Article
Nutrition & Dietetics
Doretta Cuffaro, Simone Bertini, Marco Macchia, Maria Digiacomo
Summary: This study examines the combination of olive leaf extract and extra virgin olive oil extract, which shows improved antioxidant and anti-inflammatory properties compared to the singular olive oil extract. This extract may have potential in the field of nutraceuticals.
Article
Chemistry, Applied
Gabriele Rocchetti, Maria Luisa Callegari, Alice Senizza, Gianluca Giuberti, Jessica Ruzzolini, Annalisa Romani, Silvia Urciuoli, Chiara Nediani, Luigi Lucini
Summary: The modulation of gut microbiota by polyphenols from olives and derived products is of increasing interest. In this study, phenolic leaf extracts (PLE) were in vitro fermented to evaluate changes in phenolic profiles and their impact on microbiota. The fermentation of PLE decreased oleuropein content and increased hydroxytyrosol and other phenolic metabolites. A significant increase in hydroxytyrosol was also observed in fermented extra-virgin olive oil (EVOO). The fermentation of PLE also significantly changed the amino acids and fatty acids profile of the faeces. Metagenomic sequencing revealed that Coriobacteriaceae at the family level and Collinsella at the genus level were the most affected by PLE fermentation.
Review
Nutrition & Dietetics
Andrea del Saz-Lara, Maria-Carmen Lopez de las Hazas, Francesco Visioli, Alberto Davalos
Summary: This article systematically reviews the effects of extra virgin olive oil (EVOO) and its phenolic compounds on the epigenetic landscape. The results show that EVOO and its phenolic compounds can induce epigenetic changes that regulate gene expression and molecular targets involved in various metabolic processes. Oleuropein and hydroxytyrosol, for example, have been shown to have epigenetic effects in cancer and other diseases. Understanding the epigenetic effects of EVOO and its phenolic compounds can contribute to the development of pharma-nutritional strategies.
ADVANCES IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Simona Bartimoccia, Vittoria Cammisotto, Cristina Nocella, Maria Del Ben, Alessandra D'Amico, Valentina Castellani, Francesco Baratta, Pasquale Pignatelli, Lorenzo Loffredo, Francesco Violi, Roberto Carnevale
Summary: The study found that extra virgin olive oil can improve postprandial glycemia by reducing low-grade endotoxemia derived from gut permeability. These results demonstrate the importance of using extra virgin olive oil for blood sugar control.
Review
Agriculture, Multidisciplinary
Beatriz T. Martins, Maria Rosario Bronze, M. Rita Ventura
Summary: Virgin olive oil is the main fat consumed in the Mediterranean basin, and its phenolic compounds are known to have health benefits. The low concentrations and limited availability of commercial standards for these compounds have hindered studies on their biological activity. Chemical synthesis is considered a convenient method for obtaining these compounds.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Martina Bartolomei, Carlotta Bollati, Maria Bellumori, Lorenzo Cecchi, Ivan Cruz-Chamorro, Guillermo Santos-Sanchez, Giulia Ranaldi, Simonetta Ferruzza, Yula Sambuy, Anna Arnoldi, Nadia Mulinacci, Carmen Lammi
Summary: This study provides a comprehensive characterization of the antioxidant properties of phenolic extract (BUO) obtained from extra virgin olive oil, cultivated in Tuscany, Italy. The findings show that BUO extract can reduce harmful substances produced in cells after oxidative stress and demonstrate selective trans-epithelial transport of some phenolic components in differentiated Caco-2 cells, a mature enterocyte model.
Article
Food Science & Technology
Laura Bayes-Garcia, Teresa Calvet
Summary: Arbequina monovarietal extra virgin olive oil (EVOO) was studied for its crystallization and polymorphic behavior through fractionation. Different crystallization and polymorphic behaviors were observed for each fraction, with solid fractions exhibiting more complex transitions and a greater number of crystalline forms.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Luca Pozzetti, Francesca Ferrara, Ludovica Marotta, Sandra Gemma, Stefania Butini, Mascia Benedusi, Fabio Fusi, Amer Ahmed, Serena Pomponi, Stefano Ferrari, Matteo Perini, Anna Ramunno, Giacomo Pepe, Pietro Campiglia, Giuseppe Valacchi, Gabriele Carullo, Giuseppe Campiani
Summary: This study evaluated the nutraceutical properties of autochthonous Tuscany EVOO and found promising anti-inflammatory and vasorelaxant effects.
