Article
Biochemistry & Molecular Biology
Yuan-ru Zheng, Chun-lin Fan, Ye Chen, Jing-yu Quan, Ling-zhu Shi, Chun-yang Tian, Xiao Shang, Ni-shan Xu, Wen-cai Ye, Lin-zhong Yu, Jun-shan Liu
Summary: This study discovered that dammarane-type triterpenoid saponins from Panax notoginseng have anti-inflammatory, anti-angiogenetic, and anti-dengue virus effects. They may be developed as potential functional foods for treating inflammation, angiogenesis, and dengue-related diseases.
Article
Biochemistry & Molecular Biology
Naoya Fukuda, Kohki Toriuchi, Rina Mimoto, Hiromasa Aoki, Hiroki Kakita, Yoshiaki Suzuki, Satoru Takeshita, Tetsuya Tamura, Hisao Yamamura, Yasumichi Inoue, Hidetoshi Hayashi, Yasumasa Yamada, Mineyoshi Aoyama
Summary: Therapeutic hypothermia (TH) suppresses microglial activation and microglia-induced neuronal damage via the TRPV4-AMPK-NF-kappa B pathway, potentially offering a novel therapeutic approach.
NEUROCHEMICAL RESEARCH
(2023)
Article
Oncology
Paula Gonzalez-Lopez, Marta Alvarez-Villarreal, Ruben Ruiz-Simon, Andrea R. Lopez-Pastor, Melina Vega de Ceniga, Leticia Esparza, Jose L. Martin-Ventura, Oscar Escribano, Almudena Gomez-Hernandez
Summary: MicroRNAs miR-15a-5p and miR-199a-3p are significantly decreased in aortic and carotid samples from atherosclerosis patients and mice. Overexpression of these miRNAs can reduce inflammation and progression of atherosclerosis. MiR-15a-5p may serve as a novel diagnostic biomarker for advanced atherosclerosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Youn Hye Jo, Go Woon Choi, Mi-Lyang Kim, Kyung Rim Sung
Summary: We characterized the gliosis induced by TRPV4 activation in Muller cells and assessed the modulatory effect of statins. The results showed that statins effectively inhibited Muller cell gliosis and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xuan Li, Wanlu Xie, Qiong Pan, Xiaoxun Zhang, Liangjun Zhang, Nan Zhao, Qiaoling Xie, Jingjing Ding, Jin Chai
Summary: This study found that both SEMA7A mutation and overexpression can activate the NF-κB p50/p65 pathway through integrin beta 1 and play a crucial role in inflammatory responses.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Heba R. Ghaiad, Mai A. Abd-Elmawla, Enas S. Gad, Kawkab A. Ahmed, Maha Abdelmonem
Summary: This study investigated the therapeutic effects of NaHS on cuprizone-induced multiple sclerosis (MS) and its potential mechanism involving the regulation of miR-146a/NF-κB/IL-1β axis. The results showed that NaHS treatment improved locomotor coordination and reduced demyelination, oxidative stress, and neuro-inflammation. Additionally, NaHS downregulated miR-146a expression and inhibited the activation of IRAK-1, NF-κB, IL-17, and IL-1β. These findings suggest that H2S-releasing compounds could be a promising approach for MS treatment.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Cell Biology
Na Li, Guanjie Zhao, Mingzhu Xu
Summary: This study investigated the effects of Kluyveromyces marxianus on high-fat diet-induced kidney injury. The results showed that K. marxianus can have a beneficial effect on kidney injury by improving gut microbiota and inhibiting the activation of TLR4/NF-kappa B pathway.
CELLULAR MICROBIOLOGY
(2023)
Review
Immunology
Zhending Gan, Meiyu Zhang, Donghui Xie, Xiaoyan Wu, Changming Hong, Jian Fu, Lijuan Fan, Shengyi Wang, Sufang Han
Summary: Glycine, acting as an inhibitory neurotransmitter, not only affects the functions of macrophages but also shapes their polarization through cellular signaling pathways and microRNAs. Additionally, glycine has beneficial effects in preventing and treating macrophage-associated diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Garrett W. D. Easson, Alireza Savadipour, Akila Anandarajah, Leanne E. Iannucci, Spencer P. Lake, Farshid Guilak, Simon Y. Tang
Summary: By using an organ culture model, this study found that activation of the TRPV4 pathway in intervertebral disc (IVD) cells leads to calcium influx and subsequent activation of NF-kappa B signaling, resulting in the production of inflammatory cytokines and degenerative changes in the IVD. Inhibition of TRPV4 can reduce inflammatory cytokine secretion and prevent IVD degeneration.
