Article
Cell Biology
Emma E. Boxer, Charlotte Seng, David Lukacsovich, JungMin Kim, Samantha Schwartz, Matthew J. Kennedy, Csaba Foldy, Jason Aoto
Summary: The study reveals multiple roles for Nrxn3 at GABAergic synapses in vSUB, showing sexually dimorphic intrinsic connectivity and synaptic function. While PVs preferentially contact RS neurons in male mice, they favor BS neurons in female mice. Nrxn3 knockout affects synapse density and postsynaptic strength in males, but enhances presynaptic release in females.
Article
Neurosciences
Ron Refaeli, Adi Doron, Aviya Benmelech-Chovav, Maya Groysman, Tirzah Kreisel, Yonatan Loewenstein, Inbal Goshen
Summary: The study utilized CLARITY technology to conduct large-scale detection of 3D astrocytic domains, revealing different distributions of neuronal content in CA1 and BLA astrocytic domains. SST neurons were found to be located in close proximity to neighboring astrocytes, relative to PV and VIP neurons.
Article
Multidisciplinary Sciences
Laure Lecoin, Bowen Dempsey, Alexandra Garancher, Steeve Bourane, Pierre-Louis Ruffault, Marie-Pierre Morin-Surun, Nathalie Rocques, Martyn Goulding, Alain Eychene, Celio Pouponnot, Gilles Fortin, Jean Champagnat
Summary: Apneas are associated with various pathological and fatal conditions. This study shows that a mutation in the transcription factor Mafa leads to an abnormally high incidence of breath holding apneas and death in newborn mice. The mutation affects GABAergic inhibitory neurons, causing decreased motor drive to muscles controlling the airways.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Shovan Naskar, Jia Qi, Francisco Pereira, Charles R. Gerfen, Soohyun Lee
Summary: Extensive hierarchical yet highly reciprocal interactions among cortical areas are crucial for information processing, but the specificity and rules governing corticocortical connections are poorly understood. The study shows that long-range projections from different areas preferentially engage specific sets of GABAergic neurons in the primary somatosensory cortex, leading to distinct feedback mechanisms between neurons.
Article
Biotechnology & Applied Microbiology
Sami Kilpinen, Heidi Heliola, Kaia Achim
Summary: In this study, single-cell -omics techniques were used to investigate the variability in genomic feature activation in GABAergic neurons of the developing mouse central nervous system. The results show a high level of concordance between genomic accessibility and gene expression in cell type definition.
Article
Cell Biology
Rym Aouci, Mey El Soudany, Zakaria Maakoul, Anastasia Fontaine, Hiroki Kurihara, Giovanni Levi, Nicolas Narboux-Neme
Summary: The study found that the regulation of Dlx5/6 genes in adult GABAergic neurons has a direct impact on the density of PV-positive neurons, anxiety and compulsivity-like behaviors, reinforcing their importance in neuropsychiatric conditions.
Article
Multidisciplinary Sciences
Camille Mazo, Antoine Nissant, Soham Saha, Enzo Peroni, Pierre-Marie Lledo, Gabriel Lepousez
Summary: In the olfactory system, a group of GABAergic neurons in the anterior olfactory cortex projects inhibitory feedback signals to the olfactory bulb, which can enhance the separation of odor responses and affect the discrimination of similar odors in the output neurons.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Evelyn M. R. Lake
Summary: A recent study demonstrates the reconfiguration of spontaneous brain activity in awake mice using functional magnetic resonance imaging.
Review
Neurosciences
Alfonso junior Apicella, Ivan Marchionni
Summary: GABAergic neurons, especially those expressing vasoactive intestinal polypeptide (VIP), play a crucial role in shaping cortical activity by exerting inhibitory effects on somatostatin-expressing inhibitory neurons and disinhibitory effects on excitatory pyramidal neurons. These neurons can also affect other GABAergic and non-GABAergic neurons, suggesting diverse circuit roles. The heterogeneity of VIP-expressing neurons indicates potential involvement in different functions via modulation of local and distal inhibitory/disinhibitory pathways, with implications for animal behavior.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biology
Ana Caulino-Rocha, Nadia Carolina Rodrigues, Joaquim Alexandre Ribeiro, Diana Cunha-Reis
Summary: Regulation of synaptic plasticity through control of disinhibition is crucial in preventing excessive plasticity, and VIP acts as a key modulator of this process through its effects on VPAC(1) receptors.
