Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

(2018) Jianfang Liu et al.   CELL

Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics

(2018) Li Ding et al.   CELL

Oncogenic Signaling Pathways in The Cancer Genome Atlas

(2018) Francisco Sanchez-Vega et al.   CELL

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

(2018) Katherine A. Hoadley et al.   CELL

Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers

(2018) Xinxin Peng et al.   Cell Reports

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

(2017) Amaia Zabala-Letona et al.   NATURE

Crosstalk between transcription and metabolism: how much enzyme is enough for a cell?

(2017) Stefano Donati et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma

(2016) A. Ari Hakimi et al.   CANCER CELL

High resolution metabolomics technology reveals widespread pathway changes of alcoholic liver disease

(2016) Aihua Zhang et al.   Molecular BioSystems

Metabolomics: Small molecules, single cells

(2016) Marissa Fessenden   NATURE

MTAPdeletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

(2016) Gregory V. Kryukov et al.   SCIENCE

A genome-scale Escherichia coli kinetic metabolic model k-ecoli457 satisfying flux data for multiple mutant strains

(2016) Ali Khodayari et al.   Nature Communications

Development and verification of the PAM50-based Prosigna breast cancer gene signature assay

(2015) Brett Wallden et al.   BMC Medical Genomics

Systems biology analysis reveals NFAT5 as a novel biomarker and master regulator of inflammatory breast cancer

(2015) Andrea Remo et al.   Journal of Translational Medicine

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Extensive Decoupling of Metabolic Genes in Cancer

(2015) Ed Reznik et al.   PLoS Computational Biology

Is Cancer a Genetic Disease or a Metabolic Disease?

(2015) David S. Wishart   EBioMedicine

The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression

(2014) A. M. Sonabend et al.   CANCER RESEARCH

Topologically associating domains are stable units of replication-timing regulation

(2014) Benjamin D. Pope et al.   NATURE

Constraint-based models predict metabolic and associated cellular functions

(2014) Aarash Bordbar et al.   NATURE REVIEWS GENETICS

The ETS family member GABPα modulates androgen receptor signalling and mediates an aggressive phenotype in prostate cancer

(2014) Naomi L. Sharma et al.   NUCLEIC ACIDS RESEARCH

Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

(2014) A. Janzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections

(2014) Rekin's Janky et al.   PLoS Computational Biology

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

(2013) Jie Hu et al.   NATURE BIOTECHNOLOGY

ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemia

(2012) J. H. A. Martens et al.   BLOOD

Tumor Necrosis Factor α As a Master Regulator of Inflammation in Erdheim-Chester Disease: Rationale for the Treatment of Patients With Infliximab

(2012) Lorenzo Dagna et al.   JOURNAL OF CLINICAL ONCOLOGY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

(2012) Wanjuan Yang et al.   NUCLEIC ACIDS RESEARCH

The Role of Master Regulators in the Metabolic/Transcriptional Coupling in Breast Carcinomas

(2012) Karol Baca-López et al.   PLoS One

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011

(2011) J. D. Orth et al.   Molecular Systems Biology

Translational recoding as a feedback controller: systems approaches reveal polyamine-specific effects on the antizyme ribosomal frameshift

(2011) Claudia Rato et al.   NUCLEIC ACIDS RESEARCH

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

Pathway Targets to Explore in the Treatment of Non-small Cell Lung Cancer

(2010) Glen J. Weiss et al.   Journal of Thoracic Oncology

Udp-glucose dehydrogenase as a novel field-specific candidate biomarker of prostate cancer

(2009) Dali Huang et al.   INTERNATIONAL JOURNAL OF CANCER

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Molecular signatures suggest a major role for stromal cells in development of invasive breast cancer

(2008) Theresa Casey et al.   BREAST CANCER RESEARCH AND TREATMENT