Article
Cell Biology
Qian Nie, Huimin Chen, Ming Zou, Ling Wang, Min Hou, Jia-Wen Xiang, Zhongwen Luo, Xiao-Dong Gong, Jia-Ling Fu, Yan Wang, Shu-Yu Zheng, Yuan Xiao, Yu-Wen Gan, Qian Gao, Yue-Yue Bai, Jing-Miao Wang, Lan Zhang, Xiang-Cheng Tang, Xuebin Hu, Lili Gong, Yizhi Liu, David Wan-Cheng Li
Summary: The protein PIAS1 plays a key role in regulating stress-induced lens pathogenesis by enhancing p53 transcription activity to promote Bax upregulation, thus facilitating stress-induced apoptosis in lens epithelial cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nutrition & Dietetics
Yebing Zhang, Haoyue Ding, Lei Xu, Suli Zhao, Shouna Hu, Aiguo Ma, Yan Ma
Summary: This study found that lutein supplementation can protect against male reproductive damage caused by excessive alcohol intake through its antioxidant, anti-inflammatory, and anti-apoptotic properties.
Article
Food Science & Technology
Luchen Wang, Lingmin Song, Juan Ma, Huimei Wang, Yingzhi Li, Danfei Huang
Summary: Alcohol has toxic effects on various organs, including the brain. Microglia cells in the brain may play a role in alcohol intoxication. This study demonstrated that alcohol alters autophagy levels or promotes apoptosis in microglia cells, providing insights into the mechanisms of alcohol neurotoxicity. The findings of this study may increase public awareness of alcohol's negative effects and contribute to the development of novel treatment approaches for alcoholism.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Mubashshir Ali, Heena Tabassum, M. Mumtaz Alam, Suhel Parvez
Summary: This study demonstrated that NAC exerts neuroprotective effects by targeting mitochondrial autophagy, regulating GSK-313/Drp1-mediated mitochondrial fission, inhibiting expression of beclin-1 and conversion of LC3, as well as activating the p-Akt pro-survival pathway to inhibit altered mitochondrial changes and cell death in I/R injury.
Article
Biochemistry & Molecular Biology
Yanan Li, Yaohong Zhu, Bingxin Chu, Ning Liu, Shiyan Chen, Jiufeng Wang, Yunjing Zou
Summary: This study found that EPEC targets mitochondria by secreting the Map virulence factor, inducing DRP-1-mediated mitochondrial fission, mitochondrial dysfunction, and endogenous apoptosis, leading to bovine mastitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Ya Feng, Tianjiao Li, Yin Li, Zhoujun Lin, Xiao Han, Xiaolin Pei, Yupeng Zhang, Fei Li, Juan Yang, Di Shao, Chenggang Li
Summary: This study identifies a novel redox-dependent mechanism in the pathogenesis of LAM and suggests that Glrx may potentially be a beneficial strategy for the treatment of LAM or other TSC-related diseases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Haruki Kitamura, Sayaka Sukegawa, Kouki Matsuda, Kousuke Tanimoto, Takuya Kobayakawa, Kazuho Takahashi, Hirokazu Tamamura, Kiyoto Tsuchiya, Hiroyuki Gatanaga, Kenji Maeda, Hiroaki Takeuchi
Summary: Combinational antiretroviral therapy (cART) successfully suppresses viral load but fails to eliminate HIV-1 reservoirs. "Shock and Kill" strategy using latently-reversing agents (LRAs) is being developed to reactivate latent HIV-1 and induce cell death. This study identified 4-phenylquinoline-8-amine (PQA) as a novel LRA candidate that effectively reactivated HIV-1 and induced cell death in latently-infected cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Pediatrics
Mete Akisu, Burak Durmaz, Ozge Altun Koroglu, Sema Unlubay, Mehmet Yalaz, Haluk Akin, Utku Ates, Meral Baka, Ferda Ozkinay, Ozgur Cogulu, Nilgun Kultursay
Summary: This study found that treatment with IGF-1 and EPO can reduce histological damage and apoptosis caused by H/R, increase telomerase activity, and enhance expression of antiapoptotic genes. These findings suggest that IGF-1 and EPO have protective effects in H/R-induced damage, potentially through regulating apoptosis and telomerase activity.
