Article
Dentistry, Oral Surgery & Medicine
Geninho Thome, Waleska Caldas, Sergio Rocha Bernardes, Carolina Accorsi Cartelli, Ana Helena Pereira Gracher, Larissa Carvalho Trojan
Summary: Comparing implant and prosthesis survival rates between full-arch immediate prostheses supported by four hydrophilic implants with bicortical anchorage and by five or six hydrophilic implants without bicortical anchorage, it was found that there were no significant differences in survival rates, but bicortical anchorage can improve the primary stability of implants.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Lingxiao Wang, Zhenhua Gao, Yucheng Su, Qian Liu, Yi Ge, Zhaochen Shan
Summary: This study compared and verified the osseointegration performance of a novel implant in vivo, showing that the novel implants could promote bone formation better than traditional implants, but further improvements are still needed in some aspects.
SCIENTIFIC REPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Danny Hadaya, Joan Pi-Anfruns, Benjamin Bellon, Benjamin E. Pippenger, Tara L. Aghaloo
Summary: In this short-term study, immediately loaded fully tapered implants obtained high survival with similar osseointegration ability as apically tapered implants when placed in healed sites and fresh extraction sockets.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yu-Sung Choi, In-Seok Song, Moon-Young Kim, Ho-Kyung Lim, Li Chongyang, Ji Suk Shim
Summary: This study aimed to evaluate the effect of aging on the changes in implant stability over time following implant placement. The results showed that the stability of implants in elderly patients is not related to age, but rather to the engagement of the implant with the bone.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Engineering, Multidisciplinary
Min-Chun Pan, Shih-Yao Wang, Chin-Sung Chen
Summary: A noncontact handheld assessment device based on resonance frequency analysis was developed to quantify dental implant stability. The device employed vibro-acoustic technique and outperformed the traditional magnetic sensing technique. In vitro and in vivo tests were conducted to verify device performance and observe osseointegration in live bodies.
Article
Dentistry, Oral Surgery & Medicine
Marta Liliana Musskopf, Amanda Finger Stadler, Tiago Fiorini, Umberto Demoner Ramos, Mariana de Sousa Rabelo, Rodrigo Nahas de Castro Pinto, Cristiano Susin
Summary: This study assessed the safety and efficacy of a new implant system using a minipig intraoral dental implant model. The results showed that the new implant system had higher bone-to-implant contact and histological performance, supporting its safety and efficacy. Further human studies should be conducted to validate these findings.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ruojing Liu, Yi Gao, Li Huang, Bing Shi, Xing Yin, Shujuan Zou
Summary: This study aimed to investigate the potential effects of alpha-ketoglutarate (alpha-KG) on implant osseointegration in an osteoporotic mouse model. The results showed that the supplementation of alpha-KG in drinking water enhanced dental implant osseointegration in ovariectomized mice, with increased osteogenic and autophagic activity, and decreased osteoclast differentiation and cell apoptosis. Moreover, alpha-KG-treated bone-marrow-derived mesenchymal stem cells exhibited enhanced proliferation, survival, colony formation, and osteogenic differentiation, as well as autophagic activity. Therefore, systemic alpha-KG supplementation effectively prevents the failure of dental implant osseointegration in mice under an osteoporotic state.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Chemistry, Physical
Roberta Michels, Carina Kampleitner, Toni Dobsak, Kevin Doppelmayer, Patrick Heimel, Stefan Lettner, Stefan Tangl, Reinhard Gruber, Cesar Augusto Magalhaes Benfatti
Summary: In rabbits, a static magnetic field generated by NdFeB magnets can enhance bone regeneration, but it is unclear whether it supports osseointegration in a canine model. Implants carrying NdFeB magnets were inserted in the tibia of six adult canines, and the potential osteogenic effect was determined. After 15 days of healing, magnetic implants showed a higher nBIC in the cortical and medullary regions compared to regular implants, but there was no significant difference in nBV/TV. These findings suggest that magnetic implants failed to support peri-implant bone formation in a canine model.
Article
Multidisciplinary Sciences
Kristian Kniha, Benita Hermanns-Sachweh, Faruk Al-Sibai, Reinhold Kneer, Stephan Christian Moehlhenrich, Marius Heitzer, Frank Hoelzle, Ali Modabber
Summary: The purpose of this rat study was to investigate the feasibility of temperature thresholds affecting bone contact at the surface of implants in vivo. The results showed that thermal necrosis should be used for implant removal in subsequent in vivo studies. The study found that temperatures ranging from 48°C to 50°C led to a decrease in the BIC ratio, with significant differences observed between the 50°C group and the control group. However, there were no significant variations within the cold temperatures.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
X. Yu, B. Feng, Y. Lan, J. Li, G. Ye, Q. Li, F. Zhao, Y. Gu, D. You, Y. Zhu, M. Yu, H. Wang, H. Yang
Summary: This study aims to design a personalized two-stage root analog implant (RAI) with a compact structure and uniform roughness to achieve better fracture resistance, initial osseointegration efficiency, and dispersed stress in immediate implantation. RAIs were manufactured using selective laser melting technology, and in vivo experiments showed that they had higher bone-implant contact and bone volume/total volume compared to conventional implants. Customized abutments were also designed for the RAIs, improving the masticatory ability of the beagle dogs.
