Article
Biotechnology & Applied Microbiology
Houri Razavi, Ali Katanforosh
Summary: This study constructed a STAD lncRNA-mRNA network and found that the high degree nodes were associated with overall survival and had been confirmed in other cancers. Through mapping lncRNAs to GO terms and cancer hallmarks, the potential associations between lncRNAs and hallmarks were predicted and confirmed through literature review. Furthermore, a lncRNA signature was developed to classify STAD patients into high and low-risk subgroups with significantly different survival outcomes.
Article
Oncology
Guo-Liang Zheng, Guo-Jun Zhang, Yan Zhao, Zhi-chao Zheng
Summary: This study developed a prognostic risk model for stomach adenocarcinoma based on data from the TCGA database, identifying three proteins as independent prognostic factors to predict patient survival risk and guide clinical treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Chien-Hung Gow, Min-Shu Hsieh, Yi-Nan Liu, Yi-Hsuan Lee, Jin-Yuan Shih
Summary: Pulmonary invasive mucinous adenocarcinoma (IMA) has unique histological patterns. This study compared clinical characteristics, pathological features, and survival outcomes of IMA patients with non-IMA-type ADC patients. A new two-tier grading system might be useful in predicting recurrence-free survival for stage I-IIIA IMAs.
Article
Oncology
Yuting Wen, Yi Wang, Yao Huang, Zhe Liu, Chan Hui
Summary: This study investigated the expression of PLVAP in stomach adenocarcinoma (STAD) patients and its value in predicting patient prognosis. The results showed that elevated PLVAP expression was associated with advanced disease and worse clinical outcomes. Furthermore, PLVAP expression was also found to be correlated with specific bacterial infections.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Min Wang, Bo Yuan, Zhen-huan Zhou, Wei-wei Han
Summary: Cervical adenocarcinoma patients present with early clinicopathological features and have 5-year and 10-year survival rates of 74.47% and 70.00% respectively. Married status, surgery, and chemotherapy are favorable prognostic indicators, while age, tumor grade, tumor size, FIGO stage, and pelvic lymph node metastasis are unfavorable prognostic factors.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Yuan Nie, Linxiang Liu, Qi Liu, Xuan Zhu
Summary: A novel metabolic-related signature was identified for predicting prognosis in stomach adenocarcinoma patients. Patients in the high-risk group had significantly poorer survival outcomes compared to those in the low-risk group, with the predictive model showing good value. Additionally, gene set enrichment analyses revealed enriched pathways that may help explain the underlying mechanisms.
Article
Pathology
Hiral Jhala, Leanne Harling, Alberto Rodrigo, Daisuke Nonaka, Emma Mclean, Wen Ng, Lawrence Okiror, Andrea Bille
Summary: The study highlights that solid predominant adenocarcinoma, intra-alveolar spread, and lymphovascular invasion are associated with a worse prognosis and can be used as prognostic tools. Adenocarcinoma subtype does not have a significant impact on disease-free survival.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Oncology
Wensheng Zhou, Zhichao Liu, Yanan Wang, Yanwei Zhang, Fangfei Qian, Jun Lu, Huimin Wang, Ping Gu, Minjuan Hu, Ya Chen, Zhengyu Yang, Ruiying Zhao, Yuqing Lou, Baohui Han, Wei Zhang
Summary: This study investigated the profile of concomitant alterations in EGFR-mutant LUAD with a size of 3 cm or less and found that TP53 mutation and EGFR amplification were poor prognostic factors for recurrence-free survival.
Article
Cell Biology
Min Fu, Yongbiao Huang, Xiaohong Peng, Xiaoyu Li, Na Luo, Wenjun Zhu, Feng Yang, Ziqi Chen, Shengling Ma, Yuanyuan Zhang, Qianxia Li, Guangyuan Hu
Summary: This study reveals the significance of tumor mutation burden on the prognosis of stomach adenocarcinoma patients, and suggests GLP2R as a potential therapeutic target for gastric cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Tian Lan, Weiguo Liu, Yunyan Lu, Hua Luo
Summary: The study identified differentially expressed mRNAs in EAC tissues and adjacent normal samples, and developed a 5-mRNA signature to predict prognosis of EAC. This signature showed promising accuracy in internal and external test sets.
Article
Clinical Neurology
Shiyuan Jing, Lei Chen, Song Han, Ning Liu, MingYang Han, Yakun Yang, Changxiang Yan
Summary: The study demonstrated that TCF7L2 is significantly overexpressed in glioblastoma and associated with long-term prognosis of the tumor. Overexpression of TCF7L2 is linked to poor overall survival and serves as an independent prognostic factor for glioma patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mengying Xu, Song Liu, Xiangmei Qiao, Lin Li, Changfeng Ji, Zhengyang Zhou
Summary: This study focused on analyzing the clinicopathological and CT findings of papillary gastric adenocarcinoma to evaluate the feasibility of a multivariate model for distinguishing papillary gastric adenocarcinomas. Differences in various factors between papillary and tubular adenocarcinomas were found, and the multivariate model based on clinical information and CT findings showed satisfactory diagnostic efficiency in discriminating papillary gastric adenocarcinomas preoperatively.
