期刊
VIRUSES-BASEL
卷 10, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/v10110639
关键词
human bocavirus; children; acute gastroenteritis
类别
资金
- Riga Stradins University [RSU ZP 17/2013]
- National Research Program BIOMEDICINE [5.6.2]
- 7FP project Unlocking infectious diseases research potential at Riga Stradins University, Baltinfect [316275]
- China Scholarship Council
- Sigrid Juselius Foundation
- Life and Health Medical Grant Association, Helsinki, Finland
Human bocaviruses (HBoVs) 1-4 belong to the Parvoviridae family, and they infect the respiratory or gastrointestinal tracts in children. We investigated the prevalence of HBoV1-4 DNAs in the blood and stool samples, and of HBoV1-4 IgG and IgM in the plasma samples, of children presenting with acute gastroenteritis (AGE). In addition, we identified HBoV co-infections with the five most frequent gastrointestinal pathogens. A total of 83 paired blood and stool samples were collected from children aged five years or less. Infection markers of HBoV1, 2, or 3 (viral DNA in blood and/or stool and/or antibodies) were detected in 61 out of 83 (73.5%) patients. HBoV1, 2, or 3 DNA as a monoinfection was revealed in 18.1%, 2.4%, and 1.2%, respectively, and 21.7% in total. In 56.1% of the HBoV DNA-positive patients, the presence in stool of another virusmost frequently norovirus or rotaviruswas observed. In conclusion, this study, for the first time, illustrates the prevalence and genetic diversity of HBoVs in Latvian children with gastroenteritis, and shows a widespread distribution of these viruses in the community. HBoV1 and 2 are commonly found as single infectious agents in children with AGE, suggesting that the viruses can be as pathogenic by themselves as other enteric agents are.
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