Article
Biotechnology & Applied Microbiology
Hailin Ke, Songling Wu, Yueyi Zhang, Guowei Zhang
Summary: miR-139-3p suppresses gastric cancer by inhibiting the proliferative, migratory, and invasive abilities of GC cells through targeting KIF18B.
Article
Biotechnology & Applied Microbiology
Qisheng Su, Zheng Yang, Xiaobin Guo, Wuning Mo, Xiaohong Li
Summary: The study revealed that TPPP3 is significantly down-regulated in NPC tissues and cells, and its overexpression can inhibit cell proliferation and invasion ability, while having no significant effect on migration ability. Overexpression of TPPP3 also decreases the expression of MMP-2 and MMP-9 mRNA.
Review
Education, Scientific Disciplines
Shupeng Liu, Yang He, Shifeng Li, Xuemin Gao, Fang Yang
Summary: Kinesin family member 3A is a crucial motor protein involved in various physiological and pathological processes. The wingless-related integration site/beta-catenin signaling pathway plays a vital role in embryonic development, organogenesis, tissue regeneration, and carcinogenesis. Recent studies have focused on the molecular mechanisms of kinesin family member 3A, particularly its interaction with the wingless-related integration site/beta-catenin signaling pathway. The upregulation and downregulation of kinesin family member 3A influence disease pathogenesis and patient outcomes through the wingless-related integration site/beta-catenin signaling pathway.
Article
Oncology
Chang Xiong, Zhongfeng Sun, Jinjin Yu, Yaying Lin
Summary: In gynecologic malignancies, ovarian cancer is the leading cause of death due to lack of sensitive tumor markers, often presenting at an advanced stage. This study found that EXOSC4 is significantly elevated in EOC tissues and cell lines, and its knockdown inhibits proliferation, migration, and invasion by suppressing the Wnt pathway. EXOSC4 shows promise as a novel biomarker and molecular target in EOC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Lili Zhang, Huixiao Chen, Fengxi He, Shiqian Zhang, Aihua Li, Aifeng Zhang, Anqi Zhang
Summary: miR-320a plays an important role in ovarian cancer progression and infiltration, promoting the proliferation, migration, and invasion of EOC cells by targeting RASSF8.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Zhuo Gao, Jannan Jiang, Lijian Hou, Bin Zhang
Summary: This study reveals the upregulation of RNF187 in colorectal cancer (CRC) and its association with poor prognosis. Inhibition of RNF187 expression suppresses the proliferation, migration, and invasion while promoting apoptosis of CRC cells. miR-144-5p is identified as a direct target of RNF187, and its downregulation in CRC tissues is negatively correlated with RNF187 expression. Restoration of miR-144-5p significantly inhibits CRC cell progression, which can be abolished by overexpression of RNF187.
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2022)
Article
Immunology
Yan Zhang, Min Zhou, Kun Li
Summary: MiR-30 is downregulated in human ovarian cancer cells and acts as a tumor suppressor by regulating the expression of RAB32. Overexpression of miR-30 inhibits cell proliferation, migration, and invasion, and alters the expression of epithelial-mesenchymal transition marker proteins in ovarian cancer cells.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Jiangtao Yu, Xiaoli Hu, Xiuxiu Chen, Qiangyong Zhou, Qi Jiang, Zhengzheng Shi, Haiyan Zhu
Summary: CNOT7 plays an important role in biological processes and has potential for treating malignant tumors. This study aimed to investigate the functions and mechanism of CNOT7 in ovarian cancer. Results showed that CNOT7 overexpression in A2780 and SKOV3 cells could be partially or completely eliminated by treatment with the AKT inhibitor LY294002.
Article
Biochemistry & Molecular Biology
Ke Li
Summary: This study revealed that miR-509-3-5p regulates the malignancy of colon cancer by suppressing target gene GTSE1. Downregulation of miR-509-3-5p in CC and its overexpression can inhibit the proliferation, migration, and invasion of CC cells. MiR-509-3-5p targets GTSE1, identified as an oncogene in colon cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Tianshui Sun, Fangfang Bi, Zhuonan Liu, Qing Yang
Summary: In ovarian cancer patients, TMEM119 is overexpressed and associated with poor survival. Experimental results indicate TMEM119 promotes proliferation, invasion, and migration of ovarian cancer cells. Additionally, TMEM119 may exert oncogenic effects by regulating PDGFRB expression and activating the PI3K/AKT signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Yao Chanjiao, Chen Chunyan, Qiu Xiaoxin, Han Youjian
Summary: MicroRNA miR-378a-3p activates the PI3K/AKT signaling pathway by modulating PDIA4 expression, promoting the growth of ovarian cancer cells and providing novel directions for targeted therapy.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Biotechnology & Applied Microbiology
Guang-Lin Song, Ming Xiao, Xiao-Ya Wan, Jun Deng, Jun-Da Ling, Ying-Guo Tian, Min Li, Jie Yin, Ren-Ying Zheng, Yi Tang, Gui-Yuan Liu
Summary: miR-130a-3p has anti-tumor activity against colorectal cancer by targeting the WNT1 pathway, making it a potential target for CRC treatment.
Article
Oncology
Si Chen, Yingling Liu, Kaiguang Zhang, Lele Chen
Summary: The study revealed that high expression levels of CST1 in gastric cancer lead to poor prognosis. CST1 promotes gastric cancer cell migration and invasion by activating the Wnt signaling pathway.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Xiaomeng Zhao, Nan Ye, Xueke Feng, Haiyan Ju, Ruixia Liu, Wenyu Lu
Summary: The study revealed that miR-29b-3p inhibits the migration and invasion of gastric cancer cells by regulating the MAZ protein, and induces apoptosis by controlling the expression of autophagy-related proteins.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Qing Zhu, Neng-Bin Wan, Hong-Wu Deng, Ling-Li Lu, Yi Zhang, Xiao He, Hao Liu, Ying He
Summary: Breast cancer is the most prevalent malignancy in women and the leading cause of cancer-related deaths in women worldwide. The study found that SEC14L3, which is underexpressed in breast cancer, can suppress the malignant phenotypes of breast cancer cells by inhibiting the activation of the Wnt pathway.
EXPERIMENTAL CELL RESEARCH
(2022)