期刊
NUTRIENTS
卷 11, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/nu11010125
关键词
thyroid cancer; phytochemicals; reactive oxygen species; radio iodine therapy; apoptosis
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - the Ministry of Education, Science and Technology (MEST) [2017R1D1A1A09000663, 2016R1D1A1A09919809]
- Global Research and Development Center (GRDC) Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2017K1A4A3014959]
- National Research Foundation of Korea [2016R1D1A1A09919809] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Thyroid cancers developed from the tissues of the thyroid gland are classified into papillary (PTC), follicular (FTC), medullary (MTC), and anaplastic thyroid cancer (ATC). Although thyroid cancers have been generally known as mild forms of cancer, undifferentiated MTC and ATC have a more unfavorable prognosis than differentiated PTC and FTC because they are more aggressive and early metastatic. A variety of therapies such as surgery, radiotherapy, and chemotherapy have been currently used to treat thyroid cancer, but they still have limitations including drug resistance or unfavorable side effects. Phytochemicals are plant-derived chemicals having various physiological activities that are expected to be effective in cancer treatment. In this review, anticancer efficacy of phytochemicals, such as resveratrol, genistein, curcumin, and other substances in each type of thyroid cancer was introduced with their chemopreventive mechanisms. English articles related with thyroid cancer and anti-thyroid cancer of phytochemicals were searched from PubMed and Google Scholar. This article mainly focused on in vitro or animal studies on phytochemicals with anti-thyroid cancer activity. These various phytochemicals have been shown to induce apoptosis in all types of thyroid cancer cells, inhibit cell proliferation and invasion, and to be helpful in enhancing the effect of radioiodine therapy that is a typical therapy to thyroid cancer. These results suggest that thyroid cancer can be more effectively treated by the combinations of phytochemicals and the existing therapies or substances.
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