JOURNAL OF DENTAL RESEARCH
(2023)
Review
Medicine, General & Internal
Li-Ching Chang
Summary: Photofunctionalization can enhance osseointegration and soft tissue seal, but does not address the challenge of oral cancer cases. More clinical trials focused on complex implant cases and non-dental fields are needed in the future.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Nicolas Rousseau, Ines Msolli, Patrick Chabrand, Arnaud Destainville, Olivier Richart, Jean-Louis Milan
Summary: This study evaluated the local effects and osseointegration of dental implants with surface micro/nanofeatures compared to untreated implants through various analyses after implantation in sheep femoral condyles for 4 and 13 weeks. The results showed that the surface-treated implants promoted faster bone healing and higher bone-to-implant contact in the coronal region compared to untreated implants.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Engineering, Multidisciplinary
Ali Temelci, Hasan Gueney Yilmaz, Guerkan uensal, Lokman Onur Uyanik, Dilek Yazman, Aysa Ayali, Giuseppe Minervini
Summary: This study aimed to compare the contact angles and wettability of implant surfaces between beta-thalassemia major (BTM) patients and healthy individuals. The results showed that the decreased deformability of BTM patients did not affect the wettability of implant surfaces in vitro. Considering the lack of in-depth studies on dental implant success in BTM patients and the high prevalence of BTM in Cyprus, this study aimed to enrich the literature.
Article
Dentistry, Oral Surgery & Medicine
Yangbo Xu, Liefen Zhang, Jiangang Xu, Jia Li, Hui Wang, Fuming He
Summary: The study showed that strontium-incorporated titanium implant surfaces by hydrothermal treatment enhanced osseointegration in diabetic rats, and also inhibited inflammation while promoting bone formation.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Xinyu Wu, Si Chen, Wei Ji, Bin Shi
Summary: The study analyzed the rate and risk factors of early implant failure before the placement of final prosthesis in patients who received dental implant placement from 2015 to 2019. It found that the risk factors varied among different sites, with implants in the posterior maxilla, specific surface modifications, and previously augmented sites being significantly associated with early implant failure.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Roberto Rotundo, Luigi Genzano, Michele Nieri, Ugo Covani, David Penarrocha-Oltra, Miguel Penarrocha-Diago
Summary: This study aimed to compare the smile esthetic impact of root coverage procedures using the Coronally Advanced Flap (CAF) either with or without the adjunct of a collagen matrix (CMX). The results showed that after 12 months of treatment, there was no significant difference in smile esthetic appearance between the CAF + CMX group and the CAF alone group. The adjunct of a collagen matrix did not show a distinct impact on smile esthetics.
Article
Dentistry, Oral Surgery & Medicine
Fabio Camacho-Alonso, Nuria Garcia-Carrillo, Antonio Julian Buendia, Jose Antonio Navarro, David Penarrocha-Oltra, Miguel Penarrocha-Diago, Jose Lacal-Lujan
Summary: The study demonstrates that using porcine AUBM and neonatal myoblasts is an effective treatment for regenerating lingual musculature in hemiglossectomized rats, showing positive outcomes in terms of weight gain, tissue occupation, and antibody positivity.
Article
Dentistry, Oral Surgery & Medicine
Antonio Pallares-Serrano, Pablo Glera-Suarez, Beatriz Tarazona-Alvarez, Maria Penarrocha-Diago, Miguel Penarrocha-Diago, David Penarrocha-Oltra
Summary: The mean healing rate of teeth after endodontic microsurgery was 81%, with significantly higher healing rate in anterior teeth compared to molars. Larger lesions were associated with lower healing rate, while other factors such as patient age, sex, presence of post, type of tooth, and restoration did not significantly impact the outcome.
JOURNAL OF ENDODONTICS
(2021)
Review
Dentistry, Oral Surgery & Medicine
Julio Rojo-Sanchis, David Soto-Penaloza, David Penarrocha-Oltra, Miguel Penarrocha-Diago, Jose Vina-Almunia
Summary: The thickness of the facial alveolar bone (FAB) varies along the apico-coronal dimensions, with factors like age, gender, and gingival phenotype influencing FAB thickness. Asian populations show the lowest FAB thickness values. The distance from CEJ to the bone crest is consistent among all teeth analyzed.
Article
Chemistry, Multidisciplinary
Saverio Cosola, Paolo Toti, Enrico Babetto, Ugo Covani, Miguel Penarrocha-Diago, David Penarrocha-Oltra
Summary: This in vitro study investigated the fatigue performance of different dental fixtures in two different emergence profiles. Results showed that the transmucosal implant design provided higher resistance to static fracture, while the equicrestal implant design improved dynamic endurance.
