Article
Cell Biology
Ruiyao Xu, Xianxian Wang, Sadia Safi, Nico Braunegger, Agnes Hipgrave Ederveen, Michelle Rottmann, Joachim Wittbrodt, Manfred Wuhrer, Janine Wesslowski, Gary Davidson
Summary: Reception of Wnt signals is mediated by Frizzled receptors and a co-receptor LRP6 or LRP5. Precise control of receptor activation is crucial to regulate Wnt/beta-catenin signaling for proper cellular function. A glycosyltransferase B3GnT2-like has been identified to modify LRP6 and enhance Wnt/beta-catenin signaling. This study highlights the importance of LRP6 as a regulatory hub in Wnt signaling and provides insight into the selective targeting of a signaling pathway component by a specific glycosyltransferase.
Article
Multidisciplinary Sciences
Ahmet Acar, Ana Hidalgo-Sastre, Michael K. Leverentz, Christopher G. Mills, Simon Woodcock, Martin Baron, Giovanna M. Collu, Keith Brennan
Summary: Notch and Wnt are two essential signaling pathways in animals, with typically opposing effects on cell fate decisions. Notch can limit Wnt signaling through mechanisms at the cell membrane and in the cell nucleus, contributing to the robustness of cell fate decisions by sharpening the distinction between opposing Notch/Wnt responses.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Min Gyu Lee, Hwamok Oh, Jong Woo Park, Jueng Soo You, Jeung-Whan Han
Summary: Nuclear S6K1 functions in the regulation of Wnt target gene expression and has an impact on cell proliferation and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Lingli Ding, Song Gu, Bingyu Zhou, Min Wang, Yage Zhang, Siluo Wu, Hong Zou, Guoping Zhao, Zhao Gao, Liangliang Xu
Summary: Fractures have a negative impact on an individual's quality of life, but Ginsenoside Compound K (CK) found in Ginseng has shown potential for promoting bone regeneration and angiogenesis. This study found that CK can promote osteogenic differentiation of rat bone marrow mesenchymal stem cells and increase tube formation capacity in human umbilical vein endothelial cells. In a rat open femoral fracture model, CK was found to improve fracture repair and increase the formation of H type vessel in the fracture callus.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Weidong Xu, Xia Du, Jiayao Li, Zhiyi Zhang, Xiaoyuan Ma, Dan Luo, Mingzhong Xiao, Quancai Sun
Summary: This study investigated the molecular mechanisms of SiNiSan in treating liver damage using mice and cell culture models. The results showed that SiNiSan alleviated liver injury and promoted liver cell regeneration. This study provides a theoretical basis for the clinical treatment of liver-related diseases with SiNiSan.
Article
Biochemistry & Molecular Biology
Roland Kotolloshi, Mieczyslaw Gajda, Marc-Oliver Grimm, Daniel Steinbach
Summary: The study revealed that BCL9L and Wnt/beta-catenin signaling play an oncogenic role in bladder cancer cells, and may be associated with the progression of bladder cancer. Mutations in UTRs of BCL9L can affect its activity, thereby influencing cell proliferation, migration, and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Shuting Liu, Liang Chen, Hua Chen, Kangkang Xu, Xi Peng, Mingchang Zhang
Summary: The study revealed that circ_0119872 is upregulated in UM cell lines and tissues, promoting the malignancy of UM cells. Additionally, circ_0119872 can directly interact with miR-622, acting as a miRNA sponge to regulate the expression of the miR-622 target gene G3BP1 and downstream Wnt/beta-catenin and mTOR signaling pathways.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biology
Claudiu V. Giuraniuc, Shabana Zain, Shahmama Ghafoor, Stefan Hoppler
Summary: Researchers used mathematical models to analyze Wnt signaling in early vertebrate embryogenesis, finding different classes of target genes for the zygotic Wnt signaling. A simplified model was able to largely describe the regulatory behavior observed experimentally, suggesting that one super-gene for each class is sufficient.