PEDIATRIC RESEARCH
(2021)
Article
Neurosciences
Saurav Bhowmick, Saleena Alikunju, P. M. Abdul-Muneer
Summary: This study aims to investigate the activation of TGF-beta 1 induced by ethanol and its associated mechanisms of neuroinflammation and apoptosis. The findings suggest that ethanol-induced activation of TGF-beta 1 impairs antioxidant signaling pathways and leads to neuroinflammation and apoptosis.
Article
Cell Biology
Gaiying Luo, Rui Wang, Hui Zhou, Xiaoling Liu
Summary: ALDOA protects cardiomyocytes from H/R-induced oxidative stress through the VEGF/Notch 1/Jagged 1 axis, potentially serving as a therapeutic target for the treatment of myocardial infarction in the future.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jiayu Li, Xifan Wang, Rongrong Zhou, Fei Cheng, Xueyang Tang, Jia Lao, Linben Xu, Wei He, Dan Wan, Hongliang Zeng, Shuihan Zhang
Summary: This study reveals the protective effect of polysaccharides on cell death in the central nervous system and its underlying mechanism. The results indicate that polysaccharides reduce ROS accumulation and ferroptosis through activation of the NRF2/HO-1 pathway, suggesting their potential for the treatment of CNS diseases.
Article
Medicine, Research & Experimental
Duojun Qiu, Shan Song, Yuhan Wang, Yawei Bian, Ming Wu, Haijiang Wu, Yonghong Shi, Huijun Duan
Summary: The study demonstrates that NQO1 plays a protective role against oxidative stress and apoptosis in diabetic nephropathy by regulating Sirt1 and increasing intracellular NAD+/NADH levels.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Xinghui Wang, Mengyao Zhu, Juan J. Loor, Qianming Jiang, Yiwei Zhu, Wei Li, Xiliang Du, Yuxiang Song, Wenwen Gao, Lin Lei, Jianguo Wang, Guowen Liu, Xinwei Li
Summary: The study aimed to investigate the impact of propionate supply on mitochondrial dysfunction, oxidative stress, and apoptosis in calf hepatocytes under high FFA load. The results demonstrated that propionate supply could alleviate mitochondrial dysfunction, oxidative stress, and apoptosis by upregulating PGC-1 alpha in FFA-treated calf hepatocytes.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Valeria Sogos, Paola Caria, Clara Porcedda, Rafaela Mostallino, Franca Piras, Cristina Miliano, Maria Antonietta De Luca, M. Paola Castelli
Summary: Novel psychoactive substances (NPS) are synthetic compounds designed to mimic the effects of scheduled drugs, but limited information is available on their pharmacology and toxicology. This study investigated the toxicity mechanisms of two emerging NPS and fentanyl, with results showing that they induce cell death through different pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Jing-Yi Liu, Yi-Chen Zhang, Rong-Rong Xie, Li-Ni Song, Wei-Li Yang, Zhong Xin, Xi Cao, Jin-Kui Yang
Summary: Nifu significantly improves cell vitality and insulin secretion function in high glucose-induced cells, inhibits oxidative stress and apoptosis factors, reduces inflammatory response, and suppresses the activation of the STAT3/SOCS3 signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Infectious Diseases
Nuria Monteagudo-Martinez, Julian Solis-Garcia del Pozo, Eduardo Nava, Ichiro Ikuta, Maria Galindo, Joaquin Jordan
Summary: Both single dose and two dose dalbavancin treatments are as effective as other antibiotics for the treatment of ABSSSIs, with two doses showing better outcomes in methicillin-resistant and methicillin-susceptible Staphylococcus aureus.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2022)
Article
Cell Biology
Marisol Cano, Sayantan Datta, Lei Wang, Tongyun Liu, Miguel Flores-Bellver, Mira Sachdeva, Debasish Sinha, James T. Handa
Summary: Studies have shown that Nrf2 deficiency affects mitochondrial antioxidant response and exacerbates mitochondrial dysfunction, leading to cell death. Furthermore, Nrf2 indirectly supplies NADPH through influencing PPP and IDH shuttle activity, which also impacts the pathobiology of AMD.
Review
Biochemistry & Molecular Biology
Luis Bonet-Ponce, Mark R. Cookson
Summary: Protein coding mutations in LRRK2 cause familial Parkinson's disease, while noncoding variations increase the risk of sporadic PD. These mutations increase LRRK2 kinase activity, influencing intracellular membrane trafficking.
Article
Cell Biology
Kang V. Li, Miguel Flores-Bellver, Silvia Aparicio-Domingo, Carson Petrash, Hannah Cobb, Conan Chen, M. Valeria Canto-Soler, Marc T. Mathias
Summary: Transplantation of stem cell-derived RPE cells is a promising therapy for retinal degenerative diseases. This study presents a set of clinically applicable devices for the subretinal implantation of RPE grafts. The devices demonstrated biocompatibility and high preservation of RPE transplants, and the surgical device allowed precise delivery of the transplants without causing damage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Victoria Valls-Belles, Cristina Abad, Maria Teresa Hernandez-Aguilar, Amalia Nacher, Carlos Guerrero, Pablo Balino, Francisco J. Romero, Maria Muriach
Summary: Mastitis can cause changes in the biochemical composition of human milk, especially in terms of oxidative status. Breast milk from mastitis-affected women shows increased antioxidant defense mechanisms, providing protection to newborns. However, oxidative damage in the mammary gland might still occur, and cranberries supplementation can improve the antioxidative state of milk.
Article
Multidisciplinary Sciences
Yaowu Qin, Jing Zhang, Savalan Babapoor-Farrokhran, Brooks Applewhite, Monika Deshpande, Haley Megarity, Miguel Flores-Bellver, Silvia Aparicio-Domingo, Tao Ma, Yuan Rui, Stephany Y. Tzeng, Jordan J. Green, M. Valeria Canto-Soler, Silvia Montaner, Akrit Sodhi
Summary: For patients with proliferative diabetic retinopathy (PDR) who do not respond adequately to pan-retinal laser photocoagulation (PRP) or anti-vascular endothelial growth factor (VEGF) therapies, targeting the HIF-2 alpha/PAI-1 axis may be an effective adjunct therapy for the treatment of PDR patients.
Article
Biochemistry & Molecular Biology
Maria Oltra, Miriam Martinez-Santos, Maria Ybarra, Hugo Rowland, Maria Muriach, Javier Romero, Javier Sancho-Pelluz, Jorge M. Barcia
Summary: Extracellular vesicles are released from cells and play major roles in various diseases, including cancer. Recent research has shown that oxidative damage can promote the release of small extracellular vesicles from the retinal pigment epithelium, leading to changes in angiogenesis and miRNA levels. This study aimed to investigate the role of miR-302a-3p, a specific miRNA found in these vesicles, in regulating angiogenesis in endothelial cell cultures.
Article
Neurosciences
Jillian H. Kluss, Luis Bonet-Ponce, Patrick A. Lewis, Mark R. Cookson
Summary: Coding mutations in the LRRK2 gene can lead to Parkinson's disease and increase the activity of LRRK2. Lysosomal membrane damage is one mechanism of LRRK2 activation, but it is unclear if activation can occur at other membranes or without membrane damage.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Cell Biology
Luis Bonet-Ponce, Mark R. Cookson
Summary: Lysosomes can form and sort tubules as a response to membrane damage, a process named LYTL. The protein LRRK2 promotes tubulation by recruiting the motor adaptor protein JIP4, and contact with tubular endoplasmic reticulum is necessary for lysosomal membrane sorting. These findings have implications for Parkinson's disease pathology and highlight organelle interactions in this model.
MOLECULAR BIOLOGY OF THE CELL
(2022)
Article
Multidisciplinary Sciences
Jillian H. Kluss, Alexandra Beilina, Chad D. Williamson, Patrick A. Lewis, Mark R. Cookson, Luis Bonet-Ponce
Summary: The activation mechanism and cellular consequences of LRRK2 on endolysosomal membranes are still poorly understood. This study found that directing LRRK2 to lysosomes and early endosomes triggers autophosphorylation of LRRK2 and phosphorylation of its substrates Rab10 and Rab12. Lysosomal positioning provides additional regulation of LRRK2-mediated Rab phosphorylation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, Research & Experimental
Jing Zhang, Deepti Sharma, Aumreetam Dinabandhu, Jaron Sanchez, Brooks Applewhite, Kathleen Jee, Monika Deshpande, Miguel Flores-Bellver, Ming-Wen Hu, Chuanyu Guo, Shaima Salman, Yousang Hwang, Nicole M. Anders, Michelle A. Rudek, Jiang Qian, M. Valeria Canto-Soler, Gregg L. Semenza, Silvia Montaner, Akrit Sodhi
Summary: Many diabetic eye disease patients do not respond well to anti-VEGF therapies, indicating involvement of other vasoactive mediators in its development. Despite anti-VEGF treatment, levels of angiogenic proteins regulated by HIF-1 and -2 remain elevated in diabetic eyes. However, inhibiting HIFs restored the expression of vasoactive mediators to normal in diabetic mice, suggesting that targeting HIFs may be an effective early treatment for diabetic retinopathy.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, Research & Experimental
Jing Zhang, Yaowu Qin, Mireya Martinez, Miguel Flores-Bellver, Murilo Rodrigues, Aumreetam Dinabandhu, Xuan Cao, Monika Deshpande, Yu Qin, Silvia Aparicio-Domingo, Yuan Rui, Stephany Y. Tzeng, Shaima Salman, Jin Yuan, Adrienne W. Scott, Jordan J. Green, M. Valeria Canto-Soler, Gregg L. Semenza, Silvia Montaner, Akrit Sodhi
Summary: Therapies targeting VEGF have limited effectiveness for treating proliferative sickle cell retinopathy (PSR), the leading cause of blindness in sickle cell disease patients. Increased expression of HIF-1 alpha and HIF-2 alpha in the ischemic inner retina of PSR eyes was observed. While both HIFs promote VEGF expression, only HIF-1 is sufficient to promote retinal neovascularization in mice. Inhibiting either HIF-1 or HIF-2 is effective for preventing retinal neovascularization in mice, but targeting both will be necessary for preventing NV in patients with PSR.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Biochemistry & Molecular Biology
M. T. Ciubuc-Batcu, N. J. C. Stapelberg, J. P. Headrick, G. M. C. Renshaw
Summary: The nervous system relies on mitochondria, and impaired mitochondrial function is associated with major depressive disorder. Modulating mitochondrial function may be a therapeutic target for treating MDD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Correction
Biochemistry & Molecular Biology
Saowaluk Saisomboon, Ryusho Kariya, Piyanard Boonnate, Kanlayanee Sawanyawisuth, Ubon Cha'on, Vor Luvira, Yaovalux Chamgramol, Chawalit Pairojkul, Wunchana Seubwai, Atit Silsirivanit, Sopit Wongkham, Seiji Okada, Sarawut Jitrapakdee, Kulthida Vaeteewoottacharn
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Pavan Thapak, Zhe Ying, Victoria Palafox-Sanchez, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla
Summary: Traumatic brain injury (TBI) impairs cellular energy demand, compromising neuronal function and plasticity. This study demonstrates that the mitochondrial activator humanin (HN) can counteract the reduction in mitochondrial bioenergetics caused by TBI, restore memory function and synaptic protein levels, and suppress inflammation and astrocyte proliferation. HN plays an integral role in normalizing fundamental aspects of TBI pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Paul Murphy, Valeria A. Buzinova, Carrie E. Johnson
Summary: Progress has been made in the treatment of Alzheimer's disease through the development of anti-A beta therapeutics, which have shown modest efficacy in slowing the progression of the disease. However, the puzzling issue remains as to why completely removing A beta does not fully stop the disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Mengxin Li, Xuanzhong Wang, Xuyang Chen, Jinghui Hong, Ye Du, Dong Song
Summary: Pancreatic adenocarcinoma (PAAD) is a common digestive malignant tumor with limited treatment options. This study demonstrates that TGM2 may serve as a marker for treatment and prognosis in pancreatic cancer patients. Co-treatment of low dose cisplatin (DDP) and the TGM2 inhibitor GK921 effectively inhibits PAAD cell viability and proliferation in vitro and in vivo, by inhibiting epithelial-to-mesenchymal transition (EMT) induced by TGM2 and enhancing cell cycle arrest and apoptosis caused by DDP. These findings suggest that the combination of GK921 and DDP holds promise as a treatment for PAAD patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Liaoran Niu, Qi Wang, Fan Feng, Wanli Yang, Zhenyu Xie, Gaozan Zheng, Wei Zhou, Lili Duan, Kunli Du, Yiding Li, Ye Tian, Junfeng Chen, Qibin Xie, Aqiang Fan, Hanjun Dan, Jinqiang Liu, Daiming Fan, Liu Hong, Jian Zhang, Jianyong Zheng