Review
Nutrition & Dietetics
Andres Jimenez-Sanchez, Antonio Jesus Martinez-Ortega, Pablo Jesus Remon-Ruiz, Ana Pinar-Gutierrez, Jose Luis Pereira-Cunill, Pedro Pablo Garcia-Luna
Summary: This narrative review synthesizes and illustrates the characteristics and clinical applications of extra virgin olive oil (EVOO) and its components in the field of clinical nutrition and dietetics. EVOO has diverse health properties and can be used in diet therapy and as a supplement to improve cardiovascular health, lipoprotein metabolism, and diabetes mellitus. However, more research is needed to provide specific recommendations for its therapeutic use in different diseases and populations.
Article
Microbiology
Andrea Celeste Arismendi Sosa, Maria Laura Mariani, Alba Edith Vega, Alicia Beatriz Penissi
Summary: This study evaluated the antibacterial effect of extra virgin olive oil (EVOO), hydroxytyrosol (HT), and oleuropein (Olp) against Helicobacter pylori in vitro, and examined the impact of oral administration of EVOO on the gastric mucosa of H. pylori-infected mice. The results demonstrated that EVOO exhibited antibacterial activity against H. pylori and reduced gastric mucosal damage in infected mice.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Paula Garcia-Oliveira, Cecilia Jimenez-Lopez, Catarina Lourenco-Lopes, Franklin Chamorro, Antia Gonzalez Pereira, Anxo Carrera-Casais, Maria Fraga-Corral, Maria Carpena, Jesus Simal-Gandara, Miguel Angel Prieto
Summary: Extra virgin olive oil is a distinctive ingredient of the Mediterranean diet with various health benefits, containing molecules capable of exerting bioactivities mainly due to unsaturated fatty acids and minor compounds. The flavor of EVOO is influenced by intrinsic factors like olive variety and extrinsic factors like growing conditions, with each oil having a unique taste and susceptible to changes during shelf-life. Flavor preservation strategies are essential for maintaining the quality of the product.
Article
Biochemistry & Molecular Biology
Alexandra Virginia Bounegru, Constantin Apetrei
Summary: This study achieved qualitative and quantitative determination of oleuropein in commercial EVOO samples using electrochemical techniques. Enzyme biosensors were constructed with successful immobilization of enzymes on carbon nanotube-modified electrodes, demonstrating efficient detection of oleuropein. The tyrosinase-based biosensor showed superior sensitivity towards oleuropein compared to the laccase-based one.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Alessia Lombardi, Domenico Carlucci, Carla Cavallo, Bernardo De Gennaro, Teresa Del Giudice, Giacomo Giannoccaro, Antonio Paparella, Luigi Roselli, Riccardo Vecchio, Gianni Cicia
Summary: The study found that only about 36% of Italian consumers truly understand authorized health claims on extra-virgin olive oil. Consumers' understanding is related to their socio-demographic, personal, and psychographic characteristics, as well as their attitudes towards using food as medicine. The role of nutrition knowledge was also shown to be central in affecting the understanding of health claims.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Food Science & Technology
Ken Abamba Omwange, Dimas Firmanda Al Riza, Yoshito Saito, Tetsuhito Suzuki, Yuichi Ogawa, Keiichiro Shiraga, Ferruccio Giametta, Naoshi Kondo
Summary: This study successfully distinguished between different ratios of adulterated EVOO and VOO using front-face fluorescence spectroscopy and UV-induced fluorescence imaging techniques, providing a fast, reliable, and inexpensive method for detecting adulteration.
Review
Food Science & Technology
Valentina Maestrello, Pavel Solovyev, Luana Bontempo, Luisa Mannina, Federica Camin
Summary: Extra virgin olive oil (EVOO) is a high-quality product that has become a target of food fraud in recent years. The use of nuclear magnetic resonance (NMR) spectroscopy is reviewed as a reliable and rapid tool to authenticate EVOOs and detect adulteration and mislabeling.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2022)
Article
Oncology
Luigi Ippolito, Giuseppina Comito, Matteo Parri, Marta Iozzo, Assia Duatti, Francesca Virgilio, Nicla Lorito, Marina Bacci, Elisa Pardella, Giada Sandrini, Francesca Bianchini, Roberta Damiano, Lavinia Ferrone, Giancarlo la Marca, Sergio Serni, Pietro Spatafora, Carlo V. Catapano, Andrea Morandi, Elisa Giannoni, Paola Chiarugi
Summary: This research reveals that lactate can promote lipid metabolism in prostate cancer cells through the regulation of gene expression, thus contributing to cancer progression and metastasis.