ABDOMINAL RADIOLOGY
(2022)
Article
Urology & Nephrology
Yifei Ge, Kang Liu, Guang Yang, Xiangbao Yu, Bin Sun, Bo Zhang, Yanggang Yuan, Ming Zeng, Ningning Wang, Changying Xing, Huijuan Mao
Summary: This study retrospectively analyzed the clinicopathological features of 76 patients with anti-glomerular basement membrane glomerulonephritis and the prognostic value of clinical and laboratory indicators on renal and patient survival. The results showed that initial kidney replacement therapy was a significant risk factor for renal survival, and older age and initial kidney replacement therapy were associated with higher all-cause mortality.
Article
Cell Biology
Na Luo, Min Fu, Yiling Zhang, Xiaoyu Li, Wenjun Zhu, Feng Yang, Ziqi Chen, Qi Mei, Xiaohong Peng, Lulu Shen, Yuanyuan Zhang, Qianxia Li, Guangyuan Hu
Summary: This study successfully constructed a prognostic model for stomach adenocarcinoma by analyzing data from TCGA and GEO databases. Through analysis of immune gene expression, it can predict patient survival rates and immune infiltration levels, providing new directions and methods for tumor treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Xiangwei Zhang, Wei Dong, Jishuai Zhang, Wenqiang Liu, Jingjing Yin, Duozhi Shi, Wei Ma
Summary: This study identified 18 nuclear mitochondrial genes (NMGs) associated with the prognosis of lung adenocarcinoma (LUAD) and established a risk signature to effectively distinguish high- and low-risk patients. The predictive capacity of the signature was validated in three independent gene expression omnibus (GEO) cohorts. Patients with high-risk NMGs signature showed a significantly lower prevalence of actionable EGFR alterations but accompanied with a more inflame immune tumor microenvironment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Shuai Guo, Muyan Shang, Zhe Dong, Jun Zhang, Yue Wang, Yan Zhao
Summary: The study evaluated the predictive ability of ELN number, LNR, and LODDS for overall survival in N3b gastric adenocarcinoma patients. Findings revealed that ELN number, LNR, and LODDS were independent prognostic factors, with LNR and LODDS showing similar and better performance in predicting OS compared to ELN number.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Yilin Tong, Yanmei Zhu, Yan Zhao, Zexing Shan, Dong Liu, Jianjun Zhang
Summary: The study compared the predictive ability of Mandard and Becker TRG in patients with locally advanced gastric cancer, and found no significant difference between the two systems in terms of survival prediction.
CANCER RESEARCH AND TREATMENT
(2021)
Review
Surgery
Xiangyu Meng, Lu Wang, Bo Zhu, Ting Sun, Shuai Guo, Yue Wang, Jun Zhang, Dong Yang, Guoliang Zheng, Tao Zhang, Zhichao Zheng, Yan Zhao
Summary: Totally laparoscopic gastrectomy (TLG) shows better surgical advantages compared to laparoscopic-assisted gastrectomy (LAG) in the treatment of gastric cancer, including shorter operation time, more lymph nodes obtained, and quicker recovery.
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
(2021)
Article
Oncology
Yilin Tong, Yan Zhao, Zexing Shan, Jianjun Zhang
Summary: This study found that CA724 is an independent prognostic factor in locally advanced GC patients undergoing NCT and curative resection, and can be used to predict lymph node metastasis and TNM stage, while AFU, AFP, and CEA showed no association with survival.
Article
Oncology
Tao Wang, Yan Zhao, Ming Wang, Peng Zhang, Guole Lin, Qian Liu, Fan Feng, Zhiguo Xiong, Junbo Hu, Bo Zhang, Yingjiang Ye, Lijian Xia, Kaixiong Tao
Summary: This study compared local excision (LE) and radical resection (RR) for low rectal gastrointestinal stromal tumors (GISTs) in a multicenter retrospective cohort study. The results showed that LE had better postoperative outcomes and comparable oncological safety for patients with tumors <= 2 cm. However, for tumors >2 cm, RR might be a more appropriate option with better recurrence-free survival (RFS).
