期刊
EPIGENOMICS
卷 10, 期 12, 页码 1603-1618出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2017-0117
关键词
coding gene; domestication; evolution; expression; lincRNAs; liver; methylation; pig; selection signal; wild
资金
- 973 program [2013CB835205]
- Research Project of Chinese Ministry of Education [113048A]
- National Natural Science Foundation of China (NSFC) [31472076]
- Science Fund for Distinguished Young Scholars of Hubei Province of China [2014CFA024]
Aim: We aimed to identify previously unreported long intergenic noncoding RNAs (lincRNAs) in the porcine liver, an important metabolic tissue, and further illustrate the epigenomic landscapes and the evolution of lincRNAs. Materials & methods: We used porcine omits data and comprehensively analyzed and identified lincRNAs and their methylation, expression and evolutionary patterns during pig domestication. Results: LincRNAs exhibit highly methylated promoter and downstream regions, as well as lower expression levels and higher tissue specificity than protein-coding genes. We identified a batch of lincRNAs with selection signals that are associated with pig domestication, which are more highly expressed in the liver than in other tissues (19:10/8/6/3/2/1/1). Interestingly, the lincRNA linc-sscg1779 and its target gene C6, which is crucial in liver metabolism, are differentially expressed during pig domestication. Conclusion: Although they may originate from noisy transcripts, lincRNAs may be subjected to artificial selection. This phenomenon implies the functional importance of lincRNAs in pig domestication.
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