期刊
MATERIALS
卷 11, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/ma11112176
关键词
drug release; electrospinning; paclitaxel; polycaprolactone; 3D matrix
类别
资金
- Russian Scientific Foundation [18-15-00080]
- Russian Science Foundation [18-15-00080] Funding Source: Russian Science Foundation
Paclitaxel is a natural, highly lipophilic anti proliferative drug widely used in medicine. We have studied the release of tritium-labeled paclitaxel (H-3-PTX) from matrices destined for the coating of vascular stents and produced by the electrospinning method from the solutions of polycaprolactone (PCL) with paclitaxel (PTX) in hexafluoisopropanol (HFIP) and/or solutions of PCL with PTX and human serum albumin (HSA) in HFIP or HIFP-dimethyl sulphoxide (DMSO) blend. The release of PTX has been shown to depend on the composition of electrospinning solution, as well as the surrounding medium, particularly the concentration of free PTX and PTX-binding biomolecules present in human serum. It was shown that 3D matrices can completely release PTX without weight loss. Two-phase PTX release from optimized 3D matrices was obtained: similar to 27% of PTX was released in the first day, another 8% were released over the next 26 days. Wherein similar to 2.8%, similar to 2.3%, and similar to 0.25% of PTX was released on day 3, 9, and 27, respectively. Considering PTX toxicity, the rate of its diffusion through the arterial wall, and the data obtained the minimum cytostatic dose of the drug in the arterial wall will be maintained for at least three months.
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