Article
Gastroenterology & Hepatology
Guo-Liang Zheng, Bao Zhang, Yue Wang, Yong Liu, Hai-Tao Zhu, Yan Zhao, Zhi-Chao Zheng
Summary: Conformal resection (CR) is a safe and feasible surgical technique for esophagogastric junction gastrointestinal stromal tumors located within 7.0 mm above the Z-line, showing advantages in terms of shorter operative time, postoperative recovery time, and hospital stay, as well as better postoperative gastroesophageal reflux and quality of life compared to proximal gastrectomy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Guoliang Zheng, GuoJun Zhang, Yan Zhao, Zhichao Zheng
Summary: A prognostic risk model for COAD was developed using miRNA-seq data, with seven miRNAs identified as predictive biomarkers. The model showed good prediction accuracy and identified high-risk patients with worse overall survival. The 7-miRNA Risk Score can serve as an independent prognostic factor and guide clinical treatment for COAD patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hongyan Cui, Yue Wang, Lili Chen, Ming Qian, Liuwei Zhang, Xiujue Zheng, Xi Yang, Li Chen, Yan Zhao, Qixian Chen, Jingyun Wang
Summary: Integrating SNAI1 knockdown with chemotherapeutic drugs using a pullulan-based nanocarrier showed promising results in targeted delivery of therapeutic payloads to solid lung tumors, enhancing chemotherapeutic efficacy and demonstrating the critical role of SNAI1 in tumorigenesis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Oncology
Wenchang Yang, Qian Liu, Guole Lin, Bo Zhang, Hui Cao, Yan Zhao, Lijian Xia, Fan Feng, Zhiguo Xiong, Junbo Hu, Yingjiang Ye, Kaixiong Tao, Peng Zhang
Summary: The study aimed to characterize the efficacy of neoadjuvant imatinib in rectal GISTs and the prognostic characteristics of patients after surgery. The results showed that neoadjuvant imatinib can shrink rectal GIST size, increasing the possibility of complete resection and anal preservation. Postoperative prognostic factors such as tumor size and mitotic count were not associated with neoadjuvant imatinib in rectal GIST patients.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Fei-Long Ning, Nan-Nan Zhang, Jun Wang, Yi-Feng Jin, Hong-Guang Quan, Jun-Peng Pei, Yan Zhao, Xian-Tao Zeng, Masanobu Abe, Chun-Dong Zhang
Summary: This study assessed the prognostic performances of three pathological classifications in gastric cancer patients and developed a novel prognostic nomogram for individually predicting overall survival (OS). The results showed that the modified Lauren classification demonstrated superior predictive ability for OS, and the new prognostic nomogram incorporating this classification outperformed the American Joint Committee on Cancer 8th edition tumor-nodemetastasis classification in terms of discriminative ability, model fitting performance, and net benefits.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Wei Wang, Ying Peng, Xingyu Feng, Yan Zhao, Sharvesh Raj Seeruttun, Jun Zhang, Zixuan Cheng, Yong Li, Zaiyi Liu, Zhiwei Zhou
Summary: Neoadjuvant therapies have been shown to improve outcomes in locally advanced gastric cancer patients. This study used pretreatment CT images and radiomics to identify relevant features that can predict treatment response, showing promising results in both training and validation cohorts.
Article
Gastroenterology & Hepatology
Jie Jia, Ming Wang, Guole Lin, Zhidong Gao, Qian Liu, Peng Zhang, Lijian Xia, Fan Feng, Yan Zhao, Junbo Hu, Zhiguo Xiong, Wenze Wan, Yuan Yin, Hui Cao, Bo Zhang, Kaixiong Tao
Summary: This study aimed to compare the surgical and oncologic results of laparoscopic versus open surgery for the treatment of rectal gastrointestinal stromal tumors. The study found that laparoscopic surgery offers superior relapse-free survival and fewer complications, especially for patients with rectal gastrointestinal stromal tumors <= 5 cm.
DISEASES OF THE COLON & RECTUM
(2022)
Article
Chemistry, Physical
Yue Wang, Xiujue Zheng, Jun Liu, Li Chen, Qixian Chen, Yan Zhao
Summary: This article introduces a method for cytoplasmic transportation of therapeutic nucleic acids through mimicking viral vectors. The proposed platform utilizes ligands and pH stimuli to transform the delivery vehicles and transport siRNA into the cytosol. The virus-mimicking platform has demonstrated significant efficacy in anti-tumor therapy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Medicine, General & Internal
Xiangyu Meng, Lu Wang, Guangcong Liu, Jun Zhang, Yue Wang, Dong Yang, Guoliang Zheng, Tao Zhang, Zhichao Zheng, Yan Zhao
Summary: Based on Chinese data, this study found that D2 radical gastrectomy plus complete mesogastrium excision (CME) provides better surgical outcomes and lower risk of complications compared to D2 radical gastrectomy alone.
CHINESE MEDICAL JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Yue Wang, Xiujue Zheng, Jun Liu, Qixian Chen, Yan Zhao
Summary: The emergence of CRISPR-based genome editing systems has revolutionized the field of molecular biology and holds great promise for the treatment of various diseases. However, the lack of suitable delivery vehicles for effective intracellular delivery of CRISPR components limits its practical applications. In this study, a nanometer-scaled vesicle platform (CRISPRsome) was developed to efficiently deliver the essential components of the CRISPR system, resulting in significant gene knockout efficacy in cancer cells. This study highlights the potential of CRISPRsome in facilitating the use of CRISPR technology in practical applications.
ACS MATERIALS LETTERS
(2022)