Summary: This review provides a comprehensive summary of the interaction between cancer cells and macrophages in the tumor microenvironment, and discusses the role of small extracellular vesicles (sEVs) in this process. It also explores the various effects of macrophage-secreted sEVs on tumor malignant transformation, and addresses the therapeutic advancements and challenges associated with these vesicles.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Neha Sawant, Sudhir Kshirsagar, P. Hemachandra Reddy, Arubala P. Reddy
Summary: Depression is a common neuropsychiatric comorbidity in Alzheimer's disease (AD) and other Tauopathies. Selective serotonin reuptake inhibitor (SSRI) treatment, such as Citalopram, not only has anti-depressive and anxiolytic effects, but also helps improve neurogenesis, reduce amyloid burden & Tau pathologies, and neuroinflammation in AD. In this study, Citalopram was found to reduce pathologically pTau level, increase synaptic gene expression and cytoskeletal structure, as well as improve cell survival, mitochondrial respiration, and mitochondrial morphology in cells expressing mutant APP and Tau. These findings suggest that Citalopram could be a promising therapeutic drug for treating depression and AD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Chen, Jiulin Tan, Chuan Yang, Zhiguo Ling, Jianzhong Xu, Dong Sun, Fei Luo
Summary: Bone is a self-healing organ that undergoes continuous regeneration through the cooperation of osteoclasts and osteoblasts. This study used ATAC-seq and RNA-Seq techniques to investigate the chromatin accessibility and transcriptomic landscape of osteoblast differentiation and mineralization. The results showed that global chromatin accessibility was extensively improved during osteoblastogenesis. Additionally, several transcription factors including MEF2A, PRRX1, Shox2, and HOXB13 were found to modulate the promoter accessibility of target genes during osteoblast differentiation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang
Summary: The study demonstrates that BCAA metabolism is involved in the development of colorectal cancer (CRC). BCAT2 deficiency promotes CRC progression by inhibiting BCAA metabolism and chronically activating the mTORC1 pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Chao Zheng, Lingling Liu, Caiyun Liu, Fengna Chu, Yue Lang, Shan Liu, Yan Mi, Jie Zhu, Tao Jin
Summary: Inducing tolerogenic dendritic cells (tDCs) with low RelB expression could effectively alleviate symptoms and reduce immune cell infiltration and demyelination in experimental autoimmune encephalomyelitis (EAE) mouse model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Hang Lam Li, Simei Go, Jung-Chin Chang, Arthur Verhoeven, Ronald Oude Elferink
Summary: This review highlights the distinct characteristics and crucial role of soluble adenylyl cyclase (sAC) in cellular processes, as well as recent significant advancements in the field of sAC research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Seco-Cervera, D. Ortiz-Masia, D. C. Macias-Ceja, S. Coll, L. Gisbert-Ferrandiz, J. Cosin-Roger, C. Bauset, M. Ortega, B. Heras-Moran, F. Navarro-Vicente, M. Millan, J. V. Esplugues, S. Calatayud, M. D. Barrachina
Summary: The study revealed the presence of resistance to apoptosis in complicated ileal Crohn's disease, with PDGFB inducing an ETS1-mediated resistance to apoptosis associated with an inflammatory and fibrogenic pattern of expression in intestinal fibroblasts. Potential targets against ileal fibrosis include PDGFRB, IL1R1, or MCL1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yunmeng Wang, Ping Cheng
Summary: Oncolytic viruses (OVs) are emerging as therapeutically relevant anticancer agents, especially when combined with genetically modified bispecific T cell engagers (BiTEs). This combination strategy can overcome the limitations of BiTEs alone and provide targeted cytotoxicity to solid tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Stephanie Tannous, Hassan Y. Naim
Summary: Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder caused by variants in the SI gene. A frameshift mutation called c.273_274delAG (p.Gly92Leufs*8) has been identified in CSID patients in Greenlandic population, which leads to loss of digestive function of SI. Surprisingly, the truncated mutant can still be located on the cell surface and interacts with wild type SI, negatively affecting its enzymatic function. Furthermore, heterozygote carriers of this mutation may also exhibit CSID symptoms.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)