EZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation

Ensembl 2018

(2017) Daniel R Zerbino et al.   NUCLEIC ACIDS RESEARCH

MUC1-C activates EZH2 expression and function in human cancer cells

(2017) Hasan Rajabi et al.   Scientific Reports

Detecting broad domains and narrow peaks in ChIP-seq data with hiddenDomains

(2016) Joshua Starmer et al.   BMC BIOINFORMATICS

Alternative Splicing of EZH2 pre-mRNA by SF3B3 Contributes to the Tumorigenic Potential of Renal Cancer

(2016) Ke Chen et al.   CLINICAL CANCER RESEARCH

Sperm is epigenetically programmed to regulate gene transcription in embryos

(2016) Marta Teperek et al.   GENOME RESEARCH

Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2

(2016) Neil Justin et al.   Nature Communications

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

(2016) Alexei Brooun et al.   Nature Communications

A High-Density Map for Navigating the Human Polycomb Complexome

(2016) Simon Hauri et al.   Cell Reports

ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization

(2015) Guangchuang Yu et al.   BIOINFORMATICS

Two distinct modes for propagation of histone PTMs across the cell cycle

(2015) Constance Alabert et al.   GENES & DEVELOPMENT

Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2

(2015) L. Jiao et al.   SCIENCE

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Repression of the soma-specific transcriptome by Polycomb-repressive complex 2 promotes male germ cell development

(2014) Weipeng Mu et al.   GENES & DEVELOPMENT

Generating genetically modified mice using CRISPR/Cas-mediated genome engineering

(2014) Hui Yang et al.   Nature Protocols

Context-dependent control of alternative splicing by RNA-binding proteins

(2014) Xiang-Dong Fu et al.   NATURE REVIEWS GENETICS

An Ancient Transcription Factor Initiates the Burst of piRNA Production during Early Meiosis in Mouse Testes

(2013) Xin Zhiguo Li et al.   MOLECULAR CELL

Occupying Chromatin: Polycomb Mechanisms for Getting to Genomic Targets, Stopping Transcriptional Traffic, and Staying Put

(2013) Jeffrey A. Simon et al.   MOLECULAR CELL

Polycomb-Dependent H3K27me1 and H3K27me2 Regulate Active Transcription and Enhancer Fidelity

(2013) Karin J. Ferrari et al.   MOLECULAR CELL

Transcriptional regulation by Polycomb group proteins

(2013) Luciano Di Croce et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The splicing landscape is globally reprogrammed during male meiosis

(2013) Ralf Schmid et al.   NUCLEIC ACIDS RESEARCH

Site-Specific Silencing of Regulatory Elements as a Mechanism of X Inactivation

(2012) J. Mauro Calabrese et al.   CELL

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

(2012) M. T. McCabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UTX and UTY Demonstrate Histone Demethylase-Independent Function in Mouse Embryonic Development

(2012) Karl B. Shpargel et al.   PLoS Genetics

A-MYB (MYBL1) transcription factor is a master regulator of male meiosis

(2011) E. Bolcun-Filas et al.   DEVELOPMENT

The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states

(2011) Tim J. Wigle et al.   FEBS LETTERS

Polycomb Protein Ezh1 Promotes RNA Polymerase II Elongation

(2011) Kambiz Mousavi et al.   MOLECULAR CELL

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

PcG Complexes Set the Stage for Epigenetic Inheritance of Gene Silencing in Early S Phase before Replication

(2011) Chiara Lanzuolo et al.   PLoS Genetics

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

(2010) D. B. Yap et al.   BLOOD

PDCD2 is essential for inner cell mass development and embryonic stem cell maintenance

(2010) Weipeng Mu et al.   DEVELOPMENTAL BIOLOGY

Quantitative Mass Spectrometry of Histones H3.2 and H3.3 inSuz12-deficient Mouse Embryonic Stem Cells Reveals Distinct, Dynamic Post-translational Modifications at Lys-27 and Lys-36

(2010) Hye Ryung Jung et al.   MOLECULAR & CELLULAR PROTEOMICS

Discovery and characterization of chromatin states for systematic annotation of the human genome

(2010) Jason Ernst et al.   NATURE BIOTECHNOLOGY

Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa

(2010) Urszula Brykczynska et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinctive chromatin in human sperm packages genes for embryo development

(2009) Saher Sue Hammoud et al.   NATURE

Establishment of Histone Modifications after Chromatin Assembly

(2009) Annette N. D. Scharf et al.   NUCLEIC ACIDS RESEARCH

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

An Allelic Series Uncovers Novel Roles of the BRCT Domain-Containing Protein PTIP in Mouse Embryonic Vascular Development

(2008) W. Mu et al.   MOLECULAR AND CELLULAR BIOLOGY

Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms

(2008) Raphael Margueron et al.   MOLECULAR CELL

EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency

(2008) Xiaohua Shen et al.   MOLECULAR CELL

Combinatorial patterns of histone acetylations and methylations in the human genome

(2008) Zhibin Wang et al.   NATURE GENETICS

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY