Depletion of RIPK1 in hepatocytes exacerbates liver damage in fulminant viral hepatitis

BiallelicRIPK1mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation

(2018) Delphine Cuchet-Lourenço et al.   SCIENCE

Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis

(2017) Trieu-My Van et al.   JOURNAL OF CLINICAL INVESTIGATION

RIPK1 protects hepatocytes from Kupffer cells-mediated TNF-induced apoptosis in mouse models of PAMP-induced hepatitis

(2017) Aveline Filliol et al.   JOURNAL OF HEPATOLOGY

RIPK1 protects hepatocytes from death in Fas-induced hepatitis

(2017) Aveline Filliol et al.   Scientific Reports

Toll-like receptor-2 exacerbates murine acute viral hepatitis

(2016) Christian Bleau et al.   IMMUNOLOGY

Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein

(2016) Liyong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

(2016) Claudia Günther et al.   JOURNAL OF CLINICAL INVESTIGATION

Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-κB

(2016) Jo Suda et al.   JOURNAL OF IMMUNOLOGY

Mouse Hepatitis Virus Infection Induces a Toll-Like Receptor 2-Dependent Activation of Inflammatory Functions in Liver Sinusoidal Endothelial Cells during Acute Hepatitis

(2016) Christian Bleau et al.   JOURNAL OF VIROLOGY

Liver transplantation in acute liver failure: A challenging scenario

(2016) Manuel Mendizabal   WORLD JOURNAL OF GASTROENTEROLOGY

RIPK1 protects from TNF-α-mediated liver damage during hepatitis

(2016) Aveline Filliol et al.   Cell Death & Disease

Transfected Poly(I:C) Activates Different dsRNA Receptors, Leading to Apoptosis or Immunoadjuvant Response in Androgen-independent Prostate Cancer Cells

(2015) Sara Palchetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

(2014) Christopher P. Dillon et al.   CELL

RIP kinases: key decision makers in cell death and innate immunity

(2014) F Humphries et al.   CELL DEATH AND DIFFERENTIATION

The nsp3 Macrodomain Promotes Virulence in Mice with Coronavirus-Induced Encephalitis

(2014) Anthony R. Fehr et al.   JOURNAL OF VIROLOGY

Tumor necrosis factor α (TNF-α) receptor-I is required for TNF-α-mediated fulminant virus hepatitis caused by murine hepatitis virus strain-3 infection

(2013) Huan Xu et al.   IMMUNOLOGY LETTERS

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic Mouse Hepatitis Virus or Poly(I:C) Induce IL-33 in Hepatocytes in Murine Models of Hepatitis

(2013) Muhammad Imran Arshad et al.   PLoS One

Expression of B and T lymphocyte attenuator (BTLA) in macrophages contributes to the fulminant hepatitis caused by murine hepatitis virus strain-3

(2012) Chengying Yang et al.   GUT

Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein

(2012) Sandrine Belouzard et al.   Viruses-Basel

Programmed necrosis: backup to and competitor with apoptosis in the immune system

(2011) Jiahuai Han et al.   NATURE IMMUNOLOGY

Programmed Death (PD)-1-Deficient Mice Are Extremely Sensitive to Murine Hepatitis Virus Strain-3 (MHV-3) Infection

(2011) Yongwen Chen et al.   PLoS Pathogens

Intrahepatic endothelial and Kupffer cells involved in immunosuppressive cytokines and natural killer (NK)/NK T cell disorders in viral acute hepatitis

(2010) A. Jacques et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Macrophage interleukin-6 and tumour necrosis factor-α are induced by coronavirus fixation to Toll-like receptor 2/heparan sulphate receptors but not carcinoembryonic cell adhesion antigen 1a

(2009) Alexandre Jacques et al.   IMMUNOLOGY

Increased Killing of Liver NK Cells by Fas/Fas Ligand and NKG2D/NKG2D Ligand Contributes to Hepatocyte Necrosis in Virus-Induced Liver Failure

(2009) Yong Zou et al.   JOURNAL OF IMMUNOLOGY

Tumor necrosis factor alpha mediates the lethal hepatotoxic effects of poly(I:C) in d-galactosamine-sensitized mice

(2008) Lien Dejager et al.   CYTOKINE