Letter
Medicine, General & Internal
Stefano Fumagalli, Giulia Ricciardi, Claudia Di Serio, Giancarlo La Marca, Niccolo Marchionni
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Pediatrics
Carlo Dani, Alessandra Cecchi, Martina Ciarcia, Francesca Miselli, Michele Luzzati, Giulia Remaschi, Maria Della Bona, Giancarlo la Marca, Luca Boni
Summary: This study aimed to verify the feasibility of intravenous or enteral administration of caffeine in the delivery room for preterm infants. The results showed that the procedure was successfully performed in all patients, but some patients did not reach the therapeutic range.
Article
Biochemistry & Molecular Biology
Elena Andreucci, Kelly Bugatti, Silvia Peppicelli, Jessica Ruzzolini, Matteo Lulli, Lido Calorini, Lucia Battistini, Franca Zanardi, Andrea Sartori, Francesca Bianchini
Summary: Growth factors and cytokines in the lung cancer microenvironment induce EMT and promote tumor progression. A novel conjugate targeting the α v β 6 integrin receptor, linked to the kinase inhibitor nintedanib, inhibits cancer cell adhesion and growth through selective delivery. The conjugate also suppresses clonogenic ability and other aspects associated with EMT transition, offering a precise strategy against non-small cell lung cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Respiratory System
Anne Munck, Daria Berger, Kevin W. Southern, Carla Carducci, Karin M. de Winter-de Groot, Silvia Gartner, Nataliya Kashirskaya, Barry Linnane, Marijke Proesmans, Dorota Sands, Olaf Sommerburg, Carlo Castellani, Juerg Barben
Summary: The study aimed to assess the current status and performance of newborn bloodspot screening (NBS) for CF in Europe. A survey was conducted among representatives of NBS programs across Europe, and performance was evaluated using a previously developed framework. The results showed that in 2022, there were 22 national and 34 regional NBS programs in Europe. The integration of DNA analysis into the NBS protocol improved the positive predictive value, but also led to increased carrier and CFSPID recognition.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Genetics & Heredity
Emanuela Abiusi, Alessandro Vaisfeld, Stefania Fiori, Agnese Novelli, Serena Spartano, Maria Vittoria Faggiano, Teresa Giovanniello, Antonio Angeloni, Giovanni Vento, Roberta Santoloci, Francesca Gigli, Adele D'Amico, Simonetta Costa, Alessia Porzi, Mara Panella, Chiara Ticci, Marta Daniotti, Michele Sacchini, Ilaria Boschi, Enrico Bertini, Antonio Lanzone, Giancarlo Lamarca, Maurizio Genuardi, Marika Pane, Maria Alice Donati, Eugenio Mercuri, Francesco Danilo Tiziano
Summary: This study reports the results of the first Italian SMA-NBS project and proposes updates to the current molecular diagnostic scenario. The incidence of SMA among newborns was found to be 1:6059, with 40% of patients showing signs suggestive of SMA at birth. The study also discusses some unusual cases.
JOURNAL OF MEDICAL GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Gemma Marcucci, Vladana Domazetovic, Chiara Nediani, Jessica Ruzzolini, Claudio Favre, Maria Luisa Brandi
Summary: This review provides a detailed report on the cellular and molecular mechanisms involved in bone remodeling, specifically in relation to oxidative stress, inflammatory factors, and estrogen deficiency. Oxidative stress is a key factor in the development of osteoporosis, leading to osteocyte apoptosis and impaired bone remodeling and resorption. Recent studies have shown that natural antioxidants found in the diet can effectively prevent and reduce the negative effects of oxidative stress on bone health. These antioxidants target osteocytes and their molecular factors, promoting bone regeneration and preventing bone loss. This suggests that incorporating antioxidants into therapeutic approaches may improve the prevention and treatment of osteoporosis and related bone diseases.
Article
Cell Biology
Elena Andreucci, Bianca Saveria Fioretto, Irene Rosa, Marco Matucci-Cerinic, Alessio Biagioni, Eloisa Romano, Lido Calorini, Mirko Manetti
Summary: This study reveals a previously unrecognized relationship between lactic acidosis and the generation of a new CAF-like cell subpopulation from adipocytic precursor cells, which sustains tumor malignancy.
