标题
CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage
作者
关键词
-
出版物
Nature Communications
Volume 10, Issue 1, Pages -
出版商
Springer Nature
发表日期
2018-12-29
DOI
10.1038/s41467-018-07971-8
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition
- (2018) Max C Richter et al. EMBO JOURNAL
- CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease
- (2018) Bence György et al. Molecular Therapy-Nucleic Acids
- CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington’s disease
- (2017) Su Yang et al. JOURNAL OF CLINICAL INVESTIGATION
- Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening
- (2017) Julia Joung et al. Nature Protocols
- Not just amyloid: physiological functions of the amyloid precursor protein family
- (2017) Ulrike C. Müller et al. NATURE REVIEWS NEUROSCIENCE
- Assembly of CRISPR ribonucleoproteins with biotinylated oligonucleotides via an RNA aptamer for precise gene editing
- (2017) Jared Carlson-Stevermer et al. Nature Communications
- Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα
- (2017) Bruce G. Mockett et al. Frontiers in Molecular Neuroscience
- Bin1 and CD2AP polarise the endocytic generation of beta‐amyloid
- (2016) Florent Ubelmann et al. EMBO REPORTS
- Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9
- (2016) Dominik Paquet et al. NATURE
- Cornerstones of CRISPR–Cas in drug discovery and therapy
- (2016) Christof Fellmann et al. NATURE REVIEWS DRUG DISCOVERY
- Gene-editing therapy for neurological disease
- (2016) Moira A. McMahon et al. Nature Reviews Neurology
- APP Receptor? To Be or Not To Be
- (2016) Carole Deyts et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer’s disease mouse model
- (2015) Romain Fol et al. ACTA NEUROPATHOLOGICA
- Trib3 Is Elevated in Parkinson's Disease and Mediates Death in Parkinson's Disease Models
- (2015) P. Aime et al. JOURNAL OF NEUROSCIENCE
- Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway
- (2015) Utpal Das et al. NATURE NEUROSCIENCE
- Fragile X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms
- (2015) Weixiang Guo et al. Cell Reports
- Reversion of FMR1 Methylation and Silencing by Editing the Triplet Repeats in Fragile X iPSC-Derived Neurons
- (2015) Chul-Yong Park et al. Cell Reports
- A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases
- (2015) Aaron Topol et al. Jove-Journal of Visualized Experiments
- Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects
- (2014) Robert Vassar et al. JOURNAL OF NEUROCHEMISTRY
- In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9
- (2014) Lukasz Swiech et al. NATURE BIOTECHNOLOGY
- CRISPR-Cas systems for editing, regulating and targeting genomes
- (2014) Jeffry D Sander et al. NATURE BIOTECHNOLOGY
- Improved vectors and genome-wide libraries for CRISPR screening
- (2014) Neville E Sanjana et al. NATURE METHODS
- Easy quantitative assessment of genome editing by sequence trace decomposition
- (2014) Eva K. Brinkman et al. NUCLEIC ACIDS RESEARCH
- Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway
- (2013) Utpal Das et al. NEURON
- Capsid Serotype and Timing of Injection Determines AAV Transduction in the Neonatal Mice Brain
- (2013) Paramita Chakrabarty et al. PLoS One
- Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system
- (2013) Etienne Morel et al. Nature Communications
- Physiological Functions of APP Family Proteins
- (2013) U. C. Muller et al. Cold Spring Harbor Perspectives in Medicine
- Early and Selective Impairments in Axonal Transport Kinetics of Synaptic Cargoes Induced by Soluble Amyloid β-Protein Oligomers
- (2012) Yong Tang et al. TRAFFIC
- Amyloid Precursor Protein Processing and Alzheimer's Disease
- (2011) Richard J. O'Brien et al. Annual Review of Neuroscience
- Nuclear signalling by membrane protein intracellular domains: The AICD enigma
- (2011) Caroline Beckett et al. CELLULAR SIGNALLING
- The physiology of the β-amyloid precursor protein intracellular domain AICD
- (2011) Raphaëlle Pardossi-Piquard et al. JOURNAL OF NEUROCHEMISTRY
- An Overview of APP Processing Enzymes and Products
- (2009) Vivian W. Chow et al. NEUROMOLECULAR MEDICINE
- Amyloid Precursor Protein Trafficking, Processing, and Function
- (2008) Gopal Thinakaran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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