期刊
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE
卷 11, 期 4, 页码 -出版社
WILEY
DOI: 10.1002/wsbm.1444
关键词
chromatin; computational biology; polymer physics
资金
- CINECA ISCRA [HP10CYFPS5, HP10CRTY8P]
- NIH [1U54DK107977-01]
- EU ITN [813282]
- Einstein BIH Fellowship
The depth and complexity of data now available on chromosome 3D architecture, derived by new technologies such as Hi-C, have triggered the development of models based on polymer physics to explain the observed patterns and the underlying molecular folding mechanisms. Here, we give an overview of some of the ideas and models from physics introduced to date, along with their progresses and limitations in the description of experimental data. In particular, we focus on the Strings&Binders and the Loop Extrusion model of chromatin architecture. This article is categorized under: Analytical and Computational Methods > Computational Methods
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