APPLIED SCIENCES-BASEL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Pablo Glera-Suarez, Antonio Pallares-Serrano, David Penarrocha-Oltra, Miguel Penarrocha-Diago, Maria Penarrocha-Diago
Summary: This study aimed to analyze the association between endoscopic findings and healing one year after periapical surgery. The study found that roots with cracks had a higher failure rate, although statistical significance was not reached. Other endoscopic findings, patient age and gender, and the type of tooth did not influence healing.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Amparo Ramis-Alario, David Soto-Penaloza, Beatriz Tarazona-Alvarez, Miguel Penarrocha-Diago, David Penarrocha-Oltra
Summary: The study compared the diagnostic outcomes of conventional radiographs and CBCT in apical lesions, finding that conventional radiographs had excellent specificity but poor sensitivity, while CBCT had advantages in specific cases, such as prioritizing patient-specific and indication-oriented criteria over therapeutic goals.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2021)
Article
Cell & Tissue Engineering
Sara Martin-Iglesias, Lara Milian, Maria Sancho-Tello, Ruben Salvador-Clavell, Jose Javier Martin de Llano, Carmen Carda, Manuel Mata
Summary: Bone tissue engineering provides an alternative approach for bone regeneration therapies. In this study, a model for in vitro osteogenic differentiation based on mesenchymal stem cells (MSCs) was developed to analyze the influence of culture media and cell origin on the efficiency of the process. The results showed that the osteogenic marker levels were influenced by the culture medium and the cell origin used, with higher levels observed when hADSCs were cultured with medium supplemented with BMP-2. Additionally, the 3D culture environment was suitable for cell survival and osteogenic induction.
STEM CELLS INTERNATIONAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mario Perez-Sayans, Pablo Castelo-Baz, David Penarrocha-Oltra, Flavio Seijas-Naya, Mercedes Conde-Amboage, Jose M. Somoza-Martin
Summary: This study analyzed the impact of abutment width on early marginal bone loss. The results showed that concave abutments had significantly less early bone loss at 6 months post-loading compared to classical cylindrical abutments.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Lara Milian, Irene Monleon-Guinot, Maria Sancho-Tello, Jose Marcelo Galbis, Antonio Cremades, Maria Almenar-Ordaz, Josep Penaroja-Martinez, Rosa Farras, Jose Javier Martin de Llano, Carmen Carda, Manuel Mata
Summary: Evidence suggests that cannabinoid agonists inhibit relevant aspects of lung cancer, such as proliferation and epithelial-to-mesenchymal transition (EMT). The effects of tetrahydrocannabinol (THC) and cannabidiol (CBD) on lung cancer-associated fibroblasts (CAFs) and normal fibroblasts (NFs) were evaluated in this study. The results demonstrate the potential of cannabinoid agonists for the treatment of lung cancer and their effects on CAFs in relation to cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biophysics
I Garcia-Arnaez, F. Romero-Gavilan, A. Cerqueira, F. Elortza, M. Azkargorta, F. Munoz, M. Mata, J. J. Martin de Llano, J. Suay, M. Gurruchaga, I Goni
Summary: This study used proteomic and histological techniques to analyze the effects of Ca-doped biomaterials in vitro and in vivo and verify the correlation between the two systems. The results showed that the proteomic analysis of biomaterials in vitro is a useful tool for predicting their impact in vivo.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Medicine, General & Internal
Sofia Soler-Alcaraz, Yolanda Guerrero-Sanchez, Mario Perez-Sayans, Juan Carlos Bernabeu-Mira, David Penarrocha-Oltra, Fabio Camacho-Alonso
Summary: The research aimed to compare the influence of different drilling methods on implant success and osseointegration process. The study found no significant differences in the trabecular architecture between biological and conventional drilling techniques. Therefore, the drilling technique does not affect the success of the procedure or the osseointegration process.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Luigi Feletto, Daniele Botticelli, Karol Apaza-Alcayhuaman, Miguel Penarrocha-Diago, Mustafa Ezzeddin-Ayoub, Regino Zaragozi-Alonso, Jose Vina-Almunia
Summary: This study evaluated the effect of placing autogenous bone on bone healing after maxillary sinus elevation. The results showed that placing autogenous bone in the sinus and the adjacent region did not enhance bone formation.
ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG
(2023)
Article
Biochemistry & Molecular Biology
Manuel Mata, Santiago Peydro, Jose Javier Martin de Llano, Maria Sancho-Tello, Carmen Carda
Summary: Periodontitis is an inflammatory disease that can lead to tooth loss. This study examined the role of surface microtopography in the differentiation of human dental pulp stem cells into cementoid-like secreting cells. The results showed that the cells cultured on dentin surfaces exhibited an odontoblastic phenotype, while cells cultured on cementum surfaces generated a well-organized tissue consisting of secretory cells and dense fibrous connective tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)