Article
Microbiology
Hironori Nishitsuji, Satoko Iwahori, Mariko Ohmori, Kunitada Shimotohno, Takayuki Murata
Summary: This study reveals the molecular mechanisms behind the induction of proinflammatory cytokines by the SARS-CoV-2 virus. The NSP6 and ORF7a proteins activate the NF-kappa B pathway through interactions with TAK1. The polyubiquitination of NSP6 and ORF7a is essential for NF-kappa B activation, with TRIM13 and RNF121 playing key roles in this process. These findings provide novel insights into the pathogenesis of SARS-CoV-2 and the host immune response.
Article
Biochemistry & Molecular Biology
Eun-Young Heo, Kyoung-Hee Lee, Jisu Woo, Jiyeon Kim, Chang-Hoon Lee, Kyung-Jin Lee, Yun-Kyu Kim, Chul-Gyu Yoo
Summary: This article investigates the role of CRBN in chronic obstructive pulmonary disease (COPD) pathogenesis. The study found that lower levels of CRBN protein were observed in COPD patients compared to never smokers and smokers. CRBN deficiency was shown to aggravate elastase-induced emphysematous changes and increase neutrophil infiltration, lung cell injury, and protein leakage into the bronchoalveolar space. Furthermore, CRBN deficiency led to elevated release of neutrophilic chemokines and inflammatory cytokines. The findings suggest that targeting CRBN could be an effective therapeutic approach for COPD treatment.
Article
Cell Biology
Enping Liu, Jiawei Sun, Jing Yang, Lin Li, Qili Yang, Jiuqin Zeng, Jiayu Zhang, Dahua Chen, Qinmiao Sun
Summary: ZDHHC11 positively regulates NF-kappa B signaling by promoting TRAF6 oligomerization and ligase activity, subsequently activating TAK1 and IKK complexes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Yanan Liu, Hongbin Fan, Xinyu Li, Jing Liu, Xuebin Qu, Xiuxiang Wu, Meiying Liu, Zhian Liu, Ruiqin Yao
Summary: The study suggests that Trpv4 regulates mitochondrial function through the SIRT1/PGC-1α pathway, further triggering Nlrp3 inflammasome activation. Knockdown of Trpv4 and Nlrp3 by siRNA can alleviate demyelination and inflammation.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wei Liu, Hao Zhang, Yun-yi Hou, Rui-yi Hu, Jun-jie Zhang, Xuan Chen, Shuang Wang, Jun-nan Hu, Zi Wang, Wei Li
Summary: This study evaluates the protective effects of arginyl-fructosyl-glucose (AFG), a major Maillard reaction product of red ginseng, against cisplatin-induced intestinal toxicity. The results showed that AFG can alleviate cisplatin-induced gastrointestinal damage and inhibit cell apoptosis by regulating the Wnt/beta-catenin signaling pathway.
Article
Chemistry, Medicinal
Junli Huang, Zeli Ma, Zichao Yang, Zengzhu He, Jingna Bao, Xiaopeng Peng, Yao Liu, Ting Chen, Shumin Cai, Jianjun Chen, Zhenhua Zeng
Summary: In this study, a novel series of Ibrutinib-based BTK PROTACs were designed, synthesized, and analyzed for their structure-activity relationship. Compound 15 showed the most potent degrading activity, with a DC50 of 3.18 nM, which was significantly better than the positive control MT802 (DC50 of 63.31 nM). Compound 15 could degrade BTK protein in LPS-stimulated cells and inhibit the activation of NF-kappaB, leading to reduced expression and secretion of proinflammatory cytokines. Additionally, compound 15 demonstrated anti-inflammatory effects in a mouse peritonitis model. Overall, this study highlights the potential of targeting BTK degradation as a therapeutic strategy for inflammatory disorders, and compound 15 represents a promising lead compound for further development as an anti-inflammatory agent.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)