Article
Endocrinology & Metabolism
Jing Song, Qin Liu, Mengqi Hao, Xiaohu Zhai, Juan Chen
Summary: This study assessed the protective effects of the purified neutral polysaccharide PGNP from Platycodon grandiflorum on high-fat diet-induced obesity. PGNP effectively alleviated metabolic syndrome in obese mice, including reductions in body weight, hepatic steatosis, lipid profile, inflammatory response, and insulin resistance. PGNP also positively influenced the gut microbiota and metabolites, increasing species diversity, and reversing the imbalance caused by the high-fat diet.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Maria Botia-Sanchez, Georgina Galicia, Lorena Albaladejo-Marico, Daniel Toro-Dominguez, Maria Morell, Raquel Marcos-Fernandez, Abelardo Margolles, Marta E. Alarcon-Riquelme
Summary: Systemic lupus erythematosus is an autoimmune disease that can cause intestinal inflammation, leading to changes in the intestinal barrier and gut microbiota composition, which can in turn affect the interaction between the host immune system and gut microbiota.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Leticia Munoz, Esther Caparros, Agustin Albillos, Ruben Frances
Summary: Cirrhosis is the end-stage of chronic liver diseases and is characterized by altered bile acids metabolism, increased blood-brain barrier permeability, and dysbiosis of intestinal microbiota. These changes disrupt gut immunity, leading to liver disease progression. This review focuses on the contribution of liver and brain metabolites in shaping intestinal immune status and discusses therapeutic approaches targeting intestinal homeostasis in cirrhosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lorena Elena Melit, Cristina Oana Marginean, Maria Oana Sasaran
Summary: Pediatric obesity is a global issue and its relationship with gut microbiota is not fully understood. Multiple factors, such as maternal diet and health, delivery method, and feeding patterns, shape the infant gut microbiome. Firmicutes and Bacteroidetes have been identified as important players in obesity risk, but there are inconsistencies in studies, especially in pediatric populations.
Article
Multidisciplinary Sciences
Guijie Chen, Yujia Peng, Yujie Huang, Minhao Xie, Zhuqing Dai, Huimei Cai, Wei Dong, Weiqi Xu, Zhiyong Xie, Dan Chen, Xia Fan, Wangting Zhou, Xuhui Kan, Tingting Yang, Chunxu Chen, Yi Sun, Xiaoxiong Zeng, Zhonghua Liu
Summary: This study investigated the effects of fluoride on obesity using a mouse model. The results showed that fluoride alone did not induce obesity in mice fed a normal diet, but exacerbated obesity in mice fed a high-fat diet. Fluoride impaired the intestinal barrier and activated the Toll-like receptor 4 (TLR4) signaling pathway, leading to obesity. The study also found that fluoride worsened the gut microbiota in high-fat diet mice, and the bloom of Erysipelatoclostridium ramosum was responsible for the exacerbation of obesity. Overall, this study provides evidence of the cross-talk mechanism between fluoride and obesity, mediated by gut microbiota and intestinal barrier.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Nutrition & Dietetics
M. Alcazar, J. Escribano, N. Ferre, R. Closa-Monasterolo, M. Selma-Royo, A. Feliu, G. Castillejo, V Luque
Summary: This study aimed to describe and characterize the gut microbiota composition and diversity in children with obesity according to their metabolic health status. The results showed that children with metabolic unhealthy status had lower microbial diversity and richness, as well as distinct relative abundances of specific microbial taxa.
