Article
Ecology
Weizhong Li, Karen E. Nelson
Summary: Recent studies suggest that many species of human gut microbiota acquired in early childhood can persist into senior adulthood, with some species showing a higher likelihood of being shared between twins, indicating a potential genetic component in microbiota transmission.
Article
Immunology
Scott J. J. Dos Santos, Zahra Pakzad, Arianne Y. K. Albert, Chelsea N. N. Elwood, Kirsten Grabowska, Matthew G. G. Links, Jennifer A. A. Hutcheon, Evelyn J. J. Maan, Amee R. R. Manges, Tim J. J. Dumonceaux, Zoe G. Hodgson, Janet Lyons, Sheona M. M. Mitchell-Foster, Soren Gantt, K. S. Joseph, Julie E. E. Van Schalkwyk, Janet E. E. Hill, Deborah M. M. Money
Summary: Birth mode has a significant effect on the composition of neonatal gut microbiome within 10 days postpartum, but this effect is not influenced by maternal vaginal microbiome composition. There is no correlation between the vaginal and stool microbiome communities of newborns. Intrapartum antibiotic administration is associated with lower abundances of specific bacterial strains in infant stool.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Environmental Sciences
Masood Ur Rehman Kayani, Kan Yu, Yushu Qiu, Yao Shen, Caixia Gao, Ru Feng, Xinxin Zeng, Weiye Wang, Lei Chen, Huang Li Su
Summary: Long-term exposure to environmental concentrations of oxytetracycline and sulfamethoxazole significantly affects the taxonomic composition and metabolic pathways of the zebrafish gut microbiome, leading to an increase in abundance of pathogenic bacteria, antibiotic resistance genes, and associated pathways.
ENVIRONMENTAL POLLUTION
(2021)
Article
Microbiology
Scott J. Dos Santos, Ishika Shukla, Janet E. Hill, Deborah M. Money
Summary: The gut microbiome plays a crucial role in human health, and alterations during critical developmental stages can have long-term effects. The lack of exposure to maternal vaginal microbes during caesarean delivery is thought to lead to gut microbiome dysbiosis. However, our study found limited transmission of the maternal vaginal microbiome to the neonatal gut, even in cases of vaginal delivery, suggesting alternative sources for the neonatal gut microbiome.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Chunhua Yin, Jingrui Chen, Xuena Wu, Yeling Liu, Quan He, Ying Cao, Yi-E Huang, Sisun Liu
Summary: This study suggests that patients who deliver preterm demonstrate altered gut microbiome that may contain higher common oral bacteria. Opportunistic pathogens, particularly Porphyromonas, Streptococcus, Fusobacterium, and Veillonella, were enriched in preterm patients, while Coprococcus and Gemmiger were markedly depleted. These potential oral-to-gut bacteria were correlated with clinical parameters reflecting maternal and fetal status.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Satoshi Morozumi, Masahiro Ueda, Nobuyuki Okahashi, Makoto Arita
Summary: Microbial lipids play a crucial role in maintaining host health and controlling disease. Variations in the structures of microbial lipids impact receptor selectivity and agonist/antagonist activity. Advanced lipidomics technologies help uncover the complex diversity of bacterial lipids and discover new functional metabolites involved in host homeostasis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Review
Neurosciences
Sheng-Yu Zhou, Zhen-Ni Guo, Yi Yang, Yang Qu, Hang Jin
Summary: After an ischemic stroke, immune cells migrate from the gut and gastrointestinal tract to the brain and immune system. Intestinal motility disorders, dysbiosis of intestinal microbiota, and a leaky gut are commonly associated with poor prognosis in patients with stroke. Recent studies have shown that intestinal inflammation and immune responses play crucial roles in the development of stroke, and may serve as potential therapeutic targets.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Brooke C. Wilson, Eadaoin M. Butler, Celia P. Grigg, Jose G. B. Derraik, Valentina Chiavaroli, Nicholas Walker, Suma Thampi, Christine Creagh, Abigail J. Reynolds, Tommi Vatanen, Justin M. O'Sullivan, Wayne S. Cutfield
Summary: Oral administration of maternal vaginal microbiota did not alter gut microbiome development in infants born by caesarean section; limited colonisation of maternal vaginal strains suggests other maternal sources, such as the perianal area, may play a larger role in seeding the neonatal gut microbiome.
