期刊
TRENDS IN BIOTECHNOLOGY
卷 37, 期 4, 页码 402-415出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2018.10.001
关键词
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资金
- German Research Foundation (DFG) [EL 135/12-1]
- EU-COST actions [CA15135, CA16225, CA16122]
- MEYS, the Ministry of Education, Youth and Sports of the Czech Republic [LTC17005, LTC18038, LTC18041]
- Czech Science Foundation [18-01163S]
Cellular communication events are mediated by interactions between cell-surface sugars and lectins, which are carbohydrate-binding proteins. Galectins are beta-galactosyl-binding lectins that bridge molecules by their sugar moieties, forming a signaling and adhesion network. Severe changes in glycosylation and galectin expression accompany major processes in oncogenesis, cardiovascular disorders, and other pathologies, making galectins attractive therapeutic targets. Here we discuss advanced strategies of chemo-enzymatic carbohydrate synthesis for creating lead glycomimetics and (neo-) glycoconjugates for galectin-1 and -3 targeting in biomedicine and biotechnology. We will describe the challenges and bottlenecks on the route into biomedical and biotechnological practice and present the first clinical candidates. The coming era will see an exciting translation of selective well-defined high-affinity galectin ligands from bench to bedside.
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