期刊
ONCOTARGETS AND THERAPY
卷 12, 期 -, 页码 549-559出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S192234
关键词
UHRF1 protein complex; epigenetic modification; ICBP90
资金
- National Natural Science Foundation of China [81272946]
- Natural Science Foundation of Liaoning Province [2015020503, 2015020473]
Ubiquitin-like with plant homeodomain and really interesting new gene finger domains 1 (UHRF1) functions as an epigenetic regulator recruiting PCNA, DNMT1, histone deacetylase 1, G9a, SuV39H, herpes virus-associated ubiquitin-specific protease, and Tat-interactive protein by multiple corresponding domains of DNA and H3 to maintain DNA methylation and histone modifications. Overexpression of UHRF1 has been found as a potential biomarker in various cancers resulting in either DNA hypermethylation or global DNA hypo-methylation, which participates in the occurrence, progression, and invasion of cancer. The role of UHRF1 in the reciprocal interaction between DNA methylation and histone modifications, the dynamic structural transformation of UHRF1 protein within epigenetic code replication machinery in epigenetic regulations, as well as modifications during cell cycle and chemotherapy targeting UHRF1 are evaluated in this study.
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