Article
Biochemistry & Molecular Biology
Sunje Kim, Seong Eun Lee, Shinae Yi, Sangmi Jun, Yoon-Sun Yi, Harsha Nagar, Cuk-Seong Kim, Chungmin Shin, Min-Kyung Yeo, Yea Eun Kang, Sang-Ha Oh
Summary: The study identified that mitochondrial dysfunction and dysregulated endoplasmic reticulum stress signaling play a role in human keloid formation, and that treatment with tauroursodeoxycholic acid (TUDCA) shows potential in reducing scar formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Elisa Mariano Pioltine, Camila Bortoliero Costa, Lais Barbosa Latorraca, Fernanda Fagali Franchi, Priscila Helena dos Santos, Gisele Zoccal Mingoti, Fabiola Freitas de Paula-Lopes, Marcelo Fabio Gouveia Nogueira
Summary: The study showed that adding 200μM of TUDCA to IVM medium reduced ROS production and increased the abundance of transcripts related to antioxidant activity in oocytes and embryos. However, a high concentration of TUDCA (1,000μM) was toxic to oocytes, decreasing nuclear maturation rate, mitochondrial activity, and increasing ER stress and cellular apoptosis related transcripts. Treatment with 200μM of TUDCA was associated with greater resistance to oxidative stress and indirectly with ER stress relief in bovine oocytes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Stephanie M. Cicalese, Josiane Fernandes da Silva, Fernanda Priviero, R. Clinton Webb, Satoru Eguchi, Rita C. Tostes
Summary: Cells respond to stress by activating defense signaling pathways for survival or cell death. Arterial hypertension and aging share mechanisms that mediate chronic cell stress, potentially leading to unresolved pathologies.
CIRCULATION RESEARCH
(2021)
Review
Endocrinology & Metabolism
Israelle Netto Freitas, Joel Alves da Silva Jr, Kenia Moreno de Oliveira, Bruna Lourenconi Alves, Thiago Dos Reis Araujo, Joao Paulo Camporez, Everardo Magalhaes Carneiro, Ana Paula Davel
Summary: Adipose tissue, an organ with metabolic and endocrine activity, undergoes morphological, functional, and molecular changes during obesity. The ER stress inhibitor TUDCA has shown therapeutic potential in minimizing adipose tissue dysfunction and metabolic alterations associated with obesity. Specifically, TUDCA has been demonstrated to inhibit ER stress, inflammation, and apoptosis in adipocytes, and may have cardiovascular protective effects through its influence on perivascular adipose tissue (PVAT) function and adiponectin release.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Pharmacology & Pharmacy
Qiao Jiang, Li Wang, Xu Si, Jin-Long Tian, Ye Zhang, Hai-Long Gui, Bin Li, De-Hong Tan
Summary: Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases, and natural polyphenols can reduce homocysteine levels by acting on oxidative stress and endoplasmic reticulum stress-related signaling pathways, thus improving vascular injury caused by high homocysteine levels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Weimin Yu, Gang Xu, Hui Chen, Li Xiao, Gang Liu, Pingping Hu, Siqi Li, Vivi Kasim, Chunyu Zeng, Xiaoyong Tong
Summary: Pulmonary hypertension (PH) is a life-threatening disease characterized by pulmonary vascular remodeling and hyperproliferation of pulmonary artery smooth muscle cells (PASMCs). This study identifies the impact of C674 oxidative inactivation on pulmonary vascular remodeling and PH development, highlighting the importance of C674 in maintaining pulmonary vascular homeostasis by restricting PASMC proliferation. The IRE1 alpha/XBP1s pathway and SERCA2 may serve as potential targets for PH therapy.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemistry & Molecular Biology
Yan-Nan Chi, Rui-Juan Ye, Jia-Mei Yang, Dong-Mei Hai, Ning Liu, Jia-Wei Ren, Juan Du, Xiao-Bing Lan, Jian-Qiang Yu, Lin Ma
Summary: The study found that geniposide can improve spermatogenic dysfunction induced by cyclophosphamide in mice, increase sperm quantity and activity, alleviate sperm DNA damage and endoplasmic reticulum stress, inhibit cell apoptosis, and protect the testis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Biochemistry & Molecular Biology
