期刊
NUTRIENTS
卷 11, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/nu11010025
关键词
inflammatory bowel disease; microbiome; dysbiosis; metabolite; metabolic receptor
资金
- Canadian Institutes of Health Research (CIHR)-CAG-CCC New Investigator Award (2015-2018)
- Canadian Foundation of Innovation John R. Evans Leadership fund [35235, 36764]
- Nova Scotia Health Research Foundation (NSHRF) establishment award
- IWK Health Centre Research Associateship
- Future Leaders in IBD
Succinate is a metabolic intermediate of the tricarboxylic acid (TCA) cycle within host cells. Succinate is also produced in large amounts during bacterial fermentation of dietary fiber. Elevated succinate levels within the gut lumen have been reported in association with microbiome disturbances (dysbiosis), as well as in patients with inflammatory bowel disease (IBD) and animal models of intestinal inflammation. Recent studies indicate that succinate can activate immune cells via its specific surface receptor, succinate receptor 1(SUCNR1), and enhance inflammation. However, the role of succinate in inflammatory processes within the gut mucosal immune system is unclear. This review includes current literature on the association of succinate with intestinal inflammation and the potential role of succinate-SUCNR1 signaling in gut immune functions.
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