Article
Cell Biology
Miao Li, Hang Zhou, Sasa Teng, Guang Yang
Summary: The dysfunction of VIP-expressing interneurons in the mPFC is associated with chronic pain, which leads to decreased prefrontal cortical outputs and increased pyramidal neuron activity in the ACC. Activation of VIP interneurons can restore neuronal responses in the mPFC-ACC pathway and attenuate pain-like behaviors.
Review
Neurosciences
Melissa Hernandez-Frausto, Olesia M. Bilash, Arjun V. Masurkar, Jayeeta Basu
Summary: GABAergic inhibitory neurons play a crucial role in maintaining the balance of excitation and inhibition in the brain, as well as dynamically modulating this balance across different spatio-temporal scales. They have specific functions in controlling single-neuron computations and behaviorally-linked network activity, and are pivotal for the formation and maintenance of episodic memories in the hippocampus.
FRONTIERS IN NEURAL CIRCUITS
(2023)
Article
Neurosciences
Viktoria K. Vereczki, Kinga Muller, Eva Krizsan, Zoltan Mate, Zsuzsanna Fekete, Laura Rovira-Esteban, Judit M. Veres, Ferenc Erdelyi, Norbert Hajos
Summary: Our study using unbiased stereology found a higher ratio of GABAergic neurons in the basal nucleus compared to the lateral nucleus. There was no difference in the ratio of GABAergic neurons between the right and left hemispheres in both male and female mice. Various types of GABAergic cells, including axo-axonic cells, basket cells, dendrite-targeting inhibitory cells, NPY-containing neurogliaform cells, interneuron-selective interneurons, and GABAergic projection neurons, were identified to compose the majority of GABAergic cells in these nuclei.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Luigi Balasco, Marco Pagani, Luca Pangrazzi, Gabriele Chelini, Alessandra Georgette Ciancone Chama, Evgenia Shlosman, Lorenzo Mattioni, Alberto Galbusera, Giuliano Iurilli, Giovanni Provenzano, Alessandro Gozzi, Yuri Bozzi
Summary: Abnormal tactile response is a common feature in Autism Spectrum Disorders (ASDs), and patients with Phelan-McDermid syndrome (PMS) also exhibit similar tactile response abnormalities. This study investigated the neural substrates involved in whisker-guided behaviors in Shank3b(-/-) mice, which showed deficits in texture discrimination and low responsiveness to repetitive whisker stimulation. Reduced activation in the primary somatosensory cortex (S1) and hippocampus was observed, suggesting impaired sensory processing. Resting-state fMRI further revealed decreased connectivity between S1 and the hippocampus, potentially impairing whisker-dependent cues recognition.
Article
Biochemistry & Molecular Biology
Yuji Sato, Yoko Iijima, Mohamed Darwish, Tadayuki Sato, Takatoshi Iijima
Summary: The study revealed the differential expression of splicing regulator SLM2 in specific GABAergic neuronal subtypes and its role in GABAergic synapse specification. Knock-down of SLM2 weakened LRRTM2-induced synapse formation, which was rescued by adding NRX AS4(-). These findings suggest a novel function of SLM2 in modifying network formation of GABAergic interneurons and contribute to a better understanding of the roles AS plays in regulating synapse specificity and neuronal molecular diversity.
NEUROCHEMICAL RESEARCH
(2022)
Article
Neurosciences
Xiao Luo, Alexandre Guet-McCreight, Vincent Villette, Ruggiero Francavilla, Beatrice Marino, Simon Chamberland, Frances K. Skinner, Lisa Topolnik
Correction
Neurosciences
Xiao Luo, Alexandre Guet-McCreight, Vincent Villette, Ruggiero Francavilla, Beatrice Marino, Simon Chamberland, Frances K. Skinner, Lisa Topolnik
Review
Neurosciences
Alexandre Guet-McCreight, Frances K. Skinner, Lisa Topolnik
FRONTIERS IN NEURAL CIRCUITS
(2020)
Article
Neurosciences
Ruggiero Francavilla, Alexandre Guet-McCreight, Sona Amalyan, Chin Wai Hui, Dimitry Topolnik, Felix Michaud, Beatrice Marino, Marie-Eve Tremblay, Frances K. Skinner, Lisa Topolnik
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Neurosciences
Chin Wai Hui, Haley A. Vecchiarelli, Etienne Gervais, Xiao Luo, Felix Michaud, Lisa Scheefhals, Kanchan Bisht, Kaushik Sharma, Lisa Topolnik, Marie-Eve Tremblay
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Review
Neurosciences
Klas Kullander, Lisa Topolnik
Summary: The passage discusses the concept of a dynamic excitation/inhibition balance tuned by circuit disinhibition, and the different subtypes of GABAergic inhibitory interneurons in cortical circuits. It highlights the central role of a subpopulation of GABAergic cells expressing VIP in disinhibitory modulation, as well as the multiple layers of disinhibition across cortical circuits regulating behavior and maintaining an excitation/inhibition balance.
