Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer’s disease-related microvascular cerebral amyloid angiopathy

Does the difference between PART and Alzheimer’s disease lie in the age-related changes in cerebral arteries that trigger the accumulation of Aβ and propagation of tau?

(2015) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

PART is part of Alzheimer disease

(2015) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Pathophysiology of Hypoperfusion of the Precuneus in Early Alzheimer's Disease

(2015) J. Scott Miners et al.   BRAIN PATHOLOGY

Neuroinflammatory Signals in Alzheimer Disease and APP/PS1 Transgenic Mice

(2015) Irene López-González et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Regional cerebral blood flow estimated by early PiB uptake is reduced in mild cognitive impairment and associated with age in an amyloid-dependent manner

(2015) Anton F. Gietl et al.   NEUROBIOLOGY OF AGING

Neutrophil elastase mediates acute pathogenesis and is a determinant of long-term behavioral recovery after traumatic injury to the immature brain

(2015) Bridgette D. Semple et al.   NEUROBIOLOGY OF DISEASE

Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy

(2015) Laura J Blair et al.   Acta Neuropathologica Communications

Effects of age and blood pressure on the retinal arterial wall, analyzed using adaptive optics scanning laser ophthalmoscopy

(2015) Shigeta Arichika et al.   Scientific Reports

Are cases with tau pathology occurring in the absence of Aβ deposits part of the AD-related pathological process?

(2014) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Primary age-related tauopathy (PART): a common pathology associated with human aging

(2014) John F. Crary et al.   ACTA NEUROPATHOLOGICA

Pathophysiology of white matter perfusion in Alzheimer’s disease and vascular dementia

(2014) Rachel Barker et al.   BRAIN

Cerebral Blood Flow is an Earlier Indicator of Perfusion Abnormalities than Cerebral Blood Volume in Alzheimer's Disease

(2014) María Lacalle-Aurioles et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-β from the mouse brain

(2013) Cheryl A. Hawkes et al.   AGING CELL

Global brain hypoperfusion and oxygenation in amnestic mild cognitive impairment

(2013) Jie Liu et al.   Alzheimers & Dementia

Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation

(2013) Ayman ElAli et al.   Acta Neuropathologica Communications

Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele

(2012) Cheryl A. Hawkes et al.   PLoS One

Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts

(2011) Yoko Okamoto et al.   ACTA NEUROPATHOLOGICA

Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice

(2011) Mario Merlini et al.   ACTA NEUROPATHOLOGICA

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

(2011) Cheryl A. Hawkes et al.   ACTA NEUROPATHOLOGICA

Neutrophil Elastase Is Produced by Pulmonary Artery Smooth Muscle Cells and Is Linked to Neointimal Lesions

(2011) Yu-Mee Kim et al.   AMERICAN JOURNAL OF PATHOLOGY

Effects of elastin degradation and surrounding matrix support on artery stability

(2011) Avione Y. Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Localized amyloids important in diseases outside the brain - lessons from the islets of Langerhans and the thoracic aorta

(2011) Gunilla T. Westermark et al.   FEBS Journal

Microvascular brain damage with aging and hypertension

(2011) Angelo Scuteri et al.   JOURNAL OF HYPERTENSION

Neutrophil elastase inhibitor prevents ischemic brain damage via reduction of vasogenic edema

(2010) Yuka Ikegame et al.   HYPERTENSION RESEARCH

Formation of amyloid-β oligomers in brain vascular smooth muscle cells transiently exposed to iron-induced oxidative stress

(2009) Janusz Frackowiak et al.   ACTA NEUROPATHOLOGICA

Microvasculature changes and cerebral amyloid angiopathy in Alzheimer’s disease and their potential impact on therapy

(2009) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study

(2009) G. Lace et al.   BRAIN

Increased Matrix Metalloproteinase 9 Activity in Mild Cognitive Impairment

(2009) Martin A. Bruno et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Hypoperfusion and Ischemia in Cerebral Amyloid Angiopathy Documented by 99mTc-ECD Brain Perfusion SPECT

(2009) Y.-A. Chung et al.   JOURNAL OF NUCLEAR MEDICINE

Vascular Extracellular Matrix and Arterial Mechanics

(2009) Jessica E. Wagenseil et al.   PHYSIOLOGICAL REVIEWS

Effect of Aging on Elastin Functionality in Human Cerebral Arteries

(2009) Edouard Fonck et al.   STROKE

Lymphatic drainage of the brain and the pathophysiology of neurological disease

(2008) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease

(2008) E. P. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebral Cortical Arteriolar Angiopathy, Vascular Beta-Amyloid, Smooth Muscle Actin, Braak Stage, and APOE Genotype

(2008) Edward G. Stopa et al.   STROKE