in the contaminated soil samples were evaluated. It was found that the most abundant phylum is proteobacteria, and some genera showed higher abundance in alkaline or acidic soil.
APPLIED SCIENCES-BASEL
(2023)
Editorial Material
Nutrition & Dietetics
Anita Ferraretto, Elena Donetti, Jaime Garcia-Mena, Gustavo Pacheco-Lopez
FRONTIERS IN NUTRITION
(2023)
Article
Medicine, Research & Experimental
Parul Singh, Noora Al Mohannadi, Selvasankar Murugesan, Fajr Almarzooqi, Basirudeen Syed Ahamed Kabeer, Alexandra Katharina Marr, Tomoshige Kino, Tobias Brummaier, Annalisa Terranegra, Rose McGready, Francois Nosten, Damien Chaussabel, Souhaila Al Khodor
Summary: This study investigated the microbial communities in breast milk of mothers with preterm deliveries and found that the microbial communities became increasingly diverse and distinct as the breast milk matured. There were significant differences in the community structures between preterm and term breast milk samples. This study highlights the significant influence of pregnancy-related complications on the composition and diversity of breast milk microbiota, paving the way for improving maternal and infant health outcomes.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Selvasankar Murugesan, Souhaila Al Khodor
Summary: This study aimed to compare the composition of salivary microbiome between hypertensive and normotensive Qatari subjects. The results showed that Bacteroides and Atopobium were more abundant in hypertensive individuals, while Cysteine and Methionine metabolism and sulphur metabolic pathways were higher in the normotensive group. Machine learning models accurately predicted hypertension. Further research is needed to confirm these findings and validate the mechanisms involved.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Maria Eugenia Torres-Chavez, Nora Magdalena Torres-Carrillo, Ana Victoria Monreal-Lugo, Sandra Garnes-Rancurello, Selvasankar Murugesan, Itzae Adonai Gutierrez-Hurtado, Jesus Raul Beltran-Ramirez, Elena Sandoval-Pinto, Norma Torres-Carrillo
Summary: Understanding the relationship between gut microbiota and neuroinflammatory processes of the CNS is crucial for understanding immune-mediated neurological diseases like multiple sclerosis. Dysbiosis of the gut microbiota can cause neuroinflammation and neuronal damage, while certain commensal bacteria have anti-inflammatory effects and can improve the integrity of the gut and blood-brain barrier.
BIOMEDICAL REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Felipe J. Silva-Aguilar, Jaime Garcia-Mena, Selvasankar Murugesan, Khemlal Nirmalkar, Elsa Cervantes-Gonzalez
Summary: This study investigated the bacterial diversity of a potential consortium used as a biosorbent for the removal of lead in water. The results showed that the bacterial consortium could tolerate high concentrations of lead exposure and enrich bacterial families and genera to remove lead from the solution.
INTERNATIONAL MICROBIOLOGY
(2023)