TRENDS IN NEUROSCIENCES
(2021)
Review
Neurosciences
Luca Pancotti, Lisa Topolnik
Summary: This article reviews the evidence regarding the modulatory effects of acetylcholine (ACh) on dendritic computations in three subtypes of hippocampal interneurons: fast-spiking parvalbumin-positive (PV+) cells, somatostatin-expressing (SOM+) oriens lacunosum moleculare cells, and vasoactive intestinal polypeptide-expressing (VIP+) interneuron-selective interneurons. The distribution and actions of cholinergic receptors on these interneurons are discussed, along with the potential modulation of dendritic Ca2+ signaling and neuronal activity. The article suggests that cholinergic modulation can shape dendritic integration and plasticity in interneurons in a cell type-specific manner, which is important for understanding their contribution to large-scale network activity.
Article
Neurosciences
Etienne Gervais, Parisa Iloun, Ekaterina Martianova, Ana Claudia Goncalves Bessa, Serge Rivest, Lisa Topolnik
Summary: The study revealed a high level of interactions between microglia and parvalbumin and somatostatin-expressing interneurons, with different patterns of interactions observed.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Biochemical Research Methods
Walther Akemann, Sebastien Wolf, Vincent Villette, Benjamin Mathieu, Astou Tangara, Jozsua Fodor, Cathie Ventalon, Jean-Francois Leger, Stephane Dieudonne, Laurent Bourdieu
Summary: The 3D-CASH technology enables recording of neuronal activity at millisecond resolution in 3D microcircuits in vivo, offering insights into information flow in the brain. By eliminating motion artifacts, it improves data accuracy and provides a new approach for studying brain function.
Correction
Biochemical Research Methods
Walther Akemann, Sebastien Wolf, Vincent Villette, Benjamin Mathieu, Astou Tangara, Jozsua Fodor, Cathie Ventalon, Jean-Francois Leger, Stephane Dieudonne, Laurent Bourdieu
Editorial Material
Neurosciences
James A. Ainge, Mariangela Chisari, Akiva Cohen, Steven J. Mennerick, Lisa Topolnik, Jochen C. Meier
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Neurosciences
Lisa Topolnik, Suhel Tamboli
Summary: GABAergic inhibitory circuits play a crucial role in hippocampal functions, and specific types of interneurons contribute to network activity. Recent studies have shown that distinct interneuron types have unique mechanisms in influencing temporal binding, synaptic plasticity, and spatial information acquisition in hippocampal memory processes.
NATURE REVIEWS NEUROSCIENCE
(2022)
Article
Cell Biology
Sona Amalyan, Suhel Tamboli, Ivan Lazarevich, Dimitry Topolnik, Leandra Harriet Bouman, Lisa Topolnik
Summary: This study reveals that asymptomatic mice carrying the C9orf72 gene mutation exhibit abnormal motor cortex output. The reduction in the number of pyramidal neurons in the M1 layer 5 and the decreased inhibitory drive in surviving neurons result in higher M1 output, particularly during high-speed animal locomotion. Furthermore, the study shows that the speed-dependent M1 output can predict the likelihood of C9orf72 genetic expansion.
Article
Biochemistry & Molecular Biology
Zhuohe Liu, Xiaoyu Lu, Vincent Villette, Yueyang Gou, Kevin L. Colbert, Shujuan Lai, Sihui Guan, Michelle A. Land, Jihwan Lee, Tensae Assefa, Daniel R. Zollinger, Maria M. Korympidou, Anna L. Vlasits, Michelle M. Pang, Sharon Su, Changjia Cai, Emmanouil Froudarakis, Na Zhou, Saumil S. Patel, Cameron L. Smith, Annick Ayon, Pierre Bizouard, Jonathan Bradley, Katrin Franke, Thomas R. Clandinin, Andrea Giovannucci, Andreas S. Tolias, Jacob Reimer, Stephane Dieudonne, Francois St-Pierre
Summary: Researchers developed a high-throughput platform to optimize genetically encoded voltage indicators for two-photon microscopy. They identified a new indicator, JEDI-2P, which is faster, brighter, more sensitive, and more photostable than previous indicators. JEDI-2P can be used to monitor voltage dynamics in various applications.