JOURNAL OF THEORETICAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Weiwei Tao, Jie Ruan, Ruyan Wu, Min Zhao, Tong Zhao, Mingming Qi, Sonata S. Y. Yau, Guangda Yao, Hongru Zhang, Yue Hu, Gang Chen
Summary: This study investigated the effects of crocin on adult hippocampal neurogenesis and the Wnt/β-catenin pathway. The results showed that crocin had antidepressant properties, promoting adult hippocampal neurogenesis and activating the Wnt/β-catenin signaling pathway.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Cell & Tissue Engineering
Kai Hang, Li Ying, Jinwu Bai, Yibo Wang, Zhihui Kuang, Deting Xue, Zhijun Pan
Summary: The study showed that the silencing of SERPINB2 can promote osteogenic differentiation of BMSCs through the Wnt/β-catenin signaling pathway. In vivo experiments demonstrated that silencing SERPINB2 effectively improves bone fracture healing, suggesting that SERPINB2 may be a novel target for bone fracture healing.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Immunology
Jing Wang, Dongdong Zhao, Zehui Lei, Pupu Ge, Zhe Lu, Qiyao Chai, Yong Zhang, Lihua Qiang, Yang Yu, Xinwen Zhang, Bingxi Li, Shu Zhu, Lingqiang Zhang, Cui Hua Liu
Summary: Dysregulation of gut homeostasis is associated with irritable bowel syndrome (IBS), a chronic functional gastrointestinal disorder. In this study, researchers found that the expression of the E3 ubiquitin ligase tripartite motif-containing 27 (TRIM27) is weakly expressed in IBS but highly expressed in inflammatory bowel disease (IBD). Knockout of Trim27 in mice causes IBS-like symptoms, and mechanistically, TRIM27 stabilizes beta-catenin and activates Wnt/beta-catenin signaling to promote intestinal stem cell (ISC) self-renewal. Targeting the TRIM27/Wnt/beta-catenin axis could be a potential treatment strategy for IBS, and TRIM27 might serve as a potential biomarker for differentiating IBS from IBD.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Janson Tse, Ryan O'Keefe, Angela Rigopolous, Annalisa L. E. Carli, Jo Waaler, Stefan Krauss, Matthias Ernst, Michael Buchert
Summary: Specific signalling thresholds of the WNT/beta-catenin pathway affect embryogenesis and tissue homeostasis. Currently, there is a lack of specific in vivo assays to evaluate inhibitors of WNT/beta-catenin signalling. We present a simple in vivo assay to assess the efficacy and bioavailability of candidate compounds.
Review
Oncology
Siwei Yu, Ruyue Han, Runliang Gan
Summary: This review aims to analyze the mechanisms of action of related molecules in the Wnt/beta-catenin pathway in hematologic malignancies and explore their feasibility as therapeutic targets.
BIOMARKER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
S. Zachary Swartz, Tzer Han Tan, Margherita Perillo, Nikta Fakhri, Gary M. Wessel, Athula H. Wikramanayake, Iain M. Cheeseman
Summary: In meiotic oocytes of the sea star Patifia miniata, the distribution dynamics of the Disheveled protein are regulated by meiotic cell cycle progression and influenced by association with Lamp1+ endosomes and pre-localized Frizzled receptors within the oocyte cortex.
Article
Chemistry, Multidisciplinary
Na Hui Kim, Minji Kwon, Jiwoo Jung, Hyo Byeong Chae, Jiwoo Lee, Yeo-Jun Yoon, In Seok Moon, Ho K. Lee, Wan Namkung, Konstantina M. Stankovic, Se A. Lee, Jong Dae Lee, Sin-Aye Park
Summary: In this study, researchers found that celastrol can inhibit the growth of vestibular schwannoma (VS) by promoting the degradation of beta-catenin through Wnt/beta-catenin signaling pathway. Celastrol showed potent inhibitory effect on the viability of VS cells and suppressed tumor growth without toxicity in mice.
ACTA PHARMACOLOGICA SINICA
(2022)