Camila Lopez-Crisosto, Raul Arias-Carrasco, Pablo Sepulveda, Luis Garrido-Olivares, Vinicius Maracaja-Coutinho, Hugo E. Verdejo, Pablo F. Castro, Sergio Lavandero
Summary: Pulmonary hypertension is a rare but high morbidity and mortality disease mainly affecting women of reproductive age. Despite recent advances in understanding the pathogenesis, the high heterogeneity in presentation among different patients makes accurate diagnosis and effective treatment challenging. Therefore, new studies focusing on personalized medicine are needed to overcome the lack of specificity and efficacy in current management.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Environmental Sciences
Junjun Peng, Xueyan Dai, Huiqin Fan, Chenghong Xing, Yu Zhuang, Xiaona Gao, Huabin Cao, Guoliang Hu, Fan Yang
Summary: Copper (Cu) at high levels can cause harm to the host physiology, specifically resulting in nephrotoxicity, although the exact mechanism remains unclear. This study explored the relationship between mitochondria-associated ER membranes (MAM) and Cu-induced kidney mitochondrial dysfunction and ER stress. The findings revealed that excessive Cu disrupted MAM integrity, leading to MAM dysfunction, mitochondrial dysfunction, and ER stress, contributing to Cu-induced nephrotoxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Undral Munkhsaikhan, Youngin Kwon, Amal M. Sahyoun, Karima Ait-Aissa, Adam Kassan, Modar Kassan
Summary: In this study, the effect of lomitapide on cardiovascular function in obesity was investigated. Lomitapide treatment attenuated body weight gain, restored lipid profile, and improved vascular function in obese mice. These effects may be attributed to the reduction of inflammation and oxidative stress.
Article
Biochemistry & Molecular Biology
Yan Zhou, Yuehan Wang, Chi Teng Vong, Yanyan Zhu, Baojun Xu, Cheng-Chao Ruan, Yitao Wang, Wai San Cheang
Summary: JAT has vasoprotective effects in diabetes and obesity by enhancing the Akt/eNOS pathway and NO bioavailability, as well as suppressing ER stress and oxidative stress to improve endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Matshediso Zachariah, Hatem Maamoun, Larissa Milano, Margaret P. Rayman, Lisiane B. Meira, Abdelali Agouni
Summary: Selenium is an essential trace element for human health, but a balanced intake is crucial for maximizing its health benefits. High selenium intake above physiological levels may increase diabetes risk and result in endothelial dysfunction. Selenium induces cancer cell apoptosis via endoplasmic reticulum stress, but its role in endothelial dysfunction remains unknown.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Nasrin Abolhasanpour, Samin Alihosseini, Sevda Golipourkhalili, Reza Badalzadeh, Javad Mahmoudi, Leila Hosseini
Summary: Ischemic stroke leads to a cascade of cellular mechanisms in the brain, with melatonin showing beneficial effects in reducing oxidative stress, inflammation, and apoptosis. Studies suggest that melatonin therapy after stroke can improve mitochondrial dysfunction and alleviate ER stress and inflammation. The impact of melatonin on mitochondrial and ER function, as well as the crosstalk between the two organelles, is discussed as a therapeutic target for stroke.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ji-Min Lee, Soyoung Park, Duckgue Lee, Rehna Paula Ginting, Man Ryul Lee, Min-Woo Lee, Jaeseok Han
Summary: The study reveals that ER stress and UPR induction are closely involved in beige adipocyte differentiation, and reducing ER stress can improve abnormal metabolic phenotypes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Medicine, Research & Experimental
Fangyi Chen, Zhe Ge, Nan Li, Zuochong Yu, Rongbo Wu, Yan Zhao, Xianwei He, Guoping Cai
Summary: The study demonstrated that TUDCA may protect against tunicamycin-induced DRG apoptosis by suppressing ER stress. The protective effect and therapeutic value of TUDCA in nervous system injury need further investigation in animal models.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Esra Sumlu, Aykut Bostanci, Gokhan Sadi, Mehmet Eray Alcigir, Fatma Akar
