Article
Nutrition & Dietetics
Mahdieh Khodarahmi, Leila Nikniaz, Mahdieh Abbasalizad Farhangi
Summary: The study revealed interactions between FADS genes and dietary quality indicators (DASH and MDS) in influencing cardio-metabolic risk factors among obese adults. Specific gene variants interacted with adherence to healthy diets to impact levels of serum triglycerides, glucose, and blood pressure.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Marie C. Conway, Emeir M. McSorley, Maria S. Mulhern, Toni Spence, Maria Weslowska, J. J. Strain, Edwin van Wijngaarden, Phil W. Davidson, Gary J. Myers, Karin E. Wahlberg, Conrad F. Shamlaye, Diego F. Cobice, Barry W. Hyland, Daniela Pineda, Karin Broberg, Alison J. Yeates
Summary: Maternal and child genetic variations in FADS genotype influence cord blood LCPUFA concentrations, even in a population with high fish intake.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Huimin Tian, Haitao Yu, Yiqi Lin, Yueting Li, Wenhui Xu, Yiru Chen, Guoliang Liu, Lin Xie
Summary: This study found significant differences in the content of n-6 PUFA in breast milk based on the transcription levels of the FADS1 gene, highlighting the importance of developing new methods and diets to optimize infant feeding.
Article
Nutrition & Dietetics
Marie C. Conway, Emeir M. McSorley, Maria S. Mulhern, Toni Spence, Edwin van Wijngaarden, Gene E. Watson, Karin Wahlberg, Daniela Pineda, Karin Broberg, Barry W. Hyland, Diego F. Cobice, J. J. Strain, Alison J. Yeates
Summary: The study found that consuming two portions of fish per week significantly increased concentrations of EPA, DHA, and total n-3 PUFA in women of childbearing age, with a lower n-6:n-3 ratio compared to those consuming no fish or one portion per week. However, fish consumption did not have a significant effect on biomarkers of oxidative stress, inflammation, and lipid profile in the current study.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Review
Nutrition & Dietetics
Floyd H. Chilton, Ani Manichaikul, Chaojie Yang, Timothy D. O'Connor, Laurel M. Johnstone, Sarah Blomquist, Susan M. Schembre, Susan Sergeant, Manja Zec, Michael Y. Tsai, Stephen S. Rich, Susan J. Bridgewater, Rasika A. Mathias, Brian Hallmark
Summary: Diets in developed countries have changed and caused health issues, and the interaction between genetic variation and the intake of certain fatty acids has impact on health.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Susan Sergeant, Brian A. Keith, Michael C. Seeds, Jimaree A. Legins, Caroline B. Young, Mara Z. Vitolins, Floyd H. Chilton
Summary: Polyunsaturated fatty acids (PUFA) and highly unsaturated fatty acid (HUFA) synthetic products and their metabolites play crucial roles in immunity, inflammation, and brain development/function. The frequency differences of variants in the fatty acid desaturase (FADS) gene cluster affect levels of HUFAs and physiological phenotypes. However, the impact of this genetic variation on the health of Hispanic/Latino populations remains unclear.
FRONTIERS IN NUTRITION
(2023)
Article
Chemistry, Applied
Xiaofang Dao, Dawei Zhang, Linlin Wang, Lina Wang
Summary: This study evaluated the fatty acid (FA) composition in the milk of lactating Tibetan women and the consequences of dietary patterns. The milk was found to have high levels of total saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA) compared to milk from other regions in China. However, total polyunsaturated fatty acids (PUFA) were slightly lower, and the concentration of docosahexaenoic acid (DHA) was significantly lower. The main n-3 FAs in human milk, including DHA and EPA, may be influenced by carbohydrate intake.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Hiromi Sato, Shintaro Narita, Masanori Ishida, Yoshiko Takahashi, Huang Mingguo, Soki Kashima, Ryohei Yamamoto, Atsushi Koizumi, Taketoshi Nara, Kazuyuki Numakura, Mitsuru Saito, Toshiaki Yoshioka, Tomonori Habuchi
Summary: A diet rich in lard increases the risk of prostate cancer development and progression. Two mouse models fed with lard-enriched diets showed enhanced prostate cancer progression and weight gain compared to a fish oil diet. The composition of gut microbiota differed significantly between the two diets, with changes in bacterial species such as Clostridiales and Lactobacillales. The proportion of Lactobacillales in the gut was negatively associated with weight gain and prostate cancer progression. The study also identified genes involved in lipid metabolism and cholesterol biosynthesis that correlated with the abundance of Lactobacillales in the gut.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Nirajan Shrestha, Alexandra McCarron, Nathan Rout-Pitt, Martin Donnelley, David W. Parsons, Deanne H. Hryciw
Summary: Adequate intake of essential fatty acids (EFA) is critical in cystic fibrosis (CF) patients. EFA deficiency is closely associated with the risk of pulmonary infection, a significant pathology in CF. Although some progress has been made in understanding the dysfunctional metabolic pathways in CF, further research is needed, particularly in investigating EFA metabolism in the liver. Adequate EFA concentrations are important for normal membrane structure and function, and investigating the effects of genotype and sex on fatty acid metabolism may support personalized nutritional therapies for CF management.