Article
Gastroenterology & Hepatology
Jacobo de la Cuesta-zuluaga, Kelsey E. Huus, Nicholas D. Youngblut, Juan S. Escobar, Ruth E. Ley
Summary: Obesity and cardiometabolic disease are associated with changes in the gut microbiome. Through studying a cohort of 408 adults from Colombia, researchers validated previously reported features of the gut microbiome function and diversity correlated with obesity or poor cardiometabolic health status. The results showed that obesity, rather than metabolic status, is the main driver of differences in gut microbiome functions and structure in individuals with or without poor cardiometabolic health.
Review
Medicine, Research & Experimental
Yukun Liu, Ligang Xu, Zhaohui Yang, Dongfang Wang, Tianyu Li, Fan Yang, Zhanfei Li, Xiangjun Bai, Yuchang Wang
Summary: The review discusses the link between alterations in the intestinal microbiota and the development of septic myopathy, and critically evaluates the potential mechanisms and therapeutic prospects of modulating the gut microbiota.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Agriculture, Dairy & Animal Science
Christiana Eleojo Aruwa, Charlene Pillay, Martin M. Nyaga, Saheed Sabiu
Summary: The gut microbiome of poultry plays a crucial role in animal productivity and health, with functions ranging from protection against pathogens to host immune system maturation. The impact of varied environments on microbiome profile and advancements in microbiome technology are key areas of research to enhance poultry growth and health.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2021)
Review
Cell Biology
Jessica Conway, Niharika A. Duggal
Summary: With advancing age, changes in the gut microbiota driven by various factors can lead to immune response issues and inflammation, affecting healthy aging. Altering the gut microbiome composition may be a novel intervention strategy to reverse immune aging clock and support overall good health in old age.
AGEING RESEARCH REVIEWS
(2021)
Article
Immunology
Irene Yang, Henry Claussen, Robert Adam Arthur, Vicki Stover Hertzberg, Nicolaas Geurs, Elizabeth J. Corwin, Anne L. Dunlop
Summary: This study aims to understand the structure and diversity of the subgingival microbiome in pregnant Black women and explore its relationship with preterm birth. The study found that although the composition of the subgingival microbiome shifted, the diversity remained stable throughout pregnancy. Additionally, several bacteria were found to be associated with spontaneous early term birth.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sally Temraz, Farah Nassar, Firas Kreidieh, Deborah Mukherji, Ali Shamseddine, Rihab Nasr
Summary: Disruptions in the human gut microbiome may be associated with a cycle of hepatocyte injury and regeneration characteristic of chronic liver disease, and can promote the development of hepatocellular carcinoma by inducing genetic and epigenetic changes. The gut microbiome affects host metabolism and immune response, potentially influencing the efficacy of immunotherapy and chemotherapy for liver cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Alexey A. Tinkov, Airton C. Martins, Daiana Silva Avila, Victor A. Gritsenko, Anatoly Skalny, Abel Santamaria, Eunsook Lee, Aaron B. Bowman, Michael Aschner
Summary: Manganese (Mn) exposure can lead to alterations in gut microbiota diversity and metabolite production, potentially contributing to neurotoxicity. Transplantation of healthy microbiota may alleviate Mn-induced neurotoxicity, highlighting the significant role of gut flora in Mn-mediated effects.
Article
Neurosciences
Roberta Celli, Pasquale Striano, Rita Citraro, Luisa Di Menna, Milena Cannella, Tiziana Imbriglio, Mahmoud Koko, Euro Epinomics-Cogie Euro Epinomics-Cogie Consortium, Giovambattista De Sarro, James A. Monn, Giuseppe Battaglia, Gilles van Luijtelaar, Ferdinando Nicoletti, Emilio Russo, Antonio Leo
Summary: Previous studies suggest that modulation of mGlu3 receptors may be a potential treatment for absence epilepsy. This study found that mGlu3 receptor expression and signaling were decreased in the somatosensory cortex and thalamus of epileptic rats, and selective activation of mGlu3 receptors reduced seizures and depressive-like behavior. However, no association was found between genetic variants of GRM3 and absence epilepsy.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Clinical Neurology
Tobias Brunger, Eduardo Perez-Palma, Ludovica Montanucci, Michael Nothnagel, Rikke S. Moller, Stephanie Schorge, Sameer Zuberi, Joseph Symonds, Johannes R. Lemke, Andreas Brunklaus, Stephen F. Traynelis, Patrick May, Dennis Lal
Summary: This study aimed to systematically identify biological features associated with variant pathogenicity in ion-channel genes and found that these features are correlated with clinical phenotypes and molecular measurements in patients with neurodevelopmental disorders. The results suggest the feasibility of clinical decision support algorithms that can predict variant pathogenicity and function in the future.