CLINICAL NUTRITION
(2022)
Review
Biology
Matthew J. Dalby
Summary: The role of gut microbiota in determining body fatness has received significant attention, but recent attempts to translate findings into humans have been unsuccessful. This review examines the mouse research that initiated this area of study and evaluates whether the results were supported by subsequent human studies.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Immunology
Yimei Wang, Tomohiro Takano, Yingyu Zhou, Rong Wang, Takayuki Toshimitsu, Toshihiro Sashihara, Masaru Tanokura, Takuya Miyakawa, Haruyo Nakajima-Adachi, Satoshi Hachimura
Summary: This study investigated the effects of Lactiplantibacillus plantarum OLL2712 on obesity-induced inflammation. It was found that the LAB strain regulated gut microbiota, suppressed intestinal inflammation, and improved gut barrier function, thereby reducing obesity-related inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yongbo Kang, Xing Kang, Hao Yang, Haixia Liu, Xiaodan Yang, Qingqing Liu, Haixia Tian, Yang Xue, Peng Ren, Xiaoyu Kuang, Yue Cai, Mingwei Tong, Lin Li, Weiping Fan
Summary: This study investigates the anti-obesity effects of potential probiotic Lactobacillus acidophilus isolated from the porcine gut. The results show that L. acidophilus reduces body weight, fat mass, inflammation, and insulin resistance. Additionally, L. acidophilus reverses gut dysbiosis, maintains intestinal barrier integrity, and improves gut microbiota functions.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Peripheral Vascular Disease
Yiqing Wang, Huijun Wang, Annie Green Howard, Matthew C. B. Tsilimigras, Christy L. Avery, Katie A. Meyer, Wei Sha, Shan Sun, Jiguo Zhang, Chang Su, Zhihong Wang, Anthony A. Fodor, Bing Zhang, Penny Gordon-Larsen
Summary: This study revealed associations between gut microbiota, plasma metabolome, and blood pressure regulation in a Chinese population, highlighting potential roles of microbiota and metabolites in blood pressure regulation, particularly involving lipid metabolism processes.
Article
Immunology
Jiuxi Liu, Jiapei Cai, Naisheng Zhang, Jiandong Tai, Peng Fan, Xue Dong, Yongguo Cao
Summary: Salidroside, a plant compound, can ameliorate high-fat diet-induced obesity by modulating gut microbiota. It reduces body weight and fat accumulation, decreases liver inflammation and metabolic endotoxemia, and repairs intestinal damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Yoredy Sarmiento-Andrade, Rosario Suarez, Beatriz Quintero, Kleber Garrochamba, Sebastian Pablo Chapela
Summary: Obesity is a globally increasing pathology with many associated disorders. In recent years, there has been growing knowledge about the influence of the microbiota on obesity and its related pathologies. This review summarizes the biology and physiology of microbiota in obese patients, as well as the therapeutic applications of prebiotics, probiotics, and fecal microbiota transplantation.
FRONTIERS IN NUTRITION
(2022)
Article
Clinical Neurology
Santosh Thapa, Jessica C. Sheu, Alamelu Venkatachalam, Jessica K. Runge, Ruth Ann Luna, Chadi A. Calarge
Summary: In this study, no significant association was found between major depressive disorder (MDD) or selective serotonin reuptake inhibitor (SSRI) use and gut microbiome in older adolescents. This suggests that the bidirectional interaction between gut bacteria and the brain may be more nuanced in this age group, requiring further investigation.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Oncology
Peijie Zhong, Hang Wu, Yuanqiao Ma, Xiaoxiao Xu, Yizhuo Jiang, Chaolei Jin, Qiaozhen Zhu, Xinlei Liu, Zhimin Suo, Junpeng Wang
Summary: This study reveals the association between gut microbiota dysbiosis and the development of inflammatory bowel disease (IBD). The P2X4 receptor plays a crucial role in regulating gut infection, inflammation, and damage, and may serve as a potential target for treating Crohn's disease (CD) and ulcerative colitis (UC).
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Tyler M. Cook, Virginie Mansuy-Aubert
Summary: The composition and signaling of gut bacteria significantly impact the regulation of peripheral neurons, which is associated with diseases like obesity and irritable bowel syndrome. Understanding how gut microbes alter host development and physiology through peripheral nervous system signaling is crucial for finding effective therapies for chronic diseases.