Summary: The present study investigated the effects of Lactobacillus plantarum and Lactobacillus helveticus supplementation on liver lipogenesis, insulin signaling, and glucose transporters in high-fructose-fed rats. The results showed that supplementation with Lactobacillus plantarum improved liver health by reducing weight, lipid accumulation, and FASN expression, while also improving IRS-1/AKT/eNOS pathway and GLUT2 expression. On the other hand, Lactobacillus helveticus supplementation had a restoring effect on lipid accumulation by decreasing FASN expression and regulating IRS-1 and GLUT2 expressions.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Chemistry, Analytical
Sukriye Nihan Karuk Elmas, Duygu Aydin, Tahir Savran, Eray Caliskan, Kenan Koran, Fatma Nur Arslan, Gokhan Sadi, Ahmet Orhan Gorgulu, Ibrahim Yilmaz
Summary: This study successfully developed a fluorene-based fluorescent turn-off sensor FLPG for the highly selective and sensitive detection of Cu2+ and Fe3+ ions, with successful bio-imaging experiments in living cells, providing a simple, inexpensive, fast, and easy-to-use detection platform for routine analysis.
CURRENT ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Omer Ekici, Esra Aslan, Tugce Aladag, Hilal Guzel, Omer Adil Korkmaz, Aykut Bostanci, Gokhan Sadi, Mehmet Bilgehan Pektas
Summary: This study aimed to evaluate the impact of high-fructose corn syrup (HFCS) intake on antioxidative structures and inflammation in the gingival tissue and masseter muscle of rats. The results showed that HFCS increased proinflammatory structures and suppressed antioxidant enzymes in these tissues, while kefir supplementation improved these undesirable changes. This study suggests that kefir consumption may have restorative effects on oral health disorders caused by high levels of fructose in the diet.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Tahir Savran, Sukriye Nihan Karuk Elmas, Gonul Akin Geyik, Aykut Bostanci, Duygu Aydin, Fatma Nur Arslan, Gokhan Sadi, Ibrahim Yilmaz
Summary: A new coumarin-based fluorescent chemosensor HBAC has been developed for rapid and accurate detection of Cu2+ in MeOH:H2O medium, showing high selectivity and low detection limit. The reaction mechanism of the HBAC-Cu2+ system was fully investigated using various analytical methods, confirming its effectiveness in detecting Cu2+ in biological and environmental systems.
Article
Andrology
Fatma Akar, Onur Gokhan Yildirim, Gozde Yucel Tenekeci, Arda Selin Tunc, Murside Ayse Demirel, Gokhan Sadi
Summary: Limited data suggests that a fructose-rich diet may have negative effects on testicular health in male rats, affecting tight junction proteins and mitogenic pathways. However, supplementing with kefir may help promote the expression of certain protective proteins and reduce testicular cell proliferation and apoptosis induced by fructose intake.
Article
Endocrinology & Metabolism
O. Ekici, E. Aslan, H. Guzel, O. A. Korkmaz, G. Sadi, A. M. Gurol, M. G. Boyaci, M. B. Pektas
Summary: The study showed that excessive consumption of HFCS can have negative effects on craniomandibular bone development, while the intake of kefir can suppress the adverse effects of HFCS.
JOURNAL OF BONE AND MINERAL METABOLISM
(2022)
Article
Medicine, Research & Experimental
Nur Banu Bal, Aykut Bostanci, Gokhan Sadi, Muhammet Oguzhan Donmez, Mecit Orhan Uludag, Emine Demirel-Yilmaz
Summary: This study compared the effects of resveratrol supplementation and regular exercise on hypertension-induced cellular stress responses of the myocardium. The results showed that both resveratrol and exercise reduced systolic blood pressure in hypertensive rats, improved cardiac muscle responses, and reduced oxidative stress. Regular exercise restored endoplasmic reticulum stress and decreased mitogenic activation, while resveratrol only improved mitophagy. Additionally, both resveratrol and exercise suppressed inflammation.