Article
Clinical Neurology
Sumaiya Iqbal, Tobias Bruenger, Eduardo Perez-Palma, Marie Macnee, Andreas Brunklaus, Mark J. Daly, Arthur J. Campbell, David Hoksza, Patrick May, Dennis Lal
Summary: Neurodevelopmental disorders (NDDs) are heterogeneous conditions, and genetic testing can identify pathogenic variants. However, the significance of most identified variants is still uncertain. We developed a consensus approach to identify essential sites on NDD-associated proteins and found that missense variants at these sites are enriched in patients. Our findings provide valuable insights for variant interpretation and drug target development.
Article
Clinical Neurology
Eva-Juliane Vollstedt, Susen Schaake, Katja Lohmann, Shalini Padmanabhan, Alexis Brice, Suzanne Lesage, Christelle Tesson, Marie Vidailhet, Isabel Wurster, Faycel Hentati, Anat Mirelman, Nir Giladi, Karen Marder, Cheryl Waters, Stanley Fahn, Meike Kasten, Norbert Bruggemann, Max Borsche, Tatiana Foroud, Eduardo Tolosa, Alicia Garrido, Grazia Annesi, Monica Gagliardi, Maria Bozi, Leonidas Stefanis, Joaquim J. Ferreira, Leonor Correia Guedes, Micol Avenali, Simona Petrucci, Lorraine Clark, Ekaterina Y. Fedotova, Natalya Y. Abramycheva, Victoria Alvarez, Manuel Menendez-Gonzalez, Silvia Jesus Maestre, Pilar Gomez-Garre, Pablo Mir, Andrea Carmine Belin, Caroline Ran, Chin-Hsien Lin, Ming-Che Kuo, David Crosiers, Zbigniew K. Wszolek, Owen A. Ross, Joseph Jankovic, Kenya Nishioka, Manabu Funayama, Jordi Clarimon, Caroline H. Williams-Gray, Marta Camacho, Mario Cornejo-Olivas, Luis Torres-Ramirez, Yih-Ru Wu, Guey-Jen Lee-Chen, Ana Morgadinho, Teeratorn Pulkes, Pichet Termsarasab, Daniela Berg, Gregor Kuhlenbaumer, Andrea A. Kuhn, Friederike Borngraeber, Giuseppe de Michele, Anna De Rosa, Alexander Zimprich, Andreas Puschmann, George D. Mellick, Jolanta Dorszewska, Jonathan Carr, Rosangela Ferese, Stefano Gambardella, Bruce Chase, Katerina Markopoulou, Wataru Satake, Tatsushi Toda, Malco Rossi, Marcelo Merello, Timothy Lynch, Diana A. Olszewska, Shen-Yang Lim, Azlina Ahmad-Annuar, Ai Huey Tan, Bashayer Al-Mubarak, Hasmet Hanagasi, Dariusz Koziorowski, Sibel Ertan, Gencer Genc, Patricia de Carvalho Aguiar, Melinda Barkhuizen, Marcia M. G. Pimentel, Rachel Saunders-Pullman, Bart van de Warrenburg, Susan Bressman, Mathias Toft, Silke Appel-Cresswell, Anthony E. Lang, Matej Skorvanek, Agnita J. W. Boon, Rejko Kruger, Esther M. Sammler, Vitor Tumas, Bao-Rong Zhang, Gaetan Garraux, Sun Ju Chung, Yun Joong Kim, Juliane Winkelmann, Carolyn M. Sue, Eng-King Tan, Joana Damasio, Peter Klivenyi, Vladimir S. Kostic, David Arkadir, Mika Martikainen, Vanderci Borges, Jens Michael Hertz, Laura Brighina, Mariana Spitz, Oksana Suchowersky, Olaf Riess, Parimal Das, Brit Mollenhauer, Emilia M. Gatto, Maria Skaalum Petersen, Nobutaka Hattori, Ruey-Meei Wu, Sergey N. Illarioshkin, Enza Maria Valente, Jan O. Aasly, Anna Aasly, Roy N. Alcalay, Avner Thaler, Matthew J. Farrer, Kathrin Brockmann, Jean-Christophe Corvol, Christine Klein
Summary: Through a worldwide online survey, we established an international cohort of individuals with PD-linked variants, providing harmonized and quality-controlled clinical and genetic data for each participant and promoting collaboration among researchers in the field of monogenic PD.