Article
Agriculture, Dairy & Animal Science
My Tuyen T. Nguyen, Jieun Kim, Nari Seo, A. Hyun Lee, Yong-Ki Kim, Ji A. Jung, Dan Li, Xuan Hong M. To, Khanh Trang N. Huynh, Thanh Van Le, Beenish Israr, Anum Nazir, Jung-A Seo, Daum Lee, Hyun Joo An, Jaehan Kim
Summary: The study found significant differences in human milk fatty acid compositions among different Asian countries, with Pakistani breast milk having high saturated fat content and low unsaturated fatty acids, indicating the need for DHA supplementation in infants. Additionally, the average DHA: ARA ratio in Asian human milk was 1.01.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Plant Sciences
Jihong Yang, Beibei Chen, Sehrish Manan, Penghui Li, Chun Liu, Guangbiao She, Shancen Zhao, Jian Zhao
Summary: This study provides a deep understanding of the biosynthesis of tea seed oils and identifies key genes and enzymes involved in the regulation of fatty acid composition. The findings will contribute to the breeding of oil tea varieties with higher oil yield and quality.
HORTICULTURE RESEARCH
(2022)
Article
Nutrition & Dietetics
Nives Bogataj Jontez, Sasa Kenig, Karin Sik Novak, Ana Petelin, Zala Jenko Praznikar, Nina Mohorko
Summary: This study compared the dietary patterns of individuals following LCHF, vegan, vegetarian, and omnivorous diets. The results showed that compared to other groups, the LCHF group had higher intakes of saturated fats, cholesterol, and animal proteins, while the intakes of sugars and dietary fibers were lower. The levels of total and LDL cholesterol were significantly higher in the LCHF group. Thus, it is recommended to select healthy fat sources, increase dietary fiber intake, and partially replace animal sources with plant sources in the LCHF diet.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Fabiola N. Velazquez, Valentina Viscardi, Julia Montemage, Leiqing Zhang, Carolena Trocchia, Megan M. Delamont, Rasheed Ahmad, Yusuf A. Hannun, Lina M. Obeid, Ashley J. Snider
Summary: Different types of high-fat diets were used to simulate breast cancer, and it was found that fatty acids from different sources may affect breast cancer metastasis.
Article
Food Science & Technology
Topi Meuronen, Maria A. Lankinen, Johan Kolmert, Vanessa de Mello Laaksonen, Taisa Sallinen, Jyrki Agren, Kirsi A. Virtanen, Markku Laakso, Craig E. Wheelock, Jussi Pihlajamaki, Ursula Schwab
Summary: This study investigated the interactions between dietary polyunsaturated fatty acids (PUFAs) and variants of fatty acid desaturase (FADS), and found that different genotypes have different effects on plasma lipid fatty acid composition and bioactive lipid mediators. These findings suggest the potential for genotype-based recommendations for PUFA consumption, which can have beneficial effects on health.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Nutrition & Dietetics
Melissa Gonzalez-Soto, David M. Mutch
Summary: This review highlights that mRNA expression and activity of desaturase and elongase enzymes are influenced by various dietary components, including macronutrients, micronutrients, and polyphenols. Understanding how these components influence LC-PUFA synthesis will help further our understanding of how dietary patterns impact disease risks, from caloric excesses to micronutrient deficiencies.
ADVANCES IN NUTRITION
(2021)
