Review
Biochemistry & Molecular Biology
Josephine Yu, Preeti Sharma, Christian M. Girgis, Jenny E. Gunton
Summary: The prevalence of type 1 diabetes is rising steadily and vitamin D may contribute to this increase. This systematic review examined studies on vitamin D and type 1 diabetes, finding strong associations between low vitamin D levels and type 1 diabetes. Animal studies and human trials also suggest that vitamin D treatment or supplementation can be beneficial in reducing the risk of type 1 diabetes. Maintaining optimal circulating 25-hydroxyvitamin D levels may help to prevent or delay the development of type 1 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Jin-Peng Zhu, Hao Gong, Cai-E Wu, Gong-Jian Fan, Ting-Ting Li, Jia-Hong Wang
Summary: This study investigated the extraction of the toxic substance MPN from Ginkgo biloba seeds and its toxic effects on human gastric epithelial cells. Results indicated that MPN inhibited cell proliferation, arrested the cell cycle, affected the cell nucleus, and induced apoptosis in GES-1 cells. Furthermore, MPN was found to reduce mitochondrial membrane potential and increase apoptotic protein expression levels in GES-1 cells, suggesting its potential to induce apoptosis and toxicity in the human body.
Article
Biochemistry & Molecular Biology
Trevor Teafatiller, Oasis Perez, Masashi Kitazawa, Anshu Agrawal, Veedamali S. Subramanian
Summary: The study reveals the important role of Nedd4-1 and the proteasomal degradation pathway in regulating the functional expression of hSVCT2 in neuronal cells.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Food Science & Technology
Silu Hou, Yuqiang Cheng, Zhaofei Wang, Luming Xia, Jian Wang, Hengan Wang, Jianhe Sun, Jingjiao Ma, Yaxian Yan
Summary: This study investigated the toxic effects of deoxynivalenol (DON) on gastric mucosal epithelial cells and found that DON can inhibit cell activity, induce DNA damage, apoptosis, and cell cycle arrest. These findings are important for understanding the cytotoxicity and gastric diseases caused by DON.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Trevor Teafatiller, Sudhanshu Agrawal, Gabriela De Robles, Farah Rahmatpanah, Veedamali S. Subramanian, Anshu Agrawal
Summary: Vitamin C exerts its antiviral and protective functions in the lungs by upregulating metabolic pathways and interferon-stimulated genes, while simultaneously downregulating pathways related to lung injury and inflammation. Additionally, vitamin C enhances the expression of viral-sensing receptors, contributing to its antiviral effects.
Article
Environmental Sciences
Yunfei Ding, Ruiqing Zhang, Boqing Li, Yunqiu Du, Jing Li, Xiaohan Tong, Yulong Wu, Xiaofei Ji, Ying Zhang
Summary: This study investigated the distribution, endocytosis, transport pathways, and cytotoxic effects of fluorescent polystyrene nanoplastics (PS-NPs) in mice and GES-1 cells. PS-NPs were found in various tissues and cells, and entry into GES-1 cells was reduced with inhibition of specific endocytosis pathways. The results highlight the potential threat of NP pollution to human health through cytotoxic effects in cells.
ENVIRONMENTAL POLLUTION
(2021)
Article
Plant Sciences
Jianxia Wen, Shihua Wu, Xiao Ma, Yanling Zhao
Summary: Zuojin pill (ZJP), a classical Chinese medicine formula, has therapeutic effects on Helicobacter pylori (H. pylori)-induced chronic atrophic gastritis (CAG). It lowers serum inflammatory markers, improves gastric tissue pathology, and reduces damage to gastric mucosal cells by inhibiting inflammation and modulating related signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ying Zhang, Jiao Liang, Hao Jiang, Min Qian, Wenhong Zhao, Weidong Bai
Summary: Lotus plumule sterols showed protective effects on ethanol-induced damage in human gastric epithelium cells by regulating ROS levels, modulating expression of apoptosis-related proteins, and maintaining mitochondrial membrane potential, suggesting their potential application as bioactive ingredients in healthy foods.