Article
Medicine, General & Internal
Sevtap Han
Summary: This study reveals the effects of the ER stress inhibitor TUDCA on liver function, plasma lipids, and oxidative stress markers in the elderly. The results showed that TUDCA decreased AST levels, increased HDL value, decreased TG value, and reduced MDA and MPO levels in the elderly. The effects on some parameters varied depending on gender.
CUKUROVA MEDICAL JOURNAL
(2022)
Article
Food Science & Technology
Esra Aslan, Goekhan Sadi, Hilal Guzel, Cigdem Karaca, Omer A. Korkmaz, Mine K. Pektas, Mehmet Celegen, Tugce Aladag, Seyma Oncu, Mehmet B. Pektas
Summary: This study evaluated the metabolic disturbances caused by high-fructose corn syrup (HFCS) on adipose tissue and the potential of kefir as a therapy. The results showed that HFCS intake suppressed apoptosis in adipose tissues, leading to tissue development and abdominal obesity, while kefir treatment reversed this process by activating apoptosis-related genes and proteins.
POLISH JOURNAL OF FOOD AND NUTRITION SCIENCES
(2023)
Article
Multidisciplinary Sciences
Ceren Guney, Nur Banu Bal, Fatma Akar
Summary: Excessive intake of fructose in the regular human diet is associated with global increases in metabolic disorders. Sugar-sweetened soft drinks, the main source of added fructose, can lead to gut permeability, inflammatory response, hepatic steatosis, abdominal adiposity, insulin resistance, and negative impacts on reproductive function. Recognizing the detrimental effects of fructose and implementing relevant public health policies are essential for preventing diet-related metabolic disorders.
Article
Chemistry, Medicinal
Gokhan Sadi, Hacer Bora, Mustafa Cicek, Kenan Koran, Ahmet Orhan Gorgulu, Ibrahim Yilmaz
Summary: This study investigated the antioxidant, antibacterial, cytotoxic, and antioxidant enzyme inhibitory properties of 7,8-dihydroxy-3-(4-methylphenyl) coumarin. It exhibited high free radical scavenging activity, total antioxidant capacity, and reducing power. The compound also demonstrated antibacterial effects and cytotoxic activity on breast cancer cells, while being non-toxic to liver cancer cells. Furthermore, it inhibited catalase enzyme and glutathione-S-transferase activities. These findings suggest the compound's potential in preventing oncogenesis and tumor progression in the liver and breast cancer.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2022)
Article
Pharmacology & Pharmacy
Nur Banu Bal, Sevtap Han, Suzan Emel Usanmaz, Mecit Orhan Uludag, Emine Demirel Yilmaz
Summary: This study found that resveratrol and regular exercise training have different effects on cellular stress response markers depending on sex and tissue.
ISTANBUL JOURNAL OF PHARMACY
(2022)
Article
Biochemistry & Molecular Biology
Mehmet Bilgehan Pektas, Esra Aslan, Hilal Guzel, Omer Adil Korkmaz, Kubra Celegen, Ayhan Pektas, Aykut Bostanci, Gokhan Sadi
Summary: This study investigates the relationship between hepatic insulin resistance-related signaling elements and phosphodiesterases (PDEs), as well as the role of kefir in treatment. The results show that high-fructose corn syrup (HFCS) upregulates hepatic PDEs, suppresses insulin signaling, and increases inflammatory markers. Kefir, on the other hand, suppresses PDE activity, normalizes insulin signaling, and reduces inflammation.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2022)
Article
Chemistry, Multidisciplinary
Duygu Aydin, Sukriye Nihan Karuk Elmas, Gonul Akin Geyik, Aykut Bostanci, Fatma Nur Arslan, Tahir Savran, Gokhan Sadi, Ibrahim Yilmaz
Summary: The novel chemoprobe NASP showed high sensitivity and selectivity towards Cys and Hcy in living cells, making it a promising tool for diagnosing biothiol-related illnesses.
NEW JOURNAL OF CHEMISTRY
(2021)