期刊
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
卷 37, 期 8, 页码 556-562出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.urolonc.2018.10.010
关键词
Tumor-associated macrophages; Therapy development; Cancer; Tumor microenvironment
资金
- NIA NIH HHS [T32 AG000213] Funding Source: Medline
Tumor-associated macrophages (TAMs) regulate an array of tumor functions and have critical roles in both the progression and the eradication of cancer. Numerous therapies targeting TAMs are under development in cancer and many have demonstrated success at the preclinical and clinical levels. Most of these therapies fall within 3 main categories: systemic depletion of TAMs, inhibition of TAM recruitment and polarization, and promoting the antitumor functions of TAMs. In this article, the rationale behind these various therapies and approaches is reviewed along with supporting preclinical and clinical data. (C) 2018 Elsevier Inc. All rights reserved.
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