Article
Immunology
Kun Zhuang, Hailing Tang, Hanqing Guo, Shanshan Yuan
Summary: Geraniol inhibits H. pylori-induced gastric carcinogen signalling, prevents cytotoxicity, ROS and apoptosis, and protects against H. pylori-induced antioxidant depletion, DNA damage and nuclear fragmentation. It also reduces the expression of phosphorylated MAPK proteins and increases the expression of antioxidant protein Prdx-1 in H. pylori-infected cells. Geraniol thus protects against H. pylori-concomitant infection and may be a potential method for preventing gastric cancer caused by H. pylori.
MICROBIAL PATHOGENESIS
(2023)
Article
Oncology
Maria Fernanda Gonzalez, Renato Burgos-Ravanal, Baohai Shao, Jay Heinecke, Manuel Valenzuela-Valderrama, Alejandro H. Corvalan, Andrew F. G. Quest
Summary: The pathophysiological changes in gastric mucosa caused by Helicobacter pylori infection can spread to non-infected areas via extracellular vesicles, contributing to the development of gastric cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tian-Yang Wu, Juan Liang, Jing-Ya Ai, Jing-Long Cui, Wei-Dong Huang, Yi-Lin You, Ji-Cheng Zhan
Summary: This study reveals the mechanism of mulberry extract in resisting alcohol damage, demonstrating its ability to reduce oxidative stress in gastric mucosal epithelial cells and regulate apoptosis-related gene expression. This provides information for the development of drugs or functional foods to mitigate ethanol injury.
Article
Biochemistry & Molecular Biology
Bo Wang, Jing Wang, Xin-Huai Zhao
Summary: Polyphenols in the diet have been found to have anticancer effects on gastric cancer cells, but their activity is weakened when they interact with proteins.
Article
Food Science & Technology
Erdong Yuan, Miao Zhou, Shiying Nie, Jiaoyan Ren
Summary: This study focused on the interaction between zinc oxide nanoparticles (ZnO NPs) and whey protein (WP). The results indicated that ZnO NPs had an inhibitory effect on cell activity, but this effect could be reduced when added at a concentration of 50 μg/ml. The interaction between ZnO NPs and WP involved both dynamic and static quenching. The binding sites between ZnO NPs and WP were considered to be hydrogen bonding and van der Waals forces. The interaction resulted in structural changes in WP and the exposure of hydrophobic groups, thereby reducing the hydrophobicity of the microenvironment. This study provides a theoretical basis for understanding the interaction between food ingredients and nanomaterials, evaluating nanomaterial toxicity, and exploring nanomaterial applications in the food industry.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Chunyan Liao, Xiang Wang, Xueying Zhou, Dequan Wang, Ziyin Zhang, Yan Liu, Xiao Wu, Ying Chen, Yifeng Tan, Xin Dai, Pei Jing, Jie Pang, Xiao Xiao, Jie Liu, Xiaoming Liao, Shiyong Zhang
Summary: Researchers have developed a nanodrug, VC@cLAV, which utilizes vitamin C (VC) and lipoic acid (LA) to efficiently kill cancer cells while protecting noncancer cells. The drug generates reactive oxygen species in cancer cells, leading to their destruction, while acting as an antioxidant in noncancer cells to prevent and repair oxidative stress-induced damage. Compared to traditional cytotoxic drugs, VC@cLAV demonstrates superior therapeutic outcomes and lacks side effects in various tumor models.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Luciano Ferrada, Rocio Magdalena, Maria Jose Barahona, Eder Ramirez, Cristian Sanzana, Jose Gutierrez, Francisco Nualart
Summary: Vitamin C plays a crucial role in regulating various cellular processes, such as proliferation, differentiation, and cell death, through its dual mechanism of action. It acts as a regulator of signaling pathways associated with gene expression and can also function as a modulator of kinases.