MOVEMENT DISORDERS
(2023)
Article
Fisheries
Christine Engblom, Lotta Landor, Conny Sjoqvist, Tiina Korkea-aho, Satu Viljamaa-Dirks, Lars Paulin, Tom Wiklund
Summary: Oomycete infections, especially Saprolegnia parasitica, are a significant disease issue in farmed fish in Finland. Molecular epidemiology analysis revealed that the infections mainly originated from one main clone of S. parasitica, rather than different strains in the farm environment. Multi Locus Sequence Typing (MLST) analysis identified four main sequence types (ST1-ST4) and 13 unique sequence types among the isolates.
JOURNAL OF FISH DISEASES
(2023)
Editorial Material
Endocrinology & Metabolism
Carine de Beaufort, Apoorva Gomber, Suzanne Sap, Lori Laffel
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Tomi Suomi, Inna Starskaia, Ubaid Ullah Kalim, Omid Rasool, Maria K. Jaakkola, Toni Gronroos, Tommi Valikangas, Caroline Brorsson, Gianluca Mazzoni, Sylvaine Bruggraber, Lut Overbergh, David Dunger, Mark Peakman, Piotr Chmura, Seren Brunak, Anke M. Schulte, Chantal Mathieu, Mikael Knip, Riitta Lahesmaa, Laura L. Elo
Summary: This study aimed to identify transcriptional changes associated with disease progression in patients with recent-onset type 1 diabetes. They found that genes and pathways related to innate immunity were downregulated during the first year after diagnosis. Associations between gene expression changes and ZnT8A autoantibody positivity were also observed. Additionally, changes in the expression of 16 genes were found to predict the decline in C-peptide at 24 months, and increased B cell levels and decreased neutrophil levels were associated with rapid progression, consistent with previous reports.
Article
Cell Biology
Maria Angeliki S. Pavlou, Kartikeya Singh, Srikanth Ravichandran, Rashi Halder, Nathalie Nicot, Cindy Birck, Luc Grandbarbe, Antonio del Sol, Alessandro Michelucci
Summary: Astrocytes, derived from neural stem cells (NSCs), are the predominant cell type in the central nervous system (CNS) and play important roles in brain development and function. Inflammation disrupts the normal differentiation process of NSCs into astrocytes, leading to abnormal astrocytic phenotypes. This study investigates the transcriptional and epigenetic changes underlying NSCs' differentiation into astrocytes in the presence of inflammation, and identifies key molecular regulators involved in this process.
Article
Health Care Sciences & Services
Martina Ruscelli, Thais Maloberti, Angelo Gianluca Corradini, Francesca Rosini, Giulia Querzoli, Marco Grillini, Annalisa Altimari, Elisa Gruppioni, Viviana Sanza, Alessia Costantino, Riccardo Ciudino, Matteo Errani, Alessia Papapietro, Sara Coluccelli, Daniela Turchetti, Martina Ferioli, Susanna Giunchi, Giulia Dondi, Marco Tesei, Gloria Ravegnini, Francesca Abbati, Daniela Rubino, Claudio Zamagni, Emanuela D'Angelo, Pierandrea De Iaco, Donatella Santini, Claudio Ceccarelli, Anna Myriam Perrone, Giovanni Tallini, Dario de Biase, Antonio De Leo
Summary: This study aims to evaluate the impact of integrated molecular and pathologic risk stratification in the clinical practice of endometrial carcinoma (EC). It found that molecular classes and risk groups were correlated with disease-free survival. The study supports the prognostic importance of EC molecular classification and the essential role of histopathologic assessment in patients' management.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Genetics & Heredity
Linnaeus Bundalian, Yin-Yuan Su, Siwei Chen, Akhil Velluva, Anna Sophia Kirstein, Antje Garten, Saskia Biskup, Florian Battke, Denni Lal, Henrike O. Heyne, Konrad Platzer, Chen-Ching Lin, Johannes R. Lemke, Diana Le Duc
Summary: A study on epilepsy-affected individuals and control individuals showed that rare genetic variants are more important in non-acquired focal epilepsy (NAFE) than in developmental and epileptic encephalopathies (DEEs) and genetic generalized epilepsy (GGE).
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Biochemical Research Methods
Patrycja Mulica, Carmen Venegas, Zied Landoulsi, Katja Badanjak, Sylvie Delcambre, Maria Tziortziou, Soraya Hezzaz, Jenny Ghelfi, Semra Smajic, Jens Schwamborn, Rejko Krueger, Paul Antony, Patrick May, Enrico Glaab, Anne Gruenewald, Sandro L. Pereira
Summary: This study compares two methods for generating iPSC-derived astrocytes and finds significant differences in the properties of the resulting cells. While one method requires a longer time and higher complexity, the astrocytes generated are more mature.
BIOLOGICAL PROCEDURES ONLINE
(2023)
Article
Genetics & Heredity
Emadeldin Hassanin, Carlo Maj, Hannah Klinkhammer, Peter Krawitz, Patrick May, Dheeraj Reddy Bobbili
Summary: This study aimed to assess the performance of European-derived polygenic risk scores (PRSs) for common metabolic diseases in South Asian individuals and to study the interaction between PRS and family history in the same population. The results showed that PRS derived from European populations can be used to stratify the risk of metabolic diseases in South Asian individuals, and with further research, the predictive power of PRS is likely to improve.
BMC MEDICAL GENOMICS
(2023)
Article
Cell Biology
Tamara Bintener, Maria Pires Pacheco, Demetra Philippidou, Christiane Margue, Ali Kishk, Greta Del Mistro, Luca Di Leo, Maria Moscardo Garcia, Rashi Halder, Lasse Sinkkonen, Daniela De Zio, Stephanie Kreis, Dagmar Kulms, Thomas Sauter
Summary: Despite high response rates to targeted kinase inhibitors, metastatic melanoma often relapses, calling for alternative therapies. This study used a refined workflow to predict common and melanoma-specific essential genes as potential drug targets. By reconstructing metabolic models, 28 candidate drugs were predicted and 12 showed high efficacy in vitro. Drug repurposing could expand treatment options for non-responders or those with acquired resistance to conventional melanoma treatments.
CELL DEATH & DISEASE
(2023)
Article
Clinical Neurology
Eric Yu, Lynne A. Krohn, Jennifer Ruskey, Farnaz Asayesh, Dan Spiegelman, Zalak Shah, Ruth Chia, Isabelle Arnulf, Michele T. M. Y. Hu, Jacques Montplaisir, Jean-Francois Gagnon, Alex Desautels, Yves Dauvilliers, Gian Luigi Gigli, Mariarosaria Valente, Francesco Janes, Andrea Bernardini, Birgit Hoegl, Ambra Stefani, Abubaker Ibrahim, Anna Heidbreder, Karel Sonka, Petr Dusek, David Kemlink, Wolfgang Oertel, Annette Janzen, Giuseppe Plazzi, Elena Antelmi, Michela Figorilli, Monica Puligheddu, Brit Mollenhauer, Claudia Trenkwalder, Friederike Sixel-Doering, Valerie Cochen De Cock, Luigi Ferini-Strambi, Femke Dijkstra, Mineke Viaene, Beatriz F. Abril, Bradley A. Boeve, Guy B. Rouleau, Ronald W. Postuma, Sonja Scholz, Ziv Gan-Or
Summary: This study found that the human leukocyte antigen (HLA) locus may play a role in synucleinopathies-related disorders such as isolated/idiopathic REM sleep behavior disorder (iRBD) and Lewy body dementia (LBD). The results showed that HLA-DRB1*11:01 was the only allele passing FDR correction in iRBD. Associations were also discovered between iRBD and HLA-DRB1 70D, 70Q, and 71R. Positions 70 and 71 were linked to iRBD. These findings suggest that the HLA locus may have different roles in various synucleinopathies.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Oncology
Camelia Alexandra Coada, Miriam Santoro, Vladislav Zybin, Marco Di Stanislao, Giulia Paolani, Cecilia Modolon, Stella Di Costanzo, Lucia Genovesi, Marco Tesei, Antonio De Leo, Gloria Ravegnini, Dario De Biase, Alessio Giuseppe Morganti, Luigi Lovato, Pierandrea De Iaco, Lidia Strigari, Anna Myriam Perrone
Summary: This study investigated the potential of radiomic features extracted from pre-surgical CT scans to predict disease-free survival (DFS) in endometrial cancer (EC) patients. Machine learning models achieved high sensitivities and specificities in both training and test sets, showing promise for predicting EC recurrence.