Article
Genetics & Heredity
Elisa Lastrucci, Marta Daniotti, Elena Procopio, Giusi Scaturro, Flavia Tubili, Rosanna Martin, Giancarlo la Marca
Summary: This study aims to investigate and objectify possible distress indicators elicited at the moment of the communication of a positive result at Expanded Newborn Screening (ENS). The parents of 32 babies expressed the presence of discomfort potentially related to the communication of a positive result at ENS.
INTERNATIONAL JOURNAL OF NEONATAL SCREENING
(2023)
Article
Geriatrics & Gerontology
Stefano Fumagalli, Giulia Spanalatte, Claudia Di Serio, Giancarlo La Marca, Giuseppe Pieraccini, Riccardo Franci Montorzi, Emanuele Santamaria, Giulia Spanalatte, Francesca Marchetti, Ginevra Corti, Laura Pinton, Niccolo Marchionni
Summary: In older patients with atrial fibrillation, IL-6 is associated with acylcarnitines and lower physical performance. Alterations in energy production, reduced physical function, and inflammation may contribute to frailty development.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Stefano Fumagalli, Giulia Ricciardi, Claudia Di Serio, Giancarlo La Marca, Giuseppe Pieraccini, Riccardo Franci Montorzi, Emanuele Santamaria, Giulia Spanalatte, Francesca Marchetti, Ginevra Corti, Laura Pinton, Niccolo Marchionni
Summary: In this study, it was found that IL-6 concentration was elevated in patients with AF and correlated with acylcarnitines. These findings suggest that abnormal energy production, reduced physical function, and inflammation may contribute to frailty development in older AF patients.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Genetics & Heredity
Margherita Ruoppolo, Sabrina Malvagia, Sara Boenzi, Carla Carducci, Carlo Dionisi-Vici, Francesca Teofoli, Alberto Burlina, Antonio Angeloni, Tommaso Aronica, Andrea Bordugo, Ines Bucci, Marta Camilot, Maria Teresa Carbone, Roberta Cardinali, Claudia Carducci, Michela Cassanello, Cinzia Castana, Chiara Cazzorla, Renzo Ciatti, Simona Ferrari, Giulia Frisso, Silvia Funghini, Francesca Furlan, Serena Gasperini, Vincenza Gragnaniello, Chiara Guzzetti, Giancarlo La Marca, Luisa La Spina, Tania Lore, Concetta Meli, MariaAnna Messina, Amelia Morrone, Francesca Nardecchia, Rita Ortolano, Giancarlo Parenti, Enza Pavanello, Damiana Pieragostino, Sara Pillai, Francesco Porta, Francesca Righetti, Claudia Rossi, Valentina Rovelli, Alessandro Salina, Laura Santoro, Pina Sauro, Maria Cristina Schiaffino, Simonetta Simonetti, Monica Vincenzi, Elisabetta Tarsi, Anna Paola Uccheddu
Summary: Newborn screening for inborn errors of metabolism is an advanced tool for early diagnosis and treatment initiation. Italy introduced expanded newborn screening in 2016-2017 and collected data from 15 Italian screening laboratories. Aminoacidemias were the most common inborn errors, and second-tier tests were effective in reducing false positives. The screening also identified conditions related to maternal deficiencies.
INTERNATIONAL JOURNAL OF NEONATAL SCREENING
(2022)
Review
Genetics & Heredity
Jaka Sikonja, Urh Groselj, Maurizio Scarpa, Giancarlo la Marca, David Cheillan, Stefan Koelker, Rolf H. Zetterstrom, Viktor Kozich, Yann Le Cam, Gulcin Gumus, Valentina Bottarelli, Mirjam van der Burg, Eugenie Dekkers, Tadej Battelino, Johan Prevot, Peter C. J. Schielen, James R. Bonham
Summary: Although individual rare disorders are uncommon, together they affect more than 30 million people in Europe, causing a substantial burden on public health. Newborn screening (NBS) can detect rare conditions in asymptomatic children, leading to early treatment and improved long-term outcomes. However, the availability and conduct of NBS programmes vary across Europe, highlighting the need for improvement to ensure equity and high-quality screening.
INTERNATIONAL JOURNAL OF NEONATAL